Pharmacist-Led Patient Self-Testing Superior to Usual Care for Warfarin Management in Mechanical Heart Valve Patients: Evidence from a Multicentre RCT in China
Posted inCardiology Internal Medicine news

Pharmacist-Led Patient Self-Testing Superior to Usual Care for Warfarin Management in Mechanical Heart Valve Patients: Evidence from a Multicentre RCT in China

A multicentre RCT in China found that pharmacist-led patient self-testing (PST) significantly improves time in therapeutic range and reduces major bleeding and thromboembolism in patients with mechanical heart valves compared to traditional outpatient clinic care.
Strategic Release of Wolbachia-Infected Mosquitoes Reduces Dengue Risk by Over 70% in Urban Singapore
Posted inInfectious Diseases news Public Health

Strategic Release of Wolbachia-Infected Mosquitoes Reduces Dengue Risk by Over 70% in Urban Singapore

A large-scale cluster-randomized trial in Singapore demonstrates that releasing male Aedes aegypti mosquitoes infected with the wAlbB Wolbachia strain significantly suppresses wild-type populations and reduces the incidence of symptomatic dengue virus infection by 71-72%, offering a transformative approach to urban vector control.
Beyond MELD: The Liver Immune Frailty Index (LIFI) Predicts Post-Transplant Mortality with High Precision
Posted inGastroenterology General Surgery news

Beyond MELD: The Liver Immune Frailty Index (LIFI) Predicts Post-Transplant Mortality with High Precision

Researchers have developed the Liver Immune Frailty Index (LIFI), a biomarker-based tool using fractalkine and MMP3 to predict post-liver transplant mortality. With a C-statistic of 0.83, LIFI identifies high-risk candidates, potentially transforming preoperative risk stratification and perioperative management.