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Unraveling Immune Dysfunction in Epstein-Barr Virus-Positive Diffuse Large B-Cell Lymphoma: The Role of Systemic Antiviral Loss and Myeloid Suppression

By MedXY 06/30/2026

EBV-positive diffuse large B-cell lymphoma exhibits severe systemic antiviral T-cell impairments and a suppressive tumor microenvironment driven by LMP1, revealing novel immunobiological insights with therapeutic implications.

Hematology-Oncology news Oncology

Impact of Diagnosis-to-Treatment Interval on Outcomes in Follicular Lymphoma Undergoing Immunochemotherapy

By MedXY 06/30/2026

Shorter diagnosis-to-treatment intervals independently predict worse outcomes in follicular lymphoma treated with immunochemotherapy, highlighting a novel prognostic factor beyond existing risk indices.

Family Medicine & Nutrition news Respiratory

Empowering Climate-Conscious Inhaler Prescribing: A Patient-Physician Conversation Aid

By MedXY 06/30/2026

A novel conversation aid was developed and refined iteratively with patients and physicians to support shared decision-making for low carbon footprint inhaler prescribing in asthma and COPD, balancing environmental impact with safety and patient preferences.

news Oncology Respiratory

Hypoxic Microenvironment Triggers Early Aggressive Progression in EGFR-Mutant Lung Adenocarcinoma

By MedXY 06/29/2026

This study reveals that hypoxia in centrally located EGFR-mutant lung adenocarcinomas drives an alveolar lineage imbalance via the ZAKα-MAPK-c-Fos pathway, promoting early tumorigenesis. Therapeutic oxygenation can restore lineage balance and limit aggressive progression.

news Ophthalmology

Posterior Segment Risk Factors Influencing Penetrating Keratoplasty Graft Survival

By MedXY 06/29/2026

This study identifies intraoperative vitreous hemorrhage and silicone oil tamponade as significant posterior segment risk factors for graft failure post-penetrating keratoplasty, highlighting critical considerations in managing complex corneal transplant cases.

Infectious Diseases news Ophthalmology

Long-Term Assessment of Rose Bengal Photodynamic Therapy in Infectious Keratitis: Insights from the REAGIR Randomized Trial

By MedXY 06/29/2026

A 12-month follow-up of the REAGIR trial found no significant benefit of adjunctive rose bengal photodynamic therapy with green light over sham treatment in improving visual acuity, scar size, or complication rates in infectious keratitis.

news Ophthalmology

Enhancing Glaucoma Research Accuracy: Contrasting Diagnostic and Treatment-Based Definitions in UK Biobank

By MedXY 06/29/2026

This study compares diagnostic-only versus combined diagnostic and treatment-based definitions of glaucoma in UK Biobank participants, revealing stronger associations of risk factors and severity biomarkers with definitions including treatment evidence, thereby informing future glaucoma research in population cohorts.

Clinical Updates news Otorhinolaryngology

Swallowing Function and Perioperative Complications After Transoral Robotic Surgery: A Comprehensive Review

By MedXY 06/29/2026

This review synthesizes evidence on swallowing function and perioperative complications following transoral robotic surgery (TORS) for oropharyngeal squamous cell carcinoma (OPSCC), highlighting excellent short-term swallowing outcomes and low complication rates with early SLP rehabilitation.

Clinical Updates news Respiratory

Pregabalin Efficacy in Treatment of Chronic Neurogenic Cough: A Comprehensive Clinical Review

By MedXY 06/29/2026

Pregabalin, a neuromodulator, significantly improves symptoms in the majority of patients with chronic neurogenic cough, offering a well-tolerated treatment option irrespective of gender or gastrointestinal comorbidities.

Emergency Medicine Neurology news

Optimizing Mild Traumatic Brain Injury Care: Safely Reducing Transfers to Higher-Level Trauma Centers

By MedXY 06/29/2026

Selective local management of mild traumatic brain injury with intracranial hemorrhage shows comparable safety and outcomes to transfer to level I trauma centers, reducing unnecessary patient transfers.

