risk stratification

Most Open-Angle Glaucoma Suspects Convert at Less Than 6% Per Year After Year 1, Supporting Risk-Stratified Follow-Up

By MedXY 06/06/2026

A large US claims-based cohort suggests that most open-angle glaucoma suspects have modest annual conversion risk after the first year, and that age- and treatment-informed surveillance intervals may help tailor follow-up intensity.

news Psychiatry Public Health

Polygenic Scores Often Rival Recurrent CNVs for Psychiatric Risk Stratification, but Both Add Clinical Insight

By MedXY 05/31/2026

A large Danish genetic study suggests recurrent CNVs and polygenic scores provide complementary psychiatric risk information, with polygenic scores often identifying more at-risk individuals and potentially modifying CNV-associated risk.

Critical Care Dermatology news

Hospital-Acquired DRESS and Clinical Severity Strongly Predict ICU Admission in a 39-Centre Paris Cohort

By MedXY 05/27/2026

In this multicentre cohort of 207 hospitalized adults with DRESS, 17% required ICU care. Hospital-acquired DRESS and greater clinical severity independently predicted ICU admission, while ICU mortality reached 20%.

Cardiology news

Validated EMPEROR-Preserved Risk Models Stratify Prognosis in FINEARTS-HF, While Finerenone Benefits Remain Consistent Across Baseline Risk

By MedXY 05/19/2026

In FINEARTS-HF, EMPEROR-Preserved biomarker-based risk models showed good prognostic discrimination in HFmrEF/HFpEF, and finerenone’s relative treatment effect was consistent across the full baseline risk spectrum.

Cardiology Emergency Medicine news

Associations of the Composite Pulmonary Embolism Shock Score in the Emergency Department With Short-Term Clinical Outcomes

By MedXY 05/18/2026

A multicenter emergency department study found that CPES performed similarly to sPESI and ESC for short-term PE outcomes, but it better predicted the need for advanced intervention.

Hematology-Oncology news

2/20/20 Model Outperforms AQUILA Criteria in Identifying High-Risk Smoldering Multiple Myeloma

By MedXY 04/24/2026

The 2/20/20 risk stratification model identifies a smaller, truly high-risk SMM group with higher progression rates than the AQUILA trial criteria, suggesting better targeting for early intervention.

Anesthesiology news Otorhinolaryngology

RAI Outperforms mFI-5 in Predicting Post-UPPP Complications: A Frailty Stratification Breakthrough

By MedXY 04/23/2026

The Risk Analysis Index (RAI) significantly outperforms the modified frailty index-5 (mFI-5) in predicting mortality and major complications after uvulopalatopharyngoplasty, supporting its adoption for preoperative risk assessment in sleep surgery.

Gastroenterology news Oncology

A New Framework to Refine Hepatocellular Cancer Surveillance with Risk Stratification Models

By MedXY 04/23/2026

The Translational Liver Cancer Consortium proposes a structured framework for developing and validating risk models to optimize HCC surveillance, addressing gaps in current clinical guidelines.

Diabetes & Endocrinology news Oncology

Validation of the 2025 ATA Risk Stratification System in a Cohort of Patients with Papillary Thyroid Carcinoma

By MedXY 04/18/2026

A real-world study validates the 2025 ATA thyroid cancer risk guidelines, showing significant patient reclassification and identifying a new 'low-intermediate-risk' group needing tailored management approaches.

Diabetes & Endocrinology news Oncology

2025 ATA Risk Stratification for Papillary Thyroid Cancer: Validation Study Reveals Significant Reclassification Shifts

By MedXY 04/18/2026

A retrospective study of 670 papillary thyroid carcinoma patients validates the 2025 ATA risk stratification system, demonstrating a shift toward higher-risk classifications. The new 'low-intermediate-risk' class emerges as a distinct entity with intermediate structural disease persistence risk, warranting dedicated prospective management studies.

Cardiology news

Exercise Unmasks Multi-Organ Deficits That Predict Heart Failure Risk: Metabolite Signatures Reveal Shared Pathways Across HFpEF and Its Comorbidities

By MedXY 04/15/2026

A landmark study reveals that exercise-induced multi-organ physiologic deficits strongly predict incident heart failure with preserved ejection fraction (HFpEF). Using invasive cardiopulmonary testing, metabolomics, and genomics across over 6,000 individuals, researchers identified seven distinct exercise deficits that, when combined, confer nearly 4-fold higher cardiovascular risk and implicate shared metabolic pathways with obesity, diabetes, and renal disease.

