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A Body Surface Area–Adjusted Bevacizumab Target Was Linked to Better Survival in Atezolizumab-Treated Unresectable Hepatocellular Carcinoma
Posted inGastroenterology news Oncology

A Body Surface Area–Adjusted Bevacizumab Target Was Linked to Better Survival in Atezolizumab-Treated Unresectable Hepatocellular Carcinoma

Posted by MedXY By MedXY 05/10/2026
A nationwide Japanese real-world study suggests that a defined body surface area–adjusted bevacizumab exposure range may improve progression-free and overall survival in unresectable HCC treated with atezolizumab plus bevacizumab, without increasing toxicity.
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A Stromal CTHRC1 Biomarker Framework May Identify Colorectal Cancers With Poor Prognosis and Limited Immunotherapy Benefit
Posted inGastroenterology news Oncology

A Stromal CTHRC1 Biomarker Framework May Identify Colorectal Cancers With Poor Prognosis and Limited Immunotherapy Benefit

Posted by MedXY By MedXY 05/10/2026
A large multiomic colorectal cancer study identifies CTHRC1-positive fibroblasts as a stromal biomarker linked to TGF-beta activity, adverse outcomes, and reduced checkpoint inhibitor benefit across both MSI and MSS disease.
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Weak Grip, Slow Walking Pace, and Sarcopenia Signal Higher Risk of Incident Stroke and Worse Poststroke Survival in UK Biobank
Posted inNeurology news Public Health

Weak Grip, Slow Walking Pace, and Sarcopenia Signal Higher Risk of Incident Stroke and Worse Poststroke Survival in UK Biobank

Posted by MedXY By MedXY 05/10/2026
In nearly 483,000 UK Biobank participants, sarcopenia, low grip strength, and slow walking pace were associated with higher risks of incident stroke and poorer survival after stroke.
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Multiple Sclerosis End-of-Life Care Remains Hospital-Centered Despite Comparable Palliative Care Use
Posted inNeurology news 看護・リハビリテーション

Multiple Sclerosis End-of-Life Care Remains Hospital-Centered Despite Comparable Palliative Care Use

Posted by MedXY By MedXY 05/10/2026
A large Ontario population study found that people with multiple sclerosis received palliative care at rates similar to other decedents, yet rural inequities and frequent hospital death persisted, highlighting the need for earlier neuropalliative integration.
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Adjunct Intra-arterial Alteplase After Successful Basilar Thrombectomy Was Safe but Did Not Improve 90-Day Outcomes in IAT-TOP
Posted inEmergency Medicine Neurology news

Adjunct Intra-arterial Alteplase After Successful Basilar Thrombectomy Was Safe but Did Not Improve 90-Day Outcomes in IAT-TOP

Posted by MedXY By MedXY 05/10/2026
In the IAT-TOP randomized trial, intra-arterial alteplase after successful EVT for acute basilar artery occlusion did not improve 90-day functional independence, while symptomatic intracranial hemorrhage and mortality were similar between groups.
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Subclinical Hyperthyroidism Carries Measurable Risks of Atrial Fibrillation, Heart Failure, and Death in Primary Care
Posted inCardiology Diabetes & Endocrinology news

Subclinical Hyperthyroidism Carries Measurable Risks of Atrial Fibrillation, Heart Failure, and Death in Primary Care

Posted by MedXY By MedXY 05/10/2026
A large Dutch primary care cohort links subclinical hyperthyroidism to higher risks of atrial fibrillation, heart failure, and all-cause mortality, with particularly notable relative risks in younger adults and in patients with more strongly suppressed TSH.
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Advanced Liver Imaging Reveals Impaired Postprandial Hepatic Glucose Handling and Hidden Metabolic Subtypes in Type 1 Diabetes
Posted inDiabetes & Endocrinology news Radiology

Advanced Liver Imaging Reveals Impaired Postprandial Hepatic Glucose Handling and Hidden Metabolic Subtypes in Type 1 Diabetes

