Enhancing Diagnostic Accuracy of Sinonasal Lesions: The Role of Narrow Band Imaging in Differentiating Inverted Papillomas from Nasal Polyps
Posted innews Otorhinolaryngology Pathology & Lab Medicine

Enhancing Diagnostic Accuracy of Sinonasal Lesions: The Role of Narrow Band Imaging in Differentiating Inverted Papillomas from Nasal Polyps

Narrow-band imaging (NBI) significantly improves the endoscopic differentiation of inverted papillomas (IPs) from nasal polyps (NPs) by highlighting mucosal microvasculature patterns, achieving superior diagnostic accuracy compared to white-light endoscopy (WLE). Combining NBI with WLE further enhances preoperative lesion assessment.
Long-Term Efficacy and ctDNA Dynamics in Early-Stage ERBB2-Positive Breast Cancer Treated with Neoadjuvant Paclitaxel, Trastuzumab, and Pertuzumab: Insights from the DAPHNe Trial
Posted innews Oncology Pathology & Lab Medicine

Long-Term Efficacy and ctDNA Dynamics in Early-Stage ERBB2-Positive Breast Cancer Treated with Neoadjuvant Paclitaxel, Trastuzumab, and Pertuzumab: Insights from the DAPHNe Trial

The DAPHNe trial demonstrates excellent 5-year outcomes for stage II–III ERBB2-positive breast cancer patients treated with an abbreviated neoadjuvant paclitaxel, trastuzumab, and pertuzumab regimen, with ultrasensitive ctDNA monitoring showing near-universal clearance post-therapy.
Donor-Derived Cell-Free DNA as a Prognostic Biomarker in Severe Cardiac Allograft Rejection: From Detection to Risk Stratification
Posted inClinical Updates news Pathology & Lab Medicine Transplantation

Donor-Derived Cell-Free DNA as a Prognostic Biomarker in Severe Cardiac Allograft Rejection: From Detection to Risk Stratification

Recent heart-transplant studies show donor-derived cell-free DNA not only detects rejection but also predicts mortality and persistent graft dysfunction, especially when elevated at diagnosis. Evidence supports a shift from binary surveillance toward risk-adapted management.