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Targeting MLCK1 May Separate Immune Checkpoint Inhibitor Colitis From Antitumour Benefit

By MedXY 05/20/2026

A Gut study identifies MLCK1-driven epithelial barrier failure as a central mechanism in immune checkpoint inhibitor colitis and suggests epicatechin as a barrier-protective strategy that preserves antitumour efficacy in preclinical models.

Neurology news Public Health

Long-Term Cognitive Recovery After Stroke: What the Oxford Cognitive Screen Reveals

By MedXY 05/20/2026

A long-term stroke study found that cognition improves most within 6 months, with memory and language recovering better than executive function. Early cognitive impairment was the strongest predictor of outcomes years later.

Neurology news

Fixed-Dose Tavapadon for Early Parkinson Disease: A Randomized Clinical Trial

By MedXY 05/20/2026

In a phase 3 trial, once-daily tavapadon improved motor symptoms in people with early Parkinson disease and was generally well tolerated, with nausea, headache, and dizziness as the most common side effects.

General Surgery Internal Medicine news Otorhinolaryngology

Fatigue After Thyroidectomy: What Patients Actually Experience

By MedXY 05/20/2026

A qualitative study found that fatigue after thyroidectomy is common, disruptive, and often unexpected. Patients described major impacts on work and daily life, and many wanted surgeons to warn them about it before surgery.

Clinical Updates Diabetes & Endocrinology news

Synergistic Protection of Pancreatic Beta Cells: GLP1-E2 and Low-Dose Anti-CD3 Combination Therapy in Autoimmune Diabetes

By MedXY 05/20/2026

Recent studies demonstrate that combining the beta-cell-targeted conjugate GLP1-E2 with low-dose anti-CD3 therapy significantly delays type 1 diabetes onset by simultaneously reducing immune infiltration and mitigating beta-cell cellular stress.

Diabetes & Endocrinology news Pediatrics

Children Born SGA Receiving Growth Hormone Have Similarly Impaired Glucose-Insulin Metabolism as Children With Obesity

By MedXY 05/19/2026

Children born SGA receiving growth hormone showed insulin resistance and prediabetes rates similar to obesity, suggesting the need for careful glucose monitoring during and after treatment.

Diabetes & Endocrinology news Public Health

A U-Shaped Association Between Blood mtDNA Copy Number and Risk of Type 2 Diabetes

By MedXY 05/19/2026

Blood mtDNA copy number showed a U-shaped association with future type 2 diabetes risk in younger adults, suggesting that both low and high levels may signal higher risk.

Cardiology Critical Care news

Cardiogenic Shock Care Still Varies Widely Across CICUs, Especially in the Choice of Inodilators

By MedXY 05/19/2026

A large CCCTN analysis found major institutional and patient-level variation in vasoactive drug selection for cardiogenic shock, highlighting persistent evidence gaps in choosing dobutamine, milrinone, and other vasoactive therapies.

Cardiology news

Validated EMPEROR-Preserved Risk Models Stratify Prognosis in FINEARTS-HF, While Finerenone Benefits Remain Consistent Across Baseline Risk

By MedXY 05/19/2026

In FINEARTS-HF, EMPEROR-Preserved biomarker-based risk models showed good prognostic discrimination in HFmrEF/HFpEF, and finerenone’s relative treatment effect was consistent across the full baseline risk spectrum.

Cardiology news

Outcomes of Heart Failure With Reduced, Mildly Reduced, or Preserved Ejection Fraction: ESC HF III Registry

By MedXY 05/19/2026

The ESC HF III Registry found substantial mortality and rehospitalization across heart failure phenotypes. Risk was highest after acute hospitalization and generally worse with reduced ejection fraction, but HFmrEF and HFpEF also carried significant one-year event rates.

Cardiology news

Multiarterial Grafting and Survival After Coronary Artery Bypass Grafting: An Instrumental Variable Analysis

By MedXY 05/19/2026

In a large Medicare study, multiarterial grafting after CABG looked beneficial in standard analysis, but the advantage disappeared with instrumental variable adjustment, suggesting earlier observational studies may have overestimated survival benefit.

Cardiology news

Evolocumab in Patients With Prior Percutaneous Coronary Intervention and No Prior MI: Results From the VESALIUS-CV Trial

By MedXY 05/19/2026

In patients with prior PCI but no prior MI, evolocumab significantly lowered LDL-C and reduced major cardiovascular events, including myocardial infarction and urgent revascularization, supporting intensive lipid lowering after coronary intervention.

news Oncology Radiology

Reduced Preoperative Radiotherapy to 36 Gy Maintains Excellent Long-Term Local Control in Myxoid Liposarcoma

By MedXY 05/19/2026

Long-term phase 2 data suggest that 36 Gy preoperative radiotherapy for localized myxoid liposarcoma preserves excellent local control while limiting wound and late toxic effects.

news Psychiatry

Efficacy and Safety of Psilocybin in Treatment-Resistant Major Depression: The EPISODE Randomized Clinical Trial

By MedXY 05/19/2026

Psilocybin-assisted psychotherapy showed promising but inconclusive antidepressant effects in treatment-resistant depression, with notable acute adverse events and safety concerns.

Critical Care news Nursing & care

Difficulty Paying for Medical Care: Links to Psychological Distress and Healthcare Perceptions Among ICU Caregivers

By MedXY 05/18/2026

More than half of ICU caregivers in a multicenter U.S. study reported difficulty paying for patient care, and financial strain was linked to higher posttraumatic stress, anxiety, depression, decisional regret, and medical mistrust.

Cardiology Emergency Medicine news

Associations of the Composite Pulmonary Embolism Shock Score in the Emergency Department With Short-Term Clinical Outcomes

By MedXY 05/18/2026

A multicenter emergency department study found that CPES performed similarly to sPESI and ESC for short-term PE outcomes, but it better predicted the need for advanced intervention.

news Psychiatry Public Health

Implementation of a Hospital-Based Screening and Treatment Program for Unhealthy Alcohol Use

By MedXY 05/18/2026

A hospital-based screening and treatment program for unhealthy alcohol use was feasible in a diverse safety-net population and was linked to short-term reductions in alcohol risk scores, especially among patients who received follow-up and medication treatment.

Family Medicine & Nutrition news Public Health

Provision of Primary Care Under Reduced Visit Time Pressures

By MedXY 05/18/2026

Reduced visit time pressure in primary care was linked to slightly more diagnoses, prescriptions, and diagnostic testing, especially for patients with multiple chronic conditions. The study highlights how appointment scheduling can influence the breadth of care delivered.

Internal Medicine news Public Health

Telemedicine After the Pandemic: Who Benefits, What Changed, and What Comes Next

By MedXY 05/18/2026

Telemedicine is no longer an emergency workaround. New policy guidance shows how virtual care can improve access, but only if payment, safety, equity, and prescribing rules evolve carefully.

Hematology-Oncology news

CBFB::MYH11 MRD After the Second Chemotherapy Cycle: A Guide to Allogeneic Transplantation in Favorable-Risk AML

By MedXY 05/18/2026

Post-cycle 2 CBFB::MYH11 MRD best predicted outcomes in favorable-risk AML. Patients with levels ≥1% had higher relapse risk, and those receiving allo-HCT in CR1 had better 3-year disease-free survival than chemotherapy consolidation.