Medxy AI – Page 25

Poverty Exposure in Standard-Risk Pediatric B-ALL Is Linked to Steroid-Resistance Programs and an Immunologically Suppressed Leukemia Microenvironment

By MedXY 05/14/2026

Single-cell RNA sequencing suggests that childhood poverty exposure is associated with steroid-resistance signatures in leukemic blasts and adverse immune remodeling at diagnosis in standard-risk B-ALL.

Hematology-Oncology news Pathology & Lab Medicine/Bệnh học

Early ctDNA MRD After Two Cycles Identifies Distinct Relapse Risk Groups in Advanced Hodgkin Lymphoma

By MedXY 05/14/2026

In the GHSG HD21 trial, a validated ctDNA assay showed that MRD positivity after two treatment cycles strongly predicted inferior progression-free survival and improved early risk stratification, especially when combined with interim PET.

Clinical Updates news Pathology & Lab Medicine

Transformative Survival Gains in Cystic Fibrosis: A Population-Level Evaluation of CFTR Modulator Therapy Effectiveness

By MedXY 05/14/2026

A large-scale retrospective study using US CFF Registry data reveals that CFTR modulator therapy reduces the hazard of death by 66% over an eight-year period, marking a significant milestone in cystic fibrosis clinical outcomes and life expectancy.

Critical Care news Respiratory

More Enteral Protein Did Not Overcome Anabolic Resistance in Mechanically Ventilated Critical Illness

By MedXY 05/13/2026

In a randomized trial, a 40 g intraduodenal whey bolus increased amino acid availability but did not significantly raise postprandial muscle protein synthesis versus 20 g in critically ill ventilated adults.

Clinical Updates news Ophthalmology Pediatrics

Persistent Challenges in Managing Monocular Deprivation Amblyopia: A Three-Decade Trend Analysis of Infant Unilateral Cataract Outcomes

By MedXY 05/13/2026

This review evaluates 30 years of clinical outcomes for monocular congenital cataracts, revealing stagnant visual acuity results, high surgical burdens, and significant rates of secondary glaucoma and nystagmus despite surgical advances.

news Ophthalmology

Association of FOXC1 Duplications With Juvenile Open-Angle Glaucoma

By MedXY 05/13/2026

A multicenter study found FOXC1 duplications in multiple glaucoma families, strongly linked to juvenile open-angle glaucoma with high penetrance and variable eye and subtle systemic features, supporting routine copy-number testing in selected patients.

news Ophthalmology

Pigmentary Glaucoma Shows Higher Procedure Use and Worse Early Failure After LTP and MIGS Than Primary Open-Angle Glaucoma

By MedXY 05/13/2026

A large IRIS Registry study found that pigmentary glaucoma undergoes more glaucoma procedures than POAG and has higher early failure after LTP and MIGS, with notable racial differences in disease severity.

General Surgery news Otorhinolaryngology

Systematic V2 Vagal Stimulation Improves Detection of Post-Thyroidectomy Vocal Cord Dysfunction and May Better Guide Staged Surgery

By MedXY 05/13/2026

A 2026 cross-sectional study suggests that routine postdissection vagal stimulation during thyroidectomy detects recurrent laryngeal nerve dysfunction more sensitively than RLN stimulation alone and may reduce the risk of bilateral vocal cord palsy.

AI General Surgery news

ChatGPT Assigned Different Traits to “Great Surgeons” by Race, Gender, and Sexual Orientation, Exposing Stereotypes Relevant to Academic Surgery

By MedXY 05/13/2026

A qualitative study found that ChatGPT 3.5 described “great surgeons” differently by demographic identity, echoing stereotypes that may shape evaluations, leadership perceptions, and inclusion in surgery.

news Public Health

How Historical Redlining and Modern Housing Discrimination Fuel Firearm Violence in Chicago

By MedXY 05/13/2026

A Chicago study found that historical redlining and current housing discrimination are both linked to higher firearm homicide rates in Black neighborhoods, highlighting housing justice as a key violence-prevention strategy.

news OB/GYN & Women’s Health Oncology

Family History Misses Actionable Germline Variants in Many Ovarian Cancer Patients Over 70

By MedXY 05/13/2026

A large real-world registry study shows that ovarian cancer patients aged 70 and older still carry clinically actionable germline variants, often without a reported family history, supporting broader age-inclusive genetic testing.

news OB/GYN & Women’s Health Public Health

Menopausal Hot Flushes and Night Sweats May Be Linked to Retirement: What an Australian Study Found

By MedXY 05/13/2026

A large Australian longitudinal study found that women with both hot flushes and night sweats had slightly higher odds of retirement, suggesting menopausal symptom burden may influence workforce participation.

Clinical Updates news OB/GYN & Women's Health

Optimizing the Second Stage of Labor: The Interplay of Parity, Fetal Position, and Epidural Analgesia on Spontaneous Delivery Success

By MedXY 05/13/2026

This review synthesizes contemporary evidence on the duration of active pushing, highlighting how epidural use, fetal malposition, and parity influence the probability of spontaneous delivery and maternal-neonatal outcomes.

news OB/GYN & Women’s Health

Six Hours May Be Enough for Intrauterine Balloon Tamponade After Postpartum Hemorrhage

By MedXY 05/13/2026

A randomized trial found that 6 hours of intrauterine balloon tamponade was noninferior to 18 hours for controlling postpartum hemorrhage after vaginal delivery, suggesting earlier removal may be reasonable in stable patients.

