Highlight
- IgG4-related disease (IgG4-RD) is not associated with an increased incidence of malignancy compared to the general U.S. population.
- Among IgG4-RD patients, smoking and older age at disease onset are significant risk factors for developing malignancy.
- Female sex and submandibular gland involvement in IgG4-RD are associated with a decreased risk of malignancy.
- The most common malignancies in this IgG4-RD cohort included lymphoma, prostate, and lung cancers.
