prognosis – Medxy AI

VEGFA and EGF Genetic Variants: Impact on Cholangiocarcinoma Susceptibility and Postoperative Prognosis

By MedXY 11/11/2026

VEGFA and EGF polymorphisms differentially affect cholangiocarcinoma susceptibility and postoperative survival, highlighting their potential as biomarkers for clinical stratification.

Clinical Updates Dentistry Superintelligence

AI Versus Clinicians: Evaluating Accuracy in 10-Year Periodontal Tooth Loss Prognosis

By MedXY 11/08/2026

A comparative study shows clinicians outperform AI in fixed-threshold periodontal prognosis, but AI matches clinician accuracy using optimal thresholds, highlighting AI’s potential alongside experts in predicting long-term tooth loss.

Clinical Updates Ophthalmology

Polygenic Risk Impact on Lifetime Risk and Prognosis of Glaucoma: Clinical Insights and Future Applications

By MedXY 11/07/2026

This review synthesizes recent evidence demonstrating that glaucoma polygenic risk scores (PRS) enhance risk stratification and prognosis, outperforming family history, and supporting PRS-guided screening and management interventions.

Dermatology news Oncology

Neutrophil-to-Lymphocyte Ratio as a Prognostic Biomarker in High-Risk Cutaneous Squamous Cell Carcinoma

By MedXY 10/21/2026

Preoperative neutrophil-to-lymphocyte ratio (NLR) predicts poor outcomes in high-risk cutaneous squamous cell carcinoma, offering a cost-effective tool to enhance risk stratification.

葡萄膜黑色素瘤的15-GEP/PRAME检测预后价值：有无确认性细胞病理学的比较

news Ophthalmology Pathology & Lab Medicine

Prognostic Value of 15-GEP/PRAME Assay With or Without Confirmatory Cytopathology in Uveal Melanoma: Insights From the Collaborative Ocular Oncology Group Study 2

By MedXY 10/20/2026

This study validates the prognostic accuracy of the 15-gene expression profiling (15-GEP) and PRAME assay in uveal melanoma patients irrespective of confirmatory cytopathology, supporting its use in clinical management when cytopathology is unavailable.

重新校准转甲状腺素蛋白淀粉样变性心肌病中的二尖瓣反流评估：一项多中心队列研究提升预后判别精度

Cardiology news

Refining Mitral Regurgitation Assessment in Transthyretin Amyloid Cardiomyopathy: A Multicenter Cohort Study Enhances Prognostic Precision

By MedXY 10/20/2026

This study establishes transthyretin amyloid cardiomyopathy-specific mitral regurgitation thresholds, revealing lower severity cutoffs than guidelines and enhancing mortality and heart failure hospitalization risk prediction.

Dermatology news Oncology

COMPASS-SCC: A Novel Prognostic and Staging System Enhancing Risk Stratification in Cutaneous Squamous Cell Carcinoma

By MedXY 10/17/2026

The COMPASS-SCC, developed from a large international cohort, offers improved prognostic accuracy for cutaneous squamous cell carcinoma compared to existing AJCC8 and BWH staging systems, aiding clinical decision-making for metastasis and mortality risk.

Dermatology news Oncology

Impact of Primary Melanoma Stage on Survival Outcomes in Advanced Disease: Insights from the Spanish Melanoma Registry GEM1801

By MedXY 10/13/2026

Systemic relapse after stage I melanoma, though rare, portends higher tumor burden and poorer survival compared with relapse after stage II/III disease, as evidenced by data from 365 metastatic melanoma patients in the Spanish Melanoma Registry GEM1801.

Hematology-Oncology news

Prognostic Significance of Telomere Length in Chronic Lymphocytic Leukemia Under Venetoclax-Based First-Line Therapy

By MedXY 10/11/2026

Telomere length serves as an independent prognostic marker for progression-free survival in chronic lymphocytic leukemia patients treated with venetoclax-based regimens, highlighting its role in risk stratification during the modern targeted therapy era.

news Respiratory

Age-Adjusted Whole Genome Sequencing Telomere Length in Idiopathic Pulmonary Fibrosis: Enhancing Diagnostic and Prognostic Precision

By MedXY 10/11/2026

Age-adjusted WGS-estimated telomere length improves identification of pathologically short telomeres and detection of telomere-related variants in IPF, associating with survival outcomes but offering limited survival prediction beyond clinical variables.

news Respiratory

Polygenic Risk Score Enhances Diagnosis and Prognostic Stratification in Idiopathic Pulmonary Fibrosis

By MedXY 10/08/2026

A polygenic risk score (PRS) significantly associates with IPF diagnosis and mortality, demonstrating potential for improving clinical risk stratification using real-world biobank data.

