randomized clinical trial

Evaluating Near-Infrared Autofluorescence for Parathyroid Preservation in Total Thyroidectomy: Long-Term Outcomes from a Prospective Randomized Trial

By MedXY 10/09/2026

This two-center randomized trial assessed near-infrared autofluorescence imaging to identify parathyroid glands during total thyroidectomy. Despite higher gland identification rates, the technology did not reduce hypoparathyroidism incidence at 3 and 12 months postoperatively.

news Orthopedics Rehabilitation Medicine

Supervised Exercise Therapy with Education Improves Outcomes in Young Adults After ACL Reconstruction: A Randomized Trial

By MedXY 10/08/2026

Physiotherapist-supervised exercise therapy combined with education significantly enhances knee function and muscle strength in young adults with persistent knee issues post-ACL reconstruction, with benefits lasting up to 12 months.

Neurology news Otorhinolaryngology

Evaluating Hearing Aid Intervention in Older Adults with Mild Cognitive Impairment: Insights from the CHOICE Randomized Clinical Trial

By MedXY 10/04/2026

The CHOICE trial investigated whether hearing aid intervention reduces dementia progression in older adults with mild cognitive impairment and hearing loss, finding no significant reduction in dementia incidence but increased cognitive improvement rates.

Dentistry news Pediatrics

Silver Diamine Fluoride: A Breakthrough Noninvasive Therapy for Severe Early Childhood Caries in US Children

By MedXY 10/02/2026

A large-scale randomized trial demonstrates that 38% silver diamine fluoride effectively arrests dentin caries lesions in young children with severe early childhood caries, offering a safe, noninvasive treatment option and supporting FDA approval.

Clinical Updates Dermatology news

Efficacy and Safety of Ruxolitinib Cream in Patients With Cutaneous Lichen Planus: A Randomized Clinical Trial Review

By MedXY 10/02/2026

This review synthesizes current evidence on ruxolitinib 1.5% cream efficacy and safety in cutaneous lichen planus, highlighting significant lesion and pruritus reduction in a pivotal phase 2 RCT, supporting its potential as a novel topical treatment.

General Surgery news OB/GYN & Women’s Health

Assessing Transvaginal Drainage Versus Laparoscopy for Tubo-Ovarian Abscess: Insights from a Multicenter Randomized Trial

By MedXY 09/28/2026

This clinical trial compares ultrasound-guided transvaginal drainage to laparoscopy for tubo-ovarian abscess evacuation, highlighting differences in cure rates, reintervention frequency, and recovery outcomes.

General Surgery news Oncology

Optimizing Postoperative Opioid Prescriptions After Intra-Abdominal Cancer Surgery: Comparing the 5x-Multiplier and 3-Tier Models

By MedXY 09/21/2026

A randomized clinical trial demonstrated that the 5x-multiplier algorithm significantly reduces opioid prescriptions at discharge without increasing consumption, refill rates, or patient dissatisfaction after major abdominal cancer surgery compared to a 3-tier prescribing model.

Neurology news Rheumatology

IVIG Plus Prednisone Enhances Recovery in Newly Diagnosed Idiopathic Inflammatory Myopathies: Insights from a Randomized Clinical Trial

By MedXY 09/16/2026

A recent randomized trial shows that adding intravenous immunoglobulin (IVIG) to high-dose prednisone significantly improves muscle strength and disease activity in newly diagnosed idiopathic inflammatory myopathies with rapid and clinically meaningful benefits.

Clinical Updates news Ophthalmology

Safety and Effects of Gildeuretinol Acetate on Retinal Atrophic Lesions in Stargardt Disease: Insights from the TEASE-1 Randomized Clinical Trial

By MedXY 09/07/2026

This review synthesizes evidence from the TEASE-1 trial and related studies on gildeuretinol acetate, highlighting its safety profile and modest efficacy in slowing retinal atrophic lesion growth in Stargardt disease over 24 months.

Diabetes & Endocrinology Internal Medicine news

Impact of the DASH4D Diet on Glycemic Biomarkers in Adults with Type 2 Diabetes: Insights from a Randomized Controlled Feeding Trial

By MedXY 08/30/2026

The DASH4D diet, a tailored DASH-style intervention for diabetes, significantly improved key glycemic biomarkers including fructosamine, fasting glucose, and HbA1c compared to a typical American diet in adults with type 2 diabetes.

