Specialties – Medxy AI

Comparative Real-World Outcomes of Hypothermic Oxygenated and Normothermic Machine Perfusion in Liver Transplantation

By MedXY 09/12/2026

This international cohort study evaluates hypothermic oxygenated perfusion (HOPE) versus normothermic machine perfusion (NMP) in liver transplantation, revealing comparable high graft survival despite differing donor risk profiles and highlighting the need for further research on NMP benefits in high-risk grafts.

Diabetes & Endocrinology news

Determinants of Serum Dexamethasone Levels During the 1-mg Overnight Dexamethasone Suppression Test: Clinical and Pharmacological Insights

By MedXY 09/12/2026

This study investigates clinical and pharmacological factors influencing serum dexamethasone levels during the 1-mg overnight dexamethasone suppression test, revealing age and BMI as key determinants and highlighting the limited impact of renal function and concurrent medications after adjustment.

Diabetes & Endocrinology Neurology news

High-Frequency 10-kHz Spinal Cord Stimulation: Advancing Pain Relief and Sensory Recovery in Painful Diabetic Neuropathy

By MedXY 09/12/2026

A multicenter RCT demonstrates that 10-kHz spinal cord stimulation significantly improves pain relief, sensory function, and nerve fiber density in painful diabetic neuropathy, suggesting potential disease-modifying effects.

Cardiology news Public Health

Tropical Cyclones and Acute Coronary Syndromes: Unraveling the Cardiovascular Burden in Mainland China

By MedXY 09/12/2026

A nationwide Chinese study reveals that exposure to tropical cyclones increases acute coronary syndrome risk by 14%, delays treatment times, and disproportionately affects vulnerable populations. Coordinated public health and clinical strategies are essential to mitigate this environmental cardiovascular risk.

Cardiology news Pediatrics

Genetic Insights into Early Heart Failure Risk in Hypoplastic Left Heart Syndrome: Findings from the NC-DEFINE Study

By MedXY 09/12/2026

A prospective study reveals that ultra-rare cardiomyopathy gene variants significantly increase risk for early heart failure in infants with hypoplastic left heart syndrome, highlighting potential for genetic risk stratification and precision medicine.

Cardiology news

Expanding Horizons in Dilated Cardiomyopathy: A Comprehensive Genetic Reassessment in 2024

By MedXY 09/12/2026

The 2024 update of the Clinical Genome Resource elucidates a rapidly expanding genetic landscape for dilated cardiomyopathy, enhancing clinical genetic interpretation with 35 genes classified as high evidence, including nine novel discoveries and notable shifts in mode of inheritance insights.

Gastroenterology news Oncology

Unraveling the S1P-TREM2 Axis: A Novel Ferroptosis-Resistance Mechanism Driving Immunosuppressive Neutrophils and Tumour Progression in Hepatocellular Carcinoma

By MedXY 09/12/2026

This study reveals how the S1P-TREM2-NRF2 signaling pathway protects tumor-associated neutrophils from ferroptosis, sustaining immunosuppression and promoting hepatocellular carcinoma progression, offering new therapeutic avenues.

Hematology-Oncology news OB/GYN & Women's Health

Impact of Conditioning Regimens on Pregnancy Outcomes in Female Survivors of Childhood and Adolescent Acute Leukemia: HSCT versus Conventional Chemotherapy

By MedXY 09/12/2026

This multicenter study reveals that total-body irradiation (TBI) conditioning before hematopoietic stem cell transplantation severely compromises pregnancy outcomes compared to alkylating agents or conventional chemotherapy in female survivors of childhood/adolescent acute leukemia.

Hematology-Oncology news

Impact of Induction Course Number on Outcomes of Allogeneic Stem Cell Transplant with Post-Transplant Cyclophosphamide in AML

By MedXY 09/12/2026

This study compares outcomes after allogeneic stem cell transplantation using post-transplant cyclophosphamide in AML patients achieving first remission with one versus two induction courses, revealing similar survival but higher relapse with two inductions.

Hematology-Oncology news

Comparative Effectiveness of Azacitidine and Decitabine in TP53-Mutant Acute Myeloid Leukemia: Insights from the COMMAND Registry

By MedXY 09/12/2026

This study analyzes outcomes of azacitidine versus decitabine, with or without venetoclax, in TP53-mutant AML, revealing comparable survival outcomes and highlighting the independent prognostic impact of multi-hit TP53 status.

