Medxy AI

Clarithromycin vs Azithromycin for Infant Pertussis: Real-World Outcomes from Italian Hospitals

By MedXY 10/03/2026

This multicentre Italian study comparing clarithromycin and azithromycin for hospitalized infants with pertussis shows clarithromycin is linked to better clinical outcomes, including lower severity and fewer ICU admissions.

Clinical Updates news Pediatrics Public Health

Immunogenicity up to Age 5 Following Single- or Two-Dose Infant Primary Series of 10-Valent and 13-Valent Pneumococcal Conjugate Vaccine with Booster in South Africa: Extended RCT Follow-Up

By MedXY 10/03/2026

This review synthesizes long-term immunogenicity data from a South African RCT comparing 1+1 and 2+1 infant PCV10 and PCV13 schedules. PCV13 1+1 schedules maintain durable immunity up to age 5, supporting schedule optimization in established programs.

Clinical Updates news Psychiatry

Health Service Utilization Among Young People Following Out-of-Area Mental Health Admissions: Evidence from a Retrospective Cohort Study in England

By MedXY 10/03/2026

Out-of-area psychiatric admissions in young people are linked to increased emergency and non-mental health hospital use up to 5 years post-discharge, underscoring service planning needs in CAMHS.

news Pediatrics Psychiatry

Childhood Predictors of Adult Well-Being in Very Preterm and Very Low Birth Weight Individuals: Insights From a 34-Year Cohort Study

By MedXY 10/03/2026

A longitudinal study identifies distinct adult functioning profiles in individuals born very preterm or with very low birth weight, highlighting cognitive ability in childhood as a key predictor of positive adult socioeconomic and social outcomes.

Infectious Diseases news Pediatrics

Clesrovimab for Prolonged Protection Against Severe RSV in High-Risk Infants: Insights From a Two-Season Randomized Trial

By MedXY 10/02/2026

This phase 3 trial demonstrates that clesrovimab, a long-acting monoclonal antibody, is safe and well-tolerated in infants at risk for severe RSV disease across two consecutive RSV seasons, supporting its role in extended RSV prophylaxis.

Dentistry news Pediatrics

Silver Diamine Fluoride: A Breakthrough Noninvasive Therapy for Severe Early Childhood Caries in US Children

By MedXY 10/02/2026

A large-scale randomized trial demonstrates that 38% silver diamine fluoride effectively arrests dentin caries lesions in young children with severe early childhood caries, offering a safe, noninvasive treatment option and supporting FDA approval.

news Pediatrics Radiology

Persistent High Rates of Head CT in Pediatric Mild Traumatic Brain Injury: Variability Among Hospital Types and Implications for Practice

By MedXY 10/02/2026

Despite guidelines recommending judicious CT use for pediatric mild TBI, national data from 2017-2023 show persistently high and variable imaging rates across hospital types, underscoring gaps in guideline adoption and the need for targeted interventions.

Diabetes & Endocrinology news Pediatrics

Behavioral Interventions in Pediatric Type 1 Diabetes: Optimizing Glycemic Control Through Family-Centered, Multicomponent Strategies

By MedXY 10/02/2026

Updated meta-analysis reveals modest HbA1C improvements with behavioral interventions in youth with type 1 diabetes, highlighting the superiority of family-focused, multicomponent approaches over single-focus programs.

Clinical Updates news Pediatrics

Enhancing Pediatric Literacy Promotion for Latino Families: Efficacy of Text Messaging and Resource Referrals in a 3-Arm Randomized Controlled Trial

By MedXY 10/02/2026

A hybrid RCT among 630 Latino caregiver-infant dyads demonstrates that text messaging and community resource referrals augment primary care literacy promotion, improving language, social-emotional development, and parenting behaviors.

news Radiology Rheumatology

Imaging Biomarkers Predicting Inflammatory Arthritis in Anti-CCP Positive Patients Without Clinical Synovitis

By MedXY 10/02/2026

MRI-detected hand tenosynovitis and ultrasound-detected bone erosions independently and jointly predict progression to inflammatory arthritis in anti-CCP positive individuals with musculoskeletal symptoms but no clinical synovitis.

