randomized clinical trial

Middle Meningeal Artery Embolization with n-Butyl Cyanoacrylate: A New Standard for Chronic Subdural Hematoma Management?

By MedXY 07/03/2026

A multicenter randomized trial shows that middle meningeal artery embolization with n-butyl cyanoacrylate, adjunct to standard care, significantly reduces recurrence and reoperation rates in chronic subdural hematoma without increasing adverse events.

news Psychiatry Public Health

Efficacy and Safety of Mirtazapine in Treating Methamphetamine Use Disorder: Insights from a Phase 3 Randomized Clinical Trial

By MedXY 07/02/2026

This randomized clinical trial evaluated mirtazapine's safety and efficacy for methamphetamine use disorder, revealing a modest but statistically significant reduction in methamphetamine use without unexpected adverse events, offering a promising pharmacotherapy option for this challenging condition.

Emergency Medicine Neurology news

Ultra-Early Remote Ischemic Postconditioning After Thrombectomy Appears Safe but Does Not Improve 90-Day Stroke Recovery

By MedXY 06/10/2026

In the EnTRIPS randomized trial, ultra-early remote ischemic postconditioning after successful endovascular thrombectomy was safe but did not significantly improve 90-day functional independence in acute ischemic stroke.

Cardiology news Public Health

Food Delivery After Heart Failure Hospitalization Was Feasible but Did Not Reduce 90-Day HF Readmissions

By MedXY 06/10/2026

A randomized trial found that medically tailored meals and fresh produce were highly feasible after HF hospitalization, but neither strategy improved the primary 90-day heart failure utilization outcome versus usual care.

Family Medicine & Nutrition Gastroenterology news

Deprescribing Intervention Reduces Proton Pump Inhibitor Use in Primary Care

By MedXY 06/06/2026

A large primary care trial found that a combined patient- and GP-focused deprescribing intervention safely reduced long-term proton pump inhibitor use more effectively than usual care or GP-only education.

Neurology news Psychiatry

Ecopipam Reduced Relapse Risk in Pediatric Tourette Syndrome Without Metabolic or Extrapyramidal Signal in a Phase 3 Randomized Withdrawal Trial

By MedXY 06/05/2026

In a phase 3 randomized withdrawal trial, ecopipam maintained tic improvement in pediatric Tourette syndrome over 24 weeks and showed a generally favorable safety profile without clinically meaningful weight, metabolic, or drug-induced movement disorder effects.

news OB/GYN & Women’s Health Oncology

Fovinaciclib for First-Line Therapy of Advanced Breast Cancer: A Randomized Clinical Trial

By MedXY 06/03/2026

Adding fovinaciclib to first-line aromatase inhibitor therapy significantly prolonged progression-free survival in hormone receptor-positive, ERBB2-negative advanced breast cancer with manageable toxicity and preserved quality of life.

news Psychiatry Public Health

Interleukin 6 as a Treatment Target for Depression: A Proof-of-Concept Randomized Clinical Trial

By MedXY 06/03/2026

A small randomized trial found that blocking IL-6 with tocilizumab showed promising, clinically meaningful trends for inflammation-related, hard-to-treat depression, especially for somatic symptoms, fatigue, anxiety, and quality of life, though results were not statistically significant.

Neurology news

Effect of Electroacupuncture on Postherpetic Neuralgia: A Randomized Clinical Trial

By MedXY 05/28/2026

A randomized clinical trial found that electroacupuncture reduced pain more than sham treatment in postherpetic neuralgia, with benefits lasting at least one month and no major safety concerns.

Family Medicine & Nutrition Infectious Diseases news

Rapid Respiratory Point-of-Care Testing and Antibiotic Use in Primary Care: A Randomized Clinical Trial

By MedXY 05/22/2026

A randomized trial found that rapid respiratory point-of-care testing did not reduce same-day antibiotic prescribing in primary care, though it was safe and may help when a virus is detected.

