Efficacy and Safety of Cagrilintide-Semaglutide Combination vs Semaglutide Alone for Weight Management in East Asian Adults with Overweight/Obesity: REDEFINE 5 Trial
Posted inDiabetes & Endocrinology news

Efficacy and Safety of Cagrilintide-Semaglutide Combination vs Semaglutide Alone for Weight Management in East Asian Adults with Overweight/Obesity: REDEFINE 5 Trial

Phase 3a trial in Japan/Taiwan shows cagrilintide-semaglutide combination delivers superior weight loss (18.4%) versus semaglutide alone (11.9%) in adults with overweight/obesity ± type 2 diabetes, with comparable safety profiles dominated by manageable gastrointestinal side effects.
Genetic Variant in CUBN Gene Identified as Key Risk Factor for Metformin-Induced Vitamin B12 Deficiency
Posted inDiabetes & Endocrinology Internal Medicine news

Genetic Variant in CUBN Gene Identified as Key Risk Factor for Metformin-Induced Vitamin B12 Deficiency

Researchers have identified a genetic variant in the cubilin gene (CUBN, rs1801222) that significantly increases the risk of metformin-induced vitamin B12 deficiency, with carriers of the AA genotype experiencing deficiency up to twice as fast as GG carriers. This discovery offers potential for targeted clinical monitoring in high-risk patients.
Dairy-Enriched High-Protein Breakfast Enhances Circadian Gene Expression and Glycemic Control in Type 2 Diabetes
Posted inDiabetes & Endocrinology Family Medicine & Nutrition news

Dairy-Enriched High-Protein Breakfast Enhances Circadian Gene Expression and Glycemic Control in Type 2 Diabetes

A randomized crossover trial demonstrates that a dairy-enriched diet with high-protein breakfast and early daytime carbohydrate restriction significantly upregulates circadian clock genes (BMAL1, REV-ERBα, CRY1), improves glycemic metrics including fasting glucose and time in range, and reduces appetite in individuals with type 2 diabetes.
Semaglutide and Nonarteritic Anterior Ischemic Optic Neuropathy: Synthesizing Evidence from Target Trial Emulations and Global Pharmacovigilance
Posted inClinical Updates Diabetes & Endocrinology news Ophthalmology

Semaglutide and Nonarteritic Anterior Ischemic Optic Neuropathy: Synthesizing Evidence from Target Trial Emulations and Global Pharmacovigilance

This review synthesizes recent evidence regarding the association between semaglutide initiation and nonarteritic anterior ischemic optic neuropathy (NAION), contrasting high-risk findings in real-world cohort studies with neutral findings in RCT meta-analyses and exploring potential mechanistic pathways.
Optimizing the ‘When’ of Exercise: Afternoon and Evening Activity as a Precision Medicine Tool for Diabetes Risk Reduction
Posted inDiabetes & Endocrinology Internal Medicine news

Optimizing the ‘When’ of Exercise: Afternoon and Evening Activity as a Precision Medicine Tool for Diabetes Risk Reduction

New evidence from the UK Biobank and NHANES suggests that the timing of moderate-to-vigorous physical activity (MVPA) significantly impacts type 2 diabetes risk. Clustering activity in the afternoon and evening provides superior metabolic protection compared to morning sessions, independent of the total volume of exercise performed.