Medxy AI

Tirzepatide vs dulaglutide: kidney outcomes in type 2 diabetes from SURPASS-CVOT

By MedXY 05/12/2026

In a pre-specified exploratory analysis of SURPASS-CVOT, tirzepatide reduced major kidney events versus dulaglutide in people with type 2 diabetes and cardiovascular disease, mainly by lowering new macroalbuminuria and slowing eGFR decline.

Cardiology Internal Medicine news

Cardiomyopathy Gene Therapy Reaches an Inflection Point: From AAV Delivery to Precision Genome Editing

By MedXY 05/12/2026

Gene therapy for cardiomyopathy is moving from concept to clinic, but durable benefit will depend on solving delivery, immunogenicity, cargo, and safety barriers in the failing human heart.

Cardiology news

Tricuspid Valve Replacement Outcomes by Baseline Tricuspid Regurgitation Severity: TRISCEND II Trial

By MedXY 05/12/2026

TRISCEND II showed that transcatheter tricuspid valve replacement with EVOQUE markedly reduced tricuspid regurgitation and improved clinical outcomes across baseline severity levels, with a stronger signal for benefit in massive or torrential TR.

Cardiology news Pathology & Lab Medicine/Bệnh học

Why the cTnI/cTnT Ratio May Matter: A New Signal for Distinguishing Acute Necrotic From Chronic Myocardial Injury

By MedXY 05/12/2026

A large multicohort and experimental study suggests the cTnI/cTnT ratio is biologically informative, separates acute from chronic myocardial injury, and modestly improves type 1 versus type 2 MI discrimination.

Cardiology Internal Medicine news

Sacubitril/Valsartan Improved Exercise Pulmonary Hemodynamics and Dynamic Atrial Functional Mitral Regurgitation in HFpEF: Interpreting the PRAISE-MR Randomized Trial

By MedXY 05/12/2026

In symptomatic HFpEF with atrial functional mitral regurgitation, sacubitril/valsartan improved exercise hemodynamics, peak VO2, symptoms, biomarkers, and stress-induced MR burden over 6 months versus standard care.

news Oncology Public Health

Rates of Systemic Treatment for Metastatic Non-Small Cell Lung Cancer Among Older Adults

By MedXY 05/12/2026

A population-based study of older adults with metastatic NSCLC found that fewer than half received systemic treatment, with only slight improvement over time. Oncology referral and biomarker testing were strongly linked to treatment, while advanced age and barriers to care lowered access.

news Oncology Public Health

Systemic Treatment Remains Underused in Older Adults With Metastatic Non-Small Cell Lung Cancer

By MedXY 05/12/2026

A large SEER-Medicare study found that fewer than half of older adults with metastatic NSCLC received systemic therapy, with only modest improvement from 2006 to 2021. Specialist referral and biomarker testing were strongly linked to treatment receipt.

Critical Care news Respiratory

Predicted Body Weight May Be Too High for Many Critically Ill Women: New Evidence Challenges a Core Assumption in Lung-Protective Ventilation

By MedXY 05/12/2026

A large analysis suggests the predicted body weight equation overestimates lung size in critically ill women, increasing the risk of higher driving pressures and contributing to excess mortality under standard tidal-volume targeting.

Clinical Updates news Respiratory

Ivermectin for COVID-19: From Pandemic Controversy to Definitive Futility in the REMAP-CAP and Global Randomized Trials

By MedXY 05/12/2026

A comprehensive evidence-based synthesis of the REMAP-CAP trial and major international RCTs, demonstrating that ivermectin fails to improve clinical outcomes, survival, or organ support requirements in hospitalized and non-hospitalized COVID-19 patients.

