Inducible laryngeal obstruction (ILO) occurs in approximately 20% of patients with hypermobile Ehlers-Danlos syndrome (hEDS) and hypermobility spectrum disorders (HSD).
Patients with ILO experience significantly increased voice, cough, and swallowing difficulties compared to those without ILO.
Mast cell activation symptoms and gastroesophageal reflux disease (GERD) are more prevalent in hEDS and HSD patients with ILO.
Chronic cough, dysphagia, and elevated mast cell activation symptom burden independently predict the presence of ILO, informing multidisciplinary assessment strategies.