Gastroenterology news Radiology

Non-contrast abbreviated MRI shows superior accuracy to ultrasound for hepatocellular carcinoma surveillance in cirrhosis: interim prospective trial results

By MedXY 05/13/2026

A prospective trial found that non-contrast abbreviated MRI detected hepatocellular carcinoma in cirrhotic patients far better than ultrasound, with most MRI-detected tumors found at an early, potentially curable stage.

Gastroenterology Neurology news

Sham-Controlled Trial Finds Translumbosacral Neuromodulation May Reduce Fecal Incontinence

By MedXY 05/13/2026

In a sham-controlled trial, translumbosacral neuromodulation with 2400 or 3600 magnetic pulses reduced fecal incontinence episodes, improved severity scores and quality of life, and was well tolerated, with the higher dose showing the strongest benefit.

Neurology news Radiology

Systemic Cardiovascular Factors and Outcomes in Dural Arteriovenous Fistulas: Insights From the CONDOR Registry

By MedXY 05/13/2026

A large international registry study found that hemorrhage in dural arteriovenous fistulas is driven mainly by venous anatomy and lesion grade, not most cardiovascular comorbidities. Surgery was most associated with angiographic cure, and baseline neurological status best predicted 90-day recovery.

Neurology news Public Health

Cerebral “Dirty-Appearing” White Matter and Its Link to Cognitive Decline and Dementia Risk

By MedXY 05/13/2026

In older adults with limited small vessel disease, “dirty-appearing” white matter on MRI was not linked to baseline cognition, cognitive decline, or dementia risk, unlike conventional white matter hyperintensities.

Neurology news

Treatment Discontinuation in Patients With Myelin Oligodendrocyte Glycoprotein Antibody-Associated Disease

By MedXY 05/13/2026

In adults with MOGAD, stopping maintenance therapy was associated with a low 1-year relapse risk, especially after longer treatment and a longer relapse-free interval. The findings support individualized decisions and close follow-up after discontinuation.

Emergency Medicine Neurology news

DISTAL at 12 Months: No Functional or Survival Advantage for Endovascular Therapy in Mild-to-Moderate Medium or Distal Vessel Occlusion Stroke

By MedXY 05/13/2026

The DISTAL trial found no 12-month disability or survival benefit from adding endovascular treatment to best medical therapy in mild-to-moderate medium or distal vessel occlusion stroke.

Poverty Exposure in Standard-Risk Pediatric B-ALL Is Linked to Steroid-Resistance Programs and an Immunologically Suppressed Leukemia Microenvironment

Early ctDNA MRD After Two Cycles Identifies Distinct Relapse Risk Groups in Advanced Hodgkin Lymphoma

Transformative Survival Gains in Cystic Fibrosis: A Population-Level Evaluation of CFTR Modulator Therapy Effectiveness

More Enteral Protein Did Not Overcome Anabolic Resistance in Mechanically Ventilated Critical Illness

Persistent Challenges in Managing Monocular Deprivation Amblyopia: A Three-Decade Trend Analysis of Infant Unilateral Cataract Outcomes

Association of FOXC1 Duplications With Juvenile Open-Angle Glaucoma

Pigmentary Glaucoma Shows Higher Procedure Use and Worse Early Failure After LTP and MIGS Than Primary Open-Angle Glaucoma

Systematic V2 Vagal Stimulation Improves Detection of Post-Thyroidectomy Vocal Cord Dysfunction and May Better Guide Staged Surgery

ChatGPT Assigned Different Traits to “Great Surgeons” by Race, Gender, and Sexual Orientation, Exposing Stereotypes Relevant to Academic Surgery

How Historical Redlining and Modern Housing Discrimination Fuel Firearm Violence in Chicago

Family History Misses Actionable Germline Variants in Many Ovarian Cancer Patients Over 70

Menopausal Hot Flushes and Night Sweats May Be Linked to Retirement: What an Australian Study Found

Optimizing the Second Stage of Labor: The Interplay of Parity, Fetal Position, and Epidural Analgesia on Spontaneous Delivery Success

Six Hours May Be Enough for Intrauterine Balloon Tamponade After Postpartum Hemorrhage

Non-contrast abbreviated MRI shows superior accuracy to ultrasound for hepatocellular carcinoma surveillance in cirrhosis: interim prospective trial results

Sham-Controlled Trial Finds Translumbosacral Neuromodulation May Reduce Fecal Incontinence

Systemic Cardiovascular Factors and Outcomes in Dural Arteriovenous Fistulas: Insights From the CONDOR Registry

Cerebral “Dirty-Appearing” White Matter and Its Link to Cognitive Decline and Dementia Risk

Treatment Discontinuation in Patients With Myelin Oligodendrocyte Glycoprotein Antibody-Associated Disease

DISTAL at 12 Months: No Functional or Survival Advantage for Endovascular Therapy in Mild-to-Moderate Medium or Distal Vessel Occlusion Stroke

Comparative 1-Year Outcomes of Semaglutide, Tirzepatide, and Sleeve Gastrectomy in Obese Adults with Type 2 Diabetes: Insights from Real-World Data

Unveiling the Phenotype of Unclassified Pulmonary Hypertension: A Hidden Spectrum of Early Heart Failure with Preserved Ejection Fraction

Biomarker, Functional Status, and Quality-of-Life Trajectories Before Modes of Death in Heart Failure: Post Hoc Analysis of the FINEARTS-HF Randomized Clinical Trial

Decoding SLC4A3 Mutations in Short QT Syndrome: Insights from hiPSC-Derived Cardiomyocytes into Ventricular Arrhythmia and Sudden Cardiac Death