Diabetes & Endocrinology – Page 15

Most Bilateral Adrenal Lesions Are Benign and Concordant, but Asynchronous Presentation Signals Higher Malignancy Risk

By MedXY 05/13/2026

A large retrospective cohort shows that bilateral adrenal masses are usually benign and concordant, but asynchronous or discordant lesions identify a clinically important subgroup enriched for malignancy and pheochromocytoma.

Diabetes & Endocrinology news Public Health

Weight Regain Can Reverse the Metabolic Benefits of Caloric Restriction: Insights From CALERIE-2

By MedXY 05/13/2026

CALERIE-2 post hoc analysis found that weight regain after caloric restriction can reverse improvements in insulin and IGF-1 signaling, while sustained weight loss preserves metabolic benefits and may lower biological aging markers.

Diabetes & Endocrinology Nephrology news

Tirzepatide vs dulaglutide: kidney outcomes in type 2 diabetes from SURPASS-CVOT

By MedXY 05/12/2026

In a pre-specified exploratory analysis of SURPASS-CVOT, tirzepatide reduced major kidney events versus dulaglutide in people with type 2 diabetes and cardiovascular disease, mainly by lowering new macroalbuminuria and slowing eGFR decline.

Diabetes & Endocrinology General Surgery news

Adrenalectomy for Mild Autonomous Cortisol Secretion Was Linked to Lower Mortality, but the Survival Signal Requires Cautious Interpretation

By MedXY 05/11/2026

In a multi-institutional retrospective cohort, adrenalectomy for mild autonomous cortisol secretion was associated with lower mortality and less new-onset diabetes than nonoperative care, although sensitivity analysis weakened the survival finding.

Diabetes & Endocrinology General Surgery news

Biliopancreatic Diversion for Severe Obesity: Landmark 50-Year Study Reveals Lifelong Benefits and Risks

By MedXY 05/11/2026

A 50-year follow-up of biliopancreatic diversion shows sustained weight loss and diabetes remission, but alarmingly high nutritional complications decades after surgery.

Cardiology Diabetes & Endocrinology news

Subclinical Hyperthyroidism Carries Measurable Risks of Atrial Fibrillation, Heart Failure, and Death in Primary Care

By MedXY 05/10/2026

A large Dutch primary care cohort links subclinical hyperthyroidism to higher risks of atrial fibrillation, heart failure, and all-cause mortality, with particularly notable relative risks in younger adults and in patients with more strongly suppressed TSH.

Diabetes & Endocrinology news Radiology

Advanced Liver Imaging Reveals Impaired Postprandial Hepatic Glucose Handling and Hidden Metabolic Subtypes in Type 1 Diabetes

By MedXY 05/10/2026

A 7 T imaging and tracer study found that adults with type 1 diabetes have abnormal postprandial hepatic glucose uptake, blunted glycogen storage, reduced suppression of endogenous glucose production, and marked metabolic heterogeneity despite similar systemic insulin exposure.

Diabetes & Endocrinology news Pediatrics

Glucocorticoid Reduction After Starting Crinecerfont in Pediatric Patients With Classic CAH: Practical Perspectives

By MedXY 05/10/2026

New expert recommendations guide glucocorticoid dose reduction in pediatric classic CAH patients using crinecerfont, prioritizing normal growth while minimizing long-term steroid complications.

Diabetes & Endocrinology news Pediatrics

Pediatric Type 1 Diabetes Care Still Misses LDL Targets Despite Clear Indications for Lipid-Lowering Therapy

By MedXY 05/10/2026

Registry data from 55,028 youths with type 1 diabetes show common LDL hypercholesterolemia, infrequent lipid-lowering therapy, and poor attainment of recommended LDL targets.

Diabetes & Endocrinology news Public Health

Multi-ancestry Polygenic Risk Scores Substantially Improve Type 2 Diabetes Risk Prediction Across Diverse Populations

By MedXY 05/10/2026

A large multi-ancestry study shows that publicly available polygenic risk scores improve prediction of type 2 diabetes onset and selected microvascular complications across major global ancestry groups.

