每8周一次长效注射卡博特韦-利匹韦林用于撒哈拉以南非洲HIV感染青少年：来自LATA试验及当代证据的启示
Posted inClinical Updates HIV/AIDS Infectious Diseases news

Long-Acting Injectable Cabotegravir-Rilpivirine Every 8 Weeks for Adolescents with HIV in Sub-Saharan Africa: Evidence from the LATA Trial and Contemporary Context

The LATA trial demonstrates that long-acting injectable cabotegravir-rilpivirine given every 8 weeks is superior to daily oral ART for maintaining virological suppression in adolescents with HIV in sub-Saharan Africa, with a favorable safety and acceptability profile, heralding a transformative option for this vulnerable population.
Individualized Treatment Effects of Cefepime vs Piperacillin-Tazobactam in Adults Hospitalized with Acute Infection: A Review of Evidence and Clinical Implications
Posted inClinical Updates Critical Care Infectious Diseases news

Individualized Treatment Effects of Cefepime vs Piperacillin-Tazobactam in Adults Hospitalized with Acute Infection: A Review of Evidence and Clinical Implications

This review synthesizes evidence on how individual patient characteristics modify the comparative effects of cefepime versus piperacillin-tazobactam on acute kidney injury and neurologic outcomes in adults hospitalized with acute infection.
Comparative Insights into Native and Allograft BK Polyomavirus Nephropathy: Clinical and Pathological Perspectives from a Matched Cohort Study
Posted inInfectious Diseases Nephrology news

Comparative Insights into Native and Allograft BK Polyomavirus Nephropathy: Clinical and Pathological Perspectives from a Matched Cohort Study

This study elucidates the distinct clinical, pathological, and prognostic differences between native and allograft BK polyomavirus nephropathy, highlighting the severity and poorer outcomes associated with native-kidney BKPyVN and stressing the importance of early detection in high-risk patients.
International Validation of Sepsis Temperature-Trajectory Subphenotypes Reveals Immune and Coagulation Profiles with Implications for Immunoglobulin Therapy
Posted inCritical Care Infectious Diseases news

International Validation of Sepsis Temperature-Trajectory Subphenotypes Reveals Immune and Coagulation Profiles with Implications for Immunoglobulin Therapy

This study validates temperature-trajectory sepsis subphenotypes in a large Chinese ICU cohort, linking immune and coagulation dysfunction with mortality and highlighting differential responses to immunoglobulin therapy, particularly benefit in hypothermic patients.
Evolving Impact of Inhaled Antibiotics on Lung Function in Cystic Fibrosis During the CFTR-Modulator Era
Posted inInfectious Diseases news Respiratory

Evolving Impact of Inhaled Antibiotics on Lung Function in Cystic Fibrosis During the CFTR-Modulator Era

This analysis of U.S. CF Foundation registry data reveals that inhaled antibiotics confer lung function benefits primarily in chronic Pseudomonas aeruginosa infections, but their treatment benefit has declined with CFTR modulator use. Risks of secondary infections are higher in Pseudomonas-negative patients who do not benefit in lung function.
Inequalities in Mortality Following SARS-CoV-2 Infection Among People with Severe Mental Illness During and After COVID-19 Vaccination Roll-Out in England: A Comprehensive Review
Posted inClinical Updates Critical Care Infectious Diseases news

Inequalities in Mortality Following SARS-CoV-2 Infection Among People with Severe Mental Illness During and After COVID-19 Vaccination Roll-Out in England: A Comprehensive Review

This review synthesizes evidence on persistent excess mortality after SARS-CoV-2 infection in people with severe mental illness (SMI) during and following COVID-19 vaccination roll-out in England, highlighting disparities in mortality risk and vaccination uptake.
Evolving Landscape of Respiratory Viral Infections in Hematopoietic Cellular and CAR T-cell Therapy Recipients Post-COVID-19 Pandemic
Posted inHematology-Oncology Infectious Diseases news

Evolving Landscape of Respiratory Viral Infections in Hematopoietic Cellular and CAR T-cell Therapy Recipients Post-COVID-19 Pandemic

This study elucidates the incidence and characteristics of respiratory viral infections (RVIs) within 100 days following hematopoietic cell transplant and CAR T-cell therapy, highlighting SARS-CoV-2 as the predominant pathogen and identifying risk factors for severe infection in the post-pandemic era.
Reevaluating Immune Tolerant Phase in Chronic Hepatitis B: High Transition Rates to Immune Active Disease and Clinical Implications from the RADICAL Consortium
Posted inGastroenterology Infectious Diseases news

Reevaluating Immune Tolerant Phase in Chronic Hepatitis B: High Transition Rates to Immune Active Disease and Clinical Implications from the RADICAL Consortium

The RADICAL consortium's large-scale study reveals a high long-term transition rate from immune tolerant to immune active chronic hepatitis B, especially in patients with high-normal ALT, suggesting the need for closer monitoring and potential early intervention.