Medxy AI

Volumetric Thresholds After Glossectomy May Predict Feeding Tube Dependence and Poor Speech

By MedXY 05/27/2026

A retrospective cohort study suggests that preoperative tumor burden, extent of tongue resection, and degree of volume restoration are strongly associated with swallowing and speech outcomes after glossectomy.

General Surgery news

Activity and Physiological Stress Within 90 Days After Minimally Invasive and Open Pancreatoduodenectomy

By MedXY 05/27/2026

Wearable activity tracking in the DIPLOMA-2 trial found that minimally invasive pancreatoduodenectomy led to more activity for about 5 weeks and less physiologic stress up to 90 days versus open surgery.

General Surgery news Oncology

Most Patients With Uncertain Response After Neoadjuvant Chemoradiotherapy for Esophageal Cancer Still Harbor Residual Disease

By MedXY 05/27/2026

In the SANO cohort, 85% of patients with uncertain post-chemoradiotherapy response had residual tumor at esophagectomy, supporting surgery for most, while highlighting a notable complete response subgroup among squamous cell carcinoma with non-traversable lesions.

news Oncology Pathology & Lab Medicine/Bệnh học

Molecular and Spatial Differences in the Tumor Microenvironment of High-Grade Serous Ovarian Cancer With Short vs Long-Term Survival

By MedXY 05/26/2026

This study found that advanced high-grade serous ovarian cancers from short-term survivors had more fibroblasts and stromal invasion signals, while tumors from long-term survivors showed stronger immune pathways, suggesting the tumor microenvironment may shape survival outcomes.

Nephrology news OB/GYN & Women’s Health

Proteinuria in Preeclampsia and Long-Term Risk of Maternal Kidney and Cardiovascular Disease

By MedXY 05/26/2026

Higher proteinuria in preeclampsia was linked to greater long-term risk of maternal hypertension and chronic kidney disease, with overall increased risk of cardiovascular disease as well.

news OB/GYN & Women’s Health

Does the order of ablation of vein-to-vein placental connections during fetoscopic laser photocoagulation affect outcomes in twin-twin transfusion syndrome?

By MedXY 05/26/2026

In TTTS, a post hoc analysis found that treating vein-to-vein placental connections at the end of fetoscopic laser surgery was linked to worse donor and recipient survival than earlier treatment.

Diabetes & Endocrinology news OB/GYN & Women’s Health

Prepregnancy Insulin Resistance and Fertility Outcomes in Women With PCOS

By MedXY 05/26/2026

Higher insulin resistance before pregnancy was linked to poorer ovulation, lower pregnancy and live-birth rates, and more gestational diabetes in women with PCOS. Improving insulin resistance during treatment was associated with better pregnancy outcomes.

Gastroenterology Internal Medicine news

Metabolic Dysfunction Did Not Worsen Short-Term Survival in Severe Alcohol-Associated Hepatitis in a Global Prospective Cohort

By MedXY 05/26/2026

In a 32-center international cohort, cardiometabolic risk factors were common in alcohol-associated hepatitis but did not independently increase 180-day mortality after adjustment for liver disease severity and competing transplant risk.

Gastroenterology news Oncology

PTEN Loss Drives MHC-I Evasion and Checkpoint Resistance in Microsatellite Stable Colorectal Cancer via NRF2-Dependent Autophagy

By MedXY 05/26/2026

A Gut study links PTEN deficiency in MSS colorectal cancer to NRF2-driven autophagic loss of MHC-I, impaired CD8+ T-cell surveillance, and resistance to anti-PD-1 therapy, while identifying NRF2 inhibition as a potential sensitizing strategy.

Neurology news

GLP-1 Receptor Agonist Use Linked to Lower Risk of Brain Aneurysm Rupture and Less Severe Bleeding

By MedXY 05/26/2026

A large real-world study found GLP-1 receptor agonist use was linked to a lower risk of intracranial aneurysm rupture and milder bleeding severity if rupture occurred.

