二甲双胍联合孕激素用于子宫内膜肿瘤保留生育治疗：FELICIA 试验带来的启示
Posted innews OB/GYN & Women's Health Oncology

Adjunctive Metformin with Progestin in Fertility-Sparing Treatment of Endometrial Neoplasia: Insights from the FELICIA Trial

The FELICIA phase IIb trial found that adding metformin to progestin therapy for fertility-sparing treatment in endometrial neoplasia did not improve 3-year recurrence-free survival or remission rates, though some reproductive outcomes favored metformin. Safety was consistent with known profiles.
腎細胞癌の下大静脈血栓摘除術前に行う定位放射線焼灼療法：新たな第2相エビデンスの総括
Posted inClinical Updates news Oncology Radiology

Neoadjuvant Stereotactic Ablative Radiotherapy Prior to Inferior Vena Cava Thrombectomy in Renal Cell Carcinoma: A Synthesis of Emerging Phase 2 Evidence

This review synthesizes phase 2 trial data supporting neoadjuvant stereotactic ablative radiotherapy for RCC with IVC tumor thrombus, highlighting improved recurrence-free survival, acceptable safety, and biomarker insights that underscore its potential as a novel preoperative strategy.
Posted innews OB/GYN & Women's Health Oncology

Expanding the Genetic Landscape in Ovarian Carcinoma: Insights from the PERSONA-Ovary Trial on Germline and Somatic Testing

The PERSONA-Ovary trial demonstrates the feasibility and clinical value of unselected germline multigene panel testing alongside somatic BRCA analysis in ovarian carcinoma, revealing a 29.7% pathogenic variant prevalence and optimal testing strategies for integrating genetics into routine care.