randomized controlled trial

Evaluating Telehealth Stepped Alcohol Treatment to Reduce Alcohol Use in Chronic Liver Disease: Insights from a 2026 Randomized Controlled Trial

By MedXY 06/27/2026

A 2026 RCT assessed telehealth stepped alcohol treatment in chronic liver disease patients, finding significant reductions in weekly alcohol consumption but no difference in achieving moderate drinking levels compared to usual care.

Gastroenterology news Pathology & Lab Medicine

Assessing the Impact of Proactive Home Fecal Calprotectin Monitoring in Ulcerative Colitis: Insights from a Prospective RCT

By MedXY 06/25/2026

A multicenter RCT shows proactive home fecal calprotectin monitoring without protocolized treatment escalation does not reduce symptomatic flares in ulcerative colitis remission. More research is needed to optimize biomarker-guided management.

Clinical Updates news Otorhinolaryngology

Digital Vestibular Rehabilitation After Acute Vertigo: What a Negative Superiority Trial Means

By MedXY 06/16/2026

A 2026 PLOS One superiority trial found that internet-based vestibular rehabilitation was not superior to structured written instructions after acute vertigo. The result is clinically useful because the comparator was active, adherence was high, and safety was reassuring.

Cardiology Clinical Updates news

Rethinking Magnesium Prophylaxis for Postoperative Atrial Fibrillation in Cardiac Surgery: A Synthesis of Clinical Evidence

By MedXY 06/02/2026

Recent high-quality randomized clinical trials and meta-analyses suggest that routine magnesium sulfate infusion does not effectively prevent postoperative atrial fibrillation in cardiac surgery, especially when used alongside standard beta-blocker protocols.

Gastroenterology news

Urgent versus early ERCP in mild-to-moderate acute cholangitis: what the trial found

By MedXY 05/28/2026

In mild-to-moderate acute cholangitis, ERCP within 24 hours did not improve mortality or organ-failure outcomes versus ERCP within 24–48 hours, and it was linked to more procedure-related adverse events.

news OB/GYN & Women’s Health

Vaginal Hysterectomy Versus Vaginal Assisted Natural Orifice Transluminal Endoscopic Surgery Hysterectomy: Results of a Randomized Controlled Trial

By MedXY 05/18/2026

A randomized trial found vaginal assisted NOTES hysterectomy improved same-day discharge, operative time, and blood loss versus standard vaginal hysterectomy, without increasing complications or affecting recovery.

Diabetes & Endocrinology news

Preventing Severe Hypoglycemia in Type 2 Diabetes: Randomized Trial of Proactive Care With or Without Psychoeducation

By MedXY 05/15/2026

A randomized trial in high-risk adults with type 2 diabetes found that proactive nurse-led care reduced severe hypoglycemia by about 50%, while adding psychoeducation did not significantly improve outcomes further.

news OB/GYN & Women’s Health

Six Hours May Be Enough for Intrauterine Balloon Tamponade After Postpartum Hemorrhage

By MedXY 05/13/2026

A randomized trial found that 6 hours of intrauterine balloon tamponade was noninferior to 18 hours for controlling postpartum hemorrhage after vaginal delivery, suggesting earlier removal may be reasonable in stable patients.

Diabetes & Endocrinology news

Real-Time CGM Outperforms SMBG in Glycemic Control for Type 2 Diabetes on Basal Insulin Plus Modern Therapies

By MedXY 04/29/2026

The FreeDM2 trial demonstrates that real-time CGM significantly improves HbA1c levels compared to SMBG in adults with type 2 diabetes on basal insulin and modern therapies, with sustained benefits over 32 weeks.

Neurology news Respiratory

Proximal Hypoglossal Nerve Stimulation Shows Promise for Moderate-to-Severe OSA in Landmark OSPREY Trial

By MedXY 04/24/2026

A recent randomized controlled trial demonstrates that proximal hypoglossal nerve stimulation significantly improves obstructive sleep apnea symptoms in patients intolerant to positive airway pressure therapy.

