Specialties – Page 8

Ecopipam Reduced Relapse Risk in Pediatric Tourette Syndrome Without Metabolic or Extrapyramidal Signal in a Phase 3 Randomized Withdrawal Trial

By MedXY 06/05/2026

In a phase 3 randomized withdrawal trial, ecopipam maintained tic improvement in pediatric Tourette syndrome over 24 weeks and showed a generally favorable safety profile without clinically meaningful weight, metabolic, or drug-induced movement disorder effects.

Neurology news Pediatrics

Efficacy and Safety of Ecopipam for Tourette Syndrome: Phase 3 Randomized Clinical Trial

By MedXY 06/05/2026

This phase 3 trial found that ecopipam reduced tic relapse and maintained symptom improvement in children and adolescents with Tourette syndrome, with mainly central nervous system side effects and no major weight or metabolic concerns.

Internal Medicine Neurology news

Acetazolamide Fails to Improve Gait in Idiopathic Normal Pressure Hydrocephalus: Swedish DRAIN Trial

By MedXY 06/05/2026

In a Swedish randomized trial, low-dose acetazolamide did not improve gait in patients with idiopathic normal pressure hydrocephalus and caused more side effects than placebo, arguing against routine use as medical therapy.

Diabetes & Endocrinology news

Phase 2 Study of XP-8121: Once-Weekly Subcutaneous Levothyroxine for Adult Hypothyroidism

By MedXY 06/05/2026

A Phase 2 trial found that once-weekly subcutaneous levothyroxine (XP-8121) was generally well tolerated and suggested a dose conversion of about four times the daily oral dose for adults with hypothyroidism.

Diabetes & Endocrinology news Oncology

Early HbA1c Control After Type 2 Diabetes Diagnosis May Shape Long-Term Cancer Risk

By MedXY 06/05/2026

In a large Hong Kong cohort with newly diagnosed type 2 diabetes, higher early HbA1c exposure was associated with greater long-term cancer risk, suggesting that glycaemic control soon after diagnosis may matter more than later improvement.

Diabetes & Endocrinology news Public Health

Food Coloring Additives Linked to Higher Type 2 Diabetes Risk in a Large French Cohort

By MedXY 06/05/2026

A large French cohort study found that higher exposure to several food coloring additives was associated with increased incidence of type 2 diabetes, highlighting the need for further research and possible reevaluation of some additives.

Cardiology news

Precardioversion Heart Rhythm Monitoring Using Smartphone Photoplethysmography: The SMARTBEATS Randomized Clinical Trial

By MedXY 06/05/2026

Smartphone photoplethysmography before planned cardioversion reduced same-day cancellations in patients with atrial fibrillation or flutter by detecting spontaneous return to sinus rhythm early.

Neurology news Public Health

Long-Term Wildfire Smoke PM2.5 Exposure Is Linked to Higher Incident Stroke Risk in Older US Adults

By MedXY 06/05/2026

In a nationwide Medicare cohort, chronic wildfire smoke PM2.5 exposure was associated with a modest but significant increase in incident stroke, with stronger effects over longer exposure windows.

Cardiology news Pediatrics

Disrupted MAML1 Phase Separation Emerges as a New Mechanism Linking Notch Failure to Congenital Heart Disease

By MedXY 06/05/2026

A Circulation study identifies MAML1 as a candidate congenital heart disease gene and shows that defective phase separation in endocardial cells suppresses Notch signaling, impairing endocardial-to-mesenchymal transition and causing septal and valvular malformations.

Gastroenterology news Oncology

Language Barriers and Treatment Delays Emerge as Modifiable Threats in Early-Onset Colorectal Cancer

By MedXY 06/05/2026

A large Texas registry study found that treatment delays beyond 6 weeks were independently associated with worse survival in early-onset colorectal cancer, with language barriers identified as a potentially modifiable contributor.

Critical Care Infectious Diseases news

Impact of Appropriate Antimicrobial Therapy on ICU Patient Outcomes: Subanalysis of the DIANA Study Dataset

By MedXY 06/05/2026

In critically ill ICU patients with confirmed bacterial infections, appropriate empiric antimicrobial therapy was common and independently linked to lower 28-day mortality and more antimicrobial-free days.

Critical Care Internal Medicine news

Enteral vs IV Magnesium Replacement in Critically Ill Patients: A Randomized Noninferiority Trial

By MedXY 06/05/2026

A randomized ICU trial found oral/enteral magnesium was not proven noninferior to IV replacement for correcting mild-to-moderate hypomagnesemia, but it lowered urinary magnesium loss, cost, waste, carbon emissions, and IV fluid use.

Emergency Medicine news Public Health

Association Between Emergency Department Undertriage or Overtriage With Timeliness of Care and Patient Outcomes

By MedXY 06/05/2026

A large multicenter study found that emergency department triage mismatches were linked to small delays in care and longer stays, especially for overtriaged patients. Better use of patient history may improve triage accuracy.

Emergency Medicine Internal Medicine news

One in Six Older Emergency Department Patients Has Delirium: New Multisite Data Highlight Missed Risk, Mixed Management, and Higher Hospital Use

By MedXY 06/04/2026

A large multisite cohort found delirium in 16% of older adults in the emergency department, including nearly 8% of those discharged, with strong links to dementia, acuity, hospitalization, and 30-day readmission.

Emergency Medicine Internal Medicine news

One in Six Older Adults Presenting to the Emergency Department Had Delirium, With Higher Admission and 30-Day Readmission Risk

By MedXY 06/04/2026

A large multi-site cohort found delirium in 16% of older ED patients, including many discharged home, and linked it to higher admission and 30-day readmission, underscoring the need for standardized screening and supportive care.

Gastroenterology news Public Health

Mailed Outreach for Colorectal Cancer Screening in Community Health Centers: CARES Pragmatic Cluster Randomized Clinical Trial

By MedXY 06/04/2026

Mailed outreach improved colorectal cancer screening in community health centers, with FIT-DNA outperforming FIT. However, colonoscopy follow-up after abnormal stool tests remained low despite navigation support.

Hematology-Oncology news Pediatrics

Pilot Study: Busulfan-Based Haploidentical Stem Cell Transplantation Plus GD2 Antibody Therapy for High-Risk Neuroblastoma

By MedXY 06/04/2026

A small pilot study found that busulfan-based haploidentical stem cell transplantation followed by dinutuximab beta was feasible and may improve long-term remission in very high-risk neuroblastoma.

Hematology-Oncology news Oncology

S1P Receptor Modulation Restores FLT3 Inhibitor Sensitivity in NRAS-Mutated FLT3-ITD Acute Myeloid Leukemia

By MedXY 06/04/2026

Preclinical data suggest fingolimod and mocravimod can resensitize NRAS-mutated FLT3-ITD AML to FLT3 inhibitors by suppressing ERK-SPHK1-AKT signaling, including activity in patient blasts and an orthotopic mouse model.

news Pediatrics Respiratory

Dietary Patterns and Asthma Endotypes in Puerto Rican Youth

By MedXY 06/04/2026

In Puerto Rican youth, an unhealthy diet was linked to higher odds of T17-high asthma, suggesting diet may influence asthma through immune pathways beyond allergy-related inflammation.

Clinical Updates news Public Health

Strengthening the Respiratory Shield: A Critical Review of the US Air Quality Index and Future Research Prioritization

By MedXY 06/04/2026

This review synthesizes the American Thoracic Society's 2026 research statement on the US Air Quality Index, identifying critical knowledge gaps and prioritizing five research domains to enhance its effectiveness for patients with respiratory disease.