Gastroenterology – Page 4

Metabolic Checkpoint Role of PCK1 Deficiency in Promoting MASH-HCC via 12-HETE-Induced CD8+ T Cell Dysfunction

By MedXY 08/22/2026

PCK1 deficiency in hepatocytes drives metabolic reprogramming that fosters MASH-HCC progression by inducing CD8+ T cell dysfunction through 12-HETE-p38 signaling, highlighting a metabolic immunotherapy target to enhance anti-PD-1 efficacy.

Clinical Updates Gastroenterology news

KIF13B-KPNA2-PPARα Axis: A Novel Target for Mitigating Alcohol-Associated Liver Steatosis

By MedXY 08/22/2026

Emerging evidence identifies KIF13B facilitating KPNA2-mediated nuclear import of PPARα as a critical mechanism to mitigate alcohol-associated liver steatosis, highlighting novel therapeutic strategies for ALD.

Gastroenterology news Rheumatology

Decoding Systemic Inflammation in Long COVID and Autoimmune Diseases: The Role of Intestinal Flagellin and the TLR5-IL-15-ARA Axis

By MedXY 08/22/2026

This article explores how intestinal flagellin drives systemic inflammation via the TLR5-IL-15-ARA pathway in long COVID, rheumatoid arthritis, ankylosing spondylitis, and IBD, highlighting potential therapeutic targets and biomarkers.

Gastroenterology news Oncology

Patterns and Implications of Local Regrowth After Neoadjuvant Chemoradiotherapy in Esophageal Cancer: Insights from the SANO Trial

By MedXY 08/21/2026

This study analyzes surgical specimens from the SANO trial, revealing that local regrowth after neoadjuvant chemoradiotherapy predominantly involves mucosa and submucosa and supports endoscopic monitoring in active surveillance, with surgery advised due to nodal disease risk.

Gastroenterology Hematology-Oncology news

Targeting NEK7-Mediated EGFR Phosphorylation to Overcome Lenvatinib Resistance in Hepatocellular Carcinoma

By MedXY 08/21/2026

NEK7 promotes acquired lenvatinib resistance in hepatocellular carcinoma by phosphorylating EGFR at serine 1070, activating key signaling pathways. Blocking this interaction offers a promising therapeutic avenue to counteract resistance.

Gastroenterology news Oncology

Multiomic Profiling and Machine Learning Reveal Distinct Molecular Subtypes of Cholangiocarcinoma and Identify TNK1 as a Novel Therapeutic Target

By MedXY 08/21/2026

This study delineates three unique molecular subtypes of cholangiocarcinoma via integrated multiomic and machine learning methodologies, highlighting TNK1 kinase as a promising targeted therapy in a metabolic subtype.

Gastroenterology news Rheumatology

Unraveling the Gut-Lung Axis: Intestinal Flagellin as a Driver of Multisystem Inflammation via the TLR5-IL-15-ARA Pathway

By MedXY 08/21/2026

Flagellated gut bacteria activate TLR5 on neutrophils, triggering IL-15 release and macrophage arachidonic acid production, driving systemic inflammation in long COVID, rheumatoid arthritis, ankylosing spondylitis, and IBD.

Gastroenterology news Oncology

Targeting NSUN6 Deficiency to Overcome Immune Suppression in Pancreatic Cancer: Insights into the KDM5A-CCL2-Macrophage Axis

By MedXY 08/21/2026

NSUN6 deficiency in pancreatic cancer promotes immune suppression by enhancing immunosuppressive macrophage infiltration via the KDM5A-CCL2 axis, leading to resistance to immune checkpoint blockade; targeting this pathway offers a promising therapeutic approach.

Diabetes & Endocrinology Gastroenterology news

Longitudinal Weight Changes in MASLD: Impact on Liver Outcomes and Disease Progression

By MedXY 08/19/2026

This study reveals that weight gain exceeding 5% in MASLD patients increases liver-related event risks and liver stiffness, whereas weight loss improves liver stiffness and may reduce adverse outcomes, especially with obesity reversal.

Gastroenterology Nephrology news

Ciliogenic Pancreatopathy: A Novel Link Between Ciliopathies and Exocrine Pancreatic Disease

By MedXY 08/19/2026

Researchers unveil ciliogenic pancreatopathy, a new pancreatic disease connected to ciliary gene mutations, highlighting its clinical significance in patients with syndromic ciliopathies and kidney dysfunction.

Gastroenterology news

WISP1 as a Therapeutic Target in Crohn’s Disease: Linking Metabolic Reprogramming to Intestinal Fibrosis

By MedXY 08/19/2026

This study reveals the pivotal role of WISP1 in driving intestinal fibrosis in Crohn’s disease through fibroblast metabolic shifts and cytoskeletal remodeling, suggesting WISP1 neutralization as a novel antifibrotic intervention.

Gastroenterology news

Epigenetic Silencing of Hepatocyte FoxO1: A Novel Mechanism Disrupting Liver Immune Balance and Driving Inflammation

By MedXY 08/18/2026

Epigenetic repression of hepatocyte FoxO1 disrupts immune homeostasis in the liver, promoting inflammation via altered NKT cell regulation, revealing promising therapeutic targets for inflammatory liver diseases.

Cardiology Clinical Updates Gastroenterology news

Gut Microbiota-Derived Imidazole Propionate as a Predictor of Cardiometabolic Risk in Coronary Artery Disease: Evidence and Clinical Implications

By MedXY 08/18/2026

Emerging evidence identifies circulating imidazole propionate, a gut microbiota-derived metabolite, as an independent predictor of major adverse cardiovascular events in patients with coronary artery disease, offering novel insights into personalized risk stratification and therapeutic targets.

Gastroenterology Neurology news

Targeting the Medial Prefrontal Cortex with Low-Frequency rTMS: A Novel Approach for Visceral Pain Relief in IBS-D

By MedXY 08/17/2026

Low-frequency repetitive transcranial magnetic stimulation targeting the medial prefrontal cortex reduces visceral pain and improves bowel symptoms in IBS-D by normalizing central neural hyperexcitability.

Gastroenterology news

Pruritus in Primary Sclerosing Cholangitis: Prevalence, Persistence, and Association with Disease Severity

By MedXY 08/17/2026

This multicenter study reveals that pruritus affects one in four patients with primary sclerosing cholangitis (PSC), persists over time, and correlates with disease severity, underscoring its clinical significance and guiding future therapeutic strategies.

Gastroenterology Infectious Diseases news

AHB-137: First-in-Human Study Shows Promising Antiviral Activity and Safety in Chronic Hepatitis B Management

By MedXY 08/16/2026

AHB-137, an antisense oligonucleotide targeting HBV mRNA, demonstrated safety, favorable pharmacokinetics, and rapid HBsAg reduction in healthy volunteers and chronic hepatitis B patients, supporting further clinical development.

Clinical Updates Gastroenterology news

Cryptogenic Steatotic Liver Disease: Characterizing a Lean Phenotype Linked to Increased Liver-Related Mortality

By MedXY 08/16/2026

Cryptogenic steatotic liver disease (SLD), representing a lean phenotype without classic cardiometabolic risk factors, is associated with adverse liver profiles and higher liver-related mortality, highlighting an underrecognized high-risk subgroup within lean SLD populations.

Gastroenterology news

Comparative Effectiveness of Shear Wave Elastography and VCTE in MASLD Risk Stratification: Insights from FIB-4-Based Two-Step Algorithms

By MedXY 08/15/2026

Shear wave elastography (SWE) shows comparable accuracy to vibration-controlled transient elastography (VCTE) for stratifying liver-related event risk in MASLD patients using FIB-4-based two-step algorithms.

Gastroenterology Internal Medicine news

Cryptogenic Steatotic Liver Disease: A Lean Phenotype Linked to Increased Liver-Related Mortality

By MedXY 08/15/2026

Cryptogenic steatotic liver disease (SLD) is a form of fatty liver disease found in lean individuals without diabetes or other metabolic risk factors, associated with significant liver injury and increased mortality risk.

Gastroenterology news

New Insights into Artificial Sweeteners and Emulsifiers in Crohn’s Disease: Biomarkers and Metabolic Mechanisms from the ENIGMA Study

By MedXY 08/14/2026

The ENIGMA study reveals altered metabolism of the emulsifier polysorbate-80 and elevated artificial sweeteners in Crohn's disease, linking these dietary additives to disease activity and potential biomarker development.