Specialties – Page 7

Deprescribing Intervention Reduces Proton Pump Inhibitor Use in Primary Care

By MedXY 06/06/2026

A large primary care trial found that a combined patient- and GP-focused deprescribing intervention safely reduced long-term proton pump inhibitor use more effectively than usual care or GP-only education.

$Off-the-Shelf, Non-Gene-Edited Allogeneic CD19 CAR-T Cells Show Early Feasibility in Relapsed or Refractory B-ALL$

Hematology-Oncology news Oncology

Off-the-Shelf, Non-Gene-Edited Allogeneic CD19 CAR-T Cells Show Early Feasibility in Relapsed or Refractory B-ALL

By MedXY 06/06/2026

A phase 1 study suggests non-gene-edited allogeneic CD19 CAR-T therapy can induce remissions in relapsed or refractory B-ALL without observed GVHD, though durability remains limited and larger trials are needed.

Hematology-Oncology news Pediatrics

Checkpoint Inhibition Is Reshaping Pediatric Lymphoma Care, Led by Breakthroughs in Hodgkin Lymphoma and Expanding into PD-L1–Positive Non-Hodgkin Subtypes

By MedXY 06/06/2026

Immune checkpoint therapy has become a major advance in pediatric Hodgkin lymphoma and is now being actively tested across selected pediatric non-Hodgkin lymphomas with strong PD-L1 biology.

Cardiology Hematology-Oncology news

Loss of the Fibrinogen αC Region, Rather Than Hypofibrinogenemia Alone, Attenuates Experimental Arterial Thrombosis

By MedXY 06/06/2026

Mouse and human observational data suggest that the fibrinogen αC region is a key determinant of arterial thrombosis under hypofibrinogenemic conditions, likely through platelet GPVI-dependent mechanisms.

news Radiology Respiratory

A Chest X-Ray AI Age Gap May Flag Early Spirometric Decline Before Overt Lung Disease

By MedXY 06/06/2026

In a large Korean health-screening cohort, chest radiograph-derived age acceleration was associated with both prevalent and incident PRISm and obstructive lung disease, supporting chest X-ray AI as a potential opportunistic marker of early pulmonary dysfunction.

Critical Care news Respiratory

Negative End-Expiratory Transpulmonary Pressure, Lung Collapse, and Non-Focal ARDS Drive Tidal Recruitment During Pressure Support Ventilation

By MedXY 06/06/2026

In spontaneously breathing ARDS patients on pressure support ventilation, tidal recruitment/derecruitment was strongly linked to more negative end-expiratory transpulmonary pressure, greater collapse, and non-focal infiltrates, while EIT-guided PEEP reduced recruitment/derecruitment compared with a low PEEP/FiO2 table approach.

news Ophthalmology Public Health

Most Open-Angle Glaucoma Suspects Convert at Less Than 6% Per Year After Year 1, Supporting Risk-Stratified Follow-Up

By MedXY 06/06/2026

A large US claims-based cohort suggests that most open-angle glaucoma suspects have modest annual conversion risk after the first year, and that age- and treatment-informed surveillance intervals may help tailor follow-up intensity.

Diabetes & Endocrinology news Ophthalmology

Veligrotug Delivers Rapid, Durable Benefit in Active Thyroid Eye Disease in the Phase 3 THRIVE Trial

By MedXY 06/06/2026

In phase 3 testing, veligrotug produced rapid and clinically meaningful reductions in proptosis, diplopia, and disease activity in active thyroid eye disease, with durable benefit through 52 weeks and a favorable short-term safety profile.

Internal Medicine news Otorhinolaryngology

Higher Oral Corticosteroid Exposure in Chronic Rhinosinusitis With Nasal Polyps Is Linked to More Systemic Harm

By MedXY 06/06/2026

A nationwide Korean nested case-control study found that longer annual duration and higher cumulative oral corticosteroid dose in chronic rhinosinusitis with nasal polyps were associated with increased systemic adverse events, supporting steroid-sparing management.

