Adverse social determinants of health (SDOH) in early to mid-adulthood are independently associated with an increased risk of early-onset stroke.
A dose-dependent relationship exists: individuals exposed to multiple adverse SDOH domains have a substantially higher stroke risk.
Key SDOH domains linked to stroke include lower household income, lower educational attainment, neighborhood deprivation, and lack of health insurance.
Racial and sex disparities modulate the impact of SDOH on stroke risk, with Black individuals and women showing stronger associations.
