Gastroenterology – Page 7

Serum Bile Acid Levels as Early Predictors of Portal Hypertension and Esophageal Varices Post-Kasai in Biliary Atresia

By MedXY 07/13/2026

Serum bile acid levels measured within the first year after Kasai procedure accurately predict portal hypertension and high-risk esophageal varices development within five years in biliary atresia patients, offering a valuable non-invasive prognostic biomarker.

Gastroenterology Internal Medicine news

Unraveling IBS Genetics: Insights into Cardiometabolic and Triglyceride-Linked Mechanisms from a Large GWAS Meta-Analysis

By MedXY 07/13/2026

A genome-wide meta-analysis of 2.8 million individuals reveals genetic links between irritable bowel syndrome, brain-gut pathways, and cardiometabolic traits, highlighting novel therapeutic targets involving triglyceride metabolism.

Gastroenterology news

Evaluating Dose Intensification Strategies for Ustekinumab in Crohn’s Disease: Insights from the REScUE Trial

By MedXY 07/13/2026

The REScUE study compared two ustekinumab dosing intensification regimens after secondary loss of response in Crohn’s disease, finding no superiority of more frequent dosing regarding steroid-free remission at 48 weeks.

Gastroenterology news Oncology

Durvalumab Plus Chemotherapy Extends Survival in Advanced Biliary Tract Cancer: Insights from the TOPAZ-1 Trial Four-Year Post Hoc Analysis

By MedXY 07/12/2026

A four-year post hoc analysis of the TOPAZ-1 trial confirms that durvalumab combined with gemcitabine and cisplatin offers a long-term survival benefit with manageable safety as first-line treatment for advanced biliary tract cancer.

Gastroenterology General Surgery news

Sustained Quality of Life After Pancreatic Surgery for IPMNs in Young Patients: Long-Term Data and Clinical Implications

By MedXY 07/11/2026

Young patients undergoing resection for intraductal papillary mucinous neoplasms (IPMNs) exhibit excellent long-term quality of life comparable to the general population despite endocrine and exocrine insufficiencies.

Gastroenterology General Surgery news

Refining Pancreatic Cystic Neoplasm Assessment: The Incremental Role of Endoscopic Ultrasound and Fine Needle Aspiration

By MedXY 07/11/2026

This study evaluates the added value of endoscopic ultrasound (EUS) and fine needle aspiration (FNA) after MRI in assessing pancreatic cystic neoplasms, demonstrating significant improvement in diagnostic specificity and clinical decision-making, especially for lesions without high-risk MRI features.

Gastroenterology Infectious Diseases news

Unraveling Hepatitis B-Induced Liver Fibrosis: The Critical Role of Pyruvate, PPARα, and Reactive Oxygen Species

By MedXY 07/10/2026

This article explores the mechanism by which HBV induces liver fibrosis through pyruvate-dependent ROS production and PPARα inhibition, highlighting novel therapeutic targets for chronic hepatitis B management.

Gastroenterology news Pediatrics

Unveiling the Role of IL-10-Neutralising Autoantibodies in Pediatric-Onset Inflammatory Bowel Disease: Prevalence, Persistence, and Clinical Implications

By MedXY 07/10/2026

This study reveals that IL-10-neutralising autoantibodies occur in 2.1% of pediatric IBD cases without monogenic causes, persist over years, and may define a distinct clinical subgroup with specific therapeutic needs.

Gastroenterology General Surgery news

Decoding Microbial Shifts in Postoperative Crohn’s Disease: Insights into Recurrence Dynamics

By MedXY 07/10/2026

This article explores how mucosa-associated microbiota changes after ileal resection in Crohn’s disease correlate with postoperative recurrence, highlighting microbial signatures and dynamic ecosystem changes along the Rutgeerts score.

Gastroenterology news Otorhinolaryngology

Antireflux Diet Versus Medication: A Comparative Analysis in Laryngopharyngeal Reflux Disease Management

By MedXY 07/08/2026

This study evaluates the effectiveness of an antireflux diet combined with stress reduction against proton pump inhibitors, alginates, and antacids in treating laryngopharyngeal reflux disease, revealing diet adherence may offer superior symptom relief.

