Cardiology – Medxy AI

Targeting Skeletal Muscle Myosin ATPase May Reduce Resting Energy Waste in Heart Failure With Reduced Ejection Fraction

By MedXY 05/06/2026

An ex vivo human skeletal muscle study suggests that myosin ATPase inhibition with mavacamten normalizes excessive resting ATP consumption in HFrEF myofibres, identifying a mechanistically novel strategy to address peripheral metabolic inefficiency and exercise intolerance.

AI Cardiology news

AI-ECG Identified Left Ventricular Systolic Dysfunction in Kenya With High Sensitivity and Excellent Rule-Out Performance

By MedXY 05/06/2026

In Kenyan outpatient clinics, an AI-enabled ECG algorithm showed strong discrimination for left ventricular systolic dysfunction, with 95.6% sensitivity and 99.1% negative predictive value against echocardiography.

Cardiology Internal Medicine news

Long-Term SAFE-PAD Data Reassure on Mortality After Paclitaxel-Coated Femoropopliteal Interventions

By MedXY 05/06/2026

In Medicare patients undergoing femoropopliteal revascularization, drug-coated devices were not associated with higher long-term mortality, supporting the safety of paclitaxel-coated technology after years of regulatory concern.

Cardiology news Pediatrics

A New Pediatric VAD Driver Shows High Reliability and Preserves Mobility Without Major Device Malfunctions

By MedXY 05/06/2026

In a prospective multicenter evaluation, the EXCOR Active Driver supported pediatric VAD care with no major device malfunctions and excellent short-term survival, while addressing a major unmet need in mobility and day-to-day function.

Cardiology Critical Care news

Earlier Mechanical Thrombectomy for Intermediate-Risk Pulmonary Embolism Improves Hemodynamics but Not In-Hospital Mortality

By MedXY 05/05/2026

In a multicenter retrospective study, early mechanical thrombectomy within 12 hours of pulmonary embolism diagnosis improved pulmonary artery pressure reduction and reduced intubation, but did not significantly lower in-hospital mortality.

Cardiology news Respiratory

Pulmonary Arterial Hypertension Therapy Preserves Gas Exchange Overall in Portopulmonary Hypertension, but New Intrapulmonary Vascular Dilatations Can Emerge

By MedXY 05/04/2026

In PoPH, PAH-specific therapy did not worsen oxygenation overall, although responses varied widely. Hemodynamic changes influenced gas exchange, and some patients developed new intrapulmonary vascular dilatations during follow-up.

Cardiology Internal Medicine news

PCSK9 Inhibition Lowers LDL Cholesterol in Heterozygous Familial Hypercholesterolemia Regardless of LDL Receptor Variant Function

By MedXY 05/03/2026

In a pooled nonrandomized phase 3 analysis, monthly lerodalcibep reduced LDL-C by about 50% in heterozygous familial hypercholesterolemia, with similar efficacy across LDLR functional variant categories and broad attainment of guideline-based LDL-C goals.

Cardiology news

Development and Validation of a Clinical Polygenic Risk Report in U.S.-Based Health Systems for 8 Cardiovascular Conditions

By MedXY 05/02/2026

Researchers developed and validated integrated polygenic risk scores for eight cardiovascular conditions using data from over 245,000 individuals. These scores demonstrated strong predictive power and improved risk classification, providing a clinically implementable framework for genetic risk reporting.

Cardiology Diabetes & Endocrinology news

GLP-1 Receptor Agonists Show Lower Heart Failure Risk Versus DPP-4 Inhibitors in Type 2 Diabetes

By MedXY 05/02/2026

New research comparing diabetes medications reveals GLP-1 receptor agonists lower heart failure hospitalization risk compared to DPP-4 inhibitors, while showing similar risk to SGLT-2 inhibitors in type 2 diabetes patients.

