SSRIs vs. Second-Generation Antipsychotics for Managing Agitation in Dementia: Real-World Evidence from Nursing Homes
Highlight Agitation is prevalent among dementia patients in nursing homes, often managed with pharmacologic agents.…
Posted inNeurology news Public Health
Long-Term Road Traffic Noise Exposure and Its Association with Parkinson Disease Risk: Insights from a Danish Nationwide Cohort Study
A nationwide Danish study links prolonged residential road traffic noise exposure with increased Parkinson disease risk, highlighting the protective effect of having a quiet building facade.
Posted inClinical Updates Neurology news Psychiatry
Mapping 2-Year Psychiatric and Neurologic Risks After Infections Across Body Systems and Age Groups: An Integrative Review
This review synthesizes evidence on 2-year psychiatric and neurologic risks post infections across body systems and age groups, highlighting infection-specific risk profiles, age-dependent vulnerability, and mechanistic insights from recent cohort and prospective studies.
Posted inCritical Care Neurology news
Enhancing Decannulation Success in Neurologic Patients: The Role of Abdominal Electrical Stimulation Combined With Airway Clearance Techniques
Combining abdominal electrical stimulation with airway clearance improves cough strength, muscle thickness, and decannulation rates in tracheostomized patients with neurologic disorders, without impacting infection or diaphragm mobility.
Posted inNeurology news Rheumatology
Assessing the Risk of CNS Demyelination Associated with TNF-α Inhibitors: Insights from a Large US Health Network
A large retrospective study reveals a small but significant increase in CNS demyelination risk among patients treated with TNF-α inhibitors, varying by agent, with generally low absolute incidence.
Posted inNeurology news Psychiatry
Familial Microvascular Traits and Neuropsychiatric Factors Reflected in Brain Perivascular Space Morphometry
Brain perivascular space morphometry reveals familial microvascular architecture and neuropsychiatric influences, offering a novel imaging biomarker of cerebral microvascular health beyond traditional vascular risk factors.
Comparative Effectiveness and Safety of Emerging Myasthenia Gravis Therapies: Insights From a Bayesian Network Meta-Analysis
A Bayesian network meta-analysis comparing FcRn inhibitors, C5 complement inhibitors, and CD19+ B-cell depletion therapies reveals comparable efficacy but varied safety profiles in generalized myasthenia gravis treatment, highlighting the need for prospective head-to-head trials.
Posted inNeurology news OB/GYN & Women’s Health
Impaired Hearing and Elevated Systolic Blood Pressure: Clinical Markers for Silent Cerebral Infarcts Following Eclampsia
A prospective study identifies impaired hearing and high systolic blood pressure as accessible clinical markers associated with silent cerebral infarcts in women after eclampsia, suggesting potential triage tools for neuroimaging and follow-up.
Optical Ministroke in the Mediodorsal Thalamus Reveals Critical Links Between Sleep Oscillations and Memory Restoration
A novel optically guided stroke model targeting the mediodorsal thalamus in mice revealed disruptions in sleep stability, thalamocortical oscillations, and working memory. Auditory stimulation during sleep restored these functions, underscoring a potential therapeutic approach for thalamic stroke recovery.
Sustained Upper Limb Recovery with Paired Vagus Nerve Stimulation Two Years Post-Stroke: Insights from the VNS-REHAB Trial
Paired vagus nerve stimulation (VNS) combined with rehabilitation achieves significant and durable improvements in upper extremity function, participation, and quality of life up to two years after chronic ischemic stroke, highlighting its potential as an enduring therapeutic option.
Posted inAllergy & Immunology Neurology news
Interleukin 6 Receptor Blockade: A Promising Strategy for Relapse Prevention in MOG Antibody-Associated Disease
IL-6 receptor blockade significantly reduces relapse rates in MOG antibody-associated disease, showing comparable efficacy to high-dose IVIG with a favorable safety profile, supporting its role in relapse prevention.
MAD-MT Score: Enhancing Patient Selection for Mechanical Thrombectomy in Distal Vessel Occlusions
The MAD-MT score integrates clinical and procedural factors to optimize mechanical thrombectomy decisions in distal and medium vessel occlusion strokes, guiding tailored treatment and improving functional outcomes.
Discriminating Prion Diseases from Alzheimer’s Disease Using Plasma Biomarkers: The Crucial Role of NfL/p-tau217 Ratio
Plasma phosphorylated tau biomarkers overlap in Alzheimer’s and prion diseases, risking diagnostic confusion. The NfL/p-tau217 ratio emerges as an accurate plasma biomarker to distinguish prion diseases from Alzheimer’s, improving diagnostic precision and guiding appropriate clinical management.
Posted inNeurology news Orthopedics
Acute Neural Biomarker Elevations After Amateur Soccer Heading: Insights Into Potential Brain Injury
This study reveals that even amateur soccer heading causes immediate, transient increases in blood biomarkers p-tau217 and S100B, indicating acute neural impact and suggesting a dose-response effect.
Posted inNeurology news Plastic Surgery
Enhancing Facial Reanimation Outcomes: The Impact of Fascia Lata Suspension in Triple Nerve Transfer Procedures
This study compares triple nerve transfer alone versus combined with fascia lata suspension, finding that fascia lata suspension significantly improves facial function, symmetry, and psychosocial outcomes in patients with severe soft tissue laxity after long-standing facial paralysis.
Posted inClinical Updates Neurology news Psychiatry
Ischemic Placental Disease and Maternal Hospitalization for Neurological and Psychiatric Disorders: A Comprehensive Review
This review synthesizes evidence linking ischemic placental disease—comprising preeclampsia, placental abruption, and fetal growth restriction—with increased postpartum maternal risk of neurological and psychiatric hospitalizations within one year of delivery, highlighting microvascular dysfunction's role in maternal brain vulnerability.
Sex Differences in Large Vessel Occlusion Screening and Thrombectomy Outcomes: Insights from a Population-Based Cohort Study in Ontario
This study reveals that female stroke patients are less frequently screened for large vessel occlusion (LVO) yet have a higher LVO prevalence and comparable thrombectomy use to males, with better long-term outcomes post-thrombectomy.
Perfusion Imaging’s Role in Endovascular Therapy Outcomes for Posterior Cerebral Artery Stroke
This study elucidates how baseline perfusion imaging parameters impact clinical outcomes and safety in isolated posterior cerebral artery occlusions treated with endovascular therapy, highlighting prognostic significance but limited predictive utility for EVT benefit.
Posted inNeurology news Public Health
Long-Term Economic Impact of Early-Onset Dementia: A 15-Year Retrospective Analysis of Income and Productivity Loss
This study reveals significant income and productivity losses up to 15 years before diagnosis in early-onset dementia, varying across subtypes, underscoring the urgent need for earlier detection and support.
Posted inGastroenterology Neurology news
From Gut Feeling to Brain Mapping: Decoding Defecation Urgency in IBS
Defecation urgency in IBS is a complex symptom intertwining sensory thresholds and emotional processing, reflected in distinct brain structural changes identified through MRI. Differentiating experimentally induced versus real-life urgency improves understanding of its multidimensional nature.