Gastroenterology – Page 5

Cardiovascular-Kidney-Metabolic Syndrome and Its Impact on Liver Fibrosis Progression and Liver-Related Events in MASLD

By MedXY 08/14/2026

This article reviews evidence linking cardiovascular-kidney-metabolic syndrome stages to liver fibrosis severity, progression, and liver-related events in metabolic dysfunction-associated steatotic liver disease (MASLD). Higher CKM stages independently predict worse liver outcomes.

Gastroenterology news

Validating Liver Stiffness Measurement as a Prognostic Tool in Primary Sclerosing Cholangitis: Insights from the Prospective FICUS Cohort

By MedXY 08/13/2026

This prospective study confirms that liver stiffness measurement (LSM) by Fibroscan® effectively predicts transplant-free survival in primary sclerosing cholangitis (PSC), highlighting both static and dynamic assessments as powerful risk stratification and potential clinical trial endpoints.

Gastroenterology news Pediatrics

Neutralising Autoantibodies against IL-10 Linked to Severe Pediatric Inflammatory Bowel Disease and HLA-DRB1*01:03 Allele

By MedXY 08/12/2026

A multicategory study reveals 2.5% of pediatric IBD patients harbor IL-10-neutralising autoantibodies associated with severe disease and HLA-DRB1*01:03 allele, underscoring a distinct pathogenic subgroup.

Diabetes & Endocrinology Gastroenterology news

Optimizing Diabetes Management in Cirrhosis: A Practical Clinical Guide

By MedXY 08/12/2026

Cirrhosis entwined with diabetes presents unique clinical challenges. This article offers a pragmatic framework for diagnosis, tailored therapies, and multidisciplinary care to enhance outcomes across liver disease stages.

Clinical Updates Gastroenterology news

Statin Use and Reduced Hepatic Decompensation Risk in Primary Biliary Cholangitis: Insights from a Target Trial Emulation Study

By MedXY 08/11/2026

This review synthesizes evidence on statin therapy reducing hepatic decompensation and major adverse liver outcomes in primary biliary cholangitis, highlighting a recent robust target trial emulation study across diverse populations.

Gastroenterology news Oncology

Surveillance Colonoscopy in Lynch Syndrome: Impact on Colorectal Cancer Outcomes in a National NHS Cohort

By MedXY 08/11/2026

This national NHS cohort study evaluates how adherence to colonoscopy surveillance affects colorectal cancer incidence and mortality among Lynch syndrome patients, revealing decreased mortality despite unchanged incidence, raising implications for surveillance strategies.

Clinical Updates Diabetes & Endocrinology Gastroenterology news

Liver, Portal, and Systemic Thyroid Hormone Alterations in End-Stage MASH: Distinct Diagnostic and Prognostic Roles for T3/rT3 Ratio and T4

By MedXY 08/11/2026

End-stage metabolic dysfunction-associated steatohepatitis (MASH) features profound disruptions in thyroid hormone metabolism across liver, portal, and systemic compartments, with the hepatic T3 level and systemic T3/rT3 ratio serving as sensitive diagnostic biomarkers and systemic T4 correlating with disease severity.

Gastroenterology news Oncology

Genomic Profiling of Primary Gastric Tumors Predicts Recurrence Patterns and Survival Outcomes

By MedXY 08/09/2026

Genomic alterations in primary gastric tumors, including KRAS and PIK3CA mutations, correlate with recurrence risk and metastatic patterns, informing personalized postoperative surveillance and treatment strategies.

Gastroenterology General Surgery news

Robotic Whole-Graft Liver Transplantation: Insights from 45 Cases and Benchmark Outcome Analysis

By MedXY 08/09/2026

This study evaluates the safety and efficacy of robotic whole-graft liver transplantation (RLT) in 44 patients, demonstrating benchmark-level perioperative outcomes with a focus on operative time improvement through the learning curve in specialized centers.

Gastroenterology news Oncology

BEACON-HCC: A North American consensus reshaping treatment allocation for hepatocellular carcinoma

By MedXY 08/09/2026

BEACON-HCC is a multidisciplinary, evidence-based North American consensus that updates HCC treatment allocation—integrating tumor biology, nuanced intrahepatic burden, vascular invasion, and newer modalities (EBRT, TARE, systemic–locoregional combinations).