Diabetes & Endocrinology news Public Health

Type 1 Diabetes in Sweden Clusters in Rural Areas, With Early-Childhood Geography Showing the Strongest Signal

By MedXY 05/07/2026

A nationwide Swedish cohort study found marked geographic variation in type 1 diabetes incidence, with the strongest clustering linked to residential location during the first 5 years of life and higher risk in rural, forested, and agricultural areas.

Diabetes & Endocrinology news OB/GYN & Women’s Health

Higher PFAS Exposure During Pregnancy Was Not Linked to Increased Gestational Diabetes in the ECHO Cohort

By MedXY 05/06/2026

In a pooled U.S. pregnancy cohort, maternal PFAS concentrations were not associated with a higher prevalence of gestational diabetes, and fasting glucose findings were largely null.

Diabetes & Endocrinology Internal Medicine news

甲状腺功能随年龄变化的自然历程：一项涵盖31项前瞻性队列研究的13.7万参与者个体数据分析

By MedXY 05/06/2026

大规模国际研究发现甲状腺功能随年龄变化存在性别和碘状态差异。虽然多数人甲状腺功能稳定且TSH轻微升高，但任何变化模式均与全因死亡风险增加1.8-2.5倍相关，这对老年甲状腺健康管理具有重要临床意义。

Diabetes & Endocrinology news Psychiatry

Semaglutide Reduced Effort Discounting and Improved Motivation Signals in Major Depressive Disorder

By MedXY 05/05/2026

In a 16-week randomized trial, adjunctive oral semaglutide improved effort-based decision-making in adults with major depressive disorder and overweight or obesity, suggesting a potential role for GLP-1 receptor agonism in reward-related dysfunction.

Diabetes & Endocrinology news Radiology

ACR TI-RADS Reduced Repeat Thyroid Ultrasound but Did Not Lower Biopsy or Surgery Rates in Real-World Practice

By MedXY 05/04/2026

In a large single-center retrospective study, ACR TI-RADS implementation decreased follow-up thyroid ultrasound but did not reduce fine-needle aspiration, surgery, cancer yield, or overall costs.

Diabetes & Endocrinology news Oncology

Calcitonin Doubling Rate Sharpens Postoperative Recurrence Risk Stratification in Medullary Thyroid Carcinoma With Biochemical Persistent Disease

By MedXY 05/04/2026

In medullary thyroid carcinoma with biochemical persistent disease after surgery, an early postoperative calcitonin doubling rate of at least 0.3/year strongly identified patients at higher recurrence risk and may help tailor surveillance intensity.

Diabetes & Endocrinology news Ophthalmology

Teprotumumab for Thyroid Eye Disease Carries a Measurable Long-Term Dysglycemia Risk

By MedXY 05/03/2026

A large multinational cohort study found that teprotumumab use in thyroid eye disease was associated with higher risks of prediabetes, diabetes, and antidiabetes medication initiation over 5 years.

Diabetes & Endocrinology news OB/GYN & Women’s Health

Gut Microbiome Signatures May Help Explain Why Gestational Diabetes Raises Later Type 2 Diabetes Risk in Hispanic/Latina Women

By MedXY 05/03/2026

In HCHS/SOL, prior gestational diabetes was linked to a proinflammatory gut microbiome, adverse metabolite patterns, and higher future type 2 diabetes risk, suggesting a plausible microbiome-mediated pathway after pregnancy.

Diabetes & Endocrinology news Pathology & Lab Medicine/Bệnh học

Urinary Free Cortisol Thresholds Sharpen the Differential Diagnosis of ACTH-Dependent Cushing’s Syndrome

By MedXY 05/03/2026

A Spanish multicenter validation study shows that urinary free cortisol expressed as multiples of the upper limit of normal can meaningfully stratify the likelihood of ectopic ACTH secretion versus Cushing’s disease.

Clinical Updates Diabetes & Endocrinology news

Cost-Effectiveness of Continuous Glucose Monitoring Combined with Remote Patient Monitoring in Pediatric Type 1 Diabetes

By MedXY 05/03/2026

A landmark simulation study demonstrates that adding remote patient monitoring to continuous glucose monitoring in pediatric T1D patients significantly improves QALYs and is highly cost-effective compared to standard care.