美学区种植的新进展：Socket-shield 技术与导板即刻种植、一步式冠修复的数字化整合
Posted innews Ophthalmology Plastic Surgery

Innovations in Esthetic Zone Implantation: Digital Integration of the Socket-Shield Technique with Guided Immediate Implant Placement and One-Step Crown

This article reviews a novel digitally guided protocol combining the socket-shield technique and immediate implant placement in the esthetic zone, highlighting a 5-year successful clinical outcome and its implications for improving implant precision and esthetics.
DNAメチル化シグネチャーが痛風を無症候性高尿酸血症から見分ける――免疫・代謝関連遺伝子座との整合も確認
Posted inInternal Medicine news Rheumatology

DNA Methylation Signatures Distinguish Gout from Asymptomatic Hyperuricaemia and Align with Genetic Risk at Immune-Metabolic Loci

This study identifies specific DNA methylation patterns in blood that differentiate gout patients from those with asymptomatic hyperuricaemia and normouricaemic controls, linking epigenetic changes to immune-metabolic genetic risk factors and offering potential for molecular disease stratification.
Cilta-cel 峰值水平的迅速扩增预示着复发/难治性多发性骨髓瘤患者会出现迟发性神经毒性：临床与转化视角
Posted inClinical Updates Hematology-Oncology news

Rapid Peak Cilta-Cel Expansion Predicts Delayed Neurotoxicity in Relapsed/Refractory Multiple Myeloma: Clinical and Translational Insights

Rapid and excessive expansion of ciltacabtagene autoleucel (cilta-cel) CAR T-cells associates with delayed neurotoxicity in relapsed/refractory multiple myeloma, with absolute lymphocyte count serving as a practical biomarker to guide early risk stratification and management.
揭示成人先天性中枢性低通气综合征的呼吸感受：静息与CO2重复吸入过程中的呼吸困难特征分析
Posted inNeurology news Respiratory

Unveiling Respiratory Sensations in Adults with Congenital Central Hypoventilation Syndrome: Insights from Dyspnea Profiling During Rest and CO2 Rebreathing

This article explores the surprising presence of conscious respiratory unpleasantness and dyspnea in adults with congenital central hypoventilation syndrome (CCHS) despite severely impaired central CO2 chemosensitivity, revealing potential alternative neural pathways for respiratory perception.
Integrating Therapies for Alcohol Use Disorder in Alcohol-Associated Hepatitis Clinical Trials: Advancing Composite Endpoints for Improved Outcomes
Posted inGastroenterology Internal Medicine news

Integrating Therapies for Alcohol Use Disorder in Alcohol-Associated Hepatitis Clinical Trials: Advancing Composite Endpoints for Improved Outcomes

Alcohol-associated hepatitis (AH) carries high morbidity and mortality, with no approved therapies addressing both liver injury and alcohol misuse. This article explores integrated trial designs using composite endpoints combining liver and alcohol-related outcomes, exemplified by the ITAALD trial.
妊娠期糖尿病中的低碳水化合物饮食：营养充足性、血糖控制及围产期结局——基于DiGest试验
Posted inClinical Updates Diabetes & Endocrinology news OB/GYN & Women's Health

Low-Carbohydrate Diets, Nutritional Adequacy, Glycemia, and Perinatal Outcomes in Women With Gestational Diabetes Mellitus: Insights from the DiGest Trial and Contemporary Evidence

This review synthesizes current evidence on low-carbohydrate diets in gestational diabetes mellitus (GDM), highlighting effects on glycemia, nutrient adequacy, and perinatal outcomes from the DiGest trial and supporting literature.