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Reversal of Roux-en-Y Gastric Bypass: A Swedish National Cohort Study
Posted inGastroenterology General Surgery news

Reversal of Roux-en-Y Gastric Bypass: A Swedish National Cohort Study

Posted by MedXY By MedXY 05/01/2026
This nationwide Swedish study reveals that RYGB reversal is rare (0.3% of procedures) but effective for complications like abdominal pain and hypoglycemia. While 86% reported symptom improvement, significant complication risks require careful patient selection and surgical expertise.
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HSP72-PRDX6 Control of PINK1 Ubiquitination Emerges as a New Mitophagy Axis in MASLD
Posted inGastroenterology Internal Medicine news

HSP72-PRDX6 Control of PINK1 Ubiquitination Emerges as a New Mitophagy Axis in MASLD

Posted by MedXY By MedXY 05/01/2026
A new Hepatology study identifies an HSP72–PRDX6 pathway that restores PINK1/Parkin mitophagy, reduces hepatic steatosis, and worsens MASLD when disrupted in mice and hepatocytes.
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Uncoupling Metabolic Reprogramming in Hepatocellular Carcinoma: The JOSD1-PGAM1 Ubiquitination-Lactylation Switch
Posted inClinical Updates Gastroenterology news Oncology

Uncoupling Metabolic Reprogramming in Hepatocellular Carcinoma: The JOSD1-PGAM1 Ubiquitination-Lactylation Switch

Posted by MedXY By MedXY 05/01/2026
This article explores how the deubiquitinase JOSD1 drives HCC progression by modulating a novel PTM switch on PGAM1, promoting glycolysis and immune evasion while providing a new target for combined immunotherapy.
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Genetic Risk of Inflammatory Bowel Disease Linked to Disease Severity
Posted inGastroenterology news

Genetic Risk of Inflammatory Bowel Disease Linked to Disease Severity

Posted by MedXY By MedXY 05/01/2026
A Danish nationwide study reveals higher genetic risk scores for IBD predict more severe disease courses, including increased surgery rates, stronger medication needs, and worse inflammatory markers in both Crohn's and ulcerative colitis patients.
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Oral Glucose Absorption Enhanced in Early Metabolic Dysfunction-Associated Steatotic Liver Disease
Posted inDiabetes & Endocrinology Gastroenterology news

Oral Glucose Absorption Enhanced in Early Metabolic Dysfunction-Associated Steatotic Liver Disease

Posted by MedXY By MedXY 04/30/2026
New research reveals accelerated glucose absorption in early MASLD patients, independent of gastric emptying. This metabolic alteration may drive liver disease progression before hepatic insulin resistance develops.
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Early MASLD Is Associated With Enhanced Oral Glucose Absorption Independent of Gastric Emptying
Posted inDiabetes & Endocrinology Gastroenterology news

Early MASLD Is Associated With Enhanced Oral Glucose Absorption Independent of Gastric Emptying

Posted by MedXY By MedXY 04/30/2026
Stable-isotope OGTT data suggest that early MASLD is linked to higher oral glucose absorption, independent of gastric emptying, with preserved hepatic insulin suppression but impaired peripheral glucose clearance.
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CD276 Identified as Key Driver of Chemoresistance in Advanced Pancreatic Cancer
Posted inGastroenterology news Oncology

CD276 Identified as Key Driver of Chemoresistance in Advanced Pancreatic Cancer

Posted by MedXY By MedXY 04/29/2026
Single-cell analysis reveals CD276/B7-H3 as a critical regulator of chemoresistance in pancreatic ductal adenocarcinoma, highlighting its dual role in promoting basal-like tumor states and immune evasion.
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Fecal Microbiota Transplant Fails to Decolonize Multidrug-Resistant Organisms in GI Patients: A Randomized Trial Analysis
Posted inGastroenterology Infectious Diseases news

Fecal Microbiota Transplant Fails to Decolonize Multidrug-Resistant Organisms in GI Patients: A Randomized Trial Analysis

Posted by MedXY By MedXY 04/27/2026
A randomized clinical trial found that FMT did not significantly decolonize MDROs or reduce AMR genes in GI disease patients, though it modulated gut microbiome composition.
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Early Enteral Nutrition Reduces Postoperative Complications in High-Risk Pancreatoduodenectomy Patients
Posted inGastroenterology General Surgery news

Early Enteral Nutrition Reduces Postoperative Complications in High-Risk Pancreatoduodenectomy Patients

Posted by MedXY By MedXY 04/26/2026
The NUTRIWHI trial demonstrates that early enteral nutrition via nasojejunal tube significantly reduces complication burden in nutritionally high-risk patients after pancreatoduodenectomy compared to oral nutrition alone.
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Mucosal Impedance: A Novel Diagnostic Tool for Refining GERD Phenotyping and Surgical Decision-Making
Posted inGastroenterology General Surgery news

Mucosal Impedance: A Novel Diagnostic Tool for Refining GERD Phenotyping and Surgical Decision-Making

Posted by MedXY By MedXY 04/26/2026
Mucosal impedance (MI) offers a groundbreaking approach to assess esophageal mucosal integrity in GERD, complementing traditional diagnostics and enhancing surgical outcomes.
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Combination Therapy with GLP-1 Receptor Agonists and SGLT-2 Inhibitors Reduces Liver and Cardiovascular Risks in MASLD and Type 2 Diabetes
Posted inDiabetes & Endocrinology Gastroenterology news

