Age, tumor nephrectomy weight (TNW), and tumor diameter (TD) have historically been used to risk-stratify children with stage I favorable histology Wilms tumor (FHWT) for treatment decisions.
Pooled analysis of 1,711 patients from Children’s Oncology Group (COG) studies shows no independent prognostic significance of these variables after adjusting for adverse tumor biology.
Adverse biology, more prevalent in older children, confounds associations previously attributed to age and tumor size.
Findings suggest refinements in risk stratification models and support individualized treatment approaches in early-stage FHWT.
