news – Page 25 – Medxy AI

Influence of Clonal Hematopoiesis and Neutropenia on CAR-T Therapy Outcomes in Hematologic Malignancies

By MedXY 10/08/2026

CHIP and pre-treatment neutropenia do not significantly affect survival or main toxicities in CAR-T therapy for hematologic cancers but may predict specific inflammatory toxicities, indicating distinct risk profiles for patient management.

Hematology-Oncology news Oncology

Targeting Leukemic Stem Cells in AML: Overcoming PI3K Inhibitor Resistance through Epigenetic Modulation

By MedXY 10/08/2026

This article explores novel therapeutic strategies in acute myeloid leukemia by combining PI3K inhibitors with EZH1/2 dual inhibitors to overcome epigenetic resistance mechanisms in leukemic stem cells, offering promising pathways to prevent relapse.

Hematology-Oncology news

Targeting ROR1 in Chronic Lymphocytic Leukemia: Insights from the Zilovertamab and Ibrutinib Combination in High-Risk del(17p) Disease

By MedXY 10/08/2026

A phase 1b/2 study evaluating zilovertamab combined with ibrutinib in relapsed/refractory CLL reveals safety, mechanistic inhibition of ROR1 signaling pathways, and a potential efficacy signal in del(17p) patients warranting further studies.

Critical Care news Respiratory

TISA-818 in ARDS Due to Pulmonary Infection: Promising Safety and Early Efficacy Signals with the 2023 Global Definition

By MedXY 10/08/2026

A phase 2 randomized trial shows that TISA-818, an anti-inflammatory montelukast-decapeptide conjugate, is safe and may improve respiratory outcomes in ARDS patients, especially non-intubated individuals, supporting larger trials.

news Radiology Respiratory

Enhanced Diagnostic Accuracy and Safety of CEUS-Guided Biopsy for Subpleural Lung Lesions: Insights from a Large Multicenter RCT

By MedXY 10/08/2026

This multicenter RCT demonstrates that contrast-enhanced ultrasound (CEUS)-guided biopsy surpasses conventional US- and CT-guided modalities in diagnostic yield, sensitivity, and safety for subpleural lung lesions, highlighting its clinical value.

Clinical Updates news Respiratory

Sputum Cellularity and Health Services Utilization in Asthma and COPD: Insights into Inflammatory Phenotypes and Clinical Outcomes

By MedXY 10/08/2026

Sputum eosinophilia is linked to increased asthma-specific health services use, while neutrophilic inflammation drives hospitalizations in COPD. Understanding these inflammatory patterns aids personalized management and resource planning.

news Respiratory

Polygenic Risk Score Enhances Diagnosis and Prognostic Stratification in Idiopathic Pulmonary Fibrosis

By MedXY 10/08/2026

A polygenic risk score (PRS) significantly associates with IPF diagnosis and mortality, demonstrating potential for improving clinical risk stratification using real-world biobank data.

news Oncology Respiratory

Evaluating Optimal Corticosteroid Duration for Mild Immune-Related Pneumonitis: Insights from a Randomized Trial

By MedXY 10/08/2026

A randomized trial shows that a 6-week corticosteroid taper is superior to a 3-week taper for mild immune-related pneumonitis, establishing 6 weeks as the evidence-based standard for short-term treatment success.

news Respiratory Rheumatology

Evaluating Mycophenolate and Azathioprine in Fibrotic Interstitial Lung Disease: Insights from a Multicenter Retrospective Study

By MedXY 10/08/2026

This study reveals mycophenolate and azathioprine do not improve 3-year transplant-free survival or lung function in fibrotic ILD, with potential harm in select subtypes. Robust randomized trials remain essential for guiding immunosuppressive therapy.

news OB/GYN & Women's Health Ophthalmology

Implications of Menopausal Hormone Therapy on Strabismus Incidence and Surgical Outcomes in Postmenopausal Women

By MedXY 10/08/2026

This retrospective cohort study indicates that menopausal hormone therapy (MHT) is associated with increased risks of strabismus diagnosis and surgery but not reoperation in menopausal women, revealing significant ocular alignment considerations during MHT.

