高冲击体力活动会影响髋、膝骨关节炎的关节置换风险吗？一项大规模纵向中介研究
Posted innews Orthopedics Rheumatology

High-Impact Physical Activity and Joint Replacement Risk in Hip and Knee Osteoarthritis: A Large-Scale Longitudinal Mediation Study

High-impact physical activity in patients with hip osteoarthritis is associated with a reduced 12-month risk of total hip replacement, without increasing knee replacement risk in knee OA patients. Functional capacity partly mediates this benefit, challenging traditional guidelines favoring only low-impact exercise.
系统性硬化症中表型特异性的嵌合性染色体异常：对疾病亚型与临床结局的启示
Posted inHematology-Oncology news Rheumatology

Phenotype-Specific Mosaic Chromosomal Alterations in Systemic Sclerosis: Implications for Disease Subtypes and Clinical Outcomes

This article explores the differential associations of mosaic chromosomal alterations (mCAs), especially chromosomal loss and mosaic loss of the X chromosome, with systemic sclerosis and its subtypes, revealing phenotype-specific genetic contributions that may influence clinical manifestations and disease onset.
高可动性Ehlers-Danlos综合征与关节过度活动谱系障碍中的可诱发性喉梗阻：临床相关性与预测因素
Posted innews Otorhinolaryngology Rheumatology

Inducible Laryngeal Obstruction in Hypermobile Ehlers-Danlos Syndrome and Hypermobility Spectrum Disorders: Clinical Correlates and Predictors

This study explores the association between inducible laryngeal obstruction (ILO) and symptoms in patients with hypermobile Ehlers-Danlos syndrome (hEDS) and hypermobility spectrum disorders (HSD), highlighting chronic cough, dysphagia, and mast cell activation as key predictors of ILO.