Highlight
- Ocular proton therapy (OPT) for uveal melanoma markedly reduces corneal subbasal nerve plexus parameters including nerve fiber density and length.
- The extent of nerve loss correlates with clinical target volume, reflecting radiation exposure levels.
- Despite structural nerve alterations, corneal sensitivity remains largely unchanged over 12-month follow-up.
- Patient-reported symptoms show limited correlation with nerve fiber loss, highlighting a discrepancy between morphological and functional outcomes.
