Dairy-Enriched High-Protein Breakfast Enhances Circadian Gene Expression and Glycemic Control in Type 2 Diabetes
Posted inDiabetes & Endocrinology Family Medicine & Nutrition news

Dairy-Enriched High-Protein Breakfast Enhances Circadian Gene Expression and Glycemic Control in Type 2 Diabetes

A randomized crossover trial demonstrates that a dairy-enriched diet with high-protein breakfast and early daytime carbohydrate restriction significantly upregulates circadian clock genes (BMAL1, REV-ERBα, CRY1), improves glycemic metrics including fasting glucose and time in range, and reduces appetite in individuals with type 2 diabetes.
Semaglutide and Nonarteritic Anterior Ischemic Optic Neuropathy: Synthesizing Evidence from Target Trial Emulations and Global Pharmacovigilance
Posted inClinical Updates Diabetes & Endocrinology news Ophthalmology

Semaglutide and Nonarteritic Anterior Ischemic Optic Neuropathy: Synthesizing Evidence from Target Trial Emulations and Global Pharmacovigilance

This review synthesizes recent evidence regarding the association between semaglutide initiation and nonarteritic anterior ischemic optic neuropathy (NAION), contrasting high-risk findings in real-world cohort studies with neutral findings in RCT meta-analyses and exploring potential mechanistic pathways.
Optimizing the ‘When’ of Exercise: Afternoon and Evening Activity as a Precision Medicine Tool for Diabetes Risk Reduction
Posted inDiabetes & Endocrinology Internal Medicine news

Optimizing the ‘When’ of Exercise: Afternoon and Evening Activity as a Precision Medicine Tool for Diabetes Risk Reduction

New evidence from the UK Biobank and NHANES suggests that the timing of moderate-to-vigorous physical activity (MVPA) significantly impacts type 2 diabetes risk. Clustering activity in the afternoon and evening provides superior metabolic protection compared to morning sessions, independent of the total volume of exercise performed.
OGTT-Derived Surrogate Indexes Outperform Fasting Measures in Predicting Type 2 Diabetes Risk: A Longitudinal Analysis
Posted inDiabetes & Endocrinology Internal Medicine news

OGTT-Derived Surrogate Indexes Outperform Fasting Measures in Predicting Type 2 Diabetes Risk: A Longitudinal Analysis

A longitudinal study of 2,260 participants confirms that oral glucose tolerance test (OGTT)-based surrogate indexes, particularly Gutt and Cederholm, are superior to fasting-only measures in predicting type 2 diabetes, providing high clinical utility for metabolic risk stratification.
Long-Term Benfotiamine Treatment Fails to Improve Diabetic Polyneuropathy: Insights from the BOND Randomized Controlled Trial
Posted inDiabetes & Endocrinology Neurology news

Long-Term Benfotiamine Treatment Fails to Improve Diabetic Polyneuropathy: Insights from the BOND Randomized Controlled Trial

The 12-month BOND study found that high-dose benfotiamine (600 mg daily) did not significantly improve corneal nerve fiber length or other neurophysiological markers in patients with type 2 diabetes and symptomatic polyneuropathy, despite successfully increasing systemic thiamine levels.