Gastroenterology – Page 6

Targeting Oncomucin-Driven Immunosuppression Improves KRAS G12D Inhibition in Pancreatic Cancer

By MedXY 05/28/2026

Oncomucins such as MUC4 and MUC16 help pancreatic cancer evade immunity through EGFR/UNC5B signaling. Targeting these mucins may enhance KRAS G12D inhibitor efficacy and reduce tumor burden.

Diabetes & Endocrinology Gastroenterology news

Adolescent MASLD Plus PCOS Signals a Higher-Risk Cardiometabolic Trajectory Into Adulthood

By MedXY 05/28/2026

In the Raine Study, adolescents with both MASLD and PCOS had a substantially worse cardiometabolic profile by age 27 than peers with either condition alone, highlighting a high-risk subgroup that may warrant earlier metabolic surveillance.

Gastroenterology Internal Medicine news

Metabolic Dysfunction Did Not Worsen Short-Term Survival in Severe Alcohol-Associated Hepatitis in a Global Prospective Cohort

By MedXY 05/26/2026

In a 32-center international cohort, cardiometabolic risk factors were common in alcohol-associated hepatitis but did not independently increase 180-day mortality after adjustment for liver disease severity and competing transplant risk.

Gastroenterology news Oncology

PTEN Loss Drives MHC-I Evasion and Checkpoint Resistance in Microsatellite Stable Colorectal Cancer via NRF2-Dependent Autophagy

By MedXY 05/26/2026

A Gut study links PTEN deficiency in MSS colorectal cancer to NRF2-driven autophagic loss of MHC-I, impaired CD8+ T-cell surveillance, and resistance to anti-PD-1 therapy, while identifying NRF2 inhibition as a potential sensitizing strategy.

Diabetes & Endocrinology Gastroenterology news

Duodenal Recombinant RORDEP1 Was Safe and Triggered Early Incretin-Insulin Responses in Healthy Men

By MedXY 05/26/2026

In a randomized crossover trial, short-term duodenal r-RORDEP1 infusion was well tolerated and produced early changes in GLP-1, GIP, insulin, C-peptide, glucose, and a measure of insulin sensitivity in healthy men.

Gastroenterology news Oncology

Intraperitoneal and Intravenous Paclitaxel Plus S-1 Improves Survival in Gastric Cancer With Peritoneal Metastasis: Phase 3 Trial

By MedXY 05/25/2026

A phase 3 trial found that adding intraperitoneal paclitaxel to intravenous paclitaxel plus S-1 improved survival in gastric cancer with peritoneal metastasis without increasing severe toxicity.

Gastroenterology Infectious Diseases news

Diabetes, Male Sex, and Low HBsAg, HDV RNA, and ALT Predict Spontaneous HDV Suppression in Chronic Hepatitis D

By MedXY 05/20/2026

In 1,610 untreated chronic hepatitis D patients, spontaneous HDV suppression was uncommon but increased over time. Diabetes, male sex, and lower baseline HBsAg, HDV RNA, and ALT predicted suppression and fewer liver-related events.

Gastroenterology news Oncology

Targeting MLCK1 May Separate Immune Checkpoint Inhibitor Colitis From Antitumour Benefit

By MedXY 05/20/2026

A Gut study identifies MLCK1-driven epithelial barrier failure as a central mechanism in immune checkpoint inhibitor colitis and suggests epicatechin as a barrier-protective strategy that preserves antitumour efficacy in preclinical models.

Gastroenterology news Oncology

Should Some Colon Cancers Be Treated Before Surgery? What a New Trial Means for Patients

By MedXY 05/18/2026

A major randomized trial found that chemotherapy before surgery did not improve 3-year disease-free survival in locally advanced colon cancer, but it still revealed important clues for more personalized treatment.

Gastroenterology news

PBC-AIH Variant: New International Consensus Clarifies Diagnosis and Treatment

By MedXY 05/18/2026

An international Delphi panel has standardized how to define, diagnose, and treat the PBC-AIH variant, emphasizing liver biopsy, periodic reassessment, and tailored immunosuppression for worse-risk patients.

