Assessing Survival Outcomes of Simultaneous Liver-Kidney Versus Liver Alone Transplantation in the Era of the 2017 OPTN Policy

Assessing Survival Outcomes of Simultaneous Liver-Kidney Versus Liver Alone Transplantation in the Era of the 2017 OPTN Policy

This analysis of over 63,000 US liver transplants reveals that simultaneous liver-kidney transplantation (SLKT) confers significant survival benefit only in patients with severe renal dysfunction (eGFR <30), with no advantage in those with better pretransplant kidney function. The 2017 OPTN policy reduced SLKT procedures without compromising survival, supporting stage-specific organ allocation and the 'Safety Net' approach.
Individualized Treatment Effects of Cefepime vs Piperacillin-Tazobactam in Adults Hospitalized with Acute Infection: A Review of Evidence and Clinical Implications

Individualized Treatment Effects of Cefepime vs Piperacillin-Tazobactam in Adults Hospitalized with Acute Infection: A Review of Evidence and Clinical Implications

This review synthesizes evidence on how individual patient characteristics modify the comparative effects of cefepime versus piperacillin-tazobactam on acute kidney injury and neurologic outcomes in adults hospitalized with acute infection.