HPV-Associated Anal Dysplasia in Solid Organ Transplant Recipients: Unraveling Transplant-Specific Mucosal Immune Dysfunction
Posted inInfectious Diseases news Oncology

HPV-Associated Anal Dysplasia in Solid Organ Transplant Recipients: Unraveling Transplant-Specific Mucosal Immune Dysfunction

Solid organ transplant recipients have increased risk of HPV-driven anal dysplasia and cancer due to unique immune alterations from immunosuppression. This article explores the transplant-specific immune dysfunction underlying persistent HPV infection and dysplastic progression, highlighting implications for screening and management.
Immunogenicity and Safety of Pentavalent Meningococcal MenABCWY Vaccine in Adolescents and Young Adults: Integrated Evidence from Late-Phase Clinical Trials
Posted inClinical Updates news Pediatrics Public Health

Immunogenicity and Safety of Pentavalent Meningococcal MenABCWY Vaccine in Adolescents and Young Adults: Integrated Evidence from Late-Phase Clinical Trials

This review synthesizes phase 2 and 3 trial data demonstrating that the pentavalent MenABCWY vaccine is immunologically non-inferior and well tolerated compared with MenB-fHbp and MenACWY-CRM vaccines, offering a simplified, effective vaccination strategy against invasive meningococcal disease in adolescents and young adults.