Polygenic Risk Scores Reveal the Complex Interplay Between Genetic Liability, Aggression, and Childhood Trauma in Suicidal Behavior
Posted innews Psychiatry Public Health

Polygenic Risk Scores Reveal the Complex Interplay Between Genetic Liability, Aggression, and Childhood Trauma in Suicidal Behavior

This large-scale case-control study examines how polygenic risk scores for suicide attempt intersect with clinical traits and environmental stressors. Findings indicate that genetic liability significantly correlates with aggression, depression severity, and childhood trauma, providing a nuanced map of suicidal risk factors.
Youth with Histories of Out-of-Home Placement Face Significantly Longer Emergency Department Stays and Higher Restraint Rates During Mental Health Crises
Posted inEmergency Medicine news Psychiatry

Youth with Histories of Out-of-Home Placement Face Significantly Longer Emergency Department Stays and Higher Restraint Rates During Mental Health Crises

A retrospective study at Mayo Clinic reveals that children with a history of out-of-home placement experience 24% longer ED stays and double the odds of physical or pharmacological restraint during psychiatric emergencies compared to their peers, highlighting critical systemic disparities in pediatric mental health care.
Semaglutide Mitigates Cardiometabolic Risk in Early-Stage Schizophrenia: Insights from a Randomized Clinical Trial
Posted inDiabetes & Endocrinology news Psychiatry

Semaglutide Mitigates Cardiometabolic Risk in Early-Stage Schizophrenia: Insights from a Randomized Clinical Trial

A landmark RCT demonstrates that adjunctive semaglutide significantly improves glycemic control and induces substantial weight loss in individuals with schizophrenia spectrum disorders treated with second-generation antipsychotics, potentially closing the mortality gap in this high-risk population.
AI-Driven Detection of Extranodal Extension Outperforms Radiologists in Predicting Outcomes for HPV-Positive Oropharyngeal Cancer
Posted inAI news Oncology

AI-Driven Detection of Extranodal Extension Outperforms Radiologists in Predicting Outcomes for HPV-Positive Oropharyngeal Cancer

A single-center study demonstrates that an AI pipeline for CT-based lymph node segmentation and extranodal extension classification significantly improves prognostic accuracy for HPV-positive oropharyngeal cancer compared to traditional radiological assessment, identifying high-risk patients more effectively.