Rheumatology – Medxy AI

Rising Global Impact and Economic Burden of Musculoskeletal Disorders Among Working-Age Adults (1990–2023)

By MedXY 11/11/2026

Musculoskeletal disorders are the leading cause of disability and productivity loss globally in working-age populations, with a projected 24% rise in burden by 2050, predominantly affecting high-income countries and driven by obesity and ergonomic risk factors.

Clinical Updates Dermatology Rheumatology

Targeting Nicotinamide N-Methyltransferase: A Novel Approach to Mitigate Fibroblast Activation and Skin Fibrosis in Systemic Sclerosis

By MedXY 11/10/2026

This article explores the pivotal role of Nicotinamide N-methyltransferase (NNMT) in fibroblast activation and extracellular matrix deposition driving skin fibrosis in systemic sclerosis, highlighting therapeutic potential of NNMT inhibition.

Clinical Updates Internal Medicine Rheumatology

Exploring HFE Genotype-Linked Arthropathy Beyond Genetic Haemochromatosis: Clinical and Pathophysiological Insights

By MedXY 11/09/2026

This study reveals that HFE gene variants can be associated with arthropathy meeting EULAR haemochromatosis arthropathy criteria, even in the absence of iron overload or classical genetic haemochromatosis, suggesting an iron-independent pathway in joint disease.

Clinical Updates Rheumatology

Prevalence and Profile of Difficult-to-Manage and Treatment-Refractory Psoriatic Arthritis in Nordic Patients on Biologic Therapies

By MedXY 11/08/2026

A study of 14,362 Nordic PsA patients reveals 2% have difficult-to-manage disease and 1.2% are treatment-refractory on b/tsDMARDs, highlighting clinical challenges and associations with female sex, depression, and opioid use.

Clinical Updates Rheumatology

Optimizing Referral Triage to Identify Inflammatory Rheumatic and Musculoskeletal Diseases: Validation and Implications

By MedXY 11/07/2026

A novel triage approach combining telephone screening and brief rheumatologist consultation effectively prioritizes patients with inflammatory rheumatic diseases, shortening wait times and improving resource allocation while underscoring the need for comprehensive evaluation.

Clinical Updates Dermatology Rheumatology

Targeting IL-4 Receptor-α in Localised Scleroderma: Promising Phase 2 Evidence for Fibrosis Modulation

By MedXY 11/06/2026

This phase 2 randomized trial demonstrates that IL-4-receptor-α blockade with dupilumab significantly improves clinical outcomes and reduces fibrosis-associated inflammation and gene signatures in localised scleroderma, supporting a novel therapeutic strategy for fibrosing diseases.

Clinical Updates Dermatology Rheumatology

Decoding Systemic Sclerosis: A New Vascular-Fibrotic Framework for Risk Stratification

By MedXY 11/06/2026

This study introduces a novel classification framework for systemic sclerosis based on vascular and fibrotic complications, identifying a high-risk mixed endotype with distinct immunologic features and prognostic relevance, offering improved personalized management potential.

Clinical Updates Rheumatology

Comparative Real-World Effectiveness and Retention of Biologic DMARDs in Psoriatic Arthritis: Insights from an Emulated Multicentre Trial

By MedXY 11/05/2026

This study evaluates the six-month effectiveness and long-term retention of TNF, IL-17, and IL-23 inhibitors in psoriatic arthritis, revealing comparable efficacy and persistence across biologic classes and highlighting disease duration as a predictor of response.

多発性筋痛症の画像診断はいつ・どう行うべきか：標的を絞ったエビデンス重視の国際推奨

Clinical Updates Rheumatology

When and How to Image Polymyalgia Rheumatica: International Recommendations for a Targeted, Evidence-Based Approach

By MedXY 11/04/2026

New international recommendations position imaging as a context-driven adjunct in polymyalgia rheumatica (PMR): not routine for clear cases, most helpful in intermediate or atypical presentations, and not recommended for routine monitoring.

Clinical Updates Orthopedics Rheumatology

Optimizing Platelet-Rich Plasma Therapy in Early Knee Osteoarthritis: A Multicenter Randomized Trial of a Standardized Clinical Pathway

By MedXY 11/04/2026

A multicenter RCT demonstrates that a standardized clinical pathway for platelet-rich plasma therapy improves 12-month pain and function outcomes with fewer adverse events in early knee osteoarthritis compared to conventional care.

