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Danish Multicenter Study Finds a 15% ADNEX Threshold Best Balances Early Detection and Referral Burden for Adnexal Masses
Posted innews OB/GYN & Women’s Health Oncology

Danish Multicenter Study Finds a 15% ADNEX Threshold Best Balances Early Detection and Referral Burden for Adnexal Masses

Posted by MedXY By MedXY 05/01/2026
In a Danish multicenter cohort of adnexal masses, IOTA-based models outperformed RMI for routine triage. A 15% ADNEX threshold best balanced sensitivity and referral burden in non-tertiary care.
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Early Pregnancy Oxylipin Biomarkers Linked to Fetal Growth Restriction Patterns
Posted innews OB/GYN & Women’s Health

Early Pregnancy Oxylipin Biomarkers Linked to Fetal Growth Restriction Patterns

Posted by MedXY By MedXY 05/01/2026
Study reveals specific inflammation and oxidative stress markers in early pregnancy urine predict distinct fetal growth restriction patterns, offering potential for early detection and intervention strategies.
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妊娠早期炎症和氧化应激oxylipin标志物与小于胎龄儿及特定胎儿生长受限表型相关
Posted innews OB/GYN & Women’s Health

妊娠早期炎症和氧化应激oxylipin标志物与小于胎龄儿及特定胎儿生长受限表型相关

Posted by MedXY By MedXY 05/01/2026
研究发现妊娠早期尿液中的血栓素代谢物与小于胎龄儿相关，尤其与晚期生长受限表型显著关联。而异前列腺素则与早期生长受限表型相关，为胎儿生长受限的预测和干预提供了新方向。
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Early Pregnancy Oxylipins Point to Distinct Inflammatory and Oxidative Stress Signals in Fetal Growth Restriction
Posted innews OB/GYN & Women’s Health

Early Pregnancy Oxylipins Point to Distinct Inflammatory and Oxidative Stress Signals in Fetal Growth Restriction

Posted by MedXY By MedXY 05/01/2026
Early pregnancy urinary oxylipins linked inflammatory and oxidative stress pathways to small-for-gestational-age birth, with distinct signatures for early- and late-onset growth restriction. Associations with large-for-gestational-age birth were not significant after multiple-testing correction.
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HSP72-PRDX6 Control of PINK1 Ubiquitination Emerges as a New Mitophagy Axis in MASLD
Posted inGastroenterology Internal Medicine news

HSP72-PRDX6 Control of PINK1 Ubiquitination Emerges as a New Mitophagy Axis in MASLD

Posted by MedXY By MedXY 05/01/2026
A new Hepatology study identifies an HSP72–PRDX6 pathway that restores PINK1/Parkin mitophagy, reduces hepatic steatosis, and worsens MASLD when disrupted in mice and hepatocytes.
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Uncoupling Metabolic Reprogramming in Hepatocellular Carcinoma: The JOSD1-PGAM1 Ubiquitination-Lactylation Switch
Posted inClinical Updates Gastroenterology news Oncology

Uncoupling Metabolic Reprogramming in Hepatocellular Carcinoma: The JOSD1-PGAM1 Ubiquitination-Lactylation Switch

Posted by MedXY By MedXY 05/01/2026
This article explores how the deubiquitinase JOSD1 drives HCC progression by modulating a novel PTM switch on PGAM1, promoting glycolysis and immune evasion while providing a new target for combined immunotherapy.
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Genetic Risk of Inflammatory Bowel Disease Linked to Disease Severity
Posted inGastroenterology news

Genetic Risk of Inflammatory Bowel Disease Linked to Disease Severity

Posted by MedXY By MedXY 05/01/2026
A Danish nationwide study reveals higher genetic risk scores for IBD predict more severe disease courses, including increased surgery rates, stronger medication needs, and worse inflammatory markers in both Crohn's and ulcerative colitis patients.
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Late-Life Stroke in ARIC Was More Often Embolic, and Atrial Disease Explained Much of the Risk
Posted inCardiology Neurology news

Late-Life Stroke in ARIC Was More Often Embolic, and Atrial Disease Explained Much of the Risk

Posted by MedXY By MedXY 05/01/2026
In ARIC, ischemic stroke at age 80 years or older was more often embolic than thrombotic. Atrial fibrillation and left atrial disease explained much of the age effect, and adding embolic factors improved prediction.
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Commercially Insured Patients Wait a Median of 25 Days for New Neurology Care, with Regional and Plan-Based Differences
Posted inNeurology news Public Health

Commercially Insured Patients Wait a Median of 25 Days for New Neurology Care, with Regional and Plan-Based Differences

Posted by MedXY By MedXY 04/30/2026
Among 114,034 commercially insured patients, the median time to a new neurology visit was 25 days. Waits varied by sex, diagnosis, region, and plan type, while neurologist density showed no association with access.
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Neurofilament Light Chain Reveals Rapid Neuroaxonal Injury in New-Onset Refractory Status Epilepticus
Posted inCritical Care Neurology news

Neurofilament Light Chain Reveals Rapid Neuroaxonal Injury in New-Onset Refractory Status Epilepticus

Posted by MedXY By MedXY 04/30/2026
In a multinational cross-sectional study, serum and CSF neurofilament light chain—unlike S100B—tracked severe acute brain injury in cryptogenic NORSE, rose rapidly over the first 3 weeks, and predicted poor short-term outcome, supporting urgent neuroprotective treatment.
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ATA Guideline Updates Reduced Thyroid Cancer Overtreatment in a 31,861-Patient South Korean Cohort
Posted inGeneral Surgery news Oncology

