randomized controlled trial

Nonopioid vs Opioid Pain Management After Laparoscopic Hysterectomy: A Noninferiority Randomized Trial

By MedXY 08/06/2026

A recent randomized controlled trial demonstrates that nonopioid analgesia is noninferior to routine opioid prescribing for pain control after minimally invasive hysterectomy, with high patient satisfaction and markedly reduced opioid use.

General Surgery news OB/GYN & Women’s Health

Decade-Long Outcomes of Surgical Options in Rectal Endometriosis: Insights from a Robust Randomized Trial

By MedXY 07/16/2026

A 10-year follow-up of a randomized trial comparing conservative nodule excision with segmental resection for rectal endometriosis reveals comparable long-term functional outcomes, low recurrence rates, and sustained symptomatic relief.

Cardiology news

ORBITA-CTO Trial: Evaluating the Impact of Percutaneous Coronary Intervention on Symptomatic Chronic Total Occlusion in Stable Angina

By MedXY 07/14/2026

The ORBITA-CTO multicenter, randomized, placebo-controlled trial demonstrates that PCI significantly improves angina symptoms and quality of life in patients with single-vessel CTO without bystander disease, compared to placebo.

Anesthesiology Clinical Updates news

WAFER Trial and Beyond: Comparative Efficacy and Pragmatic Implications of WALANT versus General and Regional Anesthesia in Flexor Tendon Repair

By MedXY 07/12/2026

This review synthesizes evidence from the WAFER trial and related studies comparing WALANT to GA/RA in flexor tendon repair, highlighting functional outcomes, safety, cost-effectiveness, and patient-centered benefits including earlier return to work.

Clinical Updates news Psychiatry

Integrating Trauma-Focused Therapy with Cognitive Behavioural Therapy for Psychosis: Insights from the STAR Trial and Related Research

By MedXY 07/12/2026

The STAR trial demonstrates that trauma-focused CBTp is a safe, effective intervention for adults with co-occurring PTSD and psychosis, improving PTSD and psychosis symptoms, with high acceptability and minimal adverse events.

Cardiology Clinical Updates Family Medicine & Nutrition news

Two Years of Menaquinone-7 Supplementation Attenuates Coronary Artery Calcification Progression: Evidence from Randomized Clinical Trials

By MedXY 07/04/2026

Menaquinone-7 (MK-7) supplementation over two years significantly slows progression of coronary artery calcification (CAC) in symptomatic coronary artery disease patients, with favorable safety and potential implications for plaque stabilization.

Diabetes & Endocrinology Internal Medicine news

Evaluating Sleep Optimization for Glycemic Control in Adults with Type 1 Diabetes: Insights from a Randomized Controlled Trial

By MedXY 07/03/2026

A 12-week randomized trial explored sleep optimization in adults with type 1 diabetes, revealing improved sleep quality and reduced diabetes distress but limited glycemic benefits except in patients with baseline A1C ≥7%.

Neurology news

ENTF Neuromodulation Significantly Enhances Recovery and Reduces Disability After Stroke: Insights from a Pooled Meta-Analysis

By MedXY 07/01/2026

A pooled individual participant data meta-analysis demonstrates that Electromagnetic Network-Targeted Field (ENTF) neuromodulation significantly improves freedom-from-disability and reduces poststroke disability compared to sham treatment, without safety concerns.

Gastroenterology Internal Medicine news

Evaluating Telehealth Stepped Alcohol Treatment to Reduce Alcohol Use in Chronic Liver Disease: Insights from a 2026 Randomized Controlled Trial

By MedXY 06/27/2026

A 2026 RCT assessed telehealth stepped alcohol treatment in chronic liver disease patients, finding significant reductions in weekly alcohol consumption but no difference in achieving moderate drinking levels compared to usual care.

Gastroenterology news Pathology & Lab Medicine

Assessing the Impact of Proactive Home Fecal Calprotectin Monitoring in Ulcerative Colitis: Insights from a Prospective RCT

By MedXY 06/25/2026

A multicenter RCT shows proactive home fecal calprotectin monitoring without protocolized treatment escalation does not reduce symptomatic flares in ulcerative colitis remission. More research is needed to optimize biomarker-guided management.

