女性心脏手术中急性等容性稀释的效果与安全性:血液保护策略是否仍需调整?

Evaluating Acute Normovolemic Hemodilution in Women Undergoing Cardiac Surgery: Efficacy, Safety, and Clinical Implications

This secondary analysis of the ANH trial found no significant reduction in allogeneic blood transfusions with acute normovolemic hemodilution in female cardiac surgery patients, but noted increased intraoperative hypotension and longer ICU and hospital stays, highlighting potential safety concerns and the need for further gender-focused research.
Timing of Initiation of Methadone Take-Home Dosing: Evidence Synthesis and Clinical Implications for Opioid Use Disorder Management

Timing of Initiation of Methadone Take-Home Dosing: Evidence Synthesis and Clinical Implications for Opioid Use Disorder Management

Early initiation of methadone take-home dosing (5-24 weeks post-induction) reduces mortality and treatment discontinuation, surpassing benefits seen with no take-home dosing. Flexible dosing policies improve retention without increasing overdose risk, emphasizing guideline refinement.