Therapeutic Hypothermia at 35°C vs. Controlled Normothermia in ICU Heatstroke: Insights from a Pilot RCT
Posted inCritical Care Emergency Medicine news

Therapeutic Hypothermia at 35°C vs. Controlled Normothermia in ICU Heatstroke: Insights from a Pilot RCT

A pilot randomized trial comparing targeted temperature management at 35°C versus normothermia in intubated heatstroke patients showed no survival or neurological benefit from hypothermia but increased gastrointestinal injury and arrhythmias, highlighting safety concerns and questioning routine hypothermia use in this setting.
Evaluating Androgen Receptor Inhibition Combined with Hormonal Therapies in Recurrent Adult-Type Ovarian Granulosa Cell Tumor: Insights from a Phase II Study
Posted innews OB/GYN & Women’s Health Oncology

Evaluating Androgen Receptor Inhibition Combined with Hormonal Therapies in Recurrent Adult-Type Ovarian Granulosa Cell Tumor: Insights from a Phase II Study

A Phase II trial assessed the combination of darolutamide, leuprolide acetate, and exemestane in recurrent adult-type ovarian granulosa cell tumor, showing limited objective response but clinically meaningful progression-free survival without severe toxicity.
Evaluating Consolidative Thoracic Radiotherapy with Atezolizumab Maintenance in Extensive-Stage Small Cell Lung Cancer: Insights from the Phase 2 TREASURE Trial
Posted innews Oncology Respiratory

Evaluating Consolidative Thoracic Radiotherapy with Atezolizumab Maintenance in Extensive-Stage Small Cell Lung Cancer: Insights from the Phase 2 TREASURE Trial

The Phase 2 TREASURE trial investigated the safety and efficacy of adding consolidative thoracic radiotherapy to atezolizumab maintenance in extensive-stage small cell lung cancer, revealing increased toxicity without survival benefit, underscoring the need for cautious patient selection.
Safety and Efficacy of Staged, Bilateral MRgFUS Pallidothalamic Tractotomy in Parkinson’s Disease Motor Complications: A Contemporary Evidence Review
Posted inClinical Updates Neurology news

Safety and Efficacy of Staged, Bilateral MRgFUS Pallidothalamic Tractotomy in Parkinson’s Disease Motor Complications: A Contemporary Evidence Review

This review synthesizes evidence on staged, bilateral MRgFUS pallidothalamic tractotomy for Parkinson's motor complications, highlighting demonstrated unilateral safety and modest bilateral efficacy with increased adverse events, underscoring critical patient selection.