Gastroenterology – Page 4

Unveiling the Role of Butyrylcholinesterase in Hepatic Fibrosis: A Novel Cholinergic Target in Liver Disease

By MedXY 09/28/2026

Butyrylcholinesterase (BuChE) modulates hepatic stellate cell activation by degrading acetylcholine, mitigating fibrogenesis via muscarinic receptor signaling and offering a new therapeutic target for liver fibrosis.

Gastroenterology news Oncology

Nationwide Dutch Study Reveals Limited Prior Endoscopic Surveillance in Barrett’s Esophagus-Related Dysplasia and Cancer Diagnosis

By MedXY 09/26/2026

In a large Dutch cohort, 90% of patients with Barrett’s esophagus-related dysplasia or cancer had no prior endoscopic surveillance, highlighting a critical gap in early detection and the need for evidence-based screening strategies.

Gastroenterology Internal Medicine news

Distinct Gut Microbiome Signatures Predict Short-term Hospitalisation Risk in Cirrhosis: Insights from a Global Metagenomic Study

By MedXY 09/26/2026

This multinational study reveals that specific gut microbiome profiles significantly correlate with 90-day hospitalisation risk in cirrhosis, enhancing prognostic accuracy beyond clinical features alone.

Gastroenterology news Oncology

Decoding Steatohepatitic Hepatocellular Carcinoma: Multi-Omics Insights and Emerging Diagnostic-Therapeutic Pathways

By MedXY 09/26/2026

This study integrates multi-omics data to characterize steatohepatitic hepatocellular carcinoma (SH-HCC), establishing robust diagnostic models and identifying FABP4 as a promising therapeutic target, with implications for personalized management strategies.

Allergy & Immunology Gastroenterology news

Zetomipzomib Shows Promise in Difficult-to-Treat Autoimmune Hepatitis: Insights from the Phase 2a PORTOLA Study

By MedXY 09/25/2026

The PORTOLA phase 2a trial evaluates zetomipzomib, a selective immunoproteasome inhibitor, demonstrating numerically improved biochemical remission and steroid-sparing effects in autoimmune hepatitis patients with inadequate response to standard treatments.

Clinical Updates Gastroenterology news Psychiatry

Gastrointestinal Interoception and Relapse in Anorexia Nervosa: Insights from Behavioral, Neural, and Computational Perspectives

By MedXY 09/25/2026

This review synthesizes evidence demonstrating disrupted gastrointestinal interoception in weight-restored anorexia nervosa, linking behavioral and neural disturbances with relapse risk and symptom severity, and highlighting novel mechanistic and clinical avenues for relapse prevention.

Clinical Updates Gastroenterology news

Steatotic Liver Disease Risk Scores for Predicting Cirrhosis and Hepatocellular Carcinoma: A Comprehensive Clinical Review

By MedXY 09/24/2026

This review assesses the clinical utility of steatotic liver disease risk scores in predicting cirrhosis and hepatocellular carcinoma, highlighting the superior performance of the SAFE score for cirrhosis and challenges in HCC risk prediction.

Gastroenterology news Oncology

Neurotensin Receptor 1: A Key Driver of Immune Exclusion and Poor Prognosis in Colorectal Cancer

By MedXY 09/23/2026

High expression of neurotensin receptor 1 (NTSR1) defines an immune-cold colorectal cancer subtype linked to worse outcomes by creating mechanical and biological barriers that exclude T-cell infiltration, highlighting a novel immunotherapeutic target.

Clinical Updates Gastroenterology news

Divergent Microbial Mechanisms and Predictive Signatures in Necrotising Enterocolitis: The Role of Gut Phages and Bacterial Resistomes

By MedXY 09/23/2026

This review synthesizes evidence on the predictive and pathogenic roles of gut phages and bacterial resistomes in necrotising enterocolitis, highlighting divergent mechanisms for early- versus late-onset disease and translational opportunities for personalized risk stratification and interventions.

Gastroenterology Infectious Diseases news

Reevaluating Immune Tolerant Phase in Chronic Hepatitis B: High Transition Rates to Immune Active Disease and Clinical Implications from the RADICAL Consortium

By MedXY 09/23/2026

The RADICAL consortium's large-scale study reveals a high long-term transition rate from immune tolerant to immune active chronic hepatitis B, especially in patients with high-normal ALT, suggesting the need for closer monitoring and potential early intervention.

