Pediatrics – Page 4

Neurological Effects and Safety of Encapsulated Dexamethasone Sodium Phosphate in Pediatric Ataxia Telangiectasia: Insights from the NEAT Phase 3 Trial

By MedXY 08/17/2026

The NEAT phase 3 trial evaluated erythrocyte-encapsulated dexamethasone sodium phosphate in children with ataxia telangiectasia aged 6–9 years, confirming safety but failing to demonstrate statistically significant neurological improvement over placebo.

Infectious Diseases news Pediatrics

Distinct Symptom Profiles and Outcomes of Respiratory Pathogens in Young US Children: Insights From a 2019-2025 Cohort Study

By MedXY 08/17/2026

This longitudinal study characterizes symptom variability and outcomes of respiratory infections among young children, revealing age-specific severity patterns and notable differences between influenza A and B.

news Ophthalmology Pediatrics

Neurodevelopmental Outcomes of Anti-VEGF versus Laser Photocoagulation for Retinopathy of Prematurity: Insights from a Comprehensive Review by the American Academy of Ophthalmology

By MedXY 08/17/2026

This review synthesizes current evidence on neurodevelopmental outcomes after treating retinopathy of prematurity with anti-VEGF injections versus laser photocoagulation, finding no significant differences in long-term cognitive or developmental effects.

news Oncology Pediatrics

Long-Term Risk of Second Primary Malignancies in Pediatric and Young Adult Differentiated Thyroid Cancer Survivors: A Four-Decade Real-World Study

By MedXY 08/17/2026

Pediatric and young adult survivors of differentiated thyroid cancer face a significant long-term risk of second primary malignancies, especially with radioactive iodine treatment, highlighting the need for extended surveillance and tailored therapy.

news OB/GYN & Women’s Health Pediatrics

Minimally Invasive Fetoscopic Repair of Spina Bifida Using Human Umbilical Cord Meningeal Patch: A Feasibility Study

By MedXY 08/16/2026

This nonrandomized clinical trial demonstrates the surgical feasibility of fetoscopic spina bifida repair using a human umbilical cord meningeal patch, showing comparable perinatal outcomes to open repair while enabling vaginal delivery and potentially reducing maternal morbidity.

Clinical Updates news Pediatrics Psychiatry

Smartphone Acquisition at Age 13 and Its Impact on Adolescent Depression, Obesity, and Sleep: A Cohort Evidence Synthesis

By MedXY 08/16/2026

This review synthesizes evidence linking smartphone acquisition and use at age 13 to depression, obesity, and sleep insufficiency at age 14, highlighting that use intensity rather than mere acquisition mediates health risks, with behavioral strategies mitigating adverse outcomes.

news OB/GYN & Women’s Health Pediatrics

Long-Term Safety of Prenatal 17-Alpha-Hydroxyprogesterone Caproate in Twins: A 14-Year Follow-Up Study

By MedXY 08/15/2026

A 14-year follow-up of twins exposed prenatally to 17-OHPC shows no significant effects on mortality, cognition, or development, indicating its long-term safety in multiple pregnancies.

Diabetes & Endocrinology news Pediatrics

Extra-Endocrine Features in Infancy as Early Clues to Multiple Endocrine Neoplasia Type 2B: A Case Series from Bambino Gesù Children’s Hospital

By MedXY 08/14/2026

We report five pediatric MEN2B cases highlighting early extra-endocrine signs such as persistent constipation and alacrimia, enabling prompt genetic diagnosis and thyroidectomy before medullary thyroid carcinoma progression.

Emergency Medicine news Pediatrics

Agency-Level Variability in Futility Determinations and Termination of Resuscitation for Pediatric Out-of-Hospital Cardiac Arrest

By MedXY 08/14/2026

A national study reveals significant variability across EMS agencies in decisions about resuscitation futility and termination for pediatric out-of-hospital cardiac arrests, highlighting critical impacts on care and outcomes.

news Pediatrics

Early Exclusive Enteral Feeding in Preterm Infants: Assessing Safety and Benefits through Meta-Analysis

By MedXY 08/14/2026

Early exclusive enteral feeding in preterm infants is associated with faster feeding advancement and shorter hospital stay without increased risks of necrotizing enterocolitis or infection, suggesting it is a feasible and beneficial nutritional strategy.

