HPV-Associated Anal Dysplasia in Solid Organ Transplant Recipients: Exploring Transplant-Specific Mucosal Immune Dysregulation
Posted inInfectious Diseases news Oncology Transplantation

HPV-Associated Anal Dysplasia in Solid Organ Transplant Recipients: Exploring Transplant-Specific Mucosal Immune Dysregulation

Solid organ transplant recipients exhibit heightened risk for HPV-associated anal dysplasia and cancer due to unique immunosuppressive alterations. A transplant-tailored model of mucosal immune dysfunction elucidates mechanisms driving persistent HPV infection and dysplasia progression, informing future screening and therapeutic strategies.
Therapeutic Hypothermia at 35°C vs. Controlled Normothermia in ICU Heatstroke: Insights from a Pilot RCT
Posted inCritical Care Emergency Medicine news

Therapeutic Hypothermia at 35°C vs. Controlled Normothermia in ICU Heatstroke: Insights from a Pilot RCT

A pilot randomized trial comparing targeted temperature management at 35°C versus normothermia in intubated heatstroke patients showed no survival or neurological benefit from hypothermia but increased gastrointestinal injury and arrhythmias, highlighting safety concerns and questioning routine hypothermia use in this setting.
Septic Shock in Allogeneic Hematopoietic Stem-Cell Transplant Recipients: Outcomes, Prognostic Factors, and Clinical Implications from a Multicenter ICU Cohort
Posted inCritical Care Hematology-Oncology news

Septic Shock in Allogeneic Hematopoietic Stem-Cell Transplant Recipients: Outcomes, Prognostic Factors, and Clinical Implications from a Multicenter ICU Cohort

Septic shock following allogeneic hematopoietic stem-cell transplantation has a high 90-day mortality rate of 63%, strongly influenced by illness severity, fungal infection, and neutropenia. Early aminoglycoside use shows complex associations with survival, highlighting the need for nuanced treatment strategies.