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Galectin-3 Regulates Smooth Muscle Contraction and Blood Pressure by Modulating CaV1.2 Channel Function

By MedXY 06/17/2026

Researchers found that Galectin-3 boosts CaV1.2 calcium channel activity in blood vessel muscle, increasing contraction and blood pressure. Blocking this interaction lowered blood pressure in animal models, suggesting a new target for hypertension treatment.

Clinical Updates news Otorhinolaryngology

Digital Vestibular Rehabilitation After Acute Vertigo: What a Negative Superiority Trial Means

By MedXY 06/16/2026

A 2026 PLOS One superiority trial found that internet-based vestibular rehabilitation was not superior to structured written instructions after acute vertigo. The result is clinically useful because the comparator was active, adherence was high, and safety was reassuring.

Diabetes & Endocrinology news Psychiatry

Restoring Cortisol Rhythm May Be Key to Recovery After Cushing Syndrome

By MedXY 06/15/2026

In treated Cushing syndrome, normal late-night salivary cortisol was linked to better mood, quality of life, and metabolic outcomes, suggesting circadian cortisol restoration may be a meaningful recovery target.

Diabetes & Endocrinology Immunology news

Long-term Follow-up of Type 1 Diabetes Immunotherapy Trials Finds Reassuring Safety Signals

By MedXY 06/15/2026

Long-term follow-up from type 1 diabetes immunotherapy trials found no excess self-reported infections, autoimmune disease, cancer, or serious hypoglycemia versus placebo, supporting an overall reassuring safety profile.

Diabetes & Endocrinology Immunology news

Long-Term Safety Signals Remain Reassuring in Type 1 Diabetes Immunotherapy Follow-up

By MedXY 06/15/2026

Extended follow-up of participants from 14 randomized trials found no excess self-reported serious adverse outcomes after type 1 diabetes immunotherapy, supporting continued long-term surveillance.

Cardiology Internal Medicine news

Mitochondrial Rescue in HFpEF: Elamipretide Restores Skeletal Muscle Performance in a Rat Model

By MedXY 06/15/2026

Elamipretide improved skeletal muscle force, titin phosphorylation, and atrophy in a HFpEF rat model, supporting cardiolipin stabilization as a promising mitochondrial-targeted strategy.

Cardiology news

Elamipretide Restores Skeletal Muscle Performance in a HFpEF Rat Model by Stabilizing Mitochondria

By MedXY 06/15/2026

In a HFpEF rat model, Elamipretide improved muscle force, reduced titin abnormalities, and prevented atrophy, supporting cardiolipin stabilization as a potential strategy for exercise intolerance.

Cardiology Internal Medicine news

Can a Mitochondrial “Membrane Stabilizer” Restore Muscle Function in HFpEF? New Rat Data on Elamipretide

By MedXY 06/15/2026

In a HFpEF rat model, elamipretide improved skeletal muscle force, reduced titin hyperphosphorylation, and prevented atrophy, supporting cardiolipin stabilization as a promising metabolic strategy.

Cardiology news

Cardiolipin Stabilization Revives Skeletal Muscle Performance in a Preclinical HFpEF Model

By MedXY 06/15/2026

In a rat model of HFpEF, the mitochondrial-targeted peptide elamipretide improved skeletal muscle force, reduced atrophy, and normalized titin phosphorylation, supporting cardiolipin stabilization as a promising mechanism.

Cardiology news OB/GYN & Women’s Health

Pregnancy-Associated SCAD in Focus: What the iSCAD Registry Reveals About a Rare but High-Stakes Cause of MI in Women

By MedXY 06/15/2026

The iSCAD Registry study highlights distinctive reproductive and psychosocial features among women with pregnancy-associated SCAD, underscoring the need for individualized counseling, heightened diagnostic suspicion, and multidisciplinary follow-up.

Cardiology news Pathology & Lab Medicine

Blood DNA Methylation Maps Atherosclerosis Across Vascular Beds: Strong Signals, but Mostly a Record of Cumulative Risk Exposure

By MedXY 06/15/2026

In 2 prospective cohorts, blood DNA methylation was associated with carotid, coronary, and peripheral atherosclerosis, but most signals overlapped with smoking and cardiometabolic risk factors rather than vessel-specific biology.

Cardiology news

Can a Sirolimus-Eluting Balloon Reduce Stent Use in De Novo Coronary Disease? New Randomized Evidence from SELUTION DeNovo

By MedXY 06/15/2026

A large randomized trial found sirolimus-eluting balloon with provisional stenting noninferior to routine DES at 1 year by intention-to-treat analysis, though repeat revascularization was slightly higher and per-protocol noninferiority was not confirmed.

Cardiology news

Can a Sirolimus-Eluting Balloon Strategy Rival Routine Stenting in De Novo Coronary Lesions? New Randomized Trial Says Maybe

By MedXY 06/15/2026

An SEB plus provisional stenting strategy was noninferior to routine DES at 1 year for target vessel failure, but repeat revascularization was modestly higher and per-protocol noninferiority was not confirmed.

news OB/GYN & Women’s Health Oncology

Avelumab Meets Methotrexate: A Promising First-Line Strategy for Low-Risk Gestational Trophoblastic Tumors

By MedXY 06/15/2026

TROPHAMET found that avelumab plus methotrexate achieved very high hCG normalization and durable remission in low-risk gestational trophoblastic tumors, with manageable toxicity and preserved fertility, but randomized trials are still needed.

news OB/GYN & Women’s Health Oncology

Avelumab Plus Methotrexate in Low-Risk Gestational Trophoblastic Tumors: A Promising First-Line Signal From TROPHAMET

By MedXY 06/15/2026

TROPHAMET found that first-line avelumab plus methotrexate achieved 96.2% hCG normalization in low-risk gestational trophoblastic tumors with manageable toxicity, no relapses at 41 months, and preserved fertility.

news Orthopedics Plastic Surgery

Restoring Physiology After Upper Extremity Amputation: What the First Human AMI Reconstruction Experience Suggests

By MedXY 06/15/2026

A small human cohort study suggests that upper extremity amputation with AMI reconstruction is feasible and may preserve residual limb volume, improve muscle mechanics, and reduce pain and phantom limb symptoms.

news Psychiatry Public Health

Earlier ADHD Diagnosis May Mark a Better Educational Trajectory: What a Finnish Registry Study Found

By MedXY 06/15/2026

In a nationwide Finnish cohort, earlier ADHD diagnosis was linked to better school performance, more academic progression, and less dropout than diagnosis closer to age 16, especially before educational track selection.

Critical Care news Psychiatry

When the ICU Trauma Lingers: How Family PTSD Symptoms Build Across the Critical Illness Journey

By MedXY 06/15/2026

Qualitative interviews show family PTSD after ICU care is shaped by cumulative stressors across the illness trajectory, highlighting the need for continuous, family-centered communication and support.

Anesthesiology Critical Care news

A New Bedside Twist on Passive Leg Raising: PPV Change Predicts Fluid Responsiveness During Pressure Support Ventilation

By MedXY 06/15/2026

In PSV patients, passive leg raising–induced PPV change predicted preload responsiveness, especially when inspiratory effort was low by P0.1.

Internal Medicine news Psychiatry

When Language Becomes a Safety Risk: English Proficiency and Hospital Restraint Practices

By MedXY 06/15/2026

A large single-center study found that hospitalized patients with limited English proficiency had higher adjusted odds of physical restraint or antipsychotic use, especially when delirium was present, raising concerns about communication-driven care disparities.