Dermatology news

Equivalence of Online and In-Person Care in Managing Atopic Dermatitis: Insights from a Large Randomized Trial

By MedXY 08/26/2026

A randomized clinical trial shows online team-based care is as effective as conventional in-person treatment for atopic dermatitis, offering an accessible alternative for chronic disease management.

General Surgery news Oncology

Evaluating Preoperative High-Dose Corticosteroids in Digestive Cancer Surgery: Insights from a Large Multicenter Randomized Trial

By MedXY 08/21/2026

A large randomized clinical trial demonstrated that preoperative high-dose corticosteroids do not reduce major postoperative complications in elective digestive cancer surgery, challenging their routine use for perioperative inflammation control.

news Otorhinolaryngology

Effective Relief for Recurrent Acute Rhinosinusitis: Insights from a Randomized Clinical Trial on Endoscopic Sinus Surgery

By MedXY 08/20/2026

Endoscopic sinus surgery significantly improves quality of life in adults with recurrent acute rhinosinusitis compared to medical treatment alone, demonstrating its safety and efficacy in managing this burdensome condition.

Clinical Updates news Oncology Respiratory

Enhancing Lung Cancer Screening Adherence: Insights from a Randomized Clinical Trial of Health Communication and Stepped Reminder Interventions

By MedXY 08/12/2026

A landmark randomized trial demonstrates that multilevel stepped reminders targeting both primary care physicians and patients markedly improve adherence to annual lung cancer screening, while health communication alone may be insufficient or counterproductive.

Neurology news Psychiatry

Connectivity- vs Scalp-Based Targeting of Accelerated Transcranial Magnetic Stimulation for Depression: A Randomized Clinical Trial

By MedXY 08/10/2026

This randomized trial compared connectivity-based versus scalp-based targeting of accelerated TMS in treatment-resistant depression, showing greater antidepressant effects with individualized connectivity-guided targeting.

Cardiology Neurology news

Evaluating Low-Dose Colchicine for Preventing Vascular Events After Acute Intracerebral Hemorrhage: Insights from a Placebo-Controlled Pilot Trial

By MedXY 08/09/2026

This pilot randomized trial demonstrates the feasibility of using low-dose colchicine after acute intracerebral hemorrhage to prevent vascular events, highlighting considerations for future larger studies regarding recruitment, adherence, and discontinuation rates.

Gastroenterology news Oncology

Improved Survival in Unresectable Hepatocellular Carcinoma with Combined Transarterial Chemoembolization and Thermal Ablation: Insights from the Phase 3 TORCH Trial

By MedXY 07/30/2026

The phase 3 TORCH trial demonstrates that adding selective radiofrequency ablation after transarterial chemoembolization significantly improves progression-free and overall survival in patients with unresectable liver-confined hepatocellular carcinoma, with acceptable safety.

news Psychiatry

Comparative Effectiveness of Dialectical Behavior Therapy and Schema Therapy in Borderline Personality Disorder: Insights from the BOOTS Trial

By MedXY 07/14/2026

The BOOTS multicenter RCT found no significant difference in long-term effectiveness between dialectical behavior therapy (DBT) and schema therapy (ST) for borderline personality disorder (BPD), with both treatments yielding substantial clinical improvements.

Clinical Updates news Pediatrics Psychiatry

Adolescent Mental Health Care and Stigma: Insights from the ARTEMIS Randomized Clinical Trial and Complementary Evidence

By MedXY 07/12/2026

This review synthesizes evidence from the ARTEMIS trial and related studies on community-based adolescent mental health care and stigma reduction, highlighting intervention efficacy, implementation challenges, and translational potentials in low- and middle-income settings.

Neurology news Radiology

Middle Meningeal Artery Embolization with n-Butyl Cyanoacrylate: A New Standard for Chronic Subdural Hematoma Management?

By MedXY 07/03/2026

A multicenter randomized trial shows that middle meningeal artery embolization with n-butyl cyanoacrylate, adjunct to standard care, significantly reduces recurrence and reoperation rates in chronic subdural hematoma without increasing adverse events.