Gastroenterology news Oncology

Extracellular Vesicles as Liquid Biopsy Biomarkers Predicting Immune Checkpoint Therapy Resistance in Hepatocellular Carcinoma

By MedXY 08/09/2026

Circulating extracellular vesicles carrying PD-1, PD-L1, and CTLA-4 can non-invasively predict responses and early resistance to immune checkpoint inhibitors in advanced hepatocellular carcinoma, improving patient stratification and management.

Gastroenterology General Surgery news

Sex-Based Disparities in Surgical Opportunities During Early Adoption of Robot-Assisted Surgery

By MedXY 08/06/2026

This study reveals significant sex-based disparities in access to robot-assisted surgery operative experience, showing female surgeons perform fewer robot-assisted procedures than males, potentially impacting career progression.

Gastroenterology Infectious Diseases news

Enhancing Hepatitis B Treatment: Pegylated Interferon After Nucleos(t)ide Withdrawal Boosts HBsAg Loss in HBeAg-Negative Patients

By MedXY 08/06/2026

Adjuvant pegylated interferon following nucleos(t)ide analogue withdrawal in HBeAg-negative chronic hepatitis B significantly increases HBsAg loss rates and reduces severe hepatic flares over three years compared to withdrawal alone.

Gastroenterology news

Subtype-Specific Enteric Neuronal Activation in IBS: Linking Faecal Proteases and Immune Signatures

By MedXY 08/06/2026

This study elucidates how faecal proteases and immune proteins distinctly activate enteric neurons in IBS subtypes, revealing subtype-specific pathological mechanisms and potential diagnostic biomarkers, highlighting novel therapeutic targets for IBS management.

Gastroenterology news

Liver Stiffness Measurements as Prognostic Tools in Primary Sclerosing Cholangitis: Insights from the Prospective FICUS Cohort

By MedXY 08/06/2026

This prospective study confirms that liver stiffness measurements by Fibroscan® strongly predict transplant-free survival in primary sclerosing cholangitis patients, validating both static values and dynamic changes as vital prognostic markers.

Diabetes & Endocrinology Gastroenterology news

Disentangling Weight Loss-Dependent and Independent Effects of Survodutide on Liver Outcomes in MASH: Insights from a Phase 2 Mediation Analysis

By MedXY 08/04/2026

This mediation analysis of a phase 2 MASH trial reveals that survodutide improves liver inflammation and fibrosis predominantly through weight-independent mechanisms, highlighting a potential direct hepatic effect beyond weight reduction.

Gastroenterology Internal Medicine news

Rapid Skeletal Muscle Loss in Cirrhosis: Predictors, Outcomes, and Implications for Clinical Management

By MedXY 08/04/2026

Rapid skeletal muscle loss occurs in a significant subset of cirrhosis patients and independently predicts waitlist mortality, highlighting sarcopenia as a critical therapeutic target in liver disease management.

Clinical Updates Gastroenterology news

Acute Colonic Ischemia Following Elective Colectomy for Cancer: Risk Factors, Procedural Associations, and Outcomes

By MedXY 08/02/2026

Postoperative colonic ischemia is a rare but severe complication after colectomy for colorectal cancer, primarily linked to specific resection types and vascular comorbidities, significantly impacting patient morbidity and mortality.

Gastroenterology news Oncology

RIPPLY1 as a Guardian Against Cancer Stemness in CTNNB1-Mutated Hepatocellular Carcinoma

By MedXY 07/31/2026

RIPPLY1 suppresses cancer stemness by targeting TBX19, improving prognosis in CTNNB1-mutated hepatocellular carcinoma through inhibition of tumor progression.

Diabetes & Endocrinology Gastroenterology news

Proteomic Insights into MASLD: Sex-Specific Endotypes and Predictive Value for Mortality

By MedXY 07/31/2026

A large-scale proteomic study identified distinct MASLD subtypes influenced by sex differences and developed a four-protein score predicting all-cause mortality, advancing personalized risk assessment beyond traditional liver-centric models.