Gastroenterology news Oncology

Harnessing Circulating Tumour DNA for Minimal Residual Disease Detection in Colorectal Cancer: Insights from the INTERCEPT Programme

By MedXY 10/05/2026

The INTERCEPT study demonstrates that longitudinal ctDNA testing effectively detects minimal residual disease post-curative treatment in colorectal cancer, enhancing recurrence prediction and refining risk stratification to guide future interventions.

Cardiology Clinical Updates news

Cardiovascular-Kidney-Metabolic Multimorbidity in Heart Failure: Prevalence, Prognostic Impact, and Clinical Implications Across Ejection Fraction Phenotypes

By MedXY 10/05/2026

Most heart failure patients harbor multiple cardiovascular-kidney-metabolic conditions, which independently escalate mortality and readmission risk, especially in HFrEF, underscoring the need for integrated management strategies tailored by ejection fraction.

Hematology-Oncology news

Soluble BCMA as a Key Biomarker Defining Tumor Phenotypes and Prognosis in Newly Diagnosed Multiple Myeloma

By MedXY 09/26/2026

Soluble BCMA levels in newly diagnosed multiple myeloma patients reveal distinct tumor phenotypes and predict prognosis more strongly than tumor volume, enabling improved risk stratification and clinical decision-making.

Cardiology news

Enhancing Prognosis in Stable Coronary Artery Disease: Insights from a Nationwide Cohort on FFR-CT

By MedXY 09/25/2026

This large nationwide study demonstrates that coronary CTA-derived FFR-CT strongly predicts future myocardial infarction, cardiovascular death, and revascularization, independent of traditional risk factors and stenosis severity, with a threshold value of 0.67 defining increased risk.

Cardiology news Respiratory

Brain Natriuretic Peptide Levels as a Prognostic Biomarker After Pulmonary Endarterectomy in Chronic Thromboembolic Pulmonary Hypertension

By MedXY 09/20/2026

This study demonstrates that elevated brain natriuretic peptide (BNP) post-pulmonary endarterectomy strongly predicts mortality in chronic thromboembolic pulmonary hypertension (CTEPH), providing valuable prognostic information beyond persistent pulmonary hypertension status.

news OB/GYN & Women's Health Oncology

Molecular Stratification of Early-Stage Vulvar Squamous Cell Carcinoma: Prognostic Impact of HPV and TP53 Status

By MedXY 09/19/2026

This study highlights how HPV and TP53 molecular subtyping in stage I vulvar squamous cell carcinoma delineates survival outcomes and recurrence risks, supporting its role in personalized management strategies.

Cardiology news

Cardiac Sarcoidosis: Nationwide Insights into Diagnosis, Management, and Outcomes from the MYSTICS Registry

By MedXY 09/17/2026

The MYSTICS Registry provides robust data on cardiac sarcoidosis, highlighting diagnostic challenges, treatment patterns, and prognostic differences among phenotypes, emphasizing tailored management strategies to improve patient outcomes.

Neurology news Otorhinolaryngology

Synergistic Impact of Age and Nerve Degeneration on Bell’s Palsy Recovery: Clinical Implications

By MedXY 09/14/2026

Older adults with severe nerve impairment in Bell's palsy experience markedly poorer recovery, highlighting the critical role of early, aggressive intervention.

Neurology news Otorhinolaryngology

Enhancing Prognosis in Bell Palsy: Electrodiagnostic Testing Beyond House-Brackmann Grade

By MedXY 09/13/2026

Electrodiagnostic tests, notably electroneuronography and electromyography, significantly improve prognosis prediction for Bell palsy recovery, including patients with moderate paralysis (H-B grade IV). These findings support broader use to refine clinical assessment.