AI-Driven Detection of Extranodal Extension Outperforms Radiologists in Predicting Outcomes for HPV-Positive Oropharyngeal Cancer

AI-Driven Detection of Extranodal Extension Outperforms Radiologists in Predicting Outcomes for HPV-Positive Oropharyngeal Cancer

A single-center study demonstrates that an AI pipeline for CT-based lymph node segmentation and extranodal extension classification significantly improves prognostic accuracy for HPV-positive oropharyngeal cancer compared to traditional radiological assessment, identifying high-risk patients more effectively.
Neural Connectivity Patterns Predict Acupuncture Response in Migraine: A Step Toward Personalized Pain Management

Neural Connectivity Patterns Predict Acupuncture Response in Migraine: A Step Toward Personalized Pain Management

This randomized clinical trial demonstrates that real acupuncture significantly reduces migraine frequency and disability compared to sham acupuncture. Crucially, baseline brain connectivity patterns within the default mode and subcortical networks can predict individual treatment responses, offering a potential biomarker for personalized neuromodulatory therapy.
Beyond Pediatric Survival: The Disproportionate Impact of Childhood-Onset Complex Chronic Conditions on Adult Hospital Systems

Beyond Pediatric Survival: The Disproportionate Impact of Childhood-Onset Complex Chronic Conditions on Adult Hospital Systems

This study reveals that young adults with childhood-onset complex chronic conditions (4Cs) account for over 10% of hospital bed-days despite being a small patient volume. They face longer stays, higher costs, and frequent readmissions, highlighting a critical gap in adult-oriented management for this vulnerable population.
Redefining CTE: New Autopsy Evidence Links Repetitive Head Impact to Extensive Spinal Cord Pathology

Redefining CTE: New Autopsy Evidence Links Repetitive Head Impact to Extensive Spinal Cord Pathology

A landmark autopsy study reveals that Chronic Traumatic Encephalopathy (CTE) involves extensive spinal cord pathology, including tau, TDP-43, and amyloid-β deposits. These findings suggest that repetitive head impacts trigger a widespread encephalomyelopathy, potentially explaining the diverse motor symptoms observed in at-risk individuals.
Cerebral Oximetry-Guided Treatment Significantly Stabilizes Oxygenation in Extremely Preterm Infants: Results from a Randomized Clinical Trial

Cerebral Oximetry-Guided Treatment Significantly Stabilizes Oxygenation in Extremely Preterm Infants: Results from a Randomized Clinical Trial

A randomized trial involving 100 extremely preterm infants shows that cerebral oximetry-guided treatment using a standardized guideline and NIRS device significantly reduces the burden of cerebral hypoxia and hyperoxia during the first five days of life, potentially improving neuroprotective care.