Gastroenterology – Page 5

Chronic Kidney Disease Worsens Short-Term Outcomes in Hospitalized Patients With Cirrhosis Across a Global Cohort

By MedXY 06/07/2026

In a large international prospective cohort of hospitalized patients with cirrhosis, chronic kidney disease was common, clustered with metabolic risk, and strongly associated with acute kidney injury, more decompensation, and higher in-hospital and 30-day mortality.

AI Gastroenterology news

Computer-Aided Detection Increased Adenoma Detection in a Large Pragmatic Cluster Randomized Colonoscopy Study

By MedXY 06/07/2026

In a large Veterans Health Administration cluster randomized study, CADe availability increased adenoma detection during colonoscopy without changing withdrawal time or nonadenomatous lesion detection.

Gastroenterology news Oncology

RETREAT Score Stratifies Long-Term Hepatocellular Carcinoma Recurrence Risk After Liver Transplantation in Real-World Practice

By MedXY 06/07/2026

A single-center validation study shows the RETREAT score reliably predicts long-term HCC recurrence after liver transplantation and identifies patients with markedly different recurrence-free and overall survival trajectories.

Family Medicine & Nutrition Gastroenterology news

Deprescribing Intervention Reduces Proton Pump Inhibitor Use in Primary Care

By MedXY 06/06/2026

A large primary care trial found that a combined patient- and GP-focused deprescribing intervention safely reduced long-term proton pump inhibitor use more effectively than usual care or GP-only education.

Gastroenterology news Transplantation

Adult Liver Transplant Candidate Evaluation: What the New AASLD/AST Guideline Changes

By MedXY 06/05/2026

The updated AASLD/AST guideline clarifies how adults should be evaluated for liver transplantation, emphasizing equitable access, multidisciplinary assessment, psychosocial readiness, and structured risk–benefit decision-making.

Critical Care Gastroenterology news

TNF-α–Driven Immune-Endothelial Injury Emerges as a Therapeutic Target in Severe Acute Pancreatitis

By MedXY 06/05/2026

Single-cell analysis of human severe acute pancreatitis identifies TNF-α–induced CD8+ T-cell endothelial injury as a driver of pancreatic microcirculatory failure, supporting TNF-α blockade as a potential targeted therapy.

Gastroenterology news Pathology & Lab Medicine/Bệnh học

Pathology-Driven Epithelial Sulfide Loss Reprograms the Redox Proteome and Triggers Barrett’s Esophagus

By MedXY 06/05/2026

A study shows that reflux-related sulfide loss rewires esophageal redox proteins, increases PGE2 signaling, and helps drive Barrett’s esophagus, revealing a new potential therapeutic target.

Gastroenterology news Oncology

Language Barriers and Treatment Delays Emerge as Modifiable Threats in Early-Onset Colorectal Cancer

By MedXY 06/05/2026

A large Texas registry study found that treatment delays beyond 6 weeks were independently associated with worse survival in early-onset colorectal cancer, with language barriers identified as a potentially modifiable contributor.

Gastroenterology news Public Health

Mailed Outreach for Colorectal Cancer Screening in Community Health Centers: CARES Pragmatic Cluster Randomized Clinical Trial

By MedXY 06/04/2026

Mailed outreach improved colorectal cancer screening in community health centers, with FIT-DNA outperforming FIT. However, colonoscopy follow-up after abnormal stool tests remained low despite navigation support.

Gastroenterology General Surgery news

Machine Learning Clustering Reveals Distinct Phenotypes in Bilateral Hepatocellular Carcinoma

By MedXY 06/04/2026

Machine learning identified two distinct bilateral hepatocellular carcinoma phenotypes with different tumor burdens, surgical approaches, and outcomes, suggesting preoperative risk stratification may improve patient selection and treatment planning.

Gastroenterology news Oncology

Y90 Radioembolization as a Bridge to Liver Transplantation in Hepatocellular Carcinoma with Portal Vein Tumor Thrombosis

By MedXY 06/03/2026

Y90 radioembolization downstaged about one-quarter of HCC patients with portal vein tumor thrombosis to transplant eligibility, and those who received liver transplantation had markedly better cancer-related outcomes and survival.

Gastroenterology news Oncology

Quorum-Sensing Molecules Elevated in Long-Standing Ulcerative Colitis May Help Drive Colitis-Associated Cancer

By MedXY 06/03/2026

Bacterial quorum-sensing molecules, especially C6-scAHL, were elevated in long-standing ulcerative colitis and promoted colon tumor growth in mice, suggesting a new microbiome-driven pathway for colitis-associated cancer.

Gastroenterology General Surgery news

Relaxing Diaphragmatic Incisions May Improve Symptom Outcomes in Difficult Hiatal Hernia Repair, but Morphologic Durability Remains Unproven

By MedXY 06/01/2026

In complex redo and giant hiatal hernia repair, lateral diaphragmatic relaxing incisions were feasible and associated with favorable patient-reported symptom control at 24 months, although objective recurrence data are still lacking.

Gastroenterology General Surgery news

Role of Relaxing Lateral Incisions as an Add-On to Difficult Hiatal Repair in Redo and Giant Hernia Cases

By MedXY 06/01/2026

A modified diaphragmatic relaxing incision technique may reduce tension during difficult redo and giant hiatal hernia repairs, with most patients reporting improved reflux symptoms and low postoperative symptom burden.

Gastroenterology news Oncology

Pancreatic Cancer Risk During IPMN Surveillance Is About 10-Fold Higher Than in the General Population

By MedXY 06/01/2026

A SEER-matched analysis found that patients undergoing IPMN surveillance have a markedly elevated malignancy risk, with substantial heterogeneity by duct dilation, obesity, age, and cyst features.

Gastroenterology news Oncology

Pancreatic Cancer Risk During IPMN Surveillance: A SEER-Based Comparison

By MedXY 06/01/2026

A SEER-based study found IPMN surveillance patients have about 10 times higher pancreatic cancer risk than the general population, with highest risk in those with main duct dilation or obesity.

Gastroenterology news OB/GYN & Women’s Health

Postmarketing Data Link Fezolinetant Primarily to Early Transaminase Elevations Rather Than Overt Liver Injury

By MedXY 06/01/2026

FAERS postmarketing data suggest fezolinetant is associated with an early hepatic adverse event reporting signal, driven mainly by liver enzyme elevations rather than consistent severe clinical liver injury.

Gastroenterology news Public Health

Exercise May Be a Disease-Modifying Strategy in Chronic Pancreatitis

By MedXY 06/01/2026

A new multimodal study links regular physical activity to lower chronic pancreatitis risk and identifies muscle-derived extracellular vesicles as a plausible mechanism limiting pancreatic inflammation, fibrosis, and ferroptosis.

Diabetes & Endocrinology Gastroenterology news

Glycemic Control and Diabetes Outcomes After Surgical Therapy for Diabetic Gastroparesis

By MedXY 05/29/2026

Surgical therapy for diabetic gastroparesis was linked to better long-term HbA1c control, less insulin use, and fewer diabetes-related complications, though mortality was unchanged.

Gastroenterology news

Urgent versus early ERCP in mild-to-moderate acute cholangitis: what the trial found

By MedXY 05/28/2026

In mild-to-moderate acute cholangitis, ERCP within 24 hours did not improve mortality or organ-failure outcomes versus ERCP within 24–48 hours, and it was linked to more procedure-related adverse events.