Cilta-cel 峰值水平的迅速扩增预示着复发/难治性多发性骨髓瘤患者会出现迟发性神经毒性：临床与转化视角
Posted inClinical Updates Hematology-Oncology news

Rapid Peak Cilta-Cel Expansion Predicts Delayed Neurotoxicity in Relapsed/Refractory Multiple Myeloma: Clinical and Translational Insights

Rapid and excessive expansion of ciltacabtagene autoleucel (cilta-cel) CAR T-cells associates with delayed neurotoxicity in relapsed/refractory multiple myeloma, with absolute lymphocyte count serving as a practical biomarker to guide early risk stratification and management.
Heightened Risk of ICU-Acquired Infections in Hematological and Immunosuppressed Cancer Patients: Insights from a Large Brazilian Cohort
Posted inCritical Care Hematology-Oncology news

Heightened Risk of ICU-Acquired Infections in Hematological and Immunosuppressed Cancer Patients: Insights from a Large Brazilian Cohort

A large nationwide cohort study reveals that patients with hematological malignancies and other immunosuppressive conditions have significantly higher risks of ICU-acquired infections, while those with solid tumors do not show increased incidence compared to non-immunosuppressed patients.
Posted inHematology-Oncology news Respiratory

Immunosuppression and Long-term Survival After Single Living-donor Lobar Lung Transplantation from the Same Donor as Prior Hematopoietic Stem Cell Transplantation: An All-Japan Case Series

This case series examines immunosuppressive management and long-term outcomes in nine Japanese patients undergoing single living-donor lobar lung transplantation from the same donor as prior HSCT, revealing viable reduced immunosuppression and favorable survival.
系统性硬化症中表型特异性的嵌合性染色体异常：对疾病亚型与临床结局的启示
Posted inHematology-Oncology news Rheumatology

Phenotype-Specific Mosaic Chromosomal Alterations in Systemic Sclerosis: Implications for Disease Subtypes and Clinical Outcomes

This article explores the differential associations of mosaic chromosomal alterations (mCAs), especially chromosomal loss and mosaic loss of the X chromosome, with systemic sclerosis and its subtypes, revealing phenotype-specific genetic contributions that may influence clinical manifestations and disease onset.