Medxy AI

Six-Week Native GIP Infusion Does Not Improve Glycaemic Control in Type 2 Diabetes, Alone or With Semaglutide

By MedXY 05/26/2026

A six-week native GIP infusion did not improve glucose control in type 2 diabetes, either alone or added to semaglutide, despite raising circulating GIP levels.

Cardiology news Pathology & Lab Medicine/Bệnh học

Circulating MicroRNA Scores May Distinguish Cellular and Antibody-Mediated Heart Transplant Rejection With High Accuracy

By MedXY 05/26/2026

A prospective multicenter study found circulating microRNA rejection scores identified ACR and AMR with strong diagnostic performance and prognostic value, supporting their development as noninvasive tools to reduce reliance on surveillance biopsy after heart transplantation.

Cardiology Diabetes & Endocrinology news

Oral Semaglutide and Cardiovascular Risk Factor Changes in High-Risk Type 2 Diabetes

By MedXY 05/26/2026

Oral semaglutide improved multiple cardiovascular risk factors in high-risk type 2 diabetes, including HbA1c, weight, systolic blood pressure, inflammation, and some lipid measures, with benefits sustained over nearly four years.

Cardiology news OB/GYN & Women’s Health

Women with Chronic Coronary Artery Disease: Long-Term Outcomes After PCI vs CABG

By MedXY 05/26/2026

In women with chronic severe coronary artery disease, CABG was linked to lower long-term rates of death, stroke, heart attack, repeat revascularization, and cardiovascular readmission than PCI.

Cardiology news

Sex- and Age-Specific Genetic Risk Across Dilated and Arrhythmogenic Cardiomyopathy: Insights From the SHaRe Registry

By MedXY 05/26/2026

A large registry study found that genetic cardiomyopathy risk varies by sex, age, and gene. TTN truncating variants were more common and earlier in males, while DSP and non-TTN sarcomeric variants were more common in females.

Cardiology Internal Medicine news

Higher Lipoprotein(a) Marks Greater Coronary Risk Without Prior MI or Stroke, While Evolocumab Delivers Similar Relative Benefit and Larger Absolute Gains

By MedXY 05/25/2026

In VESALIUS-CV, elevated baseline Lp(a) independently predicted major coronary events, especially MI, in patients without prior MI or stroke. Evolocumab reduced relative risk similarly across Lp(a) levels, with numerically greater absolute benefit in those with higher Lp(a).

Gastroenterology news Oncology

Intraperitoneal and Intravenous Paclitaxel Plus S-1 Improves Survival in Gastric Cancer With Peritoneal Metastasis: Phase 3 Trial

By MedXY 05/25/2026

A phase 3 trial found that adding intraperitoneal paclitaxel to intravenous paclitaxel plus S-1 improved survival in gastric cancer with peritoneal metastasis without increasing severe toxicity.

news Oncology Otorhinolaryngology

Anti-EBV BNLF2b Antibody Shows High Accuracy for Outpatient Diagnosis of Suspected Nasopharyngeal Carcinoma

By MedXY 05/25/2026

In a prospective multicenter cohort, P85-Ab achieved 93.0% sensitivity and 97.3% specificity for suspected nasopharyngeal carcinoma, outperforming conventional EBV serologies in outpatient practice.

Hematology-Oncology news Otorhinolaryngology

Diagnostic Performance of Anti-Epstein-Barr Virus BNLF2b in Suspected Nasopharyngeal Carcinoma

By MedXY 05/25/2026

P85-Ab, an anti-EBV BNLF2b antibody test, showed excellent accuracy for suspected nasopharyngeal carcinoma and outperformed older EBV markers in most outpatient settings.

Cardiology General Surgery news

Frozen Elephant Trunk for Acute Type A Aortic Dissection Delivers Durable 20-Year Outcomes and Fewer Late Aortic Events Than Hemiarch Repair

By MedXY 05/24/2026

A 20-year single-center experience suggests frozen elephant trunk plus total arch replacement offers durable survival and fewer late adverse aortic events than hemiarch repair in acute type A aortic dissection.

