Ophthalmology – Medxy AI

Optimized AAV5-RPGR Gene Therapy Rescues Photoreceptor Integrity and Function in X-Linked Retinitis Pigmentosa Mouse Model

By MedXY 06/13/2026

An optimized AAV5 vector delivering a stabilized human RPGR ORF15 gene significantly restores photoreceptor structure and function in RPGR-deficient mice, demonstrating a promising gene therapy for X-linked retinitis pigmentosa.

news Ophthalmology

Familial Patterns of Strabismus and Subnormal Stereopsis in Parents of Affected Children: Implications for Genetic Research

By MedXY 06/12/2026

A large prospective study reveals high prevalence of strabismus and decreased stereopsis in parents of children with strabismus, underscoring familial inheritance and subclinical phenotypes useful for genetic studies.

Diabetes & Endocrinology news Ophthalmology

Semaglutide and Neovascular Age-Related Macular Degeneration Among Adults with Type 2 Diabetes: An OHDSI Network Study

By MedXY 06/10/2026

In a large OHDSI network study of adults with type 2 diabetes, semaglutide was not associated with a higher or lower risk of neovascular age-related macular degeneration.

Clinical Updates news Ophthalmology

Subclinical Peripheral Vascular Leakage in Demyelinating Disease-Associated Uveitis: What Ultra-Widefield Angiography Adds Beyond Clinical Quiescence

By MedXY 06/08/2026

A new cohort study suggests ultra-widefield fluorescein angiography frequently detects persistent peripheral leakage in clinically inactive demyelinating disease-associated uveitis, highlighting a potential gap between examination-based remission and angiographic activity.

news Ophthalmology Pediatrics

Retinal Nerve Fiber Layer Thickness at 36 Weeks May Help Predict 2-Year Neurodevelopment in Very Preterm Infants

By MedXY 06/08/2026

In very preterm infants, thicker retinal nerve fiber layer on OCT at 36 weeks’ postmenstrual age was associated with better motor and cognitive outcomes at 2 years, supporting retinal imaging as a potential early neurodevelopmental biomarker.

Diabetes & Endocrinology news Ophthalmology

Poor Glycemic Control and Higher Blood Pressure Track With Early Diabetic Retinal Disease in Youth With Type 1 Diabetes

By MedXY 06/08/2026

A large retrospective study links higher HbA1c and elevated blood pressure to diabetic retinopathy in youth with type 1 diabetes, while worse glycemia also correlates with thinner inner retinal layers suggestive of early neurodegeneration.

news Ophthalmology Public Health

Most Open-Angle Glaucoma Suspects Convert at Less Than 6% Per Year After Year 1, Supporting Risk-Stratified Follow-Up

By MedXY 06/06/2026

A large US claims-based cohort suggests that most open-angle glaucoma suspects have modest annual conversion risk after the first year, and that age- and treatment-informed surveillance intervals may help tailor follow-up intensity.

Diabetes & Endocrinology news Ophthalmology

Veligrotug Delivers Rapid, Durable Benefit in Active Thyroid Eye Disease in the Phase 3 THRIVE Trial

By MedXY 06/06/2026

In phase 3 testing, veligrotug produced rapid and clinically meaningful reductions in proptosis, diplopia, and disease activity in active thyroid eye disease, with durable benefit through 52 weeks and a favorable short-term safety profile.

news Oncology Ophthalmology

Immune Checkpoint Inhibitor-Associated Uveitis: Comparative Risk Across Cancers and Drug Classes

By MedXY 06/04/2026

A multicenter study found that immune checkpoint inhibitor–associated uveitis risk varies by cancer type and drug class, with melanoma showing the highest intrinsic risk and RCC risk largely linked to ipilimumab/nivolumab exposure.

news Ophthalmology Public Health

A Clinically Relevant Threshold of Impaired Contrast Sensitivity Among Older US Adults

By MedXY 06/04/2026

A large U.S. study found that a contrast sensitivity score of 1.60 logCS marks the point where older adults are more likely to experience everyday vision disability, even when standard visual acuity may seem acceptable.

Diabetes & Endocrinology news Ophthalmology

No Signal for Increased Neovascular AMD Risk With Semaglutide in Adults With Type 2 Diabetes: Interpretation of a Large OHDSI Network Study

By MedXY 06/04/2026

A multinational OHDSI network analysis found no meaningful association between semaglutide use and neovascular age-related macular degeneration among adults with type 2 diabetes across cohort and self-controlled designs.

news Ophthalmology

Progression in Preperimetric Glaucoma Eyes With and Without Microvasculature Dropout

By MedXY 06/02/2026

In preperimetric glaucoma, baseline microvasculature dropout on OCTA predicted faster capillary density loss and a higher risk of later visual field damage, suggesting it may help identify eyes needing closer follow-up.

news Ophthalmology

Progression in Preperimetric Glaucoma Eyes With and Without Microvasculature Dropout

By MedXY 06/02/2026

Eyes with preperimetric glaucoma and baseline microvasculature dropout progressed faster in capillary density loss and were more likely to develop visual field damage.

news Ophthalmology

Pathologic Myopia Globe Shape and Long-Term Prognosis

By MedXY 06/01/2026

Three-dimensional eye shape on MRI predicted 15-year outcomes in high myopia. Nasally distorted and conical eyes had the highest risk of rapid elongation, macular thinning, myopic degeneration, and visual field defects.

Neurology news Ophthalmology

A Pain-Predominant Dry Eye Phenotype Emerges: Severe Symptoms, Few Ocular Signs, and Strong Links to Migraine and Psychiatric Disease

By MedXY 06/01/2026

A 2026 Ophthalmology report identified a pain-predominant dry eye phenotype in 6.9% of patients, marked by high symptom burden, minimal surface signs, and enrichment for migraine and psychiatric comorbidity.

news Ophthalmology

Optical Coherence Tomography Features of Inactive Multifocal Choroiditis with Panuveitis and Punctate Inner Choroidopathy Lesions

By MedXY 05/29/2026

OCT imaging revealed that inactive MFCPU/PIC lesions commonly show Bruch’s membrane disruption, inner retinal herniation, and focal choroidal excavation, helping distinguish them from inflammatory and infectious mimickers.

news Ophthalmology Rheumatology

Ocular Inflammation Linked to Higher Risk of Anti-Adalimumab Antibodies in Autoimmune Disease Patients

By MedXY 05/29/2026

Ocular inflammation was linked to a higher risk of anti-adalimumab antibody formation in patients treated with adalimumab. More than 20% developed antibodies, supporting closer monitoring and therapeutic drug testing in high-risk patients.

news Ophthalmology

Predictors of 1-Year Visual Outcome in Central-Involving Submacular Hemorrhage Secondary to Neovascular AMD

By MedXY 05/27/2026

This study found that younger age, better baseline vision, smaller hemorrhage size, and thicker subfoveal choroid predicted better 1-year visual outcomes after fovea-involving submacular hemorrhage from nAMD or PCV.

news Ophthalmology

Genomic Risk Profiling May Help Predict Which Patients With Fuchs Endothelial Corneal Dystrophy Progress to Keratoplasty

By MedXY 05/27/2026

A 2026 Ophthalmology study suggests that combining CTG18.1 expansion testing with a FECD-specific polygenic risk score can improve prediction of keratoplasty risk across independent cohorts.