Cardiology – Page 3

Refining Non-Invasive Diagnosis of HFpEF: Enhanced Exercise Stress Echocardiography with Left Atrial Compliance Assessment

By MedXY 09/14/2026

This multicentre study reveals that combining resting left atrial compliance with exercise stress echocardiography significantly improves diagnostic accuracy for HFpEF, potentially reducing the need for invasive testing in patients with unexplained dyspnoea.

Cardiology news Public Health

Heart Failure in Portuguese Adults Aged 50 and Above: Insights from the PORTHOS Study on Prevalence and Predominant Phenotypes

By MedXY 09/14/2026

The PORTHOS study reveals a 16.5% prevalence of heart failure among Portuguese adults aged 50+, with HFpEF constituting over 90% of cases, mostly undiagnosed, highlighting the need for enhanced screening strategies in aging populations.

Cardiology news

Physiological Left Atrial Staging as a Predictor of New-Onset Atrial Fibrillation in Hypertrophic Cardiomyopathy

By MedXY 09/14/2026

A novel left atrial (LA) staging system, integrating hemodynamic load and contractile function, predicts new-onset atrial fibrillation risk in hypertrophic cardiomyopathy and may guide tailored AF surveillance.

Cardiology news

Metabolic Splicing Nexus: HNRNPK Lactylation Drives Inflammation and Injury in Myocardial Ischemia/Reperfusion

By MedXY 09/14/2026

Lactylation of HNRNPK at K405 links metabolic stress to inflammatory RNA splicing, promoting pathological Jag2 isoform expression and exacerbating myocardial ischemia/reperfusion injury, revealing novel therapeutic targets.

Cardiology Clinical Updates news Pediatrics Respiratory

Rapid Immunoassay for Molecular Subphenotyping in Pediatric Acute Cardiorespiratory Failure: Clinical Implications and Future Directions

By MedXY 09/13/2026

Rapid immunoassay-based classifiers accurately identify hyper- and hypoinflammatory subphenotypes in critically ill children, preserving prognostic and predictive utility and enabling precision therapies in acute pediatric cardiorespiratory failure.

Cardiology news OB/GYN & Women's Health

Menopausal Hormone Therapy and Cardiovascular Risk in Midlife Women with Vasomotor Symptoms: Insights from the SWAN Study

By MedXY 09/13/2026

Initiation of menopausal hormone therapy during perimenopause or early postmenopause in women with vasomotor symptoms is associated with a reduced cardiovascular risk, especially among Black women and those starting therapy within 10 years of menopause onset.

Cardiology news

Molecular Subtypes in Transthyretin Cardiac Amyloidosis: Insights from Proteomics Profiling and Tafamidis Efficacy

By MedXY 09/13/2026

Comprehensive plasma proteomics reveal three molecular subtypes of transthyretin cardiac amyloidosis linked to distinct prognoses and differential tafamidis treatment responses, highlighting personalized therapeutic opportunities.

Cardiology news Oncology

Unraveling the Vascular Impact of Immune Checkpoint and VEGF Inhibitors: Insights from PET Imaging and Immune Profiling

By MedXY 09/13/2026

This study reveals that immune checkpoint and VEGF inhibitors, alone or combined, do not induce detectable arterial inflammation by PET, suggesting macrophage-driven plaque activation is not the main cause of related atherothrombotic events.

Cardiology news Public Health

Tropical Cyclones and Acute Coronary Syndromes: Unraveling the Cardiovascular Burden in Mainland China

By MedXY 09/12/2026

A nationwide Chinese study reveals that exposure to tropical cyclones increases acute coronary syndrome risk by 14%, delays treatment times, and disproportionately affects vulnerable populations. Coordinated public health and clinical strategies are essential to mitigate this environmental cardiovascular risk.

Cardiology news Pediatrics

Genetic Insights into Early Heart Failure Risk in Hypoplastic Left Heart Syndrome: Findings from the NC-DEFINE Study

By MedXY 09/12/2026

A prospective study reveals that ultra-rare cardiomyopathy gene variants significantly increase risk for early heart failure in infants with hypoplastic left heart syndrome, highlighting potential for genetic risk stratification and precision medicine.