Gastroenterology General Surgery news

Comparing Cholecystectomy, ERCP, and Conservative Management for Gallstone-Related Acute Pancreatitis: Evidence from a Nationwide Cohort

By MedXY 06/29/2026

A nationwide Swedish cohort study shows same-admission cholecystectomy significantly reduces recurrence and complications after gallstone-related acute pancreatitis compared to ERCP alone or no intervention.

General Surgery news Oncology

Refining Prognostic Assessment in Perihilar Cholangiocarcinoma: The Clinical Utility of Dual Radial Margin Distance Cutoffs

By MedXY 06/29/2026

This study identifies dual cutoff values of 0 and 1 mm for radial margin distance in perihilar cholangiocarcinoma, providing a simple and effective stratification tool for postoperative recurrence risk and survival prediction.

news OB/GYN & Women’s Health Oncology

PRO-PLATINUM Trial: Probiotic Modulation of the Microbiome to Enhance Outcomes in Ovarian Cancer Chemotherapy

By MedXY 06/29/2026

The PRO-PLATINUM trial evaluates a novel 5-strain probiotic's effect on gut and vaginal microbiome composition and clinical outcomes in ovarian cancer patients undergoing platinum chemotherapy, assessing safety, feasibility, and translational biomarkers.

news OB/GYN & Women’s Health

Impact of Ring Pessary on Pelvic Anatomy in Upright Position: Insights from Prospective Upright MRI Study

By MedXY 06/28/2026

Upright MRI shows pessary insertion lifts pelvic organs in women with prolapse, with lasting uterine repositioning but transient bladder elevation, informing symptom relief mechanisms.

news OB/GYN & Women’s Health

Unveiling Posttraumatic Stress Trajectories Following Vaginal Delivery: Implications for Early Identification and Intervention

By MedXY 06/28/2026

This multicenter prospective study identifies distinct posttraumatic stress symptom trajectories after vaginal delivery and highlights associated risk factors, providing insights to enhance postpartum PTSD screening and prevention strategies.

news OB/GYN & Women’s Health

Optimizing Postpartum Care: Evaluating High-Dose Oxytocin Infusion to Reduce Blood Loss After Vaginal Delivery

By MedXY 06/28/2026

A quality-improvement study shows that higher prophylactic oxytocin infusion rates after vaginal birth significantly reduce postpartum blood loss and decrease the need for additional uterotonic medications, without increasing transfusion or hemorrhage rates.

Gastroenterology news Oncology

Strategic Sequencing of Systemic Therapies in Advanced Hepatocellular Carcinoma: Beyond the Second Line

By MedXY 06/28/2026

This article reviews evolving therapeutic sequences in advanced hepatocellular carcinoma, highlighting the integration of immune-based combinations, tyrosine kinase inhibitors, liver function preservation, and the emerging multidimensional CUSE framework to optimize patient outcomes beyond second-line treatment.

Clinical Updates Gastroenterology Infectious Diseases news

Functional Anti-preS1 Antibody Responses and Their Role in Viral Control in Chronic Hepatitis B

By MedXY 06/28/2026

This review synthesizes evidence on preS1 antigen and anti-preS1 IgG dynamics in chronic hepatitis B, highlighting their correlations with viral replication, liver inflammation, and functional cure, and elucidates the neutralising potential of anti-preS1 antibodies as markers of endogenous viral control.

Cardiology Neurology news

Left Atrial to Ventricular Volume Ratio: A Novel Imaging Biomarker Enhancing Detection of Atrial Cardiopathy and Stroke Risk

By MedXY 06/28/2026

The left atrial to ventricular volume ratio (LA:LV ratio) emerges as a superior marker over left atrial volume index (LAVi) for atrial cardiopathy, showing stronger association with ischemic stroke risk, cognitive decline, and atrial fibrillation detection in large cohorts.

Neurology news

Incidental DWI-Positive Lesions as Emerging Biomarkers in Cerebral Small Vessel Disease: Insights from CAA and CADASIL Cohorts

By MedXY 06/28/2026

Incidental DWI-positive lesions are prevalent in cerebral amyloid angiopathy and CADASIL, showing disease-specific distributions and associations with neurodegeneration and MRI biomarkers. These findings underscore their potential role as markers of small vessel disease.