Highlights
- Mindfulness-Oriented Recovery Enhancement (MORE) significantly alters prefrontal cortical activity associated with reward and salience processing in patients with opioid use disorder (OUD).
- MORE reduces drug cue reactivity and shifts neural responsivity from drug-related to natural reward cues, correlating with decreased craving.
- This neural reorganization is linked with increased duration of abstinence approximately 4 months post-intervention, highlighting its clinical efficacy.
- Functional MRI evidence positions MORE as a biologically grounded behavioral adjunct to existing pharmacotherapies, targeting core addiction-related neurocircuitry.
Background
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For clinical reference; use professional judgment.
