Beyond Total Area: The GAWAIN Index Bridges the Gap Between Retinal Structure and Functional Vision in Geographic Atrophy
Posted innews Ophthalmology

Beyond Total Area: The GAWAIN Index Bridges the Gap Between Retinal Structure and Functional Vision in Geographic Atrophy

Researchers have developed and validated GAWAIN, a novel structural measure for geographic atrophy that weights macular regions by their functional importance. This index correlates significantly better with visual acuity than traditional area-based measurements, potentially revolutionizing clinical trial endpoints.
Quantitative Retinal Leakage on Ultra-Widefield Imaging: A New Biomarker for Predicting Diabetic Retinopathy Progression
Posted inDiabetes & Endocrinology news Ophthalmology

Quantitative Retinal Leakage on Ultra-Widefield Imaging: A New Biomarker for Predicting Diabetic Retinopathy Progression

A post hoc analysis of the DRCR Retina Network Protocol AA reveals that automated quantitative leakage index on ultra-widefield fluorescein angiography independently predicts the 4-year risk of DRSS worsening and vision-threatening complications in patients with nonproliferative diabetic retinopathy.
NT-501 Encapsulated Cell Therapy Successfully Slows Photoreceptor Loss in Macular Telangiectasia Type 2: Results from Two Phase 3 Trials
Posted innews Ophthalmology

NT-501 Encapsulated Cell Therapy Successfully Slows Photoreceptor Loss in Macular Telangiectasia Type 2: Results from Two Phase 3 Trials

Two Phase 3 trials show that NT-501 encapsulated cell therapy significantly reduces ellipsoid zone area loss in Macular Telangiectasia Type 2. While functional outcomes were inconsistent, the treatment demonstrated a robust neuroprotective effect against photoreceptor degeneration over 24 months.
Medical and Surgical Treatments for Neurotrophic Keratopathy: What Randomized Trials Tell Us (and What They Don’t)
Posted innews Ophthalmology

Medical and Surgical Treatments for Neurotrophic Keratopathy: What Randomized Trials Tell Us (and What They Don’t)

A Cochrane review of seven RCTs (494 participants) finds low- to very low-certainty evidence that select medical therapies — notably recombinant human nerve growth factor — may improve corneal re-epithelialization in neurotrophic keratopathy; evidence on vision, sensitivity, and surgical options remains inconclusive.
Rigid Gas-Permeable Contact Lenses Improve Visual Rehabilitation After Primary Congenital Glaucoma Surgery: Results of the CLEVR‑PCG Randomized Trial
Posted innews Ophthalmology Pediatrics

Rigid Gas-Permeable Contact Lenses Improve Visual Rehabilitation After Primary Congenital Glaucoma Surgery: Results of the CLEVR‑PCG Randomized Trial

In children after primary congenital glaucoma surgery with poor spectacle response, rigid gas‑permeable contact lenses produced greater improvements in worse‑eye visual acuity, contrast sensitivity, and near stereoacuity over 12 months compared with continued spectacle wear.