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Observation Reduces CT Use in Pediatric Blunt Abdominal Trauma Without Missing Critical Injuries
Posted inEmergency Medicine news Pediatrics Radiology

Observation Reduces CT Use in Pediatric Blunt Abdominal Trauma Without Missing Critical Injuries

Posted by MedXY By MedXY 04/21/2026
A multicenter study shows that observation with deferred CT decision-making significantly reduces CT use in children with blunt abdominal trauma, particularly in cases with intermediate clinician suspicion, without increasing missed injuries.
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Digital Mental Health Interventions Show Promise for Black and Female Health Care Workers
Posted innews Psychiatry Public Health

Digital Mental Health Interventions Show Promise for Black and Female Health Care Workers

Posted by MedXY By MedXY 04/21/2026
A proactive digital mental health platform improved mental health outcomes for health care workers, with notable benefits for Black and female participants in work productivity and sustained depression reduction.
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Produce Prescription for Diabetes Falls Short in Improving Health Outcomes
Posted inDiabetes & Endocrinology news Public Health

Produce Prescription for Diabetes Falls Short in Improving Health Outcomes

Posted by MedXY By MedXY 04/21/2026
A randomized trial found that a $80 monthly produce prescription did not significantly improve HbA1c levels or reduce healthcare utilization in diabetic patients at risk of food insecurity.
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AI vs. Human Clinicians: Study Reveals Gaps in AI-Generated Clinical Notes
Posted inAI Family Medicine & Nutrition news

AI vs. Human Clinicians: Study Reveals Gaps in AI-Generated Clinical Notes

Posted by MedXY By MedXY 04/21/2026
A cross-sectional evaluation of AI-generated clinical notes found significant quality deficits compared to human-produced notes, particularly in thoroughness, organization, and usefulness.
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Blast-Phase MPNs: One-Third Achieve Long-Term Survival with Allogeneic Transplantation
Posted inHematology-Oncology Internal Medicine news

Blast-Phase MPNs: One-Third Achieve Long-Term Survival with Allogeneic Transplantation

Posted by MedXY By MedXY 04/21/2026
Allogeneic hematopoietic stem cell transplantation offers a potential cure for blast-phase myeloproliferative neoplasms, with one-third of patients achieving long-term survival. Key factors influencing outcomes include TP53 mutations and peripheral blast burden.
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Lenalidomide-Rituximab vs. Lenalidomide-Rituximab-Bendamustine in Relapsed/Refractory Follicular Lymphoma: A Phase II Showdown
Posted inHematology-Oncology news

Lenalidomide-Rituximab vs. Lenalidomide-Rituximab-Bendamustine in Relapsed/Refractory Follicular Lymphoma: A Phase II Showdown

Posted by MedXY By MedXY 04/21/2026
The HOVON110/ReBeL study compares R2 and R2B regimens in R/R FL, revealing comparable efficacy but higher toxicity with bendamustine addition. Despite low CT-based CR rates, R2B showed numerically better EFS and OS.
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Breaking Ferroptosis Resistance: PRMT5 Inhibition Emerges as a Game-Changer in B-Cell Lymphoma Therapy
Posted inHematology-Oncology news Oncology

Breaking Ferroptosis Resistance: PRMT5 Inhibition Emerges as a Game-Changer in B-Cell Lymphoma Therapy

Posted by MedXY By MedXY 04/21/2026
PRMT5 inhibition sensitizes B-cell lymphomas to ferroptosis by disrupting the PRMT5-ATF5-SLC7A11 axis, offering a novel therapeutic strategy for relapsed or refractory disease.
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New Statistical Model Predicts Chronic ITP in Children at Diagnosis
Posted inHematology-Oncology news Pediatrics Public Health

New Statistical Model Predicts Chronic ITP in Children at Diagnosis

Posted by MedXY By MedXY 04/21/2026
A novel statistical model predicts chronic immune thrombocytopenia (ITP) in children at diagnosis, using age, sex, immunoglobulin levels, and lab values, offering early clinical guidance.
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Association of Deep Optic Nerve Head Structural Remodeling with Choroidal Microvasculature Dropout in Glaucoma with and without Myopia
Posted innews Ophthalmology

Association of Deep Optic Nerve Head Structural Remodeling with Choroidal Microvasculature Dropout in Glaucoma with and without Myopia

Posted by MedXY By MedXY 04/21/2026
Study reveals significant links between optic nerve head structural changes and choroidal microvascular dropout in glaucomatous eyes, particularly in myopia. Deep structural parameters like neural canal geometry strongly correlate with microvascular damage severity.
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Open Globe Repair Carries the Highest Endophthalmitis Risk, and Pediatric Cataract Surgery Outpaces Adult Surgery in IRIS Registry Data
Posted innews Ophthalmology Pediatrics

Open Globe Repair Carries the Highest Endophthalmitis Risk, and Pediatric Cataract Surgery Outpaces Adult Surgery in IRIS Registry Data

Posted by MedXY By MedXY 04/21/2026
An IRIS Registry analysis of 17.5 million procedures found endophthalmitis was rare overall but highest after open globe repair, with pediatric cataract surgery carrying more risk than adult surgery.
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Amivantamab Falls Short of Tumor Shrinkage in Recurrent or Metastatic Adenoid Cystic Carcinoma, but Disease Stabilization Was Common
Posted inHematology-Oncology news Otorhinolaryngology

Amivantamab Falls Short of Tumor Shrinkage in Recurrent or Metastatic Adenoid Cystic Carcinoma, but Disease Stabilization Was Common