Gastroenterology Hematology-Oncology news

New EHR-Based Model PRIME Achieves 0.75 AUC in Predicting Pancreatic Cancer Risk Across 11 Million Patients

By MedXY 04/07/2026

Researchers developed PRIME, a parsimonious risk stratification model for pancreatic ductal adenocarcinoma using electronic health record data. Validated across US health systems and the UK Biobank, PRIME retained 19 predictors and achieved strong discrimination, enabling targeted early detection in high-risk populations.

news Otorhinolaryngology

Beyond Binary: A 4-Stage Risk Stratification Tool Transforms Cochlear Implant Candidacy Assessment

By MedXY 04/02/2026

Researchers developed a novel 4-level classification system using routine audiometric data to estimate cochlear implant candidacy likelihood, moving beyond traditional binary screening approaches to support personalized shared decision-making in clinical practice.

Cardiology news

Sex-Specific Risk Thresholds in Aortic Regurgitation: Challenging the One-Size-Fits-All Approach to LV Remodeling

By MedXY 03/26/2026

A multicenter study reveals that women with moderate-severe aortic regurgitation face higher mortality risk at lower ventricular volumes than men. Findings suggest current guidelines may require revision to include sex-specific volumetric thresholds and lower linear diameter cutoffs to optimize surgical timing.

Clinical Updates Gastroenterology news

Stratifying Risk in Incidentally Detected Splenomegaly: Quantitative Thresholds for Hematologic and Hepatic Surveillance

By MedXY 03/21/2026

This review synthesizes large-scale cohort data defining specific spleen length and volume thresholds that significantly increase the 5-year absolute risk of hematologic cancers and chronic liver disease.

Cardiology news Radiology

Refining ARVC Risk Stratification: Does Left Ventricular Late Gadolinium Enhancement Add Incremental Value to Clinical Risk Calculators?

By MedXY 03/03/2026

A multi-center study of 385 ARVC patients reveals that while Left Ventricular Late Gadolinium Enhancement (LV LGE) correlates with ventricular arrhythmias, it fails to provide incremental prognostic value beyond the established ARVC risk calculator, reinforcing the calculator's role as the primary tool for clinical decision-making.

Cardiology news

Integrating Serum Metabolomics and Polygenic Risk Scores Redefines 5-Year Atrial Fibrillation Prediction

By MedXY 03/01/2026

A massive UK Biobank study demonstrates that combining serum metabolomics with polygenic risk scores and clinical data significantly improves the prediction of incident atrial fibrillation, identifying key metabolic markers like linoleic acid that enhance traditional risk stratification tools.

General Surgery news Oncology Pathology & Lab Medicine

Preoperative ctDNA Detects Occult Nodal Metastasis and Predicts Recurrence in Early-Stage Esophageal Squamous Cell Carcinoma

By MedXY 02/20/2026

A multi-center study demonstrates that preoperative ctDNA detection significantly outperforms traditional clinical criteria in predicting nodal upstaging and survival outcomes for patients with clinical stage I/II ESCC, potentially redefining neoadjuvant treatment strategies.

news Oncology Urology

Low Baseline PSA Predicts Exceptional Long-Term Safety: A 20-Year Paradigm Shift in Prostate Cancer Screening

By MedXY 02/09/2026

A 20-year cohort study shows that baseline PSA levels in men aged 45-70 are highly predictive of long-term prostate cancer risk, with PSA <1.0 ng/mL indicating a very low 20-year incidence of 3.3%, supporting extended screening intervals for low-risk individuals.

Gastroenterology news Oncology

Time-Varying Risks in Colorectal Adenoma Recurrence: Why Histology and Demographics Demand a Personalized Surveillance Calendar

By MedXY 02/05/2026

A massive cohort study reveals that colorectal adenoma recurrence risk is not static; high-grade dysplasia, villous histology, obesity, and sex-based factors exhibit distinct time-varying patterns, necessitating a shift toward personalized, long-term surveillance strategies.