Gastroenterology General Surgery news

Impact of Modified Frailty Index on Liver Transplant Outcomes: Insights from a Multicenter Cohort Study

By MedXY 07/08/2026

This study demonstrates that the 5-variable Modified Frailty Index effectively predicts short- and long-term morbidity and mortality after liver transplantation, supporting its use in pretransplant assessment and perioperative planning.

Gastroenterology news Respiratory

Unraveling the KLF9-NR4A1-p38 MAPK Axis: A Novel Mechanism Linking Intermittent Hypoxia to MASLD in Obstructive Sleep Apnea

By MedXY 07/08/2026

This study elucidates how KLF9 mediates intermittent hypoxia-induced MASLD by suppressing NR4A1 and p38 MAPK signaling, paving the way for targeted therapies in OSA-associated metabolic liver disease.

Gastroenterology news Oncology

Targeting SMPD1-Driven Sphingolipid Metabolism to Disrupt KRAS Signaling in Pancreatic Ductal Adenocarcinoma

By MedXY 07/08/2026

This study reveals that dysregulated sphingolipid metabolism via SMPD1 supports KRAS-driven pancreatic cancer progression, identifying SMPD1 as a promising therapeutic target in pancreatic ductal adenocarcinoma.

Gastroenterology Neurology news

From Gut Feeling to Brain Mapping: Decoding Defecation Urgency in IBS

By MedXY 07/08/2026

Defecation urgency in IBS is a complex symptom intertwining sensory thresholds and emotional processing, reflected in distinct brain structural changes identified through MRI. Differentiating experimentally induced versus real-life urgency improves understanding of its multidimensional nature.

Clinical Updates Gastroenterology news Oncology Pathology & Lab Medicine

Circulating Methylated SEPT9 as a Novel Biomarker for Early Detection of Hepatocellular Carcinoma in Cirrhotic Patients

By MedXY 07/07/2026

Combining circulating methylated SEPT9 with alpha-fetoprotein significantly enhances early hepatocellular carcinoma detection in cirrhotic patients, outperforming AFP alone and allowing improved surveillance sensitivity and specificity.

Gastroenterology General Surgery news

Fistulotomy with Primary Sphincteroplasty for Complex Anal Fistulas: Balancing Cure with Continence Preservation

By MedXY 07/05/2026

This study demonstrates that fistulotomy combined with primary sphincteroplasty offers a high success rate and minimal incontinence risk for complex anal fistulas, supporting its use as an effective single-stage treatment.

Diabetes & Endocrinology Gastroenterology news

Development and Validation of a Noninvasive Score for At-Risk Metabolic Dysfunction-Associated Steatohepatitis in Individuals with Obesity Undergoing Bariatric Surgery

By MedXY 07/05/2026

Researchers developed and validated the FMO score, a noninvasive, cost-effective tool to identify at-risk metabolic dysfunction-associated steatohepatitis (MASH) in obese patients, showing strong predictive performance across multiple international cohorts.

Gastroenterology news Pediatrics

Decoding the Gut-Brain Axis: How Early Life Stress Shapes Gut Motility and Pain Through Neural Pathways

By MedXY 07/05/2026

Early life stress disrupts gut motility and pain regulation via enteric and sympathetic nervous system alterations, with human pediatric data confirming its clinical relevance and suggesting novel therapeutic targets.

Gastroenterology news Oncology

Circulating Tumor DNA Status and Adjuvant Chemotherapy in Resected Colorectal Liver Metastases

By MedXY 07/04/2026

This study reveals that circulating tumor DNA (ctDNA) status after colorectal liver metastasis surgery predicts survival outcomes and benefits from adjuvant chemotherapy, guiding personalized treatment.

Diabetes & Endocrinology Gastroenterology news

Global Insights into MASLD: Predictors of Fibrosis, Clinical Events, and Mortality from the Global-MASLD Study

By MedXY 07/03/2026

The Global-MASLD study identifies key predictors of advanced fibrosis and mortality in metabolic dysfunction-associated steatotic liver disease, highlighting the prognostic value of noninvasive fibrosis markers across diverse populations.