数字疗法可显著减轻慢性髌股关节疼痛
Posted inClinical Updates Orthopedics

Integrated Digital Therapeutic Combining Exercise and Cognitive-Behavioural Therapy Significantly Reduces Chronic Patellofemoral Pain: A Multicentre RCT

An 8-week smartphone-based digital therapeutic offering personalized exercise and cognitive-behavioural therapy significantly improved pain, knee function, quality of life, and psychological outcomes in patients with chronic patellofemoral pain compared with education and exercise instruction alone.
Immunogenicity up to Age 5 Following Single- or Two-Dose Infant Primary Series of 10-Valent and 13-Valent Pneumococcal Conjugate Vaccine with Booster in South Africa: Extended RCT Follow-Up
Posted inClinical Updates news Pediatrics Public Health

Immunogenicity up to Age 5 Following Single- or Two-Dose Infant Primary Series of 10-Valent and 13-Valent Pneumococcal Conjugate Vaccine with Booster in South Africa: Extended RCT Follow-Up

This review synthesizes long-term immunogenicity data from a South African RCT comparing 1+1 and 2+1 infant PCV10 and PCV13 schedules. PCV13 1+1 schedules maintain durable immunity up to age 5, supporting schedule optimization in established programs.