Designing Rigorous Trials of Systemic Therapy with Surgery and Locoregional Treatment in Hepatocellular Carcinoma: Key Recommendations from an HCC-Live Expert Consensus

Designing Rigorous Trials of Systemic Therapy with Surgery and Locoregional Treatment in Hepatocellular Carcinoma: Key Recommendations from an HCC-Live Expert Consensus

A multidisciplinary consensus provides practical, trial-design focused recommendations for testing systemic therapies around surgery or combined with locoregional treatment in hepatocellular carcinoma, emphasizing patient selection, endpoints, safety, and statistical strategies.
Venous Drainage Integrity as a Crucial Factor in Preventing Nipple-Areolar Complex Necrosis Post Nipple-Sparing Mastectomy: Insights from Cadaveric and Clinical Studies

Venous Drainage Integrity as a Crucial Factor in Preventing Nipple-Areolar Complex Necrosis Post Nipple-Sparing Mastectomy: Insights from Cadaveric and Clinical Studies

This study reveals that venous injury significantly contributes to nipple-areolar complex necrosis after nipple-sparing mastectomy and presents a predictive model integrating near-infrared vein imaging with indocyanine green angiography to optimize surgical outcomes.
Contemporary Surgical Management of Vulvar Cancer: Balancing Improved Survival with Increased Reoperation Rates — Insights from a Finnish Nationwide Study

Contemporary Surgical Management of Vulvar Cancer: Balancing Improved Survival with Increased Reoperation Rates — Insights from a Finnish Nationwide Study

This review synthesizes evidence that modern personalized surgical strategies for vulvar squamous cell carcinoma enhance survival outcomes despite higher reoperation rates, emphasizing evolving surgical techniques, sentinel lymph node biopsy, and reconstructive approaches.