Cardiology news

Expanding Horizons in Dilated Cardiomyopathy: A Comprehensive Genetic Reassessment in 2024

By MedXY 09/12/2026

The 2024 update of the Clinical Genome Resource elucidates a rapidly expanding genetic landscape for dilated cardiomyopathy, enhancing clinical genetic interpretation with 35 genes classified as high evidence, including nine novel discoveries and notable shifts in mode of inheritance insights.

Cardiology Neurology news

Global Trends in the Burden of Ischemic Stroke Attributable to Diabetes Versus Atrial Fibrillation

By MedXY 09/11/2026

This study analyzes global trends comparing ischemic stroke burdens linked to diabetes and atrial fibrillation, revealing a rising impact of diabetes-related stroke and highlighting the need for targeted interventions.

Cardiology Clinical Updates news

Aspirin Use, Lipoprotein(a), and Calcific Aortic Valve Disease: Insights from the Multi-Ethnic Study of Atherosclerosis

By MedXY 09/11/2026

This review synthesizes evidence linking aspirin use to reduced risk of calcific aortic valve disease in persons with elevated lipoprotein(a), highlighting the potential for targeted preventive strategies.

Cardiology news

Advancing Prognostic Precision in HFpEF: The LIFE-Preserved Risk Prediction Model

By MedXY 09/11/2026

The LIFE-Preserved model accurately predicts short-term and lifetime risks of heart failure hospitalization or cardiovascular death in HFpEF patients, enabling tailored clinical risk stratification and improved management.

Cardiology news Public Health

Linking Air Pollution to Heart Health: Chronic PM2.5 Exposure and Coronary Endothelial Dysfunction

By MedXY 09/11/2026

Chronic exposure to fine particulate matter (PM2.5) is linked to epicardial coronary endothelial dysfunction, an early marker of coronary artery disease, as demonstrated by invasive coronary vasoreactivity testing.

Cardiology news

Long-Term Benefits of Quantitative Flow Ratio-Guided PCI: Insights from the 5-Year FAVOR III China Trial

By MedXY 09/11/2026

The FAVOR III China trial demonstrates that QFR-guided percutaneous coronary intervention significantly reduces major adverse cardiac events over 5 years, mainly by decreasing myocardial infarction and ischemia-driven revascularization compared to angiographic guidance.

Cardiology news

Advancing Arrhythmic Risk Stratification in Nonischemic Dilated Cardiomyopathy: The Role of LGE Corridors and Genetic Markers

By MedXY 09/11/2026

Integration of late gadolinium enhancement corridors and high-risk genotypes markedly improves ventricular arrhythmic risk prediction beyond traditional ejection fraction metrics in nonischemic dilated cardiomyopathy.

Cardiology Clinical Updates news

Macrotroponin Complexes and Risk of Cardiovascular Events: Implications for Cardiac Troponin Testing in Population Risk Stratification

By MedXY 09/11/2026

Macrotroponin complexes commonly cause discordant cardiac troponin elevations in the general population, notably troponin I, without conferring increased cardiovascular risk, underscoring the need to recognize assay interference for accurate risk prediction.

Cardiology news Respiratory

Early Identification of PVOD/PCH in Pulmonary Arterial Hypertension: Introducing a Novel Clinical Likelihood Score

By MedXY 09/10/2026

A newly developed clinical likelihood score accurately distinguishes pulmonary arterial hypertension patients with venous or capillary involvement (PVOD/PCH), enabling earlier diagnosis, tailored therapy, and timely transplant referral.

Cardiology Neurology news

Ischaemic Stroke Risk in Atrial Flutter Versus Atrial Fibrillation: Insights from a Finnish Nationwide Registry Study

By MedXY 09/09/2026

This Finnish nationwide study demonstrates that patients with atrial flutter have a substantially lower risk of ischaemic stroke compared to those with atrial fibrillation, highlighting important differences in thromboembolic risk profiles between these arrhythmias.