Cardiovascular and Respiratory Responses During Graded Exercise in Adolescents After Sport-Related Concussion: A Synthesis of Current Evidence
Posted inCardiology Clinical Updates news Rehabilitation Medicine Respiratory

Cardiovascular and Respiratory Responses During Graded Exercise in Adolescents After Sport-Related Concussion: A Synthesis of Current Evidence

Exploring altered cardiopulmonary dynamics and exercise intolerance in adolescents post-sport-related concussion reveals attenuated cardiovascular responses independent of aerobic deconditioning, highlighting autonomic dysregulation as a key mechanism.
Brensocatib Shows Imaging Signals of Structural Benefit in Non‑CF Bronchiectasis: CT Substudy from ASPEN Suggests Reduced Mucus Plugging and Modest Airway Change
Posted innews Respiratory

Brensocatib Shows Imaging Signals of Structural Benefit in Non‑CF Bronchiectasis: CT Substudy from ASPEN Suggests Reduced Mucus Plugging and Modest Airway Change

A 100‑patient CT substudy from the ASPEN program found that brensocatib, especially the 25‑mg dose, reduced mucus plugging and increased healthy parenchyma at 52 weeks, providing preliminary imaging evidence that it may modify disease biology in noncystic fibrosis bronchiectasis.
Evaluating the Cost-Effectiveness of Early In-Bed Cycling Plus Routine Physiotherapy in Mechanically Ventilated ICU Patients: Insights from the CYCLE Trial
Posted inCritical Care news Rehabilitation Medicine Respiratory

Evaluating the Cost-Effectiveness of Early In-Bed Cycling Plus Routine Physiotherapy in Mechanically Ventilated ICU Patients: Insights from the CYCLE Trial

This economic evaluation from the CYCLE randomized trial found no significant cost or quality-adjusted life-year benefit by adding early in-bed cycling to usual physiotherapy for ICU patients on mechanical ventilation, underscoring a need for further research to clarify its value.
Evaluating Portable HEPA Purifiers to Reduce Respiratory Viral Exposure in Elementary Schools: Insights from a Randomized Clinical Trial Secondary Analysis
Posted innews Pediatrics Public Health Respiratory

Evaluating Portable HEPA Purifiers to Reduce Respiratory Viral Exposure in Elementary Schools: Insights from a Randomized Clinical Trial Secondary Analysis

A secondary analysis of a cluster-randomized trial found that portable HEPA purifiers modestly reduced viral diversity but did not significantly lower high respiratory viral exposure in elementary school classrooms, suggesting multi-faceted interventions are needed to protect children in schools.