Racial and Ethnic Disparities in Treatment Initiation and Survival Among Patients With Endometrial Cancer: Socioeconomic Modifiers and Clinical Implications
Posted inClinical Updates news OB/GYN & Women's Health Oncology

Racial and Ethnic Disparities in Treatment Initiation and Survival Among Patients With Endometrial Cancer: Socioeconomic Modifiers and Clinical Implications

This review synthesizes recent evidence demonstrating persistent racial and ethnic disparities in treatment initiation and survival among patients with advanced endometrial cancer, highlighting the critical influence of socioeconomic status and social determinants on outcomes.
Impact of Clonal Hematopoiesis and Pre-treatment Neutropenia on CAR-T Cell Therapy Outcomes in Hematological Malignancies
Posted inHematology-Oncology news Oncology

Impact of Clonal Hematopoiesis and Pre-treatment Neutropenia on CAR-T Cell Therapy Outcomes in Hematological Malignancies

This study evaluates how clonal hematopoiesis of indeterminate potential (CHIP) and pre-treatment neutropenia affect clinical outcomes and toxicities in patients undergoing CAR-T therapy for hematologic cancers, revealing nuanced risks for specific toxicities without compromising survival outcomes.
Long-Term Efficacy and Safety of First-Line Ibrutinib-Venetoclax in Older Patients with Chronic Lymphocytic Leukemia: Insights from the 67-Month GLOW Study
Posted inHematology-Oncology news Oncology

Long-Term Efficacy and Safety of First-Line Ibrutinib-Venetoclax in Older Patients with Chronic Lymphocytic Leukemia: Insights from the 67-Month GLOW Study

The GLOW phase III trial demonstrates that fixed-duration ibrutinib-venetoclax provides superior overall survival, progression-free survival, and safety compared to chlorambucil-obinutuzumab in older/comorbid CLL patients, with durable disease control and reduced need for second-line therapy.
Testosterone Inhibition and Reduced Risk of Laryngeal and Hypopharyngeal Squamous Cell Carcinoma in Men: Insights from a Large Swedish Cohort
Posted innews Oncology Otorhinolaryngology

Testosterone Inhibition and Reduced Risk of Laryngeal and Hypopharyngeal Squamous Cell Carcinoma in Men: Insights from a Large Swedish Cohort

A population-based cohort study in Sweden found that use of 5α-reductase inhibitors, which reduce bioactive testosterone, is associated with a 17% lower risk of laryngeal and hypopharyngeal squamous cell carcinoma in men, supporting the hormonal influence on these cancers' male predominance.
Liver Transplantation for Hepatocellular Carcinoma: Prognostic Impact of Complete Pathologic Response and Influence of Treatment Modality—A US National Database Study
Posted inClinical Updates news Oncology Transplantation

Liver Transplantation for Hepatocellular Carcinoma: Prognostic Impact of Complete Pathologic Response and Influence of Treatment Modality—A US National Database Study

Complete pathologic response (cPR) after locoregional therapies notably improves survival in hepatocellular carcinoma (HCC) patients undergoing liver transplantation. Yttrium-90 radioembolization shows superior cPR rates, particularly when administered early and in patients with higher tumor burden.
Evaluating Pembrolizumab, Bevacizumab, and Oral Metronomic Cyclophosphamide in Heavily Pretreated Platinum-Resistant Ovarian Cancer: Real-World Outcomes and Clinical Implications
Posted innews OB/GYN & Women's Health Oncology

Evaluating Pembrolizumab, Bevacizumab, and Oral Metronomic Cyclophosphamide in Heavily Pretreated Platinum-Resistant Ovarian Cancer: Real-World Outcomes and Clinical Implications

This study assesses the efficacy and safety of pembrolizumab combined with bevacizumab and oral metronomic cyclophosphamide in heavily pretreated platinum-resistant ovarian cancer patients, showing modest disease control with manageable toxicity in a real-world setting.
Genetic Testing in Endometrial Cancer: Prevalence of Pathogenic Germline Variants and Implications for Clinical Practice in a Diverse Community Cohort
Posted innews OB/GYN & Women's Health Oncology

Genetic Testing in Endometrial Cancer: Prevalence of Pathogenic Germline Variants and Implications for Clinical Practice in a Diverse Community Cohort

In a large, diverse cohort of women with endometrial cancer, 11.9% harbored pathogenic germline variants, including Lynch syndrome and homologous recombination deficiency-related mutations. Testing at diagnosis identified most Lynch syndrome cases, highlighting the need for expanded genetic screening strategies.