Gastroenterology – Medxy AI

Immune Checkpoint Inhibitors Deliver Durable Responses in MSI-H Gastroesophageal Adenocarcinoma

By MedXY 06/18/2026

MSI-H/dMMR gastroesophageal adenocarcinoma showed high response rates to immune checkpoint inhibitors, including durable complete responses in locoregional disease that may support carefully selected nonoperative management.

Gastroenterology news Oncology

Checkpoint Blockade Delivers Deep, Durable Responses in MSI-H Gastroesophageal Adenocarcinoma

By MedXY 06/18/2026

This single-center cohort found high and durable checkpoint inhibitor responses in dMMR/MSI-H gastroesophageal adenocarcinoma, including complete responses in locoregional disease that may support carefully selected nonoperative management.

Gastroenterology Internal Medicine news

Lower-Dose Vitamin E Works as Well as Higher Doses in MASLD, VEDS Trial Finds

By MedXY 06/17/2026

In adults with suspected MASH, 200 IU/day vitamin E lowered ALT as effectively as 400 IU/day and 800 IU/day over 24 weeks, with no short-term safety signal, supporting lower-dose use if vitamin E is chosen.

Gastroenterology news Oncology

SPP1-Positive Macrophages Shape Immunosuppression in Colorectal Cancer Lymph Nodes

By MedXY 06/17/2026

Single-cell profiling of colorectal cancer lymph nodes revealed an SPP1–CD44–NF-κB1 pathway that promotes CD137+ regulatory T-cell maturation and may be therapeutically targetable.

Gastroenterology news Public Health

Validated Early Detection Metrics Could Narrow Liver Fibrosis Screening Without Losing Clinical Signal

By MedXY 06/17/2026

A validation study suggests current liver fibrosis screening criteria are too broad. A refined risk-based approach reduced eligibility from 60–76% to 10–22% of adults while improving the yield of elevated liver stiffness and predicting future liver events.

Gastroenterology Infectious Diseases news

Post-infection Gut-Brain Disorders Affect About 1 in 10 People With DGBI Worldwide, With Distinct Psychological and Regional Patterns

By MedXY 06/10/2026

A large 26-country survey found that post-infection disorders of gut-brain interaction account for 10.5% of DGBI cases and are linked to younger age, male sex, urban living, anxiety, and greater somatic symptom burden.

Gastroenterology news Pediatrics

PRDM9 Deficiency Identifies a Predominant Molecular Subgroup in Sporadic Hirschsprung Disease and Enables Blood-based Risk Stratification

By MedXY 06/10/2026

A 2026 Gastroenterology study links PRDM9 deficiency to ectopic DNA breaks, mosaic promoter deletions, and impaired enteric neuronal differentiation in sporadic Hirschsprung disease, while introducing a blood-based molecular score that improves case discrimination, especially when combined with polygenic risk.

Gastroenterology General Surgery news

Role of Relaxing Lateral Incisions as an Add-On to Difficult Hiatal Repair in Redo and Giant Hernia Cases

By MedXY 06/10/2026

Lateral relaxing diaphragmatic incisions may help reduce tension during difficult hiatal hernia repairs, improving symptom control in redo and giant hernia cases, though long-term recurrence data are still needed.

Gastroenterology news Oncology

Intraperitoneal and Intravenous Paclitaxel Plus S-1 for Gastric Cancer With Peritoneal Metastasis: Phase 3 Trial

By MedXY 06/10/2026

A phase 3 trial found that adding intraperitoneal paclitaxel to intravenous paclitaxel plus S-1 improved survival in gastric cancer with peritoneal metastasis without increasing severe toxicity.

Gastroenterology Infectious Diseases news

When a Stomach Bug Doesn’t End: The Hidden Global Burden of Post-Infection Gut Disorders

By MedXY 06/10/2026

A major global study shows that some people develop lasting gut-brain disorders after acute gastroenteritis, linking infections to chronic digestive and psychological symptoms.

