Post-Transplant Cyclophosphamide as a Potent Strategy for Bronchiolitis Obliterans Syndrome Prevention: A Comprehensive Clinical Synthesis
Posted inClinical Updates news Respiratory Transplantation

Post-Transplant Cyclophosphamide as a Potent Strategy for Bronchiolitis Obliterans Syndrome Prevention: A Comprehensive Clinical Synthesis

This review evaluates the role of post-transplant cyclophosphamide (PTCy) in reducing the risk of bronchiolitis obliterans syndrome (BOS), highlighting recent multicenter data that demonstrates a 75% risk reduction mediated by the prevention of chronic graft-versus-host disease.
Dietary Lipid Sequestration and Metabolic Rewiring in Colorectal Cancer: New Mechanistic Frontiers and Therapeutic Potential
Posted inClinical Updates Gastroenterology news Oncology

Dietary Lipid Sequestration and Metabolic Rewiring in Colorectal Cancer: New Mechanistic Frontiers and Therapeutic Potential

This review synthesizes recent evidence on how colorectal cancer tissues directly absorb extrinsic long-chain fatty acids from the intestinal lumen, particularly in right-sided tumors, and explores the critical interplay between lipid metabolism, the gut microbiome, and cancer cell proliferation.
Levothyroxine in the Ageing Patient: Re-evaluating Cardiovascular Outcomes in Subclinical Hypothyroidism through the ACEL-UK-ETT Trial
Posted inCardiology Clinical Updates Diabetes & Endocrinology news

Levothyroxine in the Ageing Patient: Re-evaluating Cardiovascular Outcomes in Subclinical Hypothyroidism through the ACEL-UK-ETT Trial

This review analyzes the ACEL-UK-ETT emulated target trial, demonstrating that long-term levothyroxine therapy in older adults with subclinical hypothyroidism significantly reduces cardiovascular events and all-cause mortality without compromising bone health, provided age-specific TSH thresholds are utilized.