Decoding Registry-Based Randomised Controlled Trials: Advancing Clinical Evidence Through Standardisation and Taxonomy
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Decoding Registry-Based Randomised Controlled Trials: Advancing Clinical Evidence Through Standardisation and Taxonomy

Registry-based randomised controlled trials (RRCTs) offer promising efficiencies and external validity over traditional RCTs, yet lack consistent definitions and registration standards. A proposed taxonomy and adherence to CONSORT-ROUTINE aim to improve their identification, quality, and impact on clinical practice.
Cardiac Resynchronization Therapy With or Without Defibrillator in Nonischemic Cardiomyopathy: Evidence Synthesis and Clinical Implications from DECIDE-CRT and Related Studies
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Cardiac Resynchronization Therapy With or Without Defibrillator in Nonischemic Cardiomyopathy: Evidence Synthesis and Clinical Implications from DECIDE-CRT and Related Studies

This review synthesizes contemporary evidence on the survival impact of adding defibrillators to CRT in nonischemic cardiomyopathy, highlighting heterogeneous results including the DECIDE-CRT study and underscoring the need for personalized risk stratification and randomized trials.
Characteristics of Higher-Education Students in England Who Died by Suspected Suicide: A National Retrospective Case Series Study
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Characteristics of Higher-Education Students in England Who Died by Suspected Suicide: A National Retrospective Case Series Study

This review synthesizes evidence on individual and institutional factors linked to suspected suicide among higher-education students in England, highlighting risk profiles, service contact patterns, and shortcomings in investigation practices, to inform targeted prevention strategies.