Posted by MedXY By MedXY 04/20/2026
In a phase 2 trial, amivantamab did not meet its primary response endpoint in recurrent/metastatic adenoid cystic carcinoma, but most patients achieved stable disease and toxicity was generally manageable.
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Cartilage Ear Piercings Carry Nearly Double the Complication Risk of Lobule Piercings in a Large Adult Survey
Posted innews Otorhinolaryngology Public Health

Cartilage Ear Piercings Carry Nearly Double the Complication Risk of Lobule Piercings in a Large Adult Survey

Posted by MedXY By MedXY 04/20/2026
In a large survey of adult ear piercings, auricular cartilage piercings had higher complication and removal rates than lobule piercings, reinforcing the need for careful counseling and informed consent.
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Adequate Lymph Node Dissection May Carry a Survival Signal in Intrahepatic Cholangiocarcinoma
Posted inGeneral Surgery news Oncology

Adequate Lymph Node Dissection May Carry a Survival Signal in Intrahepatic Cholangiocarcinoma

Posted by MedXY By MedXY 04/20/2026
An updated meta-analysis suggests lymph node dissection in intrahepatic cholangiocarcinoma may improve survival when it is truly adequate, especially when at least six nodes are retrieved and confounding is reduced.
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腹腔鏡と開腹手術による小腸閉塞癒着剥離の長期転帰:LASSO無作為化臨床試験
Posted inGastroenterology General Surgery news

腹腔鏡と開腹手術による小腸閉塞癒着剥離の長期転帰:LASSO無作為化臨床試験

Posted by MedXY By MedXY 04/20/2026
小腸閉塞手術における腹腔鏡アプローチは短期回復が早いが、5年間の追跡調査では再発率、ヘルニア発生率、QOLにおいて開腹手術と同等の結果を示した。術式選択は患者個別の要因に基づくべきである。
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Maryland’s Global Budget Revenue Model Was Linked to Better Cancer Surgery Outcomes and Lower Medicare Spending
Posted innews Public Health Urology

Maryland’s Global Budget Revenue Model Was Linked to Better Cancer Surgery Outcomes and Lower Medicare Spending

Posted by MedXY By MedXY 04/20/2026
In a large Medicare study, hospitals under Maryland’s global budget model showed modest but significant improvements in cancer surgery outcomes, driven by fewer complications and shorter stays, with lower inpatient spending.
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Prophylactic Antibiotics Did Not Significantly Reduce Infection After Vulvar Surgery, Cohort Study Finds
Posted innews OB/GYN & Women’s Health Oncology

Prophylactic Antibiotics Did Not Significantly Reduce Infection After Vulvar Surgery, Cohort Study Finds

Posted by MedXY By MedXY 04/20/2026
In a prospective cohort of 172 vulvar surgery patients, prophylactic antibiotics were not associated with fewer postoperative infections or complications, supporting the need for a randomized trial.
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OCE-205 Signals a Potential New Direction for Hepatorenal Syndrome-AKI, with Tolerability at the Center
Posted inGastroenterology Nephrology news

OCE-205 Signals a Potential New Direction for Hepatorenal Syndrome-AKI, with Tolerability at the Center

Posted by MedXY By MedXY 04/20/2026
In a phase 2 randomized trial, OCE-205 improved HRS-AKI in more patients than placebo and showed no excess ischemic or respiratory toxicity, but the study was underpowered after early termination.
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A Blood-Based Extracellular Vesicle RNA Signature May Offer a New Way to Diagnose Chronic Pancreatitis
Posted inGastroenterology news Pathology & Lab Medicine/Bệnh học

A Blood-Based Extracellular Vesicle RNA Signature May Offer a New Way to Diagnose Chronic Pancreatitis

Posted by MedXY By MedXY 04/20/2026
A five-RNA extracellular vesicle signature showed strong diagnostic performance for chronic pancreatitis and may also reflect acinar-to-ductal metaplasia and disease-related metabolic features.
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Even the Largest Stroke Cores May Benefit from Thrombectomy, LASTE Ancillary Analysis Suggests
Posted inNeurology news Radiology

Even the Largest Stroke Cores May Benefit from Thrombectomy, LASTE Ancillary Analysis Suggests

Posted by MedXY By MedXY 04/19/2026
In patients aged under 80 with ASPECTS 0-2, endovascular thrombectomy improved disability outcomes and reduced mortality versus medical care alone, challenging the idea that very large infarcts should automatically exclude treatment.
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Corticostriatal Connectivity Reorganizes Before and After Motor Decline in Parkinson Disease
Posted inNeurology news

Corticostriatal Connectivity Reorganizes Before and After Motor Decline in Parkinson Disease

Posted by MedXY By MedXY 04/19/2026
Resting-state MRI and PET data suggest that corticostriatal networks remodel across nigrostriatal degeneration in Parkinson disease, with posterior caudate hyperconnectivity preceding major motor decline and posterior putaminal disconnection tracking symptom worsening.
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  • CD276 Identified as Key Driver of Chemoresistance in Advanced Pancreatic Cancer
  • Intracranial Hemorrhage Patterns and Outcomes in Minor Stroke: Insights from the TEMPO-2 Trial
  • Superior Efficacy of Cenobamate in Drug-Resistant Focal Epilepsy: Real-World Evidence
  • Microplastics in Human Thyroid: A Potential Trigger for Autoimmune Thyroiditis
  • Ethnicity, Migration, and Mental Health: Independent Risk Factors Persist in Type 2 Diabetes Disparities
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