CEUS-guided percutaneous lung needle biopsy (PLNB) achieves significantly higher diagnostic yield and sensitivity compared to conventional ultrasound (US) and computed tomography (CT) guidance in diagnosing subpleural lung lesions (SLLs).
CEUS guidance improves diagnostic sensitivity particularly for malignant subtypes and specific benign pulmonary diseases.
CEUS-guided biopsy is associated with a markedly lower overall complication rate than US- and CT-guided biopsies, reinforcing its safety profile.
This multicenter randomized controlled trial (RCT) represents the largest comparative clinical study addressing guidance modalities in SLL biopsy, establishing CEUS as an optimal diagnostic tool.
