Medxy AI

Vagal Nerve Stimulation in HFrEF Was Safe but Did Not Improve the Primary Composite Outcome in the ANTHEM-HFrEF Trial

By MedXY 05/23/2026

In ANTHEM-HFrEF, vagal nerve stimulation in symptomatic HFrEF was feasible and safe, but the underpowered trial did not meet its primary efficacy endpoint after premature sponsor-driven termination.

Cardiology news

SREBP1 Activation of NHE3 Weakens Heart Contraction and Worsens Heart Failure

By MedXY 05/23/2026

Researchers found that SREBP1 directly activates NHE3 in failing hearts, causing sodium and calcium overload, weaker cardiac contraction, and worse heart failure. The findings reveal a new mechanism in HFrEF and suggest a potential therapeutic target.

Clinical Updates news

Bireociclib Plus Fulvestrant in Advanced Breast Cancer After Endocrine Progression: The BRIGHT-2 Phase 3 Randomized Clinical Trial and Comparative Synthesis

By MedXY 05/23/2026

This review synthesizes the BRIGHT-2 trial findings and meta-analytical data, confirming that bireociclib plus fulvestrant significantly improves progression-free survival in HR+/HER2- advanced breast cancer.

news Psychiatry Public Health

Health Plan Disenrollment and Mortality After Starting Medications for Opioid Use Disorder

By MedXY 05/23/2026

A large cohort study found that health plan disenrollment after starting buprenorphine or naltrexone for opioid use disorder was linked to higher all-cause and overdose mortality, highlighting the importance of continuous coverage and treatment access.

Critical Care news Respiratory

Out-of-Bed Armchair Positioning Improves Oxygenation in Spontaneously Breathing ICU Patients

By MedXY 05/23/2026

A randomized ICU trial found that sitting spontaneously breathing patients in an armchair for 3 hours improved oxygenation more than staying semi-recumbent in bed, with no serious adverse events.

Critical Care Internal Medicine news

ICU Readmission Raises 60-Day Mortality Substantially Regardless of Frailty, but Frail Patients Carry the Highest Absolute Risk

By MedXY 05/22/2026

In a binational registry study of 615,719 ICU admissions, ICU readmission was linked to a similar absolute increase in 60-day mortality in frail and nonfrail patients, although frail readmitted patients had the highest overall mortality.

Emergency Medicine Neurology news

Intravenous Magnesium Sulfate for Acute Nontraumatic Headache in the Emergency Department

By MedXY 05/22/2026

Intravenous magnesium sulfate added to paracetamol increased early headache-treatment success in the emergency department, but the pain relief was modest and below usual clinical importance thresholds. It also reduced rescue analgesia needs while causing slightly more mild side effects.

Family Medicine & Nutrition news Public Health

Do Digital Specialist Consults Really Keep Patients Out of the Hospital?

By MedXY 05/22/2026

A new Dutch study suggests e-consults may not dramatically cut hospital referrals overall, but they still offer important benefits when used in the right patients, specialties, and workflows.

Infectious Diseases news Primary Care

Rapid Respiratory Point-of-Care Testing and Antibiotic Use in Primary Care: A Randomized Clinical Trial

By MedXY 05/22/2026

A randomized trial found that rapid respiratory point-of-care testing did not reduce same-day antibiotic prescribing in primary care, though it was safe and may help when a virus is detected.

Internal Medicine news Public Health

ACP Calls for Stronger Oversight of Medicare Advantage to Protect Patients, Payment Accuracy, and Quality

By MedXY 05/22/2026

The American College of Physicians urges major reforms to Medicare Advantage, including more accurate payment, simpler quality measures, tighter oversight of marketing and prior authorization, and stronger transparency to better protect beneficiaries.

Hematology-Oncology news Oncology

Frontline Allogeneic Transplantation Outperforms Pretransplant IPSS-M Downstaging in Myelodysplastic Neoplasms

By MedXY 05/21/2026

In adults with myelodysplastic neoplasms undergoing allogeneic transplantation, pretransplant cytoreduction modestly improved IPSS-M in some patients but did not improve post-transplant survival and was associated with higher non-relapse mortality.

AI Hematology-Oncology news

Choosing a Stem Cell Donor: Why Age Matters More in Some Transplants Than Others

By MedXY 05/21/2026

A major 2026 study suggests donor age affects survival differently in haploidentical and matched unrelated stem cell transplants, offering a more practical framework for choosing the best donor.

Internal Medicine news Respiratory

Effectiveness of Automatically-Adjusted vs Manually-Adjusted Noninvasive Ventilation in Obesity Hypoventilation Syndrome: A Randomized Clinical Trial

By MedXY 05/21/2026

In ambulatory patients with obesity hypoventilation syndrome, automatically-adjusted noninvasive ventilation was as effective as manually adjusted NIV over 12 months and more cost-effective, offering a simpler path to treatment.

Anesthesiology news Ophthalmology

Anesthesia-Related Neurologic Risk in Patients of Venezuelan Descent: Implications for Ophthalmology

By MedXY 05/21/2026

A rare, severe neurologic complication has been linked to general anesthesia in patients of maternal Venezuelan descent. Ophthalmologists should screen for ancestry and family history, involve anesthesiology early, and consider genetic evaluation before elective surgery.

news Ophthalmology Pathology & Lab Medicine/Bệnh học

Small Copy Number-Neutral Intrachromosomal Translocation of PAX6 and Aniridia

By MedXY 05/21/2026

Optical genome mapping and long-read sequencing uncovered a tiny balanced rearrangement that separated PAX6 from its control region, explaining classic aniridia after prior testing was negative.

news Ophthalmology

Intraoperative Intravitreal Bevacizumab Extended Trabeculectomy Survival to 3 Years in a Randomized Trial

By MedXY 05/20/2026

A double-blind randomized trial found that a single intraoperative intravitreal bevacizumab injection improved 3-year trabeculectomy survival and reduced postoperative medication needs versus placebo.

news Oncology Pathology & Lab Medicine/Bệnh học

Body Mass Index and Nutritional Status With Immunotherapy Response in Head and Neck Cancer

By MedXY 05/20/2026

In advanced head and neck squamous cell carcinoma, pretreatment weight loss and low prognostic nutritional index were linked to shorter progression-free survival after immunotherapy, while baseline BMI was not predictive.

Neurology news Otorhinolaryngology

Earlier Cricopharyngeal Intervention May Improve Oral Intake in Absent UES Opening After Neurological Injury

By MedXY 05/20/2026

A small retrospective series suggests that cricopharyngeus-targeted procedures can improve upper esophageal sphincter opening and oral intake after neurological injury, but aspiration risk often persists and ongoing swallowing therapy remains essential.

Emergency Medicine news Public Health

Unequal Paths to Care: How Region, Rurality, and Deprivation Shape Transport to Verified Trauma Centers Among the Critically Injured

By MedXY 05/20/2026

A large U.S. study found major geographic and socioeconomic differences in how critically injured patients are transported to verified trauma centers, with outcomes varying by region, rurality, and neighborhood deprivation.

General Surgery news Pediatrics

Higher-Fidelity Enhanced Recovery Shortened Stay and Reduced Complications in Children Undergoing GI Surgery, Even Though the Overall Trial Was Neutral

By MedXY 05/20/2026

In a stepped-wedge trial across 18 US centers, a pediatric GI surgery enhanced recovery protocol did not improve length of stay overall, but patients receiving at least 13 protocol elements had shorter stays, fewer complications, faster diet advancement, and lower inpatient opioid use.