Dermatology – Medxy AI

低剂量病灶内注射 Cemiplimab 在早期皮肤鳞状细胞癌中显示出良好疗效：来自 1 期剂量递增研究的启示

Low-Dose Intralesional Cemiplimab Shows Promising Efficacy in Early-Stage Cutaneous Squamous Cell Carcinoma: Insights from a Phase 1 Dose-Escalation Study

By MedXY 11/11/2026

A phase 1 study demonstrates that low-dose intralesional cemiplimab is safe and achieves high complete response rates in early-stage cutaneous squamous cell carcinoma, supporting further clinical exploration.

Clinical Updates Dermatology Internal Medicine

Targeting the Autotaxin/Lysophosphatidic Acid Axis: A Novel Approach to Modulate Bone Loss and Inflammation in Periodontitis

By MedXY 11/10/2026

This article explores how the autotaxin/lysophosphatidic acid axis regulates macrophage-driven osteoclastogenesis and inflammation in periodontitis, highlighting the therapeutic potential of autotaxin inhibitors to prevent alveolar bone resorption.

Clinical Updates Dermatology Rheumatology

Targeting Nicotinamide N-Methyltransferase: A Novel Approach to Mitigate Fibroblast Activation and Skin Fibrosis in Systemic Sclerosis

By MedXY 11/10/2026

This article explores the pivotal role of Nicotinamide N-methyltransferase (NNMT) in fibroblast activation and extracellular matrix deposition driving skin fibrosis in systemic sclerosis, highlighting therapeutic potential of NNMT inhibition.

Allergy & Immunology Clinical Updates Dermatology

Dual T Helper 17/Type 2 Immune Dysregulation in Taiwanese Psoriasis: Implications for Precision Medicine

By MedXY 11/10/2026

This study reveals a distinctive dual Th17/Th2 immune endotype and pronounced IL-36 activation in Taiwanese patients with psoriasis, highlighting the need for tailored therapeutic approaches in this ethnic group.

Clinical Updates Dermatology Infectious Diseases

Development and Validation of a Clinical Score for Predicting High Tuberculosis Risk in Chinese Psoriasis Patients Prior to Biologic Therapy

By MedXY 11/09/2026

A multicenter Chinese study developed and externally validated the Psoriasis TB Risk Score (PTRS) to stratify psoriasis patients' risk of high interferon-γ release assay (IGRA) responses before biologic treatment, facilitating tailored TB screening in high-burden settings.

Dupilumab 促进重症特应性皮炎患儿生长并改善骨健康：来自 3 期试验的研究发现

Clinical Updates Dermatology Pediatrics

Dupilumab Enhances Growth and Bone Health in Pediatric Severe Atopic Dermatitis: Insights from a Phase 3 Trial

By MedXY 11/08/2026

Dupilumab treatment in children aged 6–11 with severe atopic dermatitis is associated with significant improvements in linear growth and bone biomarker levels over one year, suggesting benefits beyond skin clearance.

Clinical Updates Dermatology Otorhinolaryngology

Enhanced Palatal Donor-Site Healing with Chitosan and Injectable PRF: Insights from a Randomized Clinical Trial

By MedXY 11/07/2026

This RCT demonstrates that chitosan sponges, especially when enriched with injectable platelet-rich fibrin, significantly improve palatal wound healing and patient comfort following free gingival graft harvesting compared to gelatine sponges.

Clinical Updates Dermatology Diabetes & Endocrinology

Physiological vs. Supraphysiological Platelet Concentrations in Diabetic Wound Healing: Implications from a Randomized Controlled Trial

By MedXY 11/07/2026

This study demonstrates that physiological concentration platelet fibrin plasma (PFP) is noninferior to supraphysiological platelet-rich plasma (PRP) in healing neuro-ischemic diabetic foot ulcers and other diabetic wounds, offering a simpler and blood-sparing alternative.

Clinical Updates Dermatology Rheumatology

Targeting IL-4 Receptor-α in Localised Scleroderma: Promising Phase 2 Evidence for Fibrosis Modulation

By MedXY 11/06/2026

This phase 2 randomized trial demonstrates that IL-4-receptor-α blockade with dupilumab significantly improves clinical outcomes and reduces fibrosis-associated inflammation and gene signatures in localised scleroderma, supporting a novel therapeutic strategy for fibrosing diseases.

Clinical Updates Dermatology Rheumatology

Decoding Systemic Sclerosis: A New Vascular-Fibrotic Framework for Risk Stratification

By MedXY 11/06/2026

This study introduces a novel classification framework for systemic sclerosis based on vascular and fibrotic complications, identifying a high-risk mixed endotype with distinct immunologic features and prognostic relevance, offering improved personalized management potential.