Gastroenterology Infectious Diseases news

HBsAg Seroclearance Lowers Hepatocellular Carcinoma Risk Beyond Viral Suppression in Cirrhosis, but Does Not Reduce Hepatic Decompensation

By MedXY 06/10/2026

In NA-treated cirrhotic chronic hepatitis B with complete viral suppression, HBsAg seroclearance was linked to lower HCC risk but not lower hepatic decompensation, reinforcing functional cure as a meaningful but incomplete clinical endpoint.

Allergy & Immunology Gastroenterology news

Colonic GPR15L Emerges as a Microbiota-Shaping Host-Defense Peptide That Protects Against Experimental Colitis

By MedXY 06/10/2026

New data identify GPR15L as an epithelial host-defense peptide that reshapes the colonic microbiota, reduces experimental colitis, and may have therapeutic relevance in inflammatory bowel disease.

Diabetes & Endocrinology Gastroenterology news

An Obesity Subphenotype With Low Endogenous GLP-1 Production Shows Markedly Greater Weight Loss With Tirzepatide

By MedXY 06/10/2026

A 2026 study identifies a biologically distinct obesity subphenotype marked by fast gastric emptying, low GLP-1 synthesis, and substantially greater 6-month weight loss with tirzepatide.

Clinical Updates Gastroenterology Internal Medicine news

Primary vs Specialist Palliative Care in End-Stage Liver Disease: Interpreting the 2026 Cluster Randomized Trial in the Broader Evidence Base

By MedXY 06/09/2026

A major 2026 cluster randomized trial shows that palliative care delivered by trained hepatologists is noninferior to specialist palliative care for improving quality of life in end-stage liver disease, supporting scalable integrated models for cirrhosis and hepatocellular carcinoma.

Gastroenterology Nephrology news

Chronic Kidney Disease Worsens Short-Term Outcomes in Hospitalized Patients With Cirrhosis Across a Global Cohort

By MedXY 06/07/2026

In a large international prospective cohort of hospitalized patients with cirrhosis, chronic kidney disease was common, clustered with metabolic risk, and strongly associated with acute kidney injury, more decompensation, and higher in-hospital and 30-day mortality.

AI Gastroenterology news

Computer-Aided Detection Increased Adenoma Detection in a Large Pragmatic Cluster Randomized Colonoscopy Study

By MedXY 06/07/2026

In a large Veterans Health Administration cluster randomized study, CADe availability increased adenoma detection during colonoscopy without changing withdrawal time or nonadenomatous lesion detection.

Gastroenterology news Oncology

RETREAT Score Stratifies Long-Term Hepatocellular Carcinoma Recurrence Risk After Liver Transplantation in Real-World Practice

By MedXY 06/07/2026

A single-center validation study shows the RETREAT score reliably predicts long-term HCC recurrence after liver transplantation and identifies patients with markedly different recurrence-free and overall survival trajectories.

Family Medicine & Nutrition Gastroenterology news

Deprescribing Intervention Reduces Proton Pump Inhibitor Use in Primary Care

By MedXY 06/06/2026

A large primary care trial found that a combined patient- and GP-focused deprescribing intervention safely reduced long-term proton pump inhibitor use more effectively than usual care or GP-only education.

Gastroenterology news Transplantation

Adult Liver Transplant Candidate Evaluation: What the New AASLD/AST Guideline Changes

By MedXY 06/05/2026

The updated AASLD/AST guideline clarifies how adults should be evaluated for liver transplantation, emphasizing equitable access, multidisciplinary assessment, psychosocial readiness, and structured risk–benefit decision-making.

Critical Care Gastroenterology news

TNF-α–Driven Immune-Endothelial Injury Emerges as a Therapeutic Target in Severe Acute Pancreatitis

By MedXY 06/05/2026

Single-cell analysis of human severe acute pancreatitis identifies TNF-α–induced CD8+ T-cell endothelial injury as a driver of pancreatic microcirculatory failure, supporting TNF-α blockade as a potential targeted therapy.