Sex, Race, and Ancestry Converge to Shape Amyloid Pathology: Evidence from a Large-Scale Admixed Autopsy Study
Posted inNeurology news Pathology & Lab Medicine/Bệnh học

Sex, Race, and Ancestry Converge to Shape Amyloid Pathology: Evidence from a Large-Scale Admixed Autopsy Study

This cross-sectional study of 2,268 autopsies reveals that female sex, APOEε4 status, and African ancestry independently and jointly influence neuritic plaque burden, suggesting that current Alzheimer’s biomarker thresholds may need refinement to account for sex and ancestral diversity.
Global Variations in Patient Radiation Exposure for Coronary Artery Disease Diagnosis: A Synthesized Review of the INCAPS 4 Findings
Posted inClinical Updates news

Global Variations in Patient Radiation Exposure for Coronary Artery Disease Diagnosis: A Synthesized Review of the INCAPS 4 Findings

This review analyzes global radiation doses in CAD diagnostic imaging based on the INCAPS 4 study. It highlights significant disparities across modalities and regions, revealing that patients in low-income countries and those undergoing CCTA face substantially higher radiation risks, necessitating urgent standardized protocols.
Beyond Objective Responses: Amivantamab Demonstrates Significant Clinical Benefit in Recurrent Adenoid Cystic Carcinoma
Posted innews Oncology Otorhinolaryngology

Beyond Objective Responses: Amivantamab Demonstrates Significant Clinical Benefit in Recurrent Adenoid Cystic Carcinoma

A Phase 2 clinical trial of amivantamab, an EGFR-MET bispecific antibody, in recurrent or metastatic adenoid cystic carcinoma (ACC) showed a 72.2% clinical benefit rate. While the primary objective response rate was low, the high rate of disease stabilization highlights its potential in managing this rare malignancy.