ATA Guideline Updates Reduced Thyroid Cancer Overtreatment in a 31,861-Patient South Korean Cohort

Posted by MedXY By MedXY 04/30/2026
A large South Korean cohort found ATA-guideline de-escalation reduced total thyroidectomy, RAI use, and permanent hypocalcemia in papillary thyroid carcinoma, without significant loss of 5-year disease-free survival.
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Oral Glucose Absorption Enhanced in Early Metabolic Dysfunction-Associated Steatotic Liver Disease
Posted inDiabetes & Endocrinology Gastroenterology news

Oral Glucose Absorption Enhanced in Early Metabolic Dysfunction-Associated Steatotic Liver Disease

Posted by MedXY By MedXY 04/30/2026
New research reveals accelerated glucose absorption in early MASLD patients, independent of gastric emptying. This metabolic alteration may drive liver disease progression before hepatic insulin resistance develops.
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Early MASLD Is Associated With Enhanced Oral Glucose Absorption Independent of Gastric Emptying
Posted inDiabetes & Endocrinology Gastroenterology news

Early MASLD Is Associated With Enhanced Oral Glucose Absorption Independent of Gastric Emptying

Posted by MedXY By MedXY 04/30/2026
Stable-isotope OGTT data suggest that early MASLD is linked to higher oral glucose absorption, independent of gastric emptying, with preserved hepatic insulin suppression but impaired peripheral glucose clearance.
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ATTR-CM Is Often Diagnosed Years After Heart Failure in Medicare Patients
Posted inCardiology news Public Health

ATTR-CM Is Often Diagnosed Years After Heart Failure in Medicare Patients

Posted by MedXY By MedXY 04/30/2026
In Medicare beneficiaries, ATTR-CM was diagnosed a median 494 days after heart failure and 840 days after loop diuretic initiation, with delays more common in women and patients with several common comorbidities.
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Standard-Dose DOACs Outperform Warfarin More Strongly in Asian Than Non-Asian Patients With Atrial Fibrillation
Posted inCardiology news

Standard-Dose DOACs Outperform Warfarin More Strongly in Asian Than Non-Asian Patients With Atrial Fibrillation

Posted by MedXY By MedXY 04/30/2026
In a patient-level meta-analysis of 10,212 Asian and 61,471 non-Asian AF patients, standard-dose DOACs outperformed warfarin more strongly in Asians, with less stroke, major bleeding, and net clinical harm. Standard-dose therapy was favored over lower-dose regimens in Asians.
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Coronary Stent Trial Site Selection Could Narrow Racial Gaps in Enrollment, but Women Remain Underrepresented
Posted inCardiology news Public Health

Coronary Stent Trial Site Selection Could Narrow Racial Gaps in Enrollment, but Women Remain Underrepresented

Posted by MedXY By MedXY 04/30/2026
In nine U.S. coronary stent PMA trials, minority participants were markedly underrepresented, while women were modestly underrepresented. Site geography and surrounding county demographics predicted minority enrollment, suggesting targeted site selection could improve racial and ethnic representation.
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Posted inInternal Medicine news

Fontan Outcomes Network Enrolls 1,121 Patients and Reveals a High Burden of Arrhythmia, Thrombosis, and Mental Health Needs

Posted by Zhang Paul By Zhang Paul 04/30/2026
Background Fontan palliation has transformed the prognosis of children born with single-ventricle heart disease, allowing…
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Posted innews OB/GYN & Women's Health Oncology

New Cervical Cancer Screening Guidelines: Patient-Collected HPV Tests Now Recommended

Posted by Zhang Paul By Zhang Paul 04/30/2026
Introduction and Context Despite being highly preventable, cervical cancer remains a significant health threat. The…
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CD276 Identified as Key Driver of Chemoresistance in Advanced Pancreatic Cancer
Posted inGastroenterology news Oncology

CD276 Identified as Key Driver of Chemoresistance in Advanced Pancreatic Cancer

Posted by MedXY By MedXY 04/29/2026
Single-cell analysis reveals CD276/B7-H3 as a critical regulator of chemoresistance in pancreatic ductal adenocarcinoma, highlighting its dual role in promoting basal-like tumor states and immune evasion.
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Intracranial Hemorrhage Patterns and Outcomes in Minor Stroke: Insights from the TEMPO-2 Trial
Posted inEmergency Medicine Neurology news

Intracranial Hemorrhage Patterns and Outcomes in Minor Stroke: Insights from the TEMPO-2 Trial

Posted by MedXY By MedXY 04/29/2026
Secondary analysis of TEMPO-2 trial data reveals intracranial hemorrhage in minor stroke patients increases 90-day mortality risk threefold, with higher hemorrhage rates in tenecteplase-treated patients despite most bleeds being non-symptomatic.
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  • Danish Multicenter Study Finds a 15% ADNEX Threshold Best Balances Early Detection and Referral Burden for Adnexal Masses
  • Early Pregnancy Oxylipin Biomarkers Linked to Fetal Growth Restriction Patterns
  • 妊娠早期炎症和氧化应激oxylipin标志物与小于胎龄儿及特定胎儿生长受限表型相关
  • Early Pregnancy Oxylipins Point to Distinct Inflammatory and Oxidative Stress Signals in Fetal Growth Restriction
  • HSP72-PRDX6 Control of PINK1 Ubiquitination Emerges as a New Mitophagy Axis in MASLD
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