Visual Whole-Body Tumor-Burden Classification via PSMA PET/CT: Advancing Prognostic Stratification and Therapy Response Prediction in Metastatic Hormone-Sensitive Prostate Cancer

Visual Whole-Body Tumor-Burden Classification via PSMA PET/CT: Advancing Prognostic Stratification and Therapy Response Prediction in Metastatic Hormone-Sensitive Prostate Cancer

A novel PSMA PET/CT-based tumor-burden classification effectively stratifies metastatic hormone-sensitive prostate cancer patients, predicting response and prognosis with androgen receptor signaling inhibitors, especially second-generation treatments.
Enhancing Prognostication in Chronic Liver Disease: The Role of Liver Corrected T1 and Magnetic Resonance Elastography in Real-World Clinical Practice

Enhancing Prognostication in Chronic Liver Disease: The Role of Liver Corrected T1 and Magnetic Resonance Elastography in Real-World Clinical Practice

This study highlights the complementary utility of liver corrected T1 (cT1) and magnetic resonance elastography (MRE) for predicting chronic liver disease progression, emphasizing the critical prognostic role of disease activity beyond fibrosis severity, especially in steatotic liver disease.
Evaluating Radiologic Extranodal Extension in HPV-Positive Oropharyngeal Cancer: Accuracy, Prognostic Value, and Clinical Implications from a Multinational Real-World Study

Evaluating Radiologic Extranodal Extension in HPV-Positive Oropharyngeal Cancer: Accuracy, Prognostic Value, and Clinical Implications from a Multinational Real-World Study

This multinational real-world study reveals limited sensitivity and prognostic value of radiologic extranodal extension (iENE) in HPV-positive oropharyngeal cancer, highlighting the enhanced accuracy with combined CT and MRI and the need for standardized diagnostic criteria.
Artificial Intelligence in Imaging-Based Extranodal Extension Detection: Advancing Prognostication in HPV-Positive Oropharyngeal Cancer

Artificial Intelligence in Imaging-Based Extranodal Extension Detection: Advancing Prognostication in HPV-Positive Oropharyngeal Cancer

An AI-driven model accurately detects imaging-based extranodal extension in HPV-positive oropharyngeal cancer from CT scans, improving outcome prediction beyond expert radiologist assessments and identifying patients at higher risk of poorer survival and recurrence.
Personalizing Radiotherapy in Ductal Carcinoma In Situ Using a 12-Gene Expression Assay: Insights from a Prospective Clinical Trial

Personalizing Radiotherapy in Ductal Carcinoma In Situ Using a 12-Gene Expression Assay: Insights from a Prospective Clinical Trial

This clinical trial prospectively evaluates how a 12-gene expression assay (DCIS score) guides postoperative radiotherapy decisions after breast-conserving surgery in ductal carcinoma in situ, showing tailored radiotherapy use may reduce ipsilateral breast events.