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Cancer Risk in Familial Adenomatous Polyposis Remains Broad Despite Preventive Surgery: Dutch Nationwide Data Highlight Rising Gastric Cancer Burden

By MedXY 05/03/2026

A nationwide Dutch cohort confirms that patients with FAP remain at markedly elevated risk for multiple gastrointestinal and extraintestinal cancers, with gastric cancer emerging as the most frequently diagnosed malignancy since 2020.

Neurology news Pediatrics

Pediatric Ischemic Stroke in Switzerland Is Still Diagnosed Too Late for Reperfusion in Most Cases

By MedXY 05/03/2026

A 24-year Swiss registry study shows modest improvement in pediatric stroke recognition, but most children are still diagnosed beyond thrombolysis and thrombectomy windows.

Neurology news Public Health

Status Epilepticus Mortality in U.S. Adults Is Rising, With the Highest Burden in Older Adults, Men, Non-Hispanic Black Populations, and the South

By MedXY 05/03/2026

A U.S. mortality analysis from 1999 to 2020 found increasing deaths from status epilepticus after 2007, with marked disparities by age, sex, race/ethnicity, and region.

Neurology news Oncology

First-Time Seizure Is Linked to a Markedly Increased Short-Term Risk of Occult Cancer

By MedXY 05/03/2026

A nationwide Danish cohort study found that adults with a first-time seizure had substantially elevated 1-year risks of neurological and nonneurological cancers, with smaller but persistent excess risk over longer follow-up.

Neurology news Pediatrics

Combined Nicotinamide Riboside and Home-Based Exercise Improved Peak VO2 Safely in Friedreich’s Ataxia

By MedXY 05/03/2026

In a phase 2 factorial trial, 12 weeks of nicotinamide riboside plus individualized exercise improved cardiopulmonary fitness in Friedreich's ataxia, with mild-to-moderate adverse events and no signal of major safety concerns.

Diabetes & Endocrinology news Ophthalmology

Teprotumumab for Thyroid Eye Disease Carries a Measurable Long-Term Dysglycemia Risk

By MedXY 05/03/2026

A large multinational cohort study found that teprotumumab use in thyroid eye disease was associated with higher risks of prediabetes, diabetes, and antidiabetes medication initiation over 5 years.

Diabetes & Endocrinology news OB/GYN & Women’s Health

Gut Microbiome Signatures May Help Explain Why Gestational Diabetes Raises Later Type 2 Diabetes Risk in Hispanic/Latina Women

By MedXY 05/03/2026

In HCHS/SOL, prior gestational diabetes was linked to a proinflammatory gut microbiome, adverse metabolite patterns, and higher future type 2 diabetes risk, suggesting a plausible microbiome-mediated pathway after pregnancy.

Diabetes & Endocrinology news Pathology & Lab Medicine/Bệnh học

Urinary Free Cortisol Thresholds Sharpen the Differential Diagnosis of ACTH-Dependent Cushing’s Syndrome

By MedXY 05/03/2026

A Spanish multicenter validation study shows that urinary free cortisol expressed as multiples of the upper limit of normal can meaningfully stratify the likelihood of ectopic ACTH secretion versus Cushing’s disease.

Clinical Updates news

Cost-Effectiveness of Continuous Glucose Monitoring Combined with Remote Patient Monitoring in Pediatric Type 1 Diabetes

By MedXY 05/03/2026

A landmark simulation study demonstrates that adding remote patient monitoring to continuous glucose monitoring in pediatric T1D patients significantly improves QALYs and is highly cost-effective compared to standard care.

Clinical Updates news

Cost-Effectiveness of Continuous Glucose Monitoring Combined with Remote Patient Monitoring in Pediatric Type 1 Diabetes

By MedXY 05/03/2026

Clinical Updates news

Cost-Effectiveness of Continuous Glucose Monitoring Combined with Remote Patient Monitoring in Pediatric Type 1 Diabetes

By MedXY 05/03/2026

Clinical Updates news

Cost-Effectiveness of Continuous Glucose Monitoring Combined with Remote Patient Monitoring in Pediatric Type 1 Diabetes

By MedXY 05/03/2026

Diabetes & Endocrinology Nephrology news

Visceral Fat Predicts Diabetic Kidney Disease Differently in Men and Women, With a High-Risk Signal in Leaner Men

By MedXY 05/03/2026

In a 93,532-person prospective diabetes cohort, visceral fat area independently predicted incident diabetic kidney disease, with striking sex- and BMI-specific patterns, including a U-shaped risk curve in men and elevated risk in low-VFA men.

Cardiology Internal Medicine news

PCSK9 Inhibition Lowers LDL Cholesterol in Heterozygous Familial Hypercholesterolemia Regardless of LDL Receptor Variant Function

By MedXY 05/03/2026

In a pooled nonrandomized phase 3 analysis, monthly lerodalcibep reduced LDL-C by about 50% in heterozygous familial hypercholesterolemia, with similar efficacy across LDLR functional variant categories and broad attainment of guideline-based LDL-C goals.

Cardiology news

Development and Validation of a Clinical Polygenic Risk Report in U.S.-Based Health Systems for 8 Cardiovascular Conditions

By MedXY 05/02/2026

Researchers developed and validated integrated polygenic risk scores for eight cardiovascular conditions using data from over 245,000 individuals. These scores demonstrated strong predictive power and improved risk classification, providing a clinically implementable framework for genetic risk reporting.

Cardiology Diabetes & Endocrinology news

GLP-1 Receptor Agonists Show Lower Heart Failure Risk Versus DPP-4 Inhibitors in Type 2 Diabetes

By MedXY 05/02/2026

New research comparing diabetes medications reveals GLP-1 receptor agonists lower heart failure hospitalization risk compared to DPP-4 inhibitors, while showing similar risk to SGLT-2 inhibitors in type 2 diabetes patients.

news Oncology Public Health

Quality of Breast Cancer Care and Patient Survival Show No Link to Hospital Safety-Net Burden

By MedXY 05/01/2026

A major study reveals that safety-net hospitals—serving vulnerable Medicaid and uninsured patients—deliver breast cancer care and survival outcomes on par with other hospitals, challenging assumptions about quality disparities in resource-constrained settings.

Gastroenterology General Surgery news

Reversal of Roux-en-Y Gastric Bypass: A Swedish National Cohort Study

By MedXY 05/01/2026

This nationwide Swedish study reveals that RYGB reversal is rare (0.3% of procedures) but effective for complications like abdominal pain and hypoglycemia. While 86% reported symptom improvement, significant complication risks require careful patient selection and surgical expertise.

news OB/GYN & Women’s Health Oncology

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By MedXY 05/01/2026

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news OB/GYN & Women’s Health Oncology

Danish Multicenter Study Finds a 15% ADNEX Threshold Best Balances Early Detection and Referral Burden for Adnexal Masses

By MedXY 05/01/2026

In a Danish multicenter cohort of adnexal masses, IOTA-based models outperformed RMI for routine triage. A 15% ADNEX threshold best balanced sensitivity and referral burden in non-tertiary care.