Neural Connectivity Patterns Predict Acupuncture Response in Migraine: A Step Toward Personalized Pain Management
Posted inNeurology news Radiology

Neural Connectivity Patterns Predict Acupuncture Response in Migraine: A Step Toward Personalized Pain Management

This randomized clinical trial demonstrates that real acupuncture significantly reduces migraine frequency and disability compared to sham acupuncture. Crucially, baseline brain connectivity patterns within the default mode and subcortical networks can predict individual treatment responses, offering a potential biomarker for personalized neuromodulatory therapy.
Cumulative Geriatric Syndrome Burden: A Potent Predictor of 90-Day Mortality in Hospitalized Older Adults
Posted inInternal Medicine news 看護・リハビリテーション

Cumulative Geriatric Syndrome Burden: A Potent Predictor of 90-Day Mortality in Hospitalized Older Adults

A large multicenter cohort study demonstrates that the number of geriatric syndromes at hospital admission is independently and incrementally associated with 90-day mortality, suggesting that cumulative geriatric burden is a critical prognostic indicator beyond traditional disease-centric models.
Beyond Pediatric Survival: The Disproportionate Impact of Childhood-Onset Complex Chronic Conditions on Adult Hospital Systems
Posted inInternal Medicine news Pediatrics

Beyond Pediatric Survival: The Disproportionate Impact of Childhood-Onset Complex Chronic Conditions on Adult Hospital Systems

This study reveals that young adults with childhood-onset complex chronic conditions (4Cs) account for over 10% of hospital bed-days despite being a small patient volume. They face longer stays, higher costs, and frequent readmissions, highlighting a critical gap in adult-oriented management for this vulnerable population.
Redefining CTE: New Autopsy Evidence Links Repetitive Head Impact to Extensive Spinal Cord Pathology
Posted inNeurology news Pathology & Lab Medicine/Bệnh học

Redefining CTE: New Autopsy Evidence Links Repetitive Head Impact to Extensive Spinal Cord Pathology

A landmark autopsy study reveals that Chronic Traumatic Encephalopathy (CTE) involves extensive spinal cord pathology, including tau, TDP-43, and amyloid-β deposits. These findings suggest that repetitive head impacts trigger a widespread encephalomyelopathy, potentially explaining the diverse motor symptoms observed in at-risk individuals.
Cerebral Oximetry-Guided Treatment Significantly Stabilizes Oxygenation in Extremely Preterm Infants: Results from a Randomized Clinical Trial
Posted inCritical Care news Pediatrics

Cerebral Oximetry-Guided Treatment Significantly Stabilizes Oxygenation in Extremely Preterm Infants: Results from a Randomized Clinical Trial

A randomized trial involving 100 extremely preterm infants shows that cerebral oximetry-guided treatment using a standardized guideline and NIRS device significantly reduces the burden of cerebral hypoxia and hyperoxia during the first five days of life, potentially improving neuroprotective care.
Safety First: Concurrent Metastases-Directed Stereotactic Radiotherapy and Biological Therapy Show Low Risk of Severe Adverse Events
Posted innews Oncology Radiology

Safety First: Concurrent Metastases-Directed Stereotactic Radiotherapy and Biological Therapy Show Low Risk of Severe Adverse Events

A prospective multicenter study of 433 patients demonstrates that combining stereotactic radiotherapy with biological cancer therapy is safe, with severe adverse events occurring in less than 10% of cases. Crucially, continuing biological therapy during radiotherapy does not increase toxicity or compromise survival outcomes.
Beyond the Count: How Product Factors and High Thresholds Shape Pediatric Platelet Transfusion Outcomes
Posted inHematology-Oncology news Pediatrics

Beyond the Count: How Product Factors and High Thresholds Shape Pediatric Platelet Transfusion Outcomes

A multicenter cohort study of 8,874 pediatric patients reveals that most prophylactic platelet transfusions occur above recommended thresholds. Factors such as pathogen reduction, additive solutions, and donor age significantly lower posttransfusion increments and increase overall transfusion burden without improving mortality or length of stay.