AI Assistant Achieves High Accuracy in Molecular-Based CNS Tumor Classification: A Multi-Institutional Validation
Posted inAI news Pathology & Lab Medicine/Bệnh học

AI Assistant Achieves High Accuracy in Molecular-Based CNS Tumor Classification: A Multi-Institutional Validation

This multi-institutional study validates Neuropath-AI, a deep-learning system that predicts CNS tumor types by inferring molecular features from histopathology slides. Achieving 80% top-1 accuracy in high-confidence samples, the model offers a scalable tool for enhancing diagnostic precision in neuro-oncology.
Fractionated Dosing of Varnimcabtagene Autoleucel Delivers Deep Remissions and Enhanced Safety in Adult B-ALL
Posted inHematology-Oncology news Oncology

Fractionated Dosing of Varnimcabtagene Autoleucel Delivers Deep Remissions and Enhanced Safety in Adult B-ALL

The CART19-BE-02 phase 2 trial demonstrates that varnimcabtagene autoleucel, utilizing a unique fractionated dose escalation strategy, achieves an 84.4% MRD-negative complete response rate in adults with relapsed or refractory B-ALL while significantly reducing the incidence of severe neurotoxicity and cytokine release syndrome.
Nearly 40 Percent of Indian Adults Impacted by MASLD: New Evidence from the Phenome India Cohort
Posted inGastroenterology news Public Health

Nearly 40 Percent of Indian Adults Impacted by MASLD: New Evidence from the Phenome India Cohort

The Phenome India study identifies a 38.9% age-adjusted prevalence **Constructing the JSON Object** Now, I'm carefully constructing the JSON object, which needs to be a valid, parseable string. I'm focusing on incorporating the main findings of the Phenome India cohort study, adding the detailed clinical context. I'm creating a comprehensive discussion on the implications of MASLD and liver fibrosis. I am making sure the summary is under 50 words, and double-checking that all the fields comply with the expected schema, and I'm prepared to handle the references and image prompt. of MASLD and significant liver fibrosis in high-risk metabolic groups, underscoring a major public health challenge in the region.
Recombinant Factor VIIa Fails to Improve Functional Outcomes in Hyperacute Intracerebral Haemorrhage Despite Reduced Bleeding: Results from the FASTEST Trial
Posted inEmergency Medicine Neurology news

Recombinant Factor VIIa Fails to Improve Functional Outcomes in Hyperacute Intracerebral Haemorrhage Despite Reduced Bleeding: Results from the FASTEST Trial

The FASTEST trial demonstrated that while recombinant factor VIIa administered within two hours of intracerebral haemorrhage onset significantly reduced hematoma growth, it failed to improve functional outcomes at 180 days and increased the risk of life-threatening thromboembolic events.
Early Inpatient Initiation of 1-Month TB Preventive Therapy Proves Non-Inferior for Patients with Advanced HIV and Cryptococcal Meningitis
Posted inHIV/AIDS Infectious Diseases news

Early Inpatient Initiation of 1-Month TB Preventive Therapy Proves Non-Inferior for Patients with Advanced HIV and Cryptococcal Meningitis

The IMPROVE trial demonstrates that starting a one-month isoniazid-rifapentine (1HP) course during hospitalization for cryptococcal meningitis is as safe and effective as outpatient initiation, potentially increasing treatment completion rates in high-risk patients with advanced HIV.
Systematic Complication Management Boosts Long-Term Survival in Pancreatic Cancer: Insights from the PORSCH Trial
Posted inGeneral Surgery news Oncology

Systematic Complication Management Boosts Long-Term Survival in Pancreatic Cancer: Insights from the PORSCH Trial

A post-hoc analysis of the nationwide PORSCH trial reveals that algorithm-based care for early recognition and management of postoperative complications significantly improves long-term overall survival in patients undergoing pancreatic resection for cancer, particularly those with pancreatic ductal adenocarcinoma.
Surgical Fixation Offers No Clinical Benefit and Zero Cost-Effectiveness for Pediatric Medial Epicondyle Fractures: Results from the SCIENCE Trial
Posted innews Orthopedics Pediatrics

Surgical Fixation Offers No Clinical Benefit and Zero Cost-Effectiveness for Pediatric Medial Epicondyle Fractures: Results from the SCIENCE Trial

The SCIENCE multicentre randomized trial demonstrates that surgical fixation for displaced medial epicondyle fractures in children provides no functional advantage over non-surgical care, carries higher complication risks, and is not a cost-effective use of healthcare resources.