Cardiology – Medxy AI

Cardiomyopathy Gene Therapy Reaches an Inflection Point: From AAV Delivery to Precision Genome Editing

By MedXY 05/12/2026

Gene therapy for cardiomyopathy is moving from concept to clinic, but durable benefit will depend on solving delivery, immunogenicity, cargo, and safety barriers in the failing human heart.

Cardiology news

Tricuspid Valve Replacement Outcomes by Baseline Tricuspid Regurgitation Severity: TRISCEND II Trial

By MedXY 05/12/2026

TRISCEND II showed that transcatheter tricuspid valve replacement with EVOQUE markedly reduced tricuspid regurgitation and improved clinical outcomes across baseline severity levels, with a stronger signal for benefit in massive or torrential TR.

Cardiology news Pathology & Lab Medicine/Bệnh học

Why the cTnI/cTnT Ratio May Matter: A New Signal for Distinguishing Acute Necrotic From Chronic Myocardial Injury

By MedXY 05/12/2026

A large multicohort and experimental study suggests the cTnI/cTnT ratio is biologically informative, separates acute from chronic myocardial injury, and modestly improves type 1 versus type 2 MI discrimination.

Cardiology Internal Medicine news

Sacubitril/Valsartan Improved Exercise Pulmonary Hemodynamics and Dynamic Atrial Functional Mitral Regurgitation in HFpEF: Interpreting the PRAISE-MR Randomized Trial

By MedXY 05/12/2026

In symptomatic HFpEF with atrial functional mitral regurgitation, sacubitril/valsartan improved exercise hemodynamics, peak VO2, symptoms, biomarkers, and stress-induced MR burden over 6 months versus standard care.

Cardiology news Respiratory

A GOLD Science Committee Perspective on Exacerbations and Cardiovascular Risk In COPD

By MedXY 05/11/2026

COPD exacerbations significantly increase cardiovascular risk for months. This article examines the link between COPD and heart disease, emphasizing proactive screening during flare-ups and evidence-based prevention strategies to improve survival rates.

Cardiology Diabetes & Endocrinology news

Subclinical Hyperthyroidism Carries Measurable Risks of Atrial Fibrillation, Heart Failure, and Death in Primary Care

By MedXY 05/10/2026

A large Dutch primary care cohort links subclinical hyperthyroidism to higher risks of atrial fibrillation, heart failure, and all-cause mortality, with particularly notable relative risks in younger adults and in patients with more strongly suppressed TSH.

Cardiology news

Rationale and Design of CARDIO-TTRansform: A Phase 3 Trial of Eplontersen for Transthyretin Amyloid Cardiomyopathy

By MedXY 05/10/2026

CARDIO-TTRansform is a global Phase 3 trial evaluating eplontersen's efficacy and safety in reducing cardiovascular events in transthyretin amyloid cardiomyopathy patients receiving standard care, including TTR stabilizers. With 1,432 participants, it aims to establish a new treatment paradigm.

Cardiology news

Sex-Based Patterns and Trends in Transcatheter Aortic Valve Implantation

By MedXY 05/10/2026

A 10-year Medicare study reveals women face higher immediate risks during TAVI procedures but demonstrate better long-term survival than men, despite declining representation in treatment.

Cardiology Clinical Updates news

Optimizing Antiplatelet Strategies in Complex PCI: Insights from the TAILORED-CHIP Trial and Evolving Evidence for Temporal Modulation

By MedXY 05/09/2026

This review synthesizes the TAILORED-CHIP trial results with recent evidence on antiplatelet modulation, highlighting the challenges of balancing ischemic and bleeding risks in high-risk PCI populations.

Cardiology Emergency Medicine news

A New hs-cTnT Generation 6 Assay Matches Generation 5 for Myocardial Infarction Diagnosis While Labeling Fewer Patients as Myocardially Injured

By MedXY 05/09/2026

In suspected myocardial infarction, hs-cTnT-gen6 showed diagnostic accuracy comparable to gen5, produced fewer myocardial injury classifications, and supported highly sensitive ESC 0/1-hour and 0/2-hour rule-out and rule-in pathways using assay-specific cutoffs.

Cardiology news

Determining the Physiological Threshold for Angina (ORBITA-FIRE): A Double-Blind, Randomized, Placebo-Controlled Study

By MedXY 05/09/2026

ORBITA-FIRE study reveals personalized physiological thresholds for angina that are lower than current diagnostic standards. These thresholds vary during exercise and predict PCI treatment success, challenging universal ischemia-based guidelines.

Cardiology Clinical Updates news

Optimizing the Referral Pathway for Mechanical Thrombectomy: Evidence-Based Perspectives on Mothership vs. Drip-and-Ship Models

By MedXY 05/09/2026

This review synthesizes recent evidence comparing 'mothership' and 'drip-and-ship' strategies in acute ischemic stroke, highlighting functional benefits of direct transport and the critical 43-minute delay threshold.

Cardiology Internal Medicine news

Targeting Skeletal Muscle Myosin ATPase May Reduce Resting Energy Waste in Heart Failure With Reduced Ejection Fraction

By MedXY 05/06/2026

An ex vivo human skeletal muscle study suggests that myosin ATPase inhibition with mavacamten normalizes excessive resting ATP consumption in HFrEF myofibres, identifying a mechanistically novel strategy to address peripheral metabolic inefficiency and exercise intolerance.

AI Cardiology news

AI-ECG Identified Left Ventricular Systolic Dysfunction in Kenya With High Sensitivity and Excellent Rule-Out Performance

By MedXY 05/06/2026

In Kenyan outpatient clinics, an AI-enabled ECG algorithm showed strong discrimination for left ventricular systolic dysfunction, with 95.6% sensitivity and 99.1% negative predictive value against echocardiography.

Cardiology Internal Medicine news

Long-Term SAFE-PAD Data Reassure on Mortality After Paclitaxel-Coated Femoropopliteal Interventions

By MedXY 05/06/2026

In Medicare patients undergoing femoropopliteal revascularization, drug-coated devices were not associated with higher long-term mortality, supporting the safety of paclitaxel-coated technology after years of regulatory concern.

Cardiology news Pediatrics

A New Pediatric VAD Driver Shows High Reliability and Preserves Mobility Without Major Device Malfunctions

By MedXY 05/06/2026

In a prospective multicenter evaluation, the EXCOR Active Driver supported pediatric VAD care with no major device malfunctions and excellent short-term survival, while addressing a major unmet need in mobility and day-to-day function.

Cardiology Clinical Updates news

Epigenetic Regulation of Myocardial Inflammation: The Role of Macrophage PRMT9 and STAT1 Degradation in Acute Myocardial Infarction

By MedXY 05/05/2026

This review explores how PRMT9-mediated symmetric dimethylation of STAT1 serves as a critical check on proinflammatory macrophage activation, offering a novel therapeutic target for mitigating cardiac injury following myocardial infarction.

Cardiology Critical Care news

Earlier Mechanical Thrombectomy for Intermediate-Risk Pulmonary Embolism Improves Hemodynamics but Not In-Hospital Mortality

By MedXY 05/05/2026

In a multicenter retrospective study, early mechanical thrombectomy within 12 hours of pulmonary embolism diagnosis improved pulmonary artery pressure reduction and reduced intubation, but did not significantly lower in-hospital mortality.

Cardiology news Respiratory

Pulmonary Arterial Hypertension Therapy Preserves Gas Exchange Overall in Portopulmonary Hypertension, but New Intrapulmonary Vascular Dilatations Can Emerge

By MedXY 05/04/2026

In PoPH, PAH-specific therapy did not worsen oxygenation overall, although responses varied widely. Hemodynamic changes influenced gas exchange, and some patients developed new intrapulmonary vascular dilatations during follow-up.

Cardiology Internal Medicine news

PCSK9 Inhibition Lowers LDL Cholesterol in Heterozygous Familial Hypercholesterolemia Regardless of LDL Receptor Variant Function

By MedXY 05/03/2026

In a pooled nonrandomized phase 3 analysis, monthly lerodalcibep reduced LDL-C by about 50% in heterozygous familial hypercholesterolemia, with similar efficacy across LDLR functional variant categories and broad attainment of guideline-based LDL-C goals.