Combination Therapy with GLP-1 Receptor Agonists and SGLT-2 Inhibitors Reduces Liver and Cardiovascular Risks in MASLD and Type 2 Diabetes

Posted by MedXY By MedXY 04/25/2026
A study reveals that combining GLP-1 receptor agonists with SGLT-2 inhibitors significantly lowers the risk of major adverse liver and cardiovascular outcomes in patients with MASLD and type 2 diabetes compared to monotherapy.
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CD16+ γδ T Cells: A Novel Player in HBV Viral Control Through Antibody-Dependent Cytotoxicity
Posted inGastroenterology Infectious Diseases news

CD16+ γδ T Cells: A Novel Player in HBV Viral Control Through Antibody-Dependent Cytotoxicity

Posted by MedXY By MedXY 04/25/2026
A study reveals CD16+ γδ T cells as key mediators of antibody-dependent cellular cytotoxicity in HBV infection, correlating with reduced viral replication and offering new therapeutic targets.
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Clonal Lymphocyte Expansions and JAK-STAT Mutations Drive Refractory Celiac Disease
Posted inGastroenterology Hematology-Oncology news

Clonal Lymphocyte Expansions and JAK-STAT Mutations Drive Refractory Celiac Disease

Posted by MedXY By MedXY 04/25/2026
This study uncovers clonal lymphocyte expansions and JAK-STAT pathway mutations as key drivers of refractory celiac disease, suggesting a shared pathogenic continuum between RCD1 and RCD2 while cautioning against JAK inhibitor monotherapy due to resistance risks.
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A New Framework to Refine Hepatocellular Cancer Surveillance with Risk Stratification Models
Posted inGastroenterology news Oncology

A New Framework to Refine Hepatocellular Cancer Surveillance with Risk Stratification Models

Posted by MedXY By MedXY 04/23/2026
The Translational Liver Cancer Consortium proposes a structured framework for developing and validating risk models to optimize HCC surveillance, addressing gaps in current clinical guidelines.
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Protein Misfolding in the Gut: A Window into Future Neurodegeneration
Posted inGastroenterology Neurology news

Protein Misfolding in the Gut: A Window into Future Neurodegeneration

Posted by MedXY By MedXY 04/23/2026
GI biopsies reveal misfolded proteins years before neurological symptoms appear, offering a new biomarker for early neurodegenerative disease prediction and intervention.
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Somatostatin in the Gut: No Diabetes-Specific Patterns Found
Posted inDiabetes & Endocrinology Gastroenterology news

Somatostatin in the Gut: No Diabetes-Specific Patterns Found

Posted by MedXY By MedXY 04/22/2026
New study reveals uniform distribution of somatostatin and its receptors throughout the intestinal tract in both healthy individuals and type 2 diabetes patients, challenging previous assumptions about its role in diabetes pathophysiology.
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Unraveling the Gut-Heart Connection: How Leaky Gut Fuels Atrial Fibrillation in Aging
Posted inCardiology Gastroenterology news

Unraveling the Gut-Heart Connection: How Leaky Gut Fuels Atrial Fibrillation in Aging

Posted by MedXY By MedXY 04/22/2026
Researchers identify JNK2 as a key mediator in gut-heart crosstalk, linking intestinal permeability to atrial fibrillation pathogenesis through inflammatory stress signals, offering new therapeutic targets.
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腹腔鏡と開腹手術による小腸閉塞癒着剥離の長期転帰:LASSO無作為化臨床試験
Posted inGastroenterology General Surgery news

腹腔鏡と開腹手術による小腸閉塞癒着剥離の長期転帰:LASSO無作為化臨床試験

Posted by MedXY By MedXY 04/20/2026
小腸閉塞手術における腹腔鏡アプローチは短期回復が早いが、5年間の追跡調査では再発率、ヘルニア発生率、QOLにおいて開腹手術と同等の結果を示した。術式選択は患者個別の要因に基づくべきである。
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OCE-205 Signals a Potential New Direction for Hepatorenal Syndrome-AKI, with Tolerability at the Center
Posted inGastroenterology Nephrology news

OCE-205 Signals a Potential New Direction for Hepatorenal Syndrome-AKI, with Tolerability at the Center

Posted by MedXY By MedXY 04/20/2026
In a phase 2 randomized trial, OCE-205 improved HRS-AKI in more patients than placebo and showed no excess ischemic or respiratory toxicity, but the study was underpowered after early termination.
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A Blood-Based Extracellular Vesicle RNA Signature May Offer a New Way to Diagnose Chronic Pancreatitis
Posted inGastroenterology news

A Blood-Based Extracellular Vesicle RNA Signature May Offer a New Way to Diagnose Chronic Pancreatitis

Posted by MedXY By MedXY 04/20/2026
A five-RNA extracellular vesicle signature showed strong diagnostic performance for chronic pancreatitis and may also reflect acinar-to-ductal metaplasia and disease-related metabolic features.
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  • First-Time Seizure Is Linked to a Markedly Increased Short-Term Risk of Occult Cancer
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  • Teprotumumab for Thyroid Eye Disease Carries a Measurable Long-Term Dysglycemia Risk
  • Gut Microbiome Signatures May Help Explain Why Gestational Diabetes Raises Later Type 2 Diabetes Risk in Hispanic/Latina Women
  • Urinary Free Cortisol Thresholds Sharpen the Differential Diagnosis of ACTH-Dependent Cushing’s Syndrome
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