Pulmonary Artery Pressure Falls After ARNI and MRA Initiation, but Not SGLT2 Inhibitors, in Hemodynamically Monitored Heart Failure: Insights From GUIDE-HF
Posted inCardiology news

Pulmonary Artery Pressure Falls After ARNI and MRA Initiation, but Not SGLT2 Inhibitors, in Hemodynamically Monitored Heart Failure: Insights From GUIDE-HF

In a GUIDE-HF analysis using CardioMEMS, new ARNI and MRA initiation was associated with modest short-term reductions in diastolic pulmonary artery pressure, whereas SGLT2 inhibitor initiation showed no detectable pressure change and β-blocker initiation showed a nonsignificant upward trend.
Genome-First Data Suggest Familial Hypercholesterolemia Is Equally Prevalent Across African and European Ancestry Groups, but Underclassified in African Ancestry Patients
Posted inCardiology news Public Health

Genome-First Data Suggest Familial Hypercholesterolemia Is Equally Prevalent Across African and European Ancestry Groups, but Underclassified in African Ancestry Patients

A large multi-cohort genome-first study found similar prevalence of pathogenic FH variants across ancestries, but more VUSs and greater LDL-C and myocardial infarction risk among African ancestry individuals, highlighting likely underclassification and underdiagnosis.