Internal Medicine news Otorhinolaryngology

Routine Hospitalist Co-Management After Head and Neck Free Flap Surgery Was Linked to Fewer Escalations of Care, but Not Shorter Stay or Lower Mortality

By MedXY 06/06/2026

In a retrospective cohort of 362 head and neck free tissue transfer patients, routine hospitalist involvement was associated with fewer transfers to a higher level of care, without significant effects on length of stay, readmission, or 90-day mortality.

General Surgery news Public Health

Irregular Sleep Timing in Surgeons May Increase Postoperative Major Adverse Events

By MedXY 06/06/2026

A multicenter prospective cohort study suggests that substantial surgeon social jet lag, but not midsleep variability alone, is associated with higher 30-day major adverse event risk after surgery and correlates with surgeon burnout.

General Surgery Nephrology news

SLA-DR–Deleted Donor Pigs Show Durable Kidney Xenograft Function and a Favorable Safety Profile in Rhesus Monkeys

By MedXY 06/06/2026

CRISPR-engineered GGTA1/B4GALNT2/SLA-DR knockout pigs remained healthy, screened negative for 55 zoonotic pathogens, and supported long-term renal xenograft function in rhesus monkeys when preformed anti-SLA antibodies were absent.

news OB/GYN & Women’s Health Oncology

Tumor Morcellation, Not Minimally Invasive Surgery Alone, Drives Worse Disease-Free Survival in Stage I Adult Granulosa Cell and Sertoli-Leydig Cell Tumors

By MedXY 06/06/2026

In stage I ovarian sex cord-stromal tumors, stage IC and tumor morcellation were independently associated with recurrence, while minimally invasive surgery itself was not after adjustment.

AI news OB/GYN & Women’s Health

Phenotyping Preeclampsia Using Unsupervised Machine Learning: A Prospective Cohort Study

By MedXY 06/06/2026

Unsupervised machine learning identified three distinct preeclampsia phenotypes linked to timing of delivery, placental dysfunction, fetal growth, and complications, suggesting a path toward more personalized risk assessment and management.

news OB/GYN & Women’s Health Public Health

Severe Maternal Morbidity at Delivery Is Linked to Shorter and Less Exclusive Breastfeeding in Nulliparous U.S. Patients

By MedXY 06/05/2026

In a large prospective U.S. cohort, severe maternal morbidity did not reduce breastfeeding initiation, but it was associated with lower odds of breastfeeding beyond 6 months and of exclusive breastfeeding.

Gastroenterology news Transplantation

Adult Liver Transplant Candidate Evaluation: What the New AASLD/AST Guideline Changes

By MedXY 06/05/2026

The updated AASLD/AST guideline clarifies how adults should be evaluated for liver transplantation, emphasizing equitable access, multidisciplinary assessment, psychosocial readiness, and structured risk–benefit decision-making.

Critical Care Gastroenterology news

TNF-α–Driven Immune-Endothelial Injury Emerges as a Therapeutic Target in Severe Acute Pancreatitis

By MedXY 06/05/2026

Single-cell analysis of human severe acute pancreatitis identifies TNF-α–induced CD8+ T-cell endothelial injury as a driver of pancreatic microcirculatory failure, supporting TNF-α blockade as a potential targeted therapy.

Gastroenterology news Pathology & Lab Medicine/Bệnh học

Pathology-Driven Epithelial Sulfide Loss Reprograms the Redox Proteome and Triggers Barrett’s Esophagus

By MedXY 06/05/2026

A study shows that reflux-related sulfide loss rewires esophageal redox proteins, increases PGE2 signaling, and helps drive Barrett’s esophagus, revealing a new potential therapeutic target.

Neurology news OB/GYN & Women’s Health

Pregnancy Complications Signal Long-Term Maternal Risk of Subarachnoid Hemorrhage in a 50-Year Swedish Cohort

By MedXY 06/05/2026

In a nationwide Swedish cohort, several adverse pregnancy outcomes were linked to higher long-term maternal risk of subarachnoid hemorrhage, supporting pregnancy as an early vascular stress test.

Neurology news Public Health

Rural-Urban Disparities in Epilepsy Outcomes in the United States

By MedXY 06/05/2026

A national U.S. study found that patients with epilepsy from rural counties had worse hospital outcomes, including higher mortality, more status epilepticus, longer stays, and less EEG use, highlighting access-related disparities.