Portal-Venous Hypothermic Oxygenated Perfusion in Liver Transplantation: Evidence Synthesis from the Bridge to HOPE Trial and Global Clinical Landscape

Portal-Venous Hypothermic Oxygenated Perfusion in Liver Transplantation: Evidence Synthesis from the Bridge to HOPE Trial and Global Clinical Landscape

This review synthesizes findings from the Bridge to HOPE multicenter trial and other recent evidence, demonstrating that portal-venous hypothermic oxygenated perfusion (HOPE) significantly reduces early allograft dysfunction, improves biliary health, and modulates donor immunogenicity in extended-criteria liver transplantation.
Higher-Fidelity Enhanced Recovery Shortened Stay and Reduced Complications in Children Undergoing GI Surgery, Even Though the Overall Trial Was Neutral

Higher-Fidelity Enhanced Recovery Shortened Stay and Reduced Complications in Children Undergoing GI Surgery, Even Though the Overall Trial Was Neutral

In a stepped-wedge trial across 18 US centers, a pediatric GI surgery enhanced recovery protocol did not improve length of stay overall, but patients receiving at least 13 protocol elements had shorter stays, fewer complications, faster diet advancement, and lower inpatient opioid use.