Internal Medicine news Respiratory

Effectiveness of Automatically-Adjusted vs Manually-Adjusted Noninvasive Ventilation in Obesity Hypoventilation Syndrome: A Randomized Clinical Trial

By MedXY 05/21/2026

In ambulatory patients with obesity hypoventilation syndrome, automatically-adjusted noninvasive ventilation was as effective as manually adjusted NIV over 12 months and more cost-effective, offering a simpler path to treatment.

Neurology news

Fixed-Dose Tavapadon for Early Parkinson Disease: A Randomized Clinical Trial

By MedXY 05/20/2026

In a phase 3 trial, once-daily tavapadon improved motor symptoms in people with early Parkinson disease and was generally well tolerated, with nausea, headache, and dizziness as the most common side effects.

news Psychiatry

Efficacy and Safety of Psilocybin in Treatment-Resistant Major Depression: The EPISODE Randomized Clinical Trial

By MedXY 05/19/2026

Psilocybin-assisted psychotherapy showed promising but inconclusive antidepressant effects in treatment-resistant depression, with notable acute adverse events and safety concerns.

news Otorhinolaryngology Psychiatry

A CBT-Based Mobile App Significantly Reduced Tinnitus Distress in a Sham-Controlled Randomized Trial

By MedXY 05/11/2026

In a 60-patient randomized trial, a digital therapeutic app delivering tinnitus education and CBT elements produced large, durable reductions in tinnitus-related distress over 16 weeks, with no serious safety concerns.

Family Medicine & Nutrition Neurology news

Dementia Screening for Family Members: No Clear Benefit or Harm Found in Landmark Trial

By MedXY 04/24/2026

A randomized clinical trial found that dementia screening for family members of older adults did not improve quality of life or caregiver preparedness, nor did it increase depression or anxiety.

news Ophthalmology

Personalized Glaucoma Coaching Boosts Medication Adherence by 20%: SEE Program Trial Results

By MedXY 04/23/2026

A 6-month personalized coaching program (SEE) significantly improved glaucoma medication adherence by 19.7% compared to standard education, reducing vision loss risk in a randomized trial of 235 patients.

news Psychiatry Public Health

Beyond Exercise Alone: The Synergistic Power of Combined High-Intensity Circuit Training and Sleep Health Interventions

By MedXY 02/23/2026

This randomized clinical trial demonstrates that combining high-intensity circuit training with targeted sleep health interventions significantly improves objective sleep quality and cardiometabolic markers in young women, outperforming either intervention alone.

Family Medicine & Nutrition news Orthopedics

Biopsychosocial Self-Management Superior to Standard Care for Reducing Disability in Acute Back Pain: Insights from the PACBACK Trial

By MedXY 12/30/2025

The PACBACK randomized trial reveals that clinician-supported biopsychosocial self-management significantly reduces one-year disability in patients with acute low back pain at high risk of chronicity, whereas spinal manipulation alone offers no significant advantage over standard medical care.

Clinical Updates Internal Medicine news Psychiatry

Tailored Weight Loss Interventions for Veterans with Serious Mental Illness: Efficacy and Implementation Insights from Recent RCT Evidence

By MedXY 12/24/2025

This review synthesizes evidence from a 2025 randomized clinical trial evaluating a tailored weight loss program, CoachToFit, for veterans with serious mental illness, highlighting its potential to improve weight outcomes via remote support technologies and peer-led interventions.

$Combined Gastric Electrical Stimulation and Pyloroplasty Achieve Superior Symptom Relief in Refractory Gastroparesis$

Gastroenterology General Surgery news

Combined Gastric Electrical Stimulation and Pyloroplasty Achieve Superior Symptom Relief in Refractory Gastroparesis

By MedXY 12/21/2025

A randomized clinical trial demonstrates that combining gastric electrical stimulation with pyloroplasty significantly outperforms pyloroplasty alone, providing superior symptom relief and reducing hospitalizations for patients with medication-refractory gastroparesis.