Nephrology news Rheumatology

Predicting Two-Year Relapse Risk in ANCA-Associated Vasculitis: Insights from the PEXIVAS Trial

By MedXY 10/02/2026

A risk prediction model derived from the PEXIVAS trial estimates the 2-year relapse probability in ANCA-associated vasculitis, integrating clinical and laboratory factors to improve individualized patient management.

news Pediatrics Rheumatology

Molecular Biomarkers Predicting Canakinumab Tapering Success in Systemic Juvenile Idiopathic Arthritis

By MedXY 10/02/2026

This study identifies serum and gene expression signatures predicting successful canakinumab tapering in systemic juvenile idiopathic arthritis, offering precision medicine strategies to reduce flares.

Infectious Diseases Nephrology news

Comparative Insights into Native and Allograft BK Polyomavirus Nephropathy: Clinical and Pathological Perspectives from a Matched Cohort Study

By MedXY 10/02/2026

This study elucidates the distinct clinical, pathological, and prognostic differences between native and allograft BK polyomavirus nephropathy, highlighting the severity and poorer outcomes associated with native-kidney BKPyVN and stressing the importance of early detection in high-risk patients.

Nephrology news

Optimizing Kidney Transplant Outcomes: Insights from a National Study on Dual Versus Single Kidney Transplantation

By MedXY 10/02/2026

This national matched cohort study highlights that dual kidney transplantation (DKT) offers improved graft and patient survival compared to single kidney transplantation (SKT) in select recipients, supporting its strategic use for hard-to-place donor kidneys in the U.S.

Clinical Updates Critical Care news Transplantation

Changing Brain Death Donation Dynamics in Spain: A National Overview of Neurocritical Care and Organ Donation Trends

By MedXY 10/02/2026

This review synthesizes national data from Spain (2015-2024) revealing a decline in brain death donation (DBD) offset by growth in controlled donation after circulatory death (cDCD), alongside evolving neurocritical care practices influencing organ donation pathways.

Gastroenterology news Public Health

Impact of Medicaid Expansion on Adult Liver Transplant Outcomes: A Decade-Long Analysis

By MedXY 10/02/2026

Medicaid expansion is associated with improved graft and patient survival following adult liver transplantation, highlighting the benefits of broader health insurance access on transplant outcomes.

Gastroenterology news Respiratory

Impaired Pulmonary Function and Dyspnea in Liver Transplant Recipients: Insights from a Nationwide Matched Cohort Study

By MedXY 10/02/2026

This study reveals that liver transplant recipients exhibit significantly reduced lung function and increased dyspnea compared to the general population, highlighting the need for heightened pulmonary surveillance in this vulnerable group.

Gastroenterology General Surgery news

Advancing Donation After Circulatory Death Liver Transplants: Comparing Normothermic Machine and Regional Perfusion Outcomes

By MedXY 10/02/2026

This study compares normothermic machine perfusion and normothermic regional perfusion in DCD liver transplants, demonstrating both advanced methods approach brain death graft survival and improve outcomes over static cold storage.

Dermatology news Pediatrics

Sustained Efficacy and Safety of Dupilumab in Children with Moderate to Severe Atopic Dermatitis: Insights from a 3-Year Dutch Cohort Study

By MedXY 10/02/2026

This study highlights dupilumab's long-term effectiveness and safety in managing pediatric atopic dermatitis over 3 years, revealing age-related differences in symptom control and treatment persistence.

Clinical Updates Dermatology news

Efficacy and Safety of Ruxolitinib Cream in Patients With Cutaneous Lichen Planus: A Randomized Clinical Trial Review

By MedXY 10/02/2026

This review synthesizes current evidence on ruxolitinib 1.5% cream efficacy and safety in cutaneous lichen planus, highlighting significant lesion and pruritus reduction in a pivotal phase 2 RCT, supporting its potential as a novel topical treatment.