Medxy AI

Development and Validation of a Clinical Polygenic Risk Report in U.S.-Based Health Systems for 8 Cardiovascular Conditions

By MedXY 05/02/2026

Researchers developed and validated integrated polygenic risk scores for eight cardiovascular conditions using data from over 245,000 individuals. These scores demonstrated strong predictive power and improved risk classification, providing a clinically implementable framework for genetic risk reporting.

Cardiology Diabetes & Endocrinology news

GLP-1 Receptor Agonists Show Lower Heart Failure Risk Versus DPP-4 Inhibitors in Type 2 Diabetes

By MedXY 05/02/2026

New research comparing diabetes medications reveals GLP-1 receptor agonists lower heart failure hospitalization risk compared to DPP-4 inhibitors, while showing similar risk to SGLT-2 inhibitors in type 2 diabetes patients.

news Oncology Public Health

Quality of Breast Cancer Care and Patient Survival Show No Link to Hospital Safety-Net Burden

By MedXY 05/01/2026

A major study reveals that safety-net hospitals—serving vulnerable Medicaid and uninsured patients—deliver breast cancer care and survival outcomes on par with other hospitals, challenging assumptions about quality disparities in resource-constrained settings.

Gastroenterology General Surgery news

Reversal of Roux-en-Y Gastric Bypass: A Swedish National Cohort Study

By MedXY 05/01/2026

This nationwide Swedish study reveals that RYGB reversal is rare (0.3% of procedures) but effective for complications like abdominal pain and hypoglycemia. While 86% reported symptom improvement, significant complication risks require careful patient selection and surgical expertise.

news OB/GYN & Women’s Health Oncology

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By MedXY 05/01/2026

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news OB/GYN & Women’s Health Oncology

Danish Multicenter Study Finds a 15% ADNEX Threshold Best Balances Early Detection and Referral Burden for Adnexal Masses

By MedXY 05/01/2026

In a Danish multicenter cohort of adnexal masses, IOTA-based models outperformed RMI for routine triage. A 15% ADNEX threshold best balanced sensitivity and referral burden in non-tertiary care.

news OB/GYN & Women’s Health

Early Pregnancy Oxylipin Biomarkers Linked to Fetal Growth Restriction Patterns

By MedXY 05/01/2026

Study reveals specific inflammation and oxidative stress markers in early pregnancy urine predict distinct fetal growth restriction patterns, offering potential for early detection and intervention strategies.

news OB/GYN & Women’s Health

妊娠早期炎症和氧化应激oxylipin标志物与小于胎龄儿及特定胎儿生长受限表型相关

By MedXY 05/01/2026

研究发现妊娠早期尿液中的血栓素代谢物与小于胎龄儿相关，尤其与晚期生长受限表型显著关联。而异前列腺素则与早期生长受限表型相关，为胎儿生长受限的预测和干预提供了新方向。

news OB/GYN & Women’s Health

Early Pregnancy Oxylipins Point to Distinct Inflammatory and Oxidative Stress Signals in Fetal Growth Restriction

By MedXY 05/01/2026

Early pregnancy urinary oxylipins linked inflammatory and oxidative stress pathways to small-for-gestational-age birth, with distinct signatures for early- and late-onset growth restriction. Associations with large-for-gestational-age birth were not significant after multiple-testing correction.

Gastroenterology Internal Medicine news

HSP72-PRDX6 Control of PINK1 Ubiquitination Emerges as a New Mitophagy Axis in MASLD

By MedXY 05/01/2026

A new Hepatology study identifies an HSP72–PRDX6 pathway that restores PINK1/Parkin mitophagy, reduces hepatic steatosis, and worsens MASLD when disrupted in mice and hepatocytes.

Clinical Updates Gastroenterology news Oncology

Uncoupling Metabolic Reprogramming in Hepatocellular Carcinoma: The JOSD1-PGAM1 Ubiquitination-Lactylation Switch

By MedXY 05/01/2026

This article explores how the deubiquitinase JOSD1 drives HCC progression by modulating a novel PTM switch on PGAM1, promoting glycolysis and immune evasion while providing a new target for combined immunotherapy.

Gastroenterology news

Genetic Risk of Inflammatory Bowel Disease Linked to Disease Severity

By MedXY 05/01/2026

A Danish nationwide study reveals higher genetic risk scores for IBD predict more severe disease courses, including increased surgery rates, stronger medication needs, and worse inflammatory markers in both Crohn's and ulcerative colitis patients.

Cardiology Neurology news

Late-Life Stroke in ARIC Was More Often Embolic, and Atrial Disease Explained Much of the Risk

By MedXY 05/01/2026

In ARIC, ischemic stroke at age 80 years or older was more often embolic than thrombotic. Atrial fibrillation and left atrial disease explained much of the age effect, and adding embolic factors improved prediction.

Neurology news Public Health

Commercially Insured Patients Wait a Median of 25 Days for New Neurology Care, with Regional and Plan-Based Differences

By MedXY 04/30/2026

Among 114,034 commercially insured patients, the median time to a new neurology visit was 25 days. Waits varied by sex, diagnosis, region, and plan type, while neurologist density showed no association with access.

$Neurofilament Light Chain Reveals Rapid Neuroaxonal Injury in New-Onset Refractory Status Epilepticus$

Critical Care Neurology news

Neurofilament Light Chain Reveals Rapid Neuroaxonal Injury in New-Onset Refractory Status Epilepticus

By MedXY 04/30/2026

In a multinational cross-sectional study, serum and CSF neurofilament light chain—unlike S100B—tracked severe acute brain injury in cryptogenic NORSE, rose rapidly over the first 3 weeks, and predicted poor short-term outcome, supporting urgent neuroprotective treatment.

General Surgery news Oncology

ATA Guideline Updates Reduced Thyroid Cancer Overtreatment in a 31,861-Patient South Korean Cohort

By MedXY 04/30/2026

A large South Korean cohort found ATA-guideline de-escalation reduced total thyroidectomy, RAI use, and permanent hypocalcemia in papillary thyroid carcinoma, without significant loss of 5-year disease-free survival.

Diabetes & Endocrinology Gastroenterology news

Oral Glucose Absorption Enhanced in Early Metabolic Dysfunction-Associated Steatotic Liver Disease

By MedXY 04/30/2026

New research reveals accelerated glucose absorption in early MASLD patients, independent of gastric emptying. This metabolic alteration may drive liver disease progression before hepatic insulin resistance develops.

Diabetes & Endocrinology Gastroenterology news

Early MASLD Is Associated With Enhanced Oral Glucose Absorption Independent of Gastric Emptying

By MedXY 04/30/2026

Stable-isotope OGTT data suggest that early MASLD is linked to higher oral glucose absorption, independent of gastric emptying, with preserved hepatic insulin suppression but impaired peripheral glucose clearance.

Cardiology news Public Health

ATTR-CM Is Often Diagnosed Years After Heart Failure in Medicare Patients

By MedXY 04/30/2026

In Medicare beneficiaries, ATTR-CM was diagnosed a median 494 days after heart failure and 840 days after loop diuretic initiation, with delays more common in women and patients with several common comorbidities.

Cardiology news

Standard-Dose DOACs Outperform Warfarin More Strongly in Asian Than Non-Asian Patients With Atrial Fibrillation

By MedXY 04/30/2026

In a patient-level meta-analysis of 10,212 Asian and 61,471 non-Asian AF patients, standard-dose DOACs outperformed warfarin more strongly in Asians, with less stroke, major bleeding, and net clinical harm. Standard-dose therapy was favored over lower-dose regimens in Asians.