Hematology-Oncology news

Refining Risk Stratification in Newly Diagnosed Multiple Myeloma: Circulating Tumor Cells Identify a Disseminated Genomic High-Risk Phenotype Within IMS-IMWG 2025 Staging

By MedXY 09/12/2026

Circulating tumor cells (CTCs) enhance the IMS-IMWG 2025 genomic staging by identifying a disseminated high-risk phenotype in newly diagnosed multiple myeloma, improving prognostic stratification and enabling minimally invasive disease monitoring.

Clinical Updates Hematology-Oncology news

IL-16 Production as a Mechanism of Resistance to BTK Inhibitors and R-CHOP in B-Cell Lymphomas: Mechanistic Insights and Therapeutic Implications

By MedXY 09/12/2026

This review synthesizes evidence on IL-16-driven resistance to BTK inhibitors and chemoimmunotherapy in B-cell lymphomas, highlighting the IL-16/CD9/PI3K axis as a targetable epigenetically regulated survival pathway overcoming drug resistance.

$Arlocabtagene Autoleucel: Advancing Treatment Paradigms in Heavily Pretreated Relapsed/Refractory Multiple Myeloma$

Hematology-Oncology news

Arlocabtagene Autoleucel: Advancing Treatment Paradigms in Heavily Pretreated Relapsed/Refractory Multiple Myeloma

By MedXY 09/12/2026

Arlocabtagene autoleucel (arlo-cel) is a novel GPRC5D-targeted CAR T-cell therapy showing promising efficacy and manageable safety in patients with relapsed/refractory multiple myeloma heavily pretreated with standard regimens, including prior BCMA therapies.

Critical Care Internal Medicine news

Understanding Physicians’ Mental Models on Goals of Care in Chronic Critical Illness: Implications for Shared Decision Making

By MedXY 09/12/2026

This study explores how intensivists conceptualize appropriate goals of care and the influences of health system factors on decision-making for patients with chronic critical illness, emphasizing predictions about quality of life and functional outcomes.

Allergy & Immunology news Respiratory

Tezepelumab Demonstrates Robust Efficacy and Safety Across Diverse Severe Asthma Phenotypes: Insights from the Phase 4 PASSAGE Study

By MedXY 09/12/2026

The PASSAGE phase 4 study reveals tezepelumab significantly reduces exacerbation rates and improves lung function and quality of life in a broad US severe asthma population, including underrepresented groups and varied phenotypes.

news Respiratory

Efficacy of Dupilumab in Reducing COPD Exacerbations, Emergency Department Visits, and Corticosteroid Use: Insights from a Pooled Phase 3 Analysis

By MedXY 09/12/2026

Dupilumab significantly reduces emergency visits, hospital admissions, and systemic corticosteroid use in COPD patients with type 2 inflammation, offering a promising therapeutic option to mitigate exacerbation-associated morbidity.

news Ophthalmology

Differential Impact of Reticular Pseudodrusen Subtypes on Retinal Sensitivity in Intermediate Age-Related Macular Degeneration

By MedXY 09/12/2026

This study elucidates how ribbon-type reticular pseudodrusen, especially when coexisting with soft drusen, significantly impair retinal sensitivity in intermediate AMD, highlighting the importance of lesion phenotype in functional risk assessment.

Dermatology news Ophthalmology

Unveiling Dupilumab-Associated Ocular Surface Disease in Atopic Dermatitis: Insights from a Large Prospective BioDay Cohort

By MedXY 09/12/2026

This study reveals that 30.7% of atopic dermatitis patients treated with dupilumab develop ocular surface disease, despite prevalent ocular symptoms at baseline and increased ophthalmic treatment during therapy, linked to reduced conjunctival mucin production.

Diabetes & Endocrinology news Ophthalmology

Satralizumab Demonstrates Promising Efficacy and Safety in Treating Thyroid Eye Disease: Insights from Phase 3 SatraGO-1 and SatraGO-2 Trials

By MedXY 09/12/2026

Phase 3 trials show satralizumab significantly improves proptosis, inflammation, and diplopia in thyroid eye disease with a favorable safety profile, marking a new therapeutic option targeting the IL-6 receptor pathway.

news Otorhinolaryngology Respiratory

Prevalence of Voice Fatigue and Its Correlation With Xerostomia in E-Cigarette Smokers

By MedXY 09/12/2026

This study explores the high prevalence of voice fatigue among e-cigarette users and its significant correlation with dry mouth (xerostomia).