Cardiology news Pediatrics

Prophylactic Acetaminophen Fails to Improve Intact Survival in Preterm Infants: Lessons from the TREOCAPA Trial

By MedXY 02/20/2026

The TREOCAPA randomized clinical trial demonstrates that while prophylactic intravenous acetaminophen effectively promotes patent ductus arteriosus closure in extremely preterm infants, it does not significantly increase survival without severe neonatal morbidities at 36 weeks' postmenstrual age.

news Pediatrics Public Health

Why Environmental Interventions in Childcare May Not Be Enough: Insights from the NAPSACC UK Trial

By MedXY 02/17/2026

The NAPSACC UK cluster RCT found that a one-year environmental intervention in early childhood education settings did not significantly improve total energy consumption or physical activity, highlighting the need for broader policy-level changes over individual setting-based initiatives.

news Orthopedics Pediatrics

Surgical Fixation Offers No Clinical Benefit and Zero Cost-Effectiveness for Pediatric Medial Epicondyle Fractures: Results from the SCIENCE Trial

By MedXY 02/16/2026

The SCIENCE multicentre randomized trial demonstrates that surgical fixation for displaced medial epicondyle fractures in children provides no functional advantage over non-surgical care, carries higher complication risks, and is not a cost-effective use of healthcare resources.

Diabetes & Endocrinology news Public Health

The Sweet Tooth Trial: Evidence Challenges the Assumption That Lowering Exposure Reduces Sweet Taste Liking

By MedXY 02/04/2026

A 6-month randomized controlled trial reveals that varying dietary sweet taste exposure does not alter sweet taste liking, energy intake, or body weight, questioning the efficacy of public health recommendations to reduce sweet exposure for palate retraining.

Orthopedics Rehabilitation Medicine

Enhanced Exercise Rehabilitation via Tailored Adherence Support Improves Outcomes in Vertebral Fragility Fractures: Insights from the OPTIN Randomised Controlled Trial

By MedXY 10/24/2025

Integrating tailored adherence support into exercise rehabilitation for vertebral fragility fractures significantly improves functional mobility and walking capacity compared to standard exercise alone at 12 months.

Family Medicine & Nutrition Neurology Nursing & care Specialties

Evaluating Combined Mind-Body Exercise, Cognitive Training, and Nurse-Led Risk Factor Modification in Mild Cognitive Impairment: Insights from a Three-Arm Randomized Controlled Trial

By MedXY 10/20/2025

A large RCT in primary care showed no significant cognitive benefits of a combined intervention integrating mind-body physical exercise, cognitive training, and nurse-led risk factor modification over nurse-led risk factor modification alone or general health advice in mild cognitive impairment. Future refinements and research are needed.

Neurology news Public Health

Iyengar Yoga and Fall Risk in Older Adults: Unexpected Outcomes from a Rigorous RCT

By MedXY 10/20/2025

A large randomized controlled trial found that an Iyengar yoga-based exercise program increased fall rates among older adults compared to seated relaxation yoga, despite improvements in physical activity and balance confidence, highlighting the need for modified fall prevention yoga programs.

OB/GYN & Women's Health Psychiatry Specialties

Evaluating the Effectiveness of Circle of Security-Parenting for Perinatal Mental Health: Insights from a Large-Scale RCT

By MedXY 10/18/2025

This study finds no significant benefit of the Circle of Security-Parenting intervention added to usual care for improving mental health and bonding among new parents in NHS settings.

General Surgery Neurology news

Efficacy and Safety of Shunt Surgery in Idiopathic Normal-Pressure Hydrocephalus: Insights from a Rigorous Randomized Controlled Trial

By MedXY 09/27/2025

A double-blind, placebo-controlled trial demonstrates that shunt surgery significantly improves gait velocity and balance in patients with idiopathic normal-pressure hydrocephalus who respond to temporary CSF drainage, with mixed safety outcomes and no cognitive or urinary symptom benefits at 3 months.

Clinical Updates Neurology news Ophthalmology

Evaluating Visual Scanning Training for Post-Stroke Homonymous Hemianopia: Insights from the SEARCH Trial

By MedXY 09/22/2025

The SEARCH trial investigated visual scanning training versus sham therapy in stroke survivors with homonymous hemianopia, finding no significant difference yet highlighting potential placebo and clinician-engagement effects, informing future rehabilitation approaches.