Clinical Updates Dermatology Plastic Surgery

Predictors and Outcomes of Complications in Retroauricular Interpolated Flaps Following Mohs Surgery: Insights from a Large Retrospective Study

By MedXY 11/05/2026

This study examines 417 retroauricular interpolated flap repairs after Mohs surgery, identifying stage-specific complication rates and risk factors such as diabetes and defect size to inform surgical risk management.

Clinical Updates Dermatology Infectious Diseases

When Secondary Syphilis is Reliably Recognizable: Clinical and Histopathologic Insights into Condyloma Lata

By MedXY 11/04/2026

This review synthesizes evidence on the characteristic clinical and histopathologic features of condyloma lata in secondary syphilis, emphasizing its reliable recognition to prevent misdiagnosis, especially at extragenital sites.

Clinical Updates Dermatology Pediatrics

Risk Factors and Clinical Profile of Infantile Hemangioma Ulceration Post Oral Propranolol Treatment: Insights from a Large Retrospective Study

By MedXY 11/03/2026

This retrospective study evaluates the incidence and risk factors for infantile hemangioma ulceration following oral propranolol therapy, highlighting subtype-related risks and anatomical protective factors to guide clinical management.

Clinical Updates Dermatology Plastic Surgery

Advancing Hair Loss Therapy: Sodium Citrate Enhances Comfort and Efficacy of Concentrated Growth Factor Treatment in Androgenetic Alopecia

By MedXY 11/03/2026

In a randomized trial, sodium citrate as an anticoagulant in concentrated growth factor therapy for androgenetic alopecia reduced injection pain, improved hair density, and increased patient satisfaction compared with heparin sodium or no anticoagulant.

Clinical Updates Dermatology OB/GYN & Women's Health

Safety of Biologic Therapy in Pregnancy for Psoriasis Patients: Insights from a Large Cohort Study

By MedXY 11/02/2026

This large cohort study demonstrates that biologic therapy in pregnant women with psoriasis is not associated with increased adverse pregnancy outcomes and may reduce risks of spontaneous abortion and gestational diabetes.

HMME-PDT 与脉冲染料激光治疗面颈部葡萄酒色斑的疗效与安全性比较：一项大型回顾性研究启示

Clinical Updates Dermatology

Comparative Effectiveness and Safety of HMME-PDT Versus Pulsed Dye Laser in Treating Facial and Neck Port-Wine Stains: Insights from a Large Retrospective Study

By MedXY 11/01/2026

A retrospective analysis reveals hematoporphyrin monomethyl ether-mediated photodynamic therapy (HMME-PDT) outperforms pulsed dye laser (PDL) in clearing facial and neck port-wine stains but with an increased risk of hyperpigmentation and scarring.

Clinical Updates Dermatology Rheumatology

Risk of Progression from Pediatric Discoid Lupus Erythematosus to Systemic Lupus Erythematosus: Insights from a Multicenter Cohort Study

By MedXY 10/31/2026

This study quantifies the risk and identifies predictors for systemic lupus erythematosus development in children presenting with skin-limited discoid lupus erythematosus, highlighting the importance of early monitoring especially in patients positive for antinuclear antibodies.

Cobratide注射液与普瑞巴林治疗急性带状疱疹神经痛：一项多中心探索性试验的新发现

Dermatology Neurology news

Cobratide Injection versus Pregabalin for Acute Herpes Zoster Neuralgia: Insights from a Multicenter Exploratory Trial

By MedXY 10/29/2026

This exploratory trial compares cobratide injection and pregabalin for moderate-to-severe acute herpes zoster neuralgia, showing similar pain relief with better tolerability for cobratide and a potential reduction in postherpetic neuralgia incidence.

口服双重 JAK1/TYK2 抑制剂 QY201 在中重度特应性皮炎中疗效与安全性可期：2 期剂量探索试验结果

Allergy & Immunology Dermatology news

QY201, a Dual JAK1/TYK2 Inhibitor, Shows Promising Efficacy and Safety in Moderate-to-Severe Atopic Dermatitis: Phase 2 Dose-Finding Trial Results

By MedXY 10/28/2026

In a phase 2 trial, oral QY201 significantly improved skin outcomes in moderate-to-severe atopic dermatitis with favorable safety, supporting further phase 3 evaluation.

Dermatology news Superintelligence

Enhancing Lentigo Maligna Detection with AI-Assisted Dermoscopy: A Clinical Reader Study on Facial Pigmented Lesions

By MedXY 10/27/2026

A deep learning model significantly improves lentigo maligna detection and dermatology resident diagnostic accuracy when applied to dermoscopic images of facial pigmented lesions, underscoring AI's adjunctive role in clinical dermatology and training.