揭示 CCL20+ 巨噬细胞在中轴型脊柱关节炎滑膜中作为 TNF 产生者的作用：靶向治疗的新启示

Clinical Updates Rheumatology

Unveiling the Role of CCL20+ Macrophages as TNF Producers in Axial Spondyloarthritis Synovium: Implications for Targeted Therapy

By MedXY 11/03/2026

This study identifies a CCL20+ macrophage subpopulation as a major source of TNF in axial spondyloarthritis synovium, driven by CD40L and an IL-1β/TNF-α autocrine loop, providing insights into disease pathogenesis and therapeutic targets.

Clinical Updates Rheumatology

Sustained Remission and Long-Term Success: A Decade of Treat-to-Target Therapy in Early Rheumatoid Arthritis

By MedXY 11/02/2026

A 10-year follow-up of early rheumatoid arthritis patients treated with a treat-to-target strategy shows sustained remission leads to lasting clinical, structural, and functional benefits, supporting current treatment guidelines.

Clinical Updates Orthopedics Rheumatology

Persistent Alterations in Inflammatory and Cartilage Biomarkers Following Anterior Cruciate Ligament Reconstruction: Insights Into Postoperative Joint Biology

By MedXY 11/02/2026

This study reveals sustained elevations in inflammatory and cartilage metabolism serum biomarkers during the first year after ACL reconstruction, indicating ongoing joint biological responses beyond surgery and rehabilitation.

Allergy & Immunology Clinical Updates Rheumatology

Isotype-Specific Autoantibody Remodeling in Antiphospholipid Syndrome via BAFF-APRIL Blockade

By MedXY 11/01/2026

This study reveals that dual BAFF-APRIL blockade with telitacicept distinctly remodels pathogenic autoantibodies in antiphospholipid syndrome, showing differential effects across immunoglobulin isotypes and identifying marrow plasma-cell clonotypes linked to persistent IgG autoantibodies.

Allergy & Immunology Clinical Updates Rheumatology

Decoding Immunological Changes Preceding Clinical Synovitis in Imminent Rheumatoid Arthritis

By MedXY 10/31/2026

This article explores distinct immune cell activations in ACPA-positive individuals progressing to rheumatoid arthritis, emphasizing type I interferon activity prior to ultrasound-detectable synovitis and subsequent inflammatory shifts marking disease onset.

Clinical Updates Dermatology Rheumatology

Risk of Progression from Pediatric Discoid Lupus Erythematosus to Systemic Lupus Erythematosus: Insights from a Multicenter Cohort Study

By MedXY 10/31/2026

This study quantifies the risk and identifies predictors for systemic lupus erythematosus development in children presenting with skin-limited discoid lupus erythematosus, highlighting the importance of early monitoring especially in patients positive for antinuclear antibodies.

DNAメチル化シグネチャーが痛風を無症候性高尿酸血症から見分ける――免疫・代謝関連遺伝子座との整合も確認

Internal Medicine news Rheumatology

DNA Methylation Signatures Distinguish Gout from Asymptomatic Hyperuricaemia and Align with Genetic Risk at Immune-Metabolic Loci

By MedXY 10/29/2026

This study identifies specific DNA methylation patterns in blood that differentiate gout patients from those with asymptomatic hyperuricaemia and normouricaemic controls, linking epigenetic changes to immune-metabolic genetic risk factors and offering potential for molecular disease stratification.

Hematology-Oncology news Rheumatology

Peripheral Blood UBA1 Variant Burden as a Prognostic Biomarker in VEXAS Syndrome: Insights from a Nationwide Prospective Study

By MedXY 10/28/2026

This prospective nationwide study identifies baseline peripheral blood UBA1 variant allele frequency as a robust predictor of poor outcomes in VEXAS syndrome, providing a new tool for risk stratification and management.

类风湿关节炎中JAK 抑制剂减量与标准剂量的比较：基于倾向评分匹配的真实世界研究洞见

news Rheumatology

Evaluating Reduced Versus Standard Dosing of Janus Kinase Inhibitors in Rheumatoid Arthritis: Insights from a Propensity Score-Matched Real-World Study

By MedXY 10/26/2026

A real-world Japanese study finds comparable 24-month treatment persistence between reduced and standard dosing of JAK inhibitors in rheumatoid arthritis patients with preserved renal function, with dose considerations influenced by poor prognostic factors and renal status.

Clinical Updates Orthopedics Rheumatology

Unveiling Molecular Subtypes in TMJ Disease: Insights from Integrated Multi-Omics Profiling Revealing Nonlinear Disease Progression

By MedXY 10/26/2026

Integrated proteomic and metabolomic profiling of TMJ disease reveals nonlinear progression, molecular heterogeneity, and identifies distinct subtypes, offering a new framework for precision diagnosis and targeted therapies.