Family Medicine & Nutrition news Public Health

Obesity Counseling Is Still Missed in Most US Office Visits, With Older Adults Least Likely to Receive Advice

By MedXY 05/12/2026

A national analysis of US office visits found that obesity counseling remains uncommon, with only 40.1% of visits including any counseling and 12.2% including weight, diet, and exercise advice together.

news OB/GYN & Women’s Health Psychiatry

Extended-Release vs Sublingual Buprenorphine in Pregnancy Through 12 Months Post Partum: A Randomized Clinical Trial

By MedXY 05/11/2026

A clinical trial found that weekly extended-release buprenorphine significantly improves illicit opioid abstinence during pregnancy compared to sublingual forms, with fewer serious adverse events, offering a safer treatment option for opioid use disorder.

Internal Medicine news Psychiatry

Initiation of Medications for Alcohol Use Disorder Among Hospitalized Veterans : A Retrospective Cohort Study

By MedXY 05/11/2026

VHA study reveals only 30% of veterans hospitalized for AUD receive evidence-based medications during or shortly after hospitalization, with significant variation across hospitals and demographic factors influencing prescription rates.

Hematology-Oncology news Oncology

Molecular Profiling Refines Relapse Risk After Allogeneic Transplant in First-Remission Acute Myeloid Leukemia

By MedXY 05/11/2026

A PETHEMA registry study shows that specific mutations, especially DNMT3A, SF3B1, TP53, and WT1, meaningfully refine relapse-free survival after allo-HSCT in first-remission AML beyond ELN risk groups.

Dermatology Hematology-Oncology news

A New CTCL-Specific Quality-of-Life Tool Shows Strong Early Validity Signals in Cutaneous T-Cell Lymphoma

By MedXY 05/11/2026

A single-center validation study suggests the CTCL-PRO-20 may provide a reliable, disease-specific measure of quality of life in patients with cutaneous T-cell lymphoma.

Hematology-Oncology news

CAR T-Cell Therapy Targeting CD117 Shows Promise Against Advanced Systemic Mastocytosis in Preclinical Studies

By MedXY 05/11/2026

Anti-CD117 CAR T-cell therapy demonstrated potent elimination of malignant mast cells in preclinical models of advanced systemic mastocytosis, offering a potential new treatment approach for this aggressive disorder.

Hematology-Oncology news Oncology

Study Finds Infusion Timing Does Not Affect CAR T-Cell Therapy Outcomes for Large B-Cell Lymphoma

By MedXY 05/11/2026

A retrospective study of 584 Australian lymphoma patients shows no significant link between CAR T-cell infusion timing and treatment outcomes, suggesting chronobiology may not influence results in large B-cell lymphoma therapy.

Cardiology news Respiratory

A GOLD Science Committee Perspective on Exacerbations and Cardiovascular Risk In COPD

By MedXY 05/11/2026

COPD exacerbations significantly increase cardiovascular risk for months. This article examines the link between COPD and heart disease, emphasizing proactive screening during flare-ups and evidence-based prevention strategies to improve survival rates.

news Ophthalmology

Genotype-phenotype correlations in RPGRIP1-associated retinal dystrophy in a nationwide Japanese cohort

By MedXY 05/11/2026

Study identifies distinct clinical patterns in Japanese patients with RPGRIP1 mutations: Leber congenital amaurosis shows severe early vision loss while achromatopsia features progressive degeneration. Exon 18 deletion emerges as a founder variant.

news Ophthalmology Pediatrics

Web-Based Amblyopia Decision Support Tool

By MedXY 05/11/2026

The Amblyopia Navigator offers evidence-based guidance for eye care professionals to improve early detection and treatment of childhood amblyopia, addressing specialist shortages through accessible digital tools.

Clinical Updates news Ophthalmology

Clobetasol Propionate Ophthalmic Suspension 0.05%: A New Therapeutic Milestone in Post-Cataract Surgery Inflammation and Pain Management

By MedXY 05/11/2026

This review synthesizes clinical evidence for CPN 0.05% (BYQLOVI®), highlighting its rapid efficacy, superior pain resolution, and favorable safety profile compared to traditional ocular steroids following cataract surgery.