Posted by MedXY By MedXY 05/10/2026
A 7 T imaging and tracer study found that adults with type 1 diabetes have abnormal postprandial hepatic glucose uptake, blunted glycogen storage, reduced suppression of endogenous glucose production, and marked metabolic heterogeneity despite similar systemic insulin exposure.
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Glucocorticoid Reduction After Starting Crinecerfont in Pediatric Patients With Classic CAH: Practical Perspectives
Posted inDiabetes & Endocrinology news Pediatrics

Glucocorticoid Reduction After Starting Crinecerfont in Pediatric Patients With Classic CAH: Practical Perspectives

Posted by MedXY By MedXY 05/10/2026
New expert recommendations guide glucocorticoid dose reduction in pediatric classic CAH patients using crinecerfont, prioritizing normal growth while minimizing long-term steroid complications.
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Pediatric Type 1 Diabetes Care Still Misses LDL Targets Despite Clear Indications for Lipid-Lowering Therapy
Posted inDiabetes & Endocrinology news Pediatrics

Pediatric Type 1 Diabetes Care Still Misses LDL Targets Despite Clear Indications for Lipid-Lowering Therapy

Posted by MedXY By MedXY 05/10/2026
Registry data from 55,028 youths with type 1 diabetes show common LDL hypercholesterolemia, infrequent lipid-lowering therapy, and poor attainment of recommended LDL targets.
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Multi-ancestry Polygenic Risk Scores Substantially Improve Type 2 Diabetes Risk Prediction Across Diverse Populations
Posted inDiabetes & Endocrinology news Public Health

Multi-ancestry Polygenic Risk Scores Substantially Improve Type 2 Diabetes Risk Prediction Across Diverse Populations

Posted by MedXY By MedXY 05/10/2026
A large multi-ancestry study shows that publicly available polygenic risk scores improve prediction of type 2 diabetes onset and selected microvascular complications across major global ancestry groups.
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Rationale and Design of CARDIO-TTRansform: A Phase 3 Trial of Eplontersen for Transthyretin Amyloid Cardiomyopathy
Posted inCardiology news

Rationale and Design of CARDIO-TTRansform: A Phase 3 Trial of Eplontersen for Transthyretin Amyloid Cardiomyopathy

Posted by MedXY By MedXY 05/10/2026
CARDIO-TTRansform is a global Phase 3 trial evaluating eplontersen's efficacy and safety in reducing cardiovascular events in transthyretin amyloid cardiomyopathy patients receiving standard care, including TTR stabilizers. With 1,432 participants, it aims to establish a new treatment paradigm.
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Sex-Based Patterns and Trends in Transcatheter Aortic Valve Implantation
Posted inCardiology news

Sex-Based Patterns and Trends in Transcatheter Aortic Valve Implantation

Posted by MedXY By MedXY 05/10/2026
A 10-year Medicare study reveals women face higher immediate risks during TAVI procedures but demonstrate better long-term survival than men, despite declining representation in treatment.
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Optimizing Antiplatelet Strategies in Complex PCI: Insights from the TAILORED-CHIP Trial and Evolving Evidence for Temporal Modulation
Posted inClinical Updates news

Optimizing Antiplatelet Strategies in Complex PCI: Insights from the TAILORED-CHIP Trial and Evolving Evidence for Temporal Modulation

Posted by MedXY By MedXY 05/09/2026
This review synthesizes the TAILORED-CHIP trial results with recent evidence on antiplatelet modulation, highlighting the challenges of balancing ischemic and bleeding risks in high-risk PCI populations.
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A New hs-cTnT Generation 6 Assay Matches Generation 5 for Myocardial Infarction Diagnosis While Labeling Fewer Patients as Myocardially Injured
Posted inCardiology Emergency Medicine news

A New hs-cTnT Generation 6 Assay Matches Generation 5 for Myocardial Infarction Diagnosis While Labeling Fewer Patients as Myocardially Injured

Posted by MedXY By MedXY 05/09/2026
In suspected myocardial infarction, hs-cTnT-gen6 showed diagnostic accuracy comparable to gen5, produced fewer myocardial injury classifications, and supported highly sensitive ESC 0/1-hour and 0/2-hour rule-out and rule-in pathways using assay-specific cutoffs.
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Determining the Physiological Threshold for Angina (ORBITA-FIRE): A Double-Blind, Randomized, Placebo-Controlled Study
Posted inCardiology news