Clinical Updates news Otorhinolaryngology

Digital Vestibular Rehabilitation After Acute Vertigo: What a Negative Superiority Trial Means

By MedXY 06/16/2026

A 2026 PLOS One superiority trial found that internet-based vestibular rehabilitation was not superior to structured written instructions after acute vertigo. The result is clinically useful because the comparator was active, adherence was high, and safety was reassuring.

Cardiology Clinical Updates news

Rethinking Magnesium Prophylaxis for Postoperative Atrial Fibrillation in Cardiac Surgery: A Synthesis of Clinical Evidence

By MedXY 06/02/2026

Recent high-quality randomized clinical trials and meta-analyses suggest that routine magnesium sulfate infusion does not effectively prevent postoperative atrial fibrillation in cardiac surgery, especially when used alongside standard beta-blocker protocols.

Gastroenterology news

Urgent versus early ERCP in mild-to-moderate acute cholangitis: what the trial found

By MedXY 05/28/2026

In mild-to-moderate acute cholangitis, ERCP within 24 hours did not improve mortality or organ-failure outcomes versus ERCP within 24–48 hours, and it was linked to more procedure-related adverse events.

news OB/GYN & Women’s Health

Vaginal Hysterectomy Versus Vaginal Assisted Natural Orifice Transluminal Endoscopic Surgery Hysterectomy: Results of a Randomized Controlled Trial

By MedXY 05/18/2026

A randomized trial found vaginal assisted NOTES hysterectomy improved same-day discharge, operative time, and blood loss versus standard vaginal hysterectomy, without increasing complications or affecting recovery.

Diabetes & Endocrinology news

Preventing Severe Hypoglycemia in Type 2 Diabetes: Randomized Trial of Proactive Care With or Without Psychoeducation

By MedXY 05/15/2026

A randomized trial in high-risk adults with type 2 diabetes found that proactive nurse-led care reduced severe hypoglycemia by about 50%, while adding psychoeducation did not significantly improve outcomes further.

news OB/GYN & Women’s Health

Six Hours May Be Enough for Intrauterine Balloon Tamponade After Postpartum Hemorrhage

By MedXY 05/13/2026

A randomized trial found that 6 hours of intrauterine balloon tamponade was noninferior to 18 hours for controlling postpartum hemorrhage after vaginal delivery, suggesting earlier removal may be reasonable in stable patients.

Diabetes & Endocrinology news

Real-Time CGM Outperforms SMBG in Glycemic Control for Type 2 Diabetes on Basal Insulin Plus Modern Therapies

By MedXY 04/29/2026

The FreeDM2 trial demonstrates that real-time CGM significantly improves HbA1c levels compared to SMBG in adults with type 2 diabetes on basal insulin and modern therapies, with sustained benefits over 32 weeks.

Neurology news Respiratory

Proximal Hypoglossal Nerve Stimulation Shows Promise for Moderate-to-Severe OSA in Landmark OSPREY Trial

By MedXY 04/24/2026

A recent randomized controlled trial demonstrates that proximal hypoglossal nerve stimulation significantly improves obstructive sleep apnea symptoms in patients intolerant to positive airway pressure therapy.

Cardiology news Pediatrics

Prophylactic Acetaminophen Fails to Improve Intact Survival in Preterm Infants: Lessons from the TREOCAPA Trial

By MedXY 02/20/2026

The TREOCAPA randomized clinical trial demonstrates that while prophylactic intravenous acetaminophen effectively promotes patent ductus arteriosus closure in extremely preterm infants, it does not significantly increase survival without severe neonatal morbidities at 36 weeks' postmenstrual age.

news Pediatrics Public Health

Why Environmental Interventions in Childcare May Not Be Enough: Insights from the NAPSACC UK Trial

By MedXY 02/17/2026

The NAPSACC UK cluster RCT found that a one-year environmental intervention in early childhood education settings did not significantly improve total energy consumption or physical activity, highlighting the need for broader policy-level changes over individual setting-based initiatives.