Pathology & Lab Medicine

Harnessing Deep Learning for Accurate Differentiation of Fibro-Osseous Jaw Lesions

By MedXY 10/16/2026

A novel deep learning model significantly improves diagnostic accuracy in distinguishing fibro-osseous jaw lesions (FD, COF, COD) from histology images, outperforming expert pathologists and offering a promising diagnostic support tool.

news Otorhinolaryngology Pathology & Lab Medicine

Advancing Surgical Precision: Confocal Ex Vivo Margin Assessment in Transoral Laser Cordectomy for Glottic Cancer

By MedXY 10/15/2026

This pilot study demonstrates the feasibility and high diagnostic accuracy of the Histolog Scanner, an ultra-fast ex vivo confocal microscopy system, for intraoperative margin assessment in transoral laser microsurgery of glottic squamous cell carcinoma.

news Oncology Pathology & Lab Medicine

Molecular Subtyping of Salivary Adenoid Cystic Carcinomas Enhances Prognostic Precision

By MedXY 10/13/2026

This study uncovers molecular subtypes of salivary adenoid cystic carcinoma based on genomic and transcriptomic analyses, introducing a novel copy number variation (CNV)-based classification that improves prognostic accuracy and could refine clinical management.

news Otorhinolaryngology Pathology & Lab Medicine

Immune Profiling in Oral Tongue Dysplasia: Identifying Biomarkers to Stratify High-Risk Patients

By MedXY 10/12/2026

This study identifies immune biomarkers, including proliferative CD8+ T cells, CD68+ macrophages, and PD-1 expression, which differentiate high-risk oral tongue epithelial dysplasia and may improve patient risk stratification beyond conventional histology.

Clinical Updates Neurology news Pathology & Lab Medicine

Quantitative Relationship Between Lumipulse G Measures of pTau217 in Plasma and Temporal Cortex Pathology in Alzheimer Disease

By MedXY 10/10/2026

Plasma pTau217 levels measured by Lumipulse G assays strongly correlate with postmortem temporal cortex pTau217 pathology, supporting plasma pTau217 as a reliable biomarker for brain tau pathology in Alzheimer disease.

Clinical Updates Neurology news Pathology & Lab Medicine

Earlier Disclosure of Blood-Based Biomarkers Enhances Diagnostic Certainty and Clinical Management in Cognitive Disorders: A Review of a Recent Randomized Clinical Trial

By MedXY 10/09/2026

Early disclosure of plasma p-tau217 and NfL biomarkers significantly improves diagnostic confidence and clinical decisions in cognitive decline without increasing emotional distress, supporting their integration into routine memory clinic care.

Internal Medicine news Pathology & Lab Medicine

Fasting Duration and Differences Across Routine Laboratory Tests

By MedXY 10/09/2026

This study evaluates how fasting length affects routine blood test results, finding significant effects only for a few analytes, supporting tailored fasting guidelines.

Clinical Updates Neurology news Pathology & Lab Medicine

Clinical Factors Associated With Discordant Plasma P-Tau217 and Established Alzheimer Disease Biomarkers: Implications for Diagnosis and Management

By MedXY 10/07/2026

This review synthesizes evidence on clinical and biological factors linked to discordance between plasma p-tau217 and standard AD biomarkers, highlighting implications for diagnosis, patient stratification, and future biomarker development.

news Otorhinolaryngology Pathology & Lab Medicine

Advancing Diagnosis of Major Salivary Gland Tumors: The Clinical Value of Core Needle Biopsy

By MedXY 10/06/2026

Core needle biopsy (CNB) demonstrates high diagnostic accuracy for major salivary gland tumors, offering a reliable tool to distinguish benign from malignant lesions and potentially reduce unnecessary surgeries.

news Otorhinolaryngology Pathology & Lab Medicine

Differentiating Allergic Fungal Rhinosinusitis from Eosinophilic Chronic Rhinosinusitis with Nasal Polyps: Insights from Structured Histopathology in a Saudi Cohort

By MedXY 10/06/2026

This study delineates distinct clinical, radiographic, laboratory, and histopathologic features separating allergic fungal rhinosinusitis from eosinophilic chronic rhinosinusitis with nasal polyps in a Middle Eastern tertiary-care cohort.

news Oncology Pathology & Lab Medicine

TESERA: Advancing Morphologic Subtyping and Prognostic Stratification in Hepatocellular Carcinoma Using H&E Whole-Slide Images

By MedXY 10/06/2026

TESERA leverages computational pathology to classify hepatocellular carcinoma into biologically distinct morphologic subtypes from standard H&E slides, offering accurate prognosis stratification competitive with clinical and molecular markers.