Cardiology news

Vagal Nerve Stimulation in HFrEF Was Safe but Did Not Improve the Primary Composite Outcome in the ANTHEM-HFrEF Trial

By MedXY 05/23/2026

In ANTHEM-HFrEF, vagal nerve stimulation in symptomatic HFrEF was feasible and safe, but the underpowered trial did not meet its primary efficacy endpoint after premature sponsor-driven termination.

Cardiology news

SREBP1 Activation of NHE3 Weakens Heart Contraction and Worsens Heart Failure

By MedXY 05/23/2026

Researchers found that SREBP1 directly activates NHE3 in failing hearts, causing sodium and calcium overload, weaker cardiac contraction, and worse heart failure. The findings reveal a new mechanism in HFrEF and suggest a potential therapeutic target.

Clinical Updates news

Bireociclib Plus Fulvestrant in Advanced Breast Cancer After Endocrine Progression: The BRIGHT-2 Phase 3 Randomized Clinical Trial and Comparative Synthesis

By MedXY 05/23/2026

This review synthesizes the BRIGHT-2 trial findings and meta-analytical data, confirming that bireociclib plus fulvestrant significantly improves progression-free survival in HR+/HER2- advanced breast cancer.

news Psychiatry Public Health

Health Plan Disenrollment and Mortality After Starting Medications for Opioid Use Disorder

By MedXY 05/23/2026

A large cohort study found that health plan disenrollment after starting buprenorphine or naltrexone for opioid use disorder was linked to higher all-cause and overdose mortality, highlighting the importance of continuous coverage and treatment access.

Critical Care news Respiratory

Out-of-Bed Armchair Positioning Improves Oxygenation in Spontaneously Breathing ICU Patients

By MedXY 05/23/2026

A randomized ICU trial found that sitting spontaneously breathing patients in an armchair for 3 hours improved oxygenation more than staying semi-recumbent in bed, with no serious adverse events.

Critical Care Internal Medicine news

ICU Readmission Raises 60-Day Mortality Substantially Regardless of Frailty, but Frail Patients Carry the Highest Absolute Risk

By MedXY 05/22/2026

In a binational registry study of 615,719 ICU admissions, ICU readmission was linked to a similar absolute increase in 60-day mortality in frail and nonfrail patients, although frail readmitted patients had the highest overall mortality.

Emergency Medicine Neurology news

Intravenous Magnesium Sulfate for Acute Nontraumatic Headache in the Emergency Department

By MedXY 05/22/2026

Intravenous magnesium sulfate added to paracetamol increased early headache-treatment success in the emergency department, but the pain relief was modest and below usual clinical importance thresholds. It also reduced rescue analgesia needs while causing slightly more mild side effects.

Family Medicine & Nutrition news Public Health

Do Digital Specialist Consults Really Keep Patients Out of the Hospital?

By MedXY 05/22/2026

A new Dutch study suggests e-consults may not dramatically cut hospital referrals overall, but they still offer important benefits when used in the right patients, specialties, and workflows.

Infectious Diseases news Primary Care

Rapid Respiratory Point-of-Care Testing and Antibiotic Use in Primary Care: A Randomized Clinical Trial

By MedXY 05/22/2026

A randomized trial found that rapid respiratory point-of-care testing did not reduce same-day antibiotic prescribing in primary care, though it was safe and may help when a virus is detected.

Internal Medicine news Public Health

ACP Calls for Stronger Oversight of Medicare Advantage to Protect Patients, Payment Accuracy, and Quality

By MedXY 05/22/2026

The American College of Physicians urges major reforms to Medicare Advantage, including more accurate payment, simpler quality measures, tighter oversight of marketing and prior authorization, and stronger transparency to better protect beneficiaries.