news Ophthalmology

Unraveling Mid-phase Hyperfluorescent Plaques in Central Serous Chorioretinopathy: Insights from Multimodal Imaging

By MedXY 10/08/2026

This study elucidates the dynamic nature and structural correlates of mid-phase hyperfluorescent plaques on ICGA in CSCR, highlighting their progression stages and OCT features that signal disease activity.

news Oncology Ophthalmology

Impact of Ocular Proton Therapy on Corneal Subbasal Nerve Plexus in Uveal Melanoma: Longitudinal Confocal Microscopy Findings

By MedXY 10/08/2026

Ocular proton therapy causes significant decreases in corneal nerve fiber parameters in uveal melanoma patients, with partial recovery by 12 months and minimal changes in corneal sensitivity and patient-reported outcomes.

news Otorhinolaryngology

A Novel Descriptive Framework Enhances Predictive Accuracy for Surgical Outcomes in Petroclival and Temporal Bone Meningiomas

By MedXY 10/08/2026

This study introduces a four-tier descriptive framework for petroclival and temporal bone meningiomas that shows significant correlation with surgical outcomes, offering a valuable tool to guide surgical planning and patient counseling.

General Surgery news Otorhinolaryngology

Elevated BMI and Open Airway Reconstruction: Disentangling the Impact on Postoperative Outcomes

By MedXY 10/08/2026

This study demonstrates that elevated BMI and obesity classification do not increase the risk of complications or prolong recovery times following open airway reconstruction surgeries, guiding surgical decision-making in overweight and obese patients.

Hematology-Oncology news Oncology

Long-Term Efficacy and Safety of First-Line Ibrutinib-Venetoclax in Older Patients with Chronic Lymphocytic Leukemia: Insights from the 67-Month GLOW Study

By MedXY 10/08/2026

The GLOW phase III trial demonstrates that fixed-duration ibrutinib-venetoclax provides superior overall survival, progression-free survival, and safety compared to chlorambucil-obinutuzumab in older/comorbid CLL patients, with durable disease control and reduced need for second-line therapy.

news Otorhinolaryngology Plastic Surgery

Evaluating Tranexamic Acid’s Safety and Efficacy in Head and Neck Free Flap Reconstruction: Insights from a Retrospective Cohort Study

By MedXY 10/08/2026

This retrospective study assesses the safety and impact of tranexamic acid on bleeding, transfusions, and complications in head and neck free flap surgery, finding no significant difference in outcomes and supporting its safe use.

Dermatology Hematology-Oncology news

Decoding CTCL: A Single-Cell Atlas Reveals Oncogenic Pathways and Immune Resistance Mechanisms

By MedXY 10/08/2026

This study presents a comprehensive single-cell RNA-sequencing atlas of CTCL, identifying oncogenic transcriptional programs and immune microenvironment features that offer new therapeutic targets for advanced-stage disease.

Gastroenterology news Nursing & care

Feasibility and Clinical Utility of Gastric Point-of-Care Ultrasound (G-POCUS) for Postoperative Gastric Content Assessment

By MedXY 10/08/2026

This prospective pilot study demonstrates that gastric point-of-care ultrasound (G-POCUS) performed by trained nurses is a feasible, well-tolerated, and reliable method to assess gastric content in patients recovering from gastrointestinal surgery, supporting its integration into routine postoperative care.

General Surgery news Oncology

Evolving Surgical Patterns and Outcomes in Young Women with Breast Cancer: Insights from a Decade of National Data

By MedXY 10/08/2026

This large-scale study reveals that adolescent and young adult women with breast cancer predominantly undergo mastectomy and experience comparable perioperative outcomes to older women, despite a higher metastatic burden.

Gastroenterology General Surgery news

Peripheral Parenteral Nutrition Reduces Inflammation and Enhances Nutritional Recovery After Colorectal Surgery: Insights from a Randomized Trial

By MedXY 10/07/2026

Early postoperative peripheral parenteral nutrition after colorectal resection reduces inflammatory markers and improves nitrogen balance without increasing complications, suggesting a beneficial supportive strategy in surgical recovery management.