Cardiology news Pathology & Lab Medicine

HEARTBiT: A Breakthrough Transcriptomic Biomarker for Early Detection of Acute Cellular Rejection Post-Heart Transplantation

By MedXY 10/04/2026

HEARTBiT, a novel transcriptomic biomarker, effectively detects moderate-to-severe acute cellular rejection within the first year after heart transplantation, offering a minimally invasive alternative to biopsy, especially during the high-risk early postoperative period.

news OB/GYN & Women's Health Pathology & Lab Medicine

Discordance Between Gastric HER2 Scoring in Endometrial Sampling Versus Hysterectomy Specimens: Clinical Implications in High-Grade Endometrial Cancer

By MedXY 09/29/2026

This study reveals significant discordance between HER2 scores from endometrial biopsy samples and hysterectomy specimens using gastric scoring criteria, impacting treatment decisions in high-grade endometrial cancer.

news OB/GYN & Women's Health Pathology & Lab Medicine

Unlocking the Diagnostic Potential of Peritoneal Fluid Small Extracellular Vesicle Proteins in Endometriosis

By MedXY 09/29/2026

Peritoneal fluid-derived small extracellular vesicles exhibit distinct proteomic profiles in endometriosis, identifying potential biomarkers for improved diagnosis independent of cycle phase or disease stage.

Diabetes & Endocrinology news Pathology & Lab Medicine

Harnessing Long-Read Sequencing to Revolutionize Diagnosis and Equity in Differences of Sex Development (DSD)

By MedXY 09/26/2026

Long-read sequencing (LRS) improves genetic diagnosis of Congenital Adrenal Hyperplasia and other DSDs by resolving complex genomic variants, tightening phenotype-genotype correlations, and closing equity gaps in clinical care.

Hematology-Oncology news Pathology & Lab Medicine

Enhancing Bone Marrow Fibrosis Diagnosis: Clinical Evaluation of AI-Driven Continuous Indexing of Fibrosis (CIF)

By MedXY 09/22/2026

This study clinically validates an AI-based quantitative tool, CIF, for bone marrow fibrosis assessment, demonstrating improved reproducibility and accuracy over manual grading without increasing assessment time.

Diabetes & Endocrinology news Pathology & Lab Medicine

Histological Subtypes of Pituitary Adenomas: Their Role in Acromegaly Surgical Outcomes and Disease Control

By MedXY 09/21/2026

This study evaluates how different pituitary adenoma histological subtypes influence remission and disease control in acromegaly post-surgery, finding no significant differences though sparsely granulated adenomas show a trend toward lower remission.

Diabetes & Endocrinology news Pathology & Lab Medicine

New Consensus on Testosterone Reference Ranges for Females and Children: Outcomes of the 2024 PCOS Challenge–CDC Stakeholder Meeting

By MedXY 09/19/2026

A stakeholder consensus sets a roadmap to develop standardized, age- and sex-specific testosterone reference intervals for women, adolescent girls, and children to improve diagnosis and care for androgen-related disorders.

news Otorhinolaryngology Pathology & Lab Medicine

Evaluating the Utility of Routine Tonsil Pathology in a Safety-Net Hospital: Low Yield of Unexpected Malignancies Supports Risk-Stratified Approach

By MedXY 09/18/2026

A retrospective cohort study at a safety-net hospital found that routine pathological examination of tonsillectomy specimens rarely reveals unexpected malignancies, supporting targeted pathology based on clinical assessment.

news OB/GYN & Women's Health Pathology & Lab Medicine

Advancing Fetal Death Detection: Identification of Novel Maternal Plasma Biomarkers Through Large-Scale Proteomic Profiling

By MedXY 09/11/2026

Large-scale proteomic analysis identifies novel maternal plasma protein biomarkers that improve detection of fetal death beyond established markers, highlighting both shared and unique pathological pathways with preeclampsia.