Diabetes & Endocrinology news Pediatrics

Vosoritide Shows Promising Growth Benefits in Children with RASopathies and Related Genetic Short Stature Disorders

By MedXY 08/13/2026

A phase II basket trial demonstrates that vosoritide significantly increases growth velocity in children with RASopathies, ACAN, and NPR2 deficiencies, with an acceptable short-term safety profile, suggesting its potential as a precision therapy targeting MAPK pathway growth disorders.

Clinical Updates news Ophthalmology Pediatrics

Efficacy and Safety of Dual-Sided Composite Defocus Spectacles for Pediatric Myopia Control: A Comprehensive Evidence Review

By MedXY 08/12/2026

This review synthesizes evidence on dual-sided composite defocus (DSCD) spectacle lenses, demonstrating significant myopia progression reduction and axial elongation control in children, contextualized within broader spectacle-based interventions and mechanistic insights.

Gastroenterology news Pediatrics

Neutralising Autoantibodies against IL-10 Linked to Severe Pediatric Inflammatory Bowel Disease and HLA-DRB1*01:03 Allele

By MedXY 08/12/2026

A multicategory study reveals 2.5% of pediatric IBD patients harbor IL-10-neutralising autoantibodies associated with severe disease and HLA-DRB1*01:03 allele, underscoring a distinct pathogenic subgroup.

Hematology-Oncology news Pediatrics

Early Inflammatory Complications After Pediatric Haploidentical HSCT with Post-Transplant Cyclophosphamide: Clinical Impact and Risk Factors

By MedXY 08/11/2026

This multicenter study identifies peripheral blood stem cell use as a key risk factor for early inflammatory complications post-haploidentical HSCT in children, linking these events to refractory acute and chronic graft-versus-host disease.

Diabetes & Endocrinology news Pediatrics

Temple Syndrome: Unveiling a Hidden Multi-System Growth Disorder and Introducing a New Diagnostic Score

By MedXY 08/11/2026

Temple syndrome is an under-recognised imprinting disorder with complex endocrine and growth abnormalities. This large-cohort study clarifies its phenotype, highlights growth hormone therapy benefits, and proposes a novel clinical scoring system to enable earlier diagnosis and tailored management.

Critical Care news Pediatrics

Ultrasound-Guided Brachiocephalic Venipuncture for Neonatal Central Venous Access: A Multicenter Study Validating Safety and Feasibility

By MedXY 08/10/2026

This multicenter observational study demonstrates that ultrasound-guided supraclavicular brachiocephalic vein cannulation is a feasible, safe, and reproducible method for central venous catheter placement in critically ill neonates, with a high first-attempt success and low complication rates.

Clinical Updates news Otorhinolaryngology Pediatrics

Team Behavior and Patient Outcome Changes Following Human Factors Training in Pediatric Airway Endoscopy: A Review of Evidence and Clinical Implications

By MedXY 08/09/2026

A multimodal human factors program enhances team communication, nontechnical skills, and workflow during pediatric airway endoscopy, supporting OR culture change despite unchanged immediate clinical outcomes.

news Otorhinolaryngology Pediatrics

Longitudinal Voice Changes in Transmasculine Adolescents and Young Adults Undergoing Testosterone Therapy: Insights from a Prospective Cohort Study

By MedXY 08/09/2026

This study prospectively characterizes voice changes over 12 months in transmasculine adolescents and young adults receiving testosterone therapy, demonstrating significant lowering of pitch, improved voice congruence, and reduced anxiety, thereby informing gender-affirming voice care.

Diabetes & Endocrinology news Pediatrics

Balancing Benefits and Risks: Prophylactic Thyroidectomy Outcomes in Pediatric MEN2 Patients

By MedXY 08/09/2026

Prophylactic thyroidectomy in children with MEN2 mutations shows excellent short-term cancer control but carries notable risk of permanent hypoparathyroidism, especially under age 5, highlighting the need for expert multidisciplinary surgical timing.

Diabetes & Endocrinology news Pediatrics

Early Identification and Monitoring of At-Risk Children Significantly Improves Outcomes in Type 1 Diabetes

By MedXY 08/08/2026

Population-based genetic screening and prospective follow-up of at-risk children reduce the severity of type 1 diabetes at diagnosis and enhance one-year treatment outcomes, including lower HbA1c and insulin requirements.