Highlight
– A polygenic risk score (PRS) strongly associates with idiopathic pulmonary fibrosis (IPF) diagnosis across multiple large biobank cohorts.
– High-risk PRS predicts increased mortality or lung transplant risk in individuals diagnosed with IPF.
– The study leverages routinely collected electronic health records (EHR) and genetic data to evaluate PRS utility in real-world settings.
– Incorporation of PRS into clinical practice could enhance early identification and prognostication in IPF, pending further validation.