Determining the Physiological Threshold for Angina (ORBITA-FIRE): A Double-Blind, Randomized, Placebo-Controlled Study

Posted by MedXY By MedXY 05/09/2026
ORBITA-FIRE study reveals personalized physiological thresholds for angina that are lower than current diagnostic standards. These thresholds vary during exercise and predict PCI treatment success, challenging universal ischemia-based guidelines.
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Tumor-Infiltrating Clonal Hematopoiesis Emerges as a Pan-Cancer Prognostic Signal in Solid Tumors
Posted inHematology-Oncology news Oncology

Tumor-Infiltrating Clonal Hematopoiesis Emerges as a Pan-Cancer Prognostic Signal in Solid Tumors

Posted by MedXY By MedXY 05/09/2026
A large whole-genome sequencing study found tumor-infiltrating clonal hematopoiesis in 18.4% of solid tumors, linked to older age, prior cytotoxic chemotherapy, and worse overall survival, with particularly strong associations in breast cancer.
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急性白血病危重成人患者的時間趨勢和預後因素：個體參與者數據薈萃分析
Posted inCritical Care Hematology-Oncology news

急性白血病危重成人患者的時間趨勢和預後因素：個體參與者數據薈萃分析

Posted by MedXY By MedXY 05/09/2026
這項涵蓋19國55個ICU的2003名患者研究發現，急性白血病危重患者總體ICU死亡率為45%，需機械通氣者達66%。年齡>65歲、AML診斷、化療期間入院等因素顯著增加死亡風險，但隨時間推移生存率有所改善。
Read More
Posted inCritical Care Hematology-Oncology news

急性白血病危重成人患者的時間趨勢和預後因素：個體參與者數據薈萃分析

Posted by MedXY By MedXY 05/09/2026
這項涵蓋19國55個ICU的2003名患者研究發現，急性白血病危重患者總體ICU死亡率為45%，需機械通氣者達66%。年齡>65歲、AML診斷、化療期間入院等因素顯著增加死亡風險，但隨時間推移生存率有所改善。
Read More
Household Income Decline and Job Loss Among Survivors of Critical Illness: A Nationwide Cohort Study
Posted inCritical Care news Public Health

Household Income Decline and Job Loss Among Survivors of Critical Illness: A Nationwide Cohort Study

Posted by MedXY By MedXY 05/09/2026
A large South Korean study reveals critical illness survivors face severe socioeconomic consequences, with 27.6% experiencing income decline and 12.3% job loss within a year, disproportionately affecting high-income households despite universal health coverage.
Read More
Optimizing the Referral Pathway for Mechanical Thrombectomy: Evidence-Based Perspectives on Mothership vs. Drip-and-Ship Models
Posted inClinical Updates news

Optimizing the Referral Pathway for Mechanical Thrombectomy: Evidence-Based Perspectives on Mothership vs. Drip-and-Ship Models

Posted by MedXY By MedXY 05/09/2026
This review synthesizes recent evidence comparing 'mothership' and 'drip-and-ship' strategies in acute ischemic stroke, highlighting functional benefits of direct transport and the critical 43-minute delay threshold.
Read More

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  • A Body Surface Area–Adjusted Bevacizumab Target Was Linked to Better Survival in Atezolizumab-Treated Unresectable Hepatocellular Carcinoma
  • A Stromal CTHRC1 Biomarker Framework May Identify Colorectal Cancers With Poor Prognosis and Limited Immunotherapy Benefit
  • Weak Grip, Slow Walking Pace, and Sarcopenia Signal Higher Risk of Incident Stroke and Worse Poststroke Survival in UK Biobank
  • Multiple Sclerosis End-of-Life Care Remains Hospital-Centered Despite Comparable Palliative Care Use
  • Adjunct Intra-arterial Alteplase After Successful Basilar Thrombectomy Was Safe but Did Not Improve 90-Day Outcomes in IAT-TOP
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