Gastroenterology news Oncology

KRAS-Driven CLDN18.2 O-GlcNAcylation Promotes Pancreatic Cancer Progression and Therapy Resistance

By MedXY 05/16/2026

KRAS mutation and high glucose promote O-GlcNAcylation of CLDN18.2 in pancreatic cancer, pushing the protein off the cell membrane, boosting metastasis, and weakening CLDN18.2-targeted therapy. Low-dose MRTX1133 may restore sensitivity.

Gastroenterology news Radiology

Non-contrast abbreviated MRI shows superior accuracy to ultrasound for hepatocellular carcinoma surveillance in cirrhosis: interim prospective trial results

By MedXY 05/13/2026

A prospective trial found that non-contrast abbreviated MRI detected hepatocellular carcinoma in cirrhotic patients far better than ultrasound, with most MRI-detected tumors found at an early, potentially curable stage.

Gastroenterology Neurology news

Sham-Controlled Trial Finds Translumbosacral Neuromodulation May Reduce Fecal Incontinence

By MedXY 05/13/2026

In a sham-controlled trial, translumbosacral neuromodulation with 2400 or 3600 magnetic pulses reduced fecal incontinence episodes, improved severity scores and quality of life, and was well tolerated, with the higher dose showing the strongest benefit.

Gastroenterology news Oncology

A Body Surface Area–Adjusted Bevacizumab Target Was Linked to Better Survival in Atezolizumab-Treated Unresectable Hepatocellular Carcinoma

By MedXY 05/10/2026

A nationwide Japanese real-world study suggests that a defined body surface area–adjusted bevacizumab exposure range may improve progression-free and overall survival in unresectable HCC treated with atezolizumab plus bevacizumab, without increasing toxicity.

Gastroenterology news Oncology

A Stromal CTHRC1 Biomarker Framework May Identify Colorectal Cancers With Poor Prognosis and Limited Immunotherapy Benefit

By MedXY 05/10/2026

A large multiomic colorectal cancer study identifies CTHRC1-positive fibroblasts as a stromal biomarker linked to TGF-beta activity, adverse outcomes, and reduced checkpoint inhibitor benefit across both MSI and MSS disease.

Gastroenterology Internal Medicine news

低剂量聚乙二醇用于住院患者肠道准备的有效性：一项多中心随机试验

By MedXY 05/09/2026

意大利多中心研究发现，1升聚乙二醇抗坏血酸方案在住院患者结肠镜检查前肠道准备中，高质量清洁率显著优于2升和4升方案，且患者耐受性更好。

Gastroenterology news Oncology

Adherence to Surveillance in the Watch and Wait Approach for Rectal Cancer

By MedXY 05/08/2026

Study finds 62% of rectal cancer patients on Watch and Wait receive optimal surveillance, with younger patients showing better adherence. Critical gaps occur in the first year, particularly in initial endoscopic/imaging exams and colonoscopies.

Gastroenterology news Oncology

Gut Microbiome Signatures Improve Diagnosis and Prognostic Stratification in Epstein-Barr Virus-Associated Nasopharyngeal Carcinoma

By MedXY 05/07/2026

A large shotgun metagenomic study links gut dysbiosis to EBV-associated nasopharyngeal carcinoma and shows that microbial markers, especially combined with EBV markers, may strengthen diagnosis and prognostic assessment.

Gastroenterology news Pathology & Lab Medicine/Bệnh học

A Simple Five-Variable Index Helps Identify Excess Alcohol Use in Steatotic Liver Disease When PEth Testing Is Not Readily Available

By MedXY 05/07/2026

A new five-component biomarker panel, MAPI, showed consistent AUROC performance of about 0.75 for detecting MetALD-ALD and may help triage confirmatory PEth testing in steatotic liver disease.

$Alpha-1-Antitrypsin Emerges as a Potential Salvage Option for Steroid- and Ruxolitinib-Refractory Gastrointestinal Acute GVHD$

Gastroenterology Hematology-Oncology news

Alpha-1-Antitrypsin Emerges as a Potential Salvage Option for Steroid- and Ruxolitinib-Refractory Gastrointestinal Acute GVHD

By MedXY 05/04/2026

A 2026 single-center retrospective study suggests alpha-1-antitrypsin may offer favorable safety and encouraging activity in heavily pretreated gastrointestinal acute GVHD, though detailed outcome data and external validation remain essential.