Neurology news Public Health

French Registry Data Show Marked Declines in Relapse Activity and Faster Diagnosis in AQP4+NMOSD and MOGAD From 2010 to 2024

By MedXY 05/26/2026

A nationwide French cohort found earlier diagnosis, falling relapse rates, and major treatment shifts in AQP4+NMOSD and MOGAD, with rituximab linked to lower disability risk in AQP4+NMOSD and overall milder disability trajectories in MOGAD.

Neurology news Public Health

Digital Sleep-Wake Cycle Metrics and Dementia Prediction in Older Adults

By MedXY 05/26/2026

Wearable accelerometer sleep-wake patterns were linked to later dementia risk in two UK cohorts and modestly improved prediction beyond age and standard risk factors.

Diabetes & Endocrinology Family Medicine & Nutrition news

Can Long-Term Thyroid Cancer Follow-Up Safely Move to Primary Care? Prospective Data Support De-Escalation After Excellent Response

By MedXY 05/26/2026

A prospective cohort study suggests that differentiated thyroid cancer patients with sustained excellent response after at least 5 years of specialist follow-up can be safely transitioned to primary care with very low recurrence risk.

Diabetes & Endocrinology Gastroenterology news

Duodenal Recombinant RORDEP1 Was Safe and Triggered Early Incretin-Insulin Responses in Healthy Men

By MedXY 05/26/2026

In a randomized crossover trial, short-term duodenal r-RORDEP1 infusion was well tolerated and produced early changes in GLP-1, GIP, insulin, C-peptide, glucose, and a measure of insulin sensitivity in healthy men.

Diabetes & Endocrinology Hematology-Oncology news

Safety and Effectiveness of Rivaroxaban Thromboprophylaxis in ACTH-Dependent Cushing Syndrome

By MedXY 05/26/2026

Routine oral rivaroxaban prophylaxis in ACTH-dependent Cushing syndrome was associated with no new VTE events after implementation and no bleeding complications, suggesting it is a safe and effective preventive strategy.

Diabetes & Endocrinology news Psychiatry

Semaglutide Improves Insulin Sensitivity in Patients With Schizophrenia, Prediabetes, and Obesity Treated With Second-Generation Antipsychotics: Findings From the HISTORI Trial

By MedXY 05/26/2026

In a 30-week randomized trial, semaglutide improved insulin sensitivity, reduced insulin resistance, lowered fasting glucose, and produced substantial weight loss in patients with schizophrenia and prediabetes taking second-generation antipsychotics.

Diabetes & Endocrinology news

Six-Week Native GIP Infusion Does Not Improve Glycaemic Control in Type 2 Diabetes, Alone or With Semaglutide

By MedXY 05/26/2026

A six-week native GIP infusion did not improve glucose control in type 2 diabetes, either alone or added to semaglutide, despite raising circulating GIP levels.

Cardiology news Pathology & Lab Medicine/Bệnh học

Circulating MicroRNA Scores May Distinguish Cellular and Antibody-Mediated Heart Transplant Rejection With High Accuracy

By MedXY 05/26/2026

A prospective multicenter study found circulating microRNA rejection scores identified ACR and AMR with strong diagnostic performance and prognostic value, supporting their development as noninvasive tools to reduce reliance on surveillance biopsy after heart transplantation.

Cardiology Diabetes & Endocrinology news

Oral Semaglutide and Cardiovascular Risk Factor Changes in High-Risk Type 2 Diabetes

By MedXY 05/26/2026

Oral semaglutide improved multiple cardiovascular risk factors in high-risk type 2 diabetes, including HbA1c, weight, systolic blood pressure, inflammation, and some lipid measures, with benefits sustained over nearly four years.

Cardiology news OB/GYN & Women’s Health

Women with Chronic Coronary Artery Disease: Long-Term Outcomes After PCI vs CABG

By MedXY 05/26/2026

In women with chronic severe coronary artery disease, CABG was linked to lower long-term rates of death, stroke, heart attack, repeat revascularization, and cardiovascular readmission than PCI.