Quantitative CT-Based Mixed Mucus Plug-Emphysema Phenotyping Predicts Exacerbation Risk in COPD: Integrating Imaging Biomarkers for Precision Medicine
Posted inClinical Updates news Radiology Respiratory

Quantitative CT-Based Mixed Mucus Plug-Emphysema Phenotyping Predicts Exacerbation Risk in COPD: Integrating Imaging Biomarkers for Precision Medicine

This review synthesizes recent evidence on quantitative CT markers of mucus plugging and emphysema in COPD, highlighting their combined impact on acute exacerbation risk and clinical heterogeneity, and discusses implications for personalized risk stratification and therapeutic targeting.
Histopathologic Insights in Chronic Rhinosinusitis Linked to Intranasal Substance Use: Implications for Clinical Management
Posted innews Otorhinolaryngology Pathology & Lab Medicine/Bệnh học

Histopathologic Insights in Chronic Rhinosinusitis Linked to Intranasal Substance Use: Implications for Clinical Management

This study reveals distinct histopathologic features in chronic rhinosinusitis patients with intranasal substance use, highlighting increased neutrophilic inflammation and epithelial remodeling, underscoring the need for targeted clinical assessment and postoperative care.
Divergent Microbial Mechanisms and Predictive Signatures in Necrotising Enterocolitis: The Role of Gut Phages and Bacterial Resistomes
Posted inClinical Updates Gastroenterology news

Divergent Microbial Mechanisms and Predictive Signatures in Necrotising Enterocolitis: The Role of Gut Phages and Bacterial Resistomes

This review synthesizes evidence on the predictive and pathogenic roles of gut phages and bacterial resistomes in necrotising enterocolitis, highlighting divergent mechanisms for early- versus late-onset disease and translational opportunities for personalized risk stratification and interventions.
Reevaluating Immune Tolerant Phase in Chronic Hepatitis B: High Transition Rates to Immune Active Disease and Clinical Implications from the RADICAL Consortium
Posted inGastroenterology Infectious Diseases news

Reevaluating Immune Tolerant Phase in Chronic Hepatitis B: High Transition Rates to Immune Active Disease and Clinical Implications from the RADICAL Consortium

The RADICAL consortium's large-scale study reveals a high long-term transition rate from immune tolerant to immune active chronic hepatitis B, especially in patients with high-normal ALT, suggesting the need for closer monitoring and potential early intervention.