Cardiology Neurology news

Late-Life Stroke in ARIC Was More Often Embolic, and Atrial Disease Explained Much of the Risk

By MedXY 05/01/2026

In ARIC, ischemic stroke at age 80 years or older was more often embolic than thrombotic. Atrial fibrillation and left atrial disease explained much of the age effect, and adding embolic factors improved prediction.

Cardiology news Public Health

ATTR-CM Is Often Diagnosed Years After Heart Failure in Medicare Patients

By MedXY 04/30/2026

In Medicare beneficiaries, ATTR-CM was diagnosed a median 494 days after heart failure and 840 days after loop diuretic initiation, with delays more common in women and patients with several common comorbidities.

Cardiology news

Standard-Dose DOACs Outperform Warfarin More Strongly in Asian Than Non-Asian Patients With Atrial Fibrillation

By MedXY 04/30/2026

In a patient-level meta-analysis of 10,212 Asian and 61,471 non-Asian AF patients, standard-dose DOACs outperformed warfarin more strongly in Asians, with less stroke, major bleeding, and net clinical harm. Standard-dose therapy was favored over lower-dose regimens in Asians.

Cardiology news Public Health

Coronary Stent Trial Site Selection Could Narrow Racial Gaps in Enrollment, but Women Remain Underrepresented

By MedXY 04/30/2026

In nine U.S. coronary stent PMA trials, minority participants were markedly underrepresented, while women were modestly underrepresented. Site geography and surrounding county demographics predicted minority enrollment, suggesting targeted site selection could improve racial and ethnic representation.

Cardiology HIV/AIDS Infectious Diseases news

Elevated Heart Failure Risk in People With HIV: Insights from the REPRIEVE Trial

By MedXY 04/29/2026

The REPRIEVE trial reveals higher heart failure incidence in people with HIV, particularly among women, Black participants in high-income regions, and those with hypertension or obesity. Traditional risk factors, not HIV-specific markers, were key predictors.

Cardiology news

Burst Exercise Testing Outperforms Traditional Bruce Protocol in CPVT Diagnosis and Management

By MedXY 04/29/2026

A new study shows that the Burst exercise stress test is more effective than the traditional Bruce protocol in detecting arrhythmias in CPVT patients, leading to better treatment decisions without safety concerns.

Cardiology Internal Medicine news

Midlife Cardiorespiratory Fitness Linked to Extended Healthspan and Reduced Multimorbidity in Aging

By MedXY 04/29/2026

Higher midlife cardiorespiratory fitness is associated with longer healthspan, fewer chronic diseases, and extended lifespan in men and women, based on a large observational cohort study linking clinical data to Medicare claims.

Cardiology Nephrology news

Exploring the Link Between Cardiovascular-Kidney-Metabolic Syndrome and Heart Failure Risk in Older Adults

By MedXY 04/29/2026

Higher CKM syndrome stages correlate with adverse cardiac remodeling and increased heart failure risk in older adults, as shown in the ARIC Study.

Cardiology Diabetes & Endocrinology news OB/GYN & Women's Health

Prolonged TSH Suppression in Postmenopausal Thyroid Cancer Patients Linked to Worse Cardiovascular and Quality-of-Life Outcomes

By MedXY 04/28/2026

Study finds long-term TSH suppression in postmenopausal women with thyroid cancer correlates with poorer cardiovascular health, reduced quality of life, and increased osteoporosis risk compared to controls.

Cardiology Critical Care news

Circulatory Support Escalation in Cardiogenic Shock: Outcomes and Predictors of Success

By MedXY 04/28/2026

A multi-center study reveals that circulatory support escalation in cardiogenic shock is associated with higher mortality and complications, but certain patient factors can predict successful outcomes.

Cardiology news

RBM20 Truncating Variants in Dilated Cardiomyopathy: Reduced Penetrance and Milder Phenotype Compared to Missense Variants

By MedXY 04/28/2026

This study highlights the role of RBM20 truncating variants in arrhythmogenic dilated cardiomyopathy, showing reduced penetrance and milder disease severity compared to pathogenic missense variants and titin truncating variants.