Gastroenterology Internal Medicine news

Sequential Lactulose and TeleTai-Chi to Prevent Falls in Cirrhosis: Insights from the LiveSMART Trial

By MedXY 09/21/2026

The LiveSMART trial demonstrates that lactulose, with or without sequential TeleTai-Chi, significantly reduces fall risk and related harms in cirrhotic patients without prior overt hepatic encephalopathy.

Gastroenterology news Oncology

Dynamic Gut Microbiome Changes Enhance Immunotherapy Outcomes in Advanced Liver Cancer

By MedXY 09/21/2026

This longitudinal study reveals that gut microbiome remodeling during immune checkpoint inhibitor therapy in advanced liver cancer patients predicts clinical benefit, improving biomarker accuracy and survival stratification.

Gastroenterology Internal Medicine news

Evaluating Non-Enteric-Coated Pancreatic Enzyme Therapy for Pain Relief in Chronic Pancreatitis: Insights from a Robust Randomized Trial

By MedXY 09/21/2026

A recent double-blind, placebo-controlled trial found that non-enteric-coated pancreatic enzyme therapy does not significantly reduce pain in chronic pancreatitis patients, highlighting the need to revisit pain management strategies in this condition.

Gastroenterology General Surgery news

Xenotransplantation in Acute Liver Failure: Bridging the Organ Gap with Genetically Modified Porcine Livers

By MedXY 09/20/2026

This article reviews advances in liver xenotransplantation using genetically modified porcine organs as a bridging strategy for acute liver failure, highlighting recent clinical progress, challenges, and future directions.

Gastroenterology Infectious Diseases news

Dissecting Gut-Vascular Barrier Failures: Macrophage Dysfunction Drives Bacterial Translocation in Cirrhosis

By MedXY 09/20/2026

This study elucidates how intestinal blood vessel-associated macrophage dysfunction contributes to gut-vascular barrier breakdown and bacterial translocation in cirrhosis, revealing novel mechanisms that underlie systemic infection risks in liver disease.

Gastroenterology General Surgery news

Out-of-Hours Liver Transplantation: Identifying High-Risk Timeframes and Implications for Patient Outcomes

By MedXY 09/19/2026

A Swedish national retrospective study reveals that liver transplantations initiated between 17:00 and 05:59 are linked to significantly increased postoperative complications and healthcare costs, highlighting the need for optimized scheduling.

Gastroenterology Internal Medicine news

VPS13D: A Crucial Regulator of Organelle Contact Sites and Lipid Metabolism in Alcohol-Associated Steatohepatitis

By MedXY 09/19/2026

VPS13D protects against alcohol-induced liver injury by maintaining mitochondria-ER contact sites, regulating phospholipid balance and promoting VLDL secretion, thus mitigating steatosis and inflammation in alcoholic hepatitis.

Allergy & Immunology Gastroenterology news

Unveiling the TL1A-LTα1β2/IL-22 Axis: A New Therapeutic Target in Crohn’s Disease with Perianal Fistulising Disease

By MedXY 09/19/2026

This study reveals that TL1A-activated CD4+ T cells drive distinct cellular and molecular changes in the rectal mucosa of Crohn's disease patients with perianal fistulising disease (PFD), highlighting a novel TL1A-LTα1β2/IL-22 axis independent of TNF signaling, with important therapeutic implications.

Gastroenterology General Surgery news

Balancing Safety and Recurrence: Cold vs Hot Snare Resection of Large Colorectal Polyps

By MedXY 09/19/2026

This meta-analysis of four RCTs compares cold and hot snare polypectomy for large colorectal polyps, demonstrating lower major adverse events but higher recurrence with cold resection, especially in adenomas with high-grade dysplasia.

Gastroenterology news Oncology

Rising Early-Onset Colorectal Cancer and Persistent Racial Disparities Despite Increased Colonoscopy Use

By MedXY 09/18/2026

From 2017 to 2023, colonoscopy use increased notably in adults under 50. Yet, early-onset colorectal cancer rates and racial disparities, particularly among Black and Hispanic populations